Fluorocarbon-based injectable gaseous microbubbles for diagnosis and therapy

Current Opinion in Colloid and Interface Science

Volumn 8, Issue 3, 2003, Pages 259-266

  Riess, Jean G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Diagnostic imaging; Drug delivery; Echocardiography; Gene delivery; Microbubble stabilization; Molecular imaging; Perfluorocarbon; Radiology; Targeting; Ultrasound contrast agent

Indexed keywords

FLUOROCARBONS; IMAGING TECHNIQUES;

MICROBUBBLES;

BUBBLES (IN FLUIDS);

ADENOVIRUS VECTOR; AI 700; BR 14; CONTRAST MEDIUM; ECHO CONTRAST MEDIUM; FIBRINOLYTIC AGENT; FLUORINE BUTANE EXPOSED SONICATED DEXTROSE ALBUMIN; FLUOROCARBON; FS 069; MACROGOL; MACROGOL DERIVATIVE; MICROBUBBLE AGENT; MP 1950; MRX 408; NAKED DNA; NC 100100; PACLITAXEL; PERFLUOROOCTYL BROMIDE; PERFLUTREN; POLYAMIDE; SONOVUE; STABILIZING AGENT; UNCLASSIFIED DRUG; UROKINASE;

ANGIOGENESIS; ATHEROSCLEROTIC PLAQUE; BLOOD FLOW; CARDIOVASCULAR MALFORMATION; COMMERCIAL PHENOMENA; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG FORMULATION; DRUG TARGETING; ECHOCARDIOGRAPHY; ECHOGRAPHY; GENE DELIVERY SYSTEM; GENE TARGETING; HUMAN; INFLAMMATION; NONHUMAN; ORGAN INJURY; REVIEW; SIDE EFFECT; THROMBUS; TISSUE PERFUSION; TUMOR; TUMOR GROWTH;

EID: 0042574192     PISSN: 13590294     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-0294(03)00047-5     Document Type: Review

References (102)

1. Thomsen HS, Muller R, Mattrey RF, editors. Medical Radiology-Diagnostic Imaging and Radiation Oncology Series. Berlin: Springer Verlag, 1999.
2. Mulvagh SL, DeMaria AN, Feinstein SB, Burns PN, Kaul S, Miller JG, et al. Contrast echography: Current and future applications. J Am Soc Echocardiogr 2000;13:331-42.
3. Becher H, Burns PN. Handbook of Contrast Echocardiography-Left Ventricular Function and Myocardial Perfusion. Berlin: Springer Verlag, 2000.
4. Goldberg BB, Raichlen JS, Forsberg F, editors. 2nd ed. Ultrasound Contrast Agents-Basic Principles and Clinical Applications. London: Martin Dunitz, 2001.
5. Schutt, ES, Klein, DH, Mattrey, RM, Riess, JG. Injectable microbubbles as contrast agents for diagnostic ultrasound imaging: The key role of perfluorochemicals. Angew Chem Int Ed, 42, (2003) in press.
6. Krafft MP. Fluorocarbons and fluorinated amphiphiles in drug delivery and biomedical research. Adv Drug Deliv Rev 2001;47:209-28.
7. Riess JG. Injectable oxygen carriers (blood substitutes)-Raison d'être, chemistry, and some physiology. Chem Rev 2001;101:2797-920.
8. Riess JG. Fluorous micro- and nanophases with a biomedical perspective. Tetrahedron 2002;58:4113-31.
9. Riess, JG. Biomedical applications of fluorous materials. In: Gladysz, JA, Curran, DP, Horváth, I editors. Handbook of Fluorous Chemistry. Weinheim: Wiley-VCH, 2003. in press.
10. Van Liew HD, Burkard ME. Behavior of bubbles of slowly permeating gas used for ultrasonic imaging contrast. Invest Radiol 1995;30:315-21.
11. Van Liew HD, Raychaudhuri S. Stabilized bubbles in the body: Pressure-radius relationships and the limits of stabilization. J Appl Physiol 1997;82:2045-53.
12. Kabalnov A, Klein D, Pelura T, Schutt E, Weers J. Dissolution of multicomponent microbubbles in the blood stream: 1. Theory. Ultrasound Med Biol 1998;24:739-49.
13. Kabalnov A, Bradley J, Flaim S, Klein D, Pelura T, Peters B, et al. Dissolution of multicomponent microbubbles in the blood stream: 2. Experiment. Ultrasound Med Biol 1998;24:751-60.
14. Forsberg F, Basude R, Liu J-B, Alessandro J, Shi WT, Rawool NM, et al. Effect of filling gases on the backscatter from contrast microbubbles: Theory and in vivo measurements. Ultrasound Med Biol 1999;25:1203-11.
15. Fisher NG, Christiansen JP, Klibanov A, Taylor RP, Kaul S, Lindner JR. Influence of microbubble surface charge on capillary transit and myocardial contrast enhancement. J Am Coll Cardiol 2002;40:811-9.
16. Hancock J, Dittrich H, Lewitt DE, Monaghan MJ. Evaluation of myocardial, hepatic, and renal perfusion in a variety of clinical conditions using an intravenous ultrasound contrast agent (Optison) and second harmonic imaging. Heart 1999;81:636-41.
17. Cwajg J, Xie F, O'Leary E, Kricsfeld D, Dittrich H, Porter TR. Detection of angiographically significant coronary artery disease with accelerated intermittent imaging after intravenous administration of ultrasound contrast material. Am Heart J 2000;139:675-83.
18. Wilson SR, Burns PN, Muradali D, Wilson JA, Lai X. Harmonic hepatic US with microbubble contrast agent: Initial experience showing improved characterization of hemangioma, hepatocellular carcinoma, and metastasis. Radiology 2000;215:153-61.
19. Reilly JP, Tunick PA, Timmermans RJ, Stein B, Rosenzweig BR, Kronzon I. Contrast echocardiography clarifies uninterpretable wall motion in intensive care patients. J Am Coll Cardiol 2000;35:485-90.
20. Swinburn JMA, Lahiri A, Senior R. Intravenous myocardial contrast echocardiography predicts recovery of dysynergic myocardium early after acute myocardial infarction. J Am Coll Cardiol 2001;38:19-25.
21. Seidel G, Meyer K, Metzler V, Toth D, Vida-Langwasser M, Aach T. Human cerebral perfusion analysis with ultrasound contrast agent constant infusion: A pilot study on healthy volunteers. Ultrasound Med Biol 2002;28:183-9.
22. Fritz TA, Unger EC, Sutherland G, Sahn D. Phase I clinical trials of MRX-115: A new ultrasound contrast agent. Invest Radiol 1997;32:735-40.
23. Tiemann K, Lohmeier S, Kuntz S, Köster J, Pohl C, Burnns P, et al. Real-time contrast echo assessment of myocardial perfusion at low emission power. Echocardiography 1999;16:799-809.
24. Maruyama H, Matsutani S, Saisho H, Kamiyama N, Yuki H, Miyata K. Grey-scale contrast enhancement in rabbit liver with DMP115 at different acoustic power levels. Ultrasound Med Biol 2000;26:1429-38.
25. Madjar H, Prömpeler HJ, DelFavero C, Hackelöer BJ, Llull JB. A new Doppler signal enhancing agent for flow assessment in breast lesions. Europ J Ultrasound 2000;12:123-30.
26. Senior R, Adersson O, Caidahll K, Carlens P, Herregods MC, Jenni R, et al. Enhanced left ventricular endocardial border delineation with an intravenous injection of SonoVue, a new echocardiographic contrast agent. Echocardiography 2000;17:705-11.
27. Bokor D, Chambers JB, Rees PJ, Mant TGK, Luzzani F, Spinazzi A. Clinical safety of SonoVue™, a new contrast agent for ultrasound imaging, in healthy volunteers and in patients with chronic obstructive pulmonary disease. Invest Radiol 2001;36:104-9.
28. Lafitte S, Higashiyama A, Masugata H, Peters B, Strachan M, Kwan OL, et al. Contrast echocardiography can assess risk area and infarct size during coronary occlusion and reperfusion: Experimental validation. J Am Coll Cardiol 2002;39:1546-54.
29. Forsberg F, Liu JB, Chiou HJ, Rawool NM, Parker L, Goldberg BB. Comparison of fundamental and wideband harmonic contrast imaging of liver tumors. Ultrasonics 2000;38:110-3.
30. Halper EJ, Verkh L, Forsberg F, Gomella LG, Mattrey RF, Goldberg BB. Initial experience with contrast-enhanced sonography of the prostate. Am J Roentgenol 2000;174:1575-80.
31. Taylor GA. Potential pediatric applications for US contrast agents: Lessons from the laboratory. Pediatr Radiol 2000;30:101-9.
32. Sirlin CB, Lee YZ, Girard MS, Peterson TM, Steinbach GC, Baker KG, et al. Contrast-enhanced B-mode US angiography in the assessment of experimental in vivo and in vitro atherosclerotic disease. Acad Radiol 2001;8:162-72.
33. Galiuto L, May-Newman K, Del Balzo U, Flaim SF, Iliceto S, DeMaria AN. Assessment of coronary stenoses of graded severity by myocardial contrast echocardiography. J Am Soc Echocardiogr 2002;1:197-205.
34. Correas J-M, Meuter AR, Singlas E, Kessler DR, Worah D, Quay SC. Human pharmacokinetics of a perfluorocarbon ultrasound contrast agent evaluated with gas chromatography. Ultrasound Med Biol 2001;27:565-70.
35. Porter TR, Li S, Jiang L, Grayburn P, Deligonul U. Real-time visualization of myocardial perfusion and wall thickening in human beings with intravenous ultrasonographic contrast and accelerated intermittent harmonic imaging. J Am Soc Echocardiogr 1999;12:266-70.
36. Rocchi G, Kasprzak JD, Galema TW, De Jong T, Ten Cate FJ. Usefulness of power Doppler contrast echocardiography to identify reperfusion after acute myocardial infarction. Am J Cardiol 2001;87:278-82.
37. Ronderos RE, Boskis M, Chung N, Corneli DB, Escudero EM, Ha JW, et al. Correlation between myocardial perfusion abnormalities detected with intermittent imaging using intravenous perfluorocarbon microbubbles and radioisotope imaging during high-dose dipyridamole stress echo. Clin Cardiol 2002;25:103-11.
38. Picard M, Pandian N, Morcerf F, Wackers F, Udelson JE, Weissman N, et al. The effects of AI-700 echo-contrast perfusion and/or wall motion imaging on detection of perfusion defects in patients with coronary artery disease. J Am Soc Echocardiogr 2001;14:460.
39. Seidel G, Meyer K, Algermissen C, Broillet A. Harmonic imaging of the brain parenchyma using a perfluorobutane-containing ultrasound contrast agent. Ultrasound Med Biol 2001;27:915-8.
40. Fisher NG, Christiansen JP, Leong-Poi H, Jayaweera AR, Linder JR, Kaul S. Myocardial and microcirculatory kinetics of BR14, a novel third-generation intravenous ultrasound contrast agent. J Am Coll Cardiol 2002;39:530-7.
41. Fisher NG, Leong-Poi H, Sakuma T, Ri S-J, Bin JP. Detection of coronary stenosis and myocardial viability using a single intravenous bolus injection of BR14. J Am Colloid Cardiol 2002;39:523-9.
42. Liu J-B, Meron DA, Goldberg BB, Rawool NM, Shi WT, Forsberg F. Contrast-enhanced two- and three-dimensional sonography for evaluation of intra-abdominal hemorrhage. J Ultrasound Med 2002;21:161-9.
43. Dayton PA, Chomas JE, Lum AFH, Allen JS, Lindner JR, Simon SI, et al. Optical and acoustical dynamics of microbubble contrast agents inside neutrophils. Biophys J 2001;80:1547-56.
44. Klibanov AL. Ultrasound contrast agents: Development of the field and current status. Topics Curr Chem 2002;222:73-106.
45. Burns PN. Harmonic imaging with ultrasound contrast agents. Clin Radiol 1996;51(Suppl. 1):50-5.
46. Krishna PD, Newhouse VL. Second harmonic characteristics of the ultrasound contrast agents Albunex and FSO69. Ultrasound Med Biol 1997;23:453-9.
47. Burns PN, Wilson SR, Simpson DH. Pulse inversion imaging of liver blood flow. Invest Radiol 2000;35:58-71.
48. Girard MS, Mattrey RF, Baker KG, Peterson T, Deiranieh LH, Steinbach GC. Comparison of standard and second harmonic B-mode sonography in the detection of segmental renal infarction with sonographic contrast in a rabbit model. J Ultrasound Med 2000;19:185-92.
49. De Jong N, Bouakaz A, Ten Cate FJ. Contrast harmonic imaging. Ultrasonics 2002;40:567-73.
50. Dayton PA, Morgan KE, Klibanov AL, Brandenburger GH, Ferrara KW. Optical and acoustical observations of the effects of ultrasound on contrast agents. IEEE Trans Ultrasonics Ferroelectrics Frequency Control 1999;46:220-32.
51. Chin CT, Burns PN. Predicting the acoustic response of a microbubble population for contrast imaging in medical ultrasound. Ultrasound Med Biol 2000;26:1293-300.
52. Sboros V, MacDonald CA, Pye SD, Moran CM, Gomatam J, McDicken WN. The dependence of ultrasound contrast agents backscatter on acoustic pressure: Theory vs. experiment. Ultrasonics 2002;40:579-83.
53. Chomas JE, Dayton PA, May D, Allen J, Klibanov A, Ferrara K. Optical observation of contrast agent destruction. Appl Phys Lett 2000;77:1056-8.
54. Wei K, Jayaweera AR, Firoozan S, Linka A, Skyba DM, Kaul S. Quantification of myocardial blood flow with ultrasound-induced destruction of microbubbles administered as a constant venous infusion. Circulation 1998;97:473-83.
55. Skyba DM, Price RJ, Linka AZ, Skalak TC, Kaul S. Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue. Circulation 1998;98:290-3.
56. Ay T, Havaux X, Van Camp G, Campanelli B, Gisellu G, Pasquet A, et al. Destruction of contrast microbubbles by ultrasound: Effect on myocardial function, coronary perfusion pressure, and microvascular integrity. Circulation 2001;104:461-6.
57. Hilgenfeldt S, Lohse D. The acoustics of diagnostic microbubbles: Dissipative effects and heat deposition. Ultrasonics 2000;38:99-104.
58. Moran CM, Anderson T, Pye SD, Sboros V, McDicken WN. Quantification of microbubble destruction of three fluorocarbon-filled ultrasonic contrast agents. Ultrasound Med Biol 2000;26:629-39.
59. Veltmann C, Lohmaier S, Schlosser T, Shai S, Ehlgen A, Pohl C, et al. On the design of a capillary flow phantom for the evaluation of ultrasound contrast agents at very low flow velocities. Ultrasound Med Biol 2002;28:625-34.
60. Masugata H, Peters B, Lafitte S, Stachan GM, Ohmori K, DeMaria AN. Quantitative assessment of myocardial perfusion during graded coronary stenosis by real-time myocardial contrast echo refilling curves. J Am Coll Cardiol 2001;37:262-9.
61. Porter TR, Xie F. Clinical experience in the detection of coronary artery disease with myocardial contrast echocardiography. Echocardiography 2002;19:399-407.
62. Main ML, Magalski A, Chee NK, Coen MM, Skolnick DG, Good TH. Full-motion pulse inversion power Doppler contrast echocardiography differentiates stunning from necrosis and predicts recovery of left ventricular function after acute myocardial infarction. J Am Coll Cardiol 2001;38:1390-4.
63. Amyot R, Morales M-A, Rovai D. Contrast echocardiography for myocardial perfusion imaging using intravenous agents: Progress and promises. Eur J Echocardiogr 2000;1:233-43.
64. Wei K, Le E, Bin J-P, Coggins M, Thorpe J, Kaul S. Quantification of renal blood flow. J Am Soc Cardiol 2001;37:1135-40.
65. Foster FS, Burns PN, Simpson DH, Wilson SR, Christopher DA, Goertz DE. Ultrasound for the visualization and quantification of tumor microcirculation. Cancer Metastasis Rev 2000;19:131-8.
66. Iordanescu I, Becker C, Zetter B, Dunning P, Taylor GA. Tumor vascularity: Evaluation in a murine model with contrast-enhanced color Doppler US - Effect of angiogenesis inhibitors. Radiology 2002;222:460-7.
67. Seidel G, Claassen L, Meyer K, Vidal-Langwasser M. Evaluation of blood flow in the cerebral microcirculation: Analysis of the refill kinetics during ultrasound contrast agent infusion. Ultrasound Med Biol 2001;27:1059-64.
68. Ferrara KW, Merritt CRB, Burns PN, Foster FS, Mattrey RF, Wickline SA. Evaluation of tumor angiogenesis with US: Imaging, Doppler, and contrast agents. Acad Radiol 2000;7:824-39.
69. Lindner JR. Evolving applications for contrast ultrasound. Am J Cardiol 2002;90(suppl):72J-80.
70. Dayton PA, Ferrara KW. Targeted imaging using ultrasound. J Magn Res Imaging 2002;16:362-77.
71. Kono Y, Steinbach GC, Peterson T, Schmid-Schöenbein GW, Mattrey RF. Mechanism of parenchymal enhancement of the liver with a microbubble-based US contrast medium: An intravital microscopy study in rats. Radiology 2002;224:253-7.
72. Lindner JR, Coggins MP, Kaul S, Klibanov AL, Brandenburger GH, Ley K. Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes. Circulation 2000;101:668-75.
73. Lindner JR, Dayton PA, Coggins MP, Ley K, Song J, Ferrara K, et al. Noninvasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles. Circulation 2000;102:531-8.
74. Lindner JR, Song J, Xu F, Klibanov AL, Singbartl K, Ley K, et al. Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes. Circulation 2000;102:2745-50.
75. Christiansen JP, Leong-Poi H, Klibanov AL, Sanjiv K, Lindner JR. Noninvasive imaging of myocardial reperfusion injury using leukocyte-targeted contrast echocardiography. Circulation 2002;105:1764-7.
76. Kim DH, Klibanov AL, Needham D. The influence of tiered layers of surface-grafted poly(ethylene glycol) on receptor-ligand-mediated adhesion between phospholipid monolayer-stabilized microbubbles and coated glass beads. Langmuir 2000;16:2808-17.
77. Villanueva FS, Jankowski RJ, Klibanov S, Pina ML, Alber SM, Watkins SC, et al. Microbubbles targeted to intercellular adhesion molecule-1 bind to activated coronary artery endothelial cells. Circulation 1998;98:1-5.
78. Lindner JR, Song J, Christiansen J, Klibanov AL, Xu F, Ley K. Ultrasound assessment of inflammation and renal tissue injury with microbubbles targeted to P-selectin. Circulation 2001;104:2107-12.
79. Wu Y, Unger EC, McCreery TP, Sweitzer RH, Shen D, Wu G, et al. Binding and lysing of blood clots using MRX-408. Invest Radiol 1998;33:880-5.
80. Takeuchi M, Ogunyankin K, Pandian NC, McCreery TP, Sweitzer RH, Caldwell VE, et al. Enhanced visualization of intravascular and left atrial appendage thrombus with the use of a thrombus-targeting ultrasonographic contrast agent (MRX-408A1): In vivo experimental echographic studies. J Am Soc Echocardiogr 1999;12:1015-21.
81. Schumann PA, Christiansen JP, Quigley RM, McCreery TP, Schweitzer RH, Unger EC, et al. Targeted-microbubble binding selectively to GPIIb IIIa receptors of platelet thrombi. Invest Radiol 2002;37:587-93.
82. v-integrins. Circulation 2003;107:455-60.
83. Porter TR, LeVeen RF, Fox R, Kricsfeld A, Xie F. Thrombolytic enhancement with perfluorocarbon-exposed sonicated dextrose albumin microbubbles. Am Heart J 1996;132:964-8.
84. Dhond MR, Nguyen TT, Dolan C, Pulido G, Bommer WJ. Ultrasound-enhanced thrombolysis at 20 kHz with air-filled and perfluorocarbon-filled contrast bispheres. J Am Soc Echocardiogr 2000;13:1025-9.
85. Price RJ, Skyba DM, Kaul S, Skalak TC. Delivery of colloidal particles and red blood cells to tissue through microvessel ruptures created by targeted microbubble destruction with ultrasound. Circulation 1998;98:1264-7.
86. Miller DL, Quddus J. Sonoporation of monolayer cells by diagnostic ultrasound activation of contrast-agent gas bodies. Ultrasound Med Biol 2000;26:661-7.
87. Ward M, Wu J, Chiu J-F. Experimental study of the effects of Optison concentration on sonoporation in vitro. Ultrasound Med Biol 2000;26:1169-75.
88. Porter TP, Iversen PL, Li S, Xie F. Interaction of diagnostic ultrasound with synthetic oligonucleotide-labeled perfluorocarbon-exposed sonicated dextrose albumin microbubbles. J Ultrasound Med 1996;15:577-84.
89. Unger EC, McCreery TP, Sweitzer RH, Caldwell VE, Wu Y. Acoustically active lipospheres containing paclitaxel. A new therapeutic ultrasound contrast agent. Invest Radiol 1998;33:886-92.
90. Van Liew HD, Burkard ME. High oxygen partial pressure in tissue delivered by stabilized microbubbles. Adv Exp Med Biol 1997;411:395-401.
91. Lundgren CEG, Bergoe GW, Tyssebotn, I. In: Syllabus, 4th International Symposium on Current Issues in Blood Substitute Research, Stockholm, July 2002. p. 40.
92. Unger EC, Hersh E, Vannan M, Matsunaga TO, McCreery T. Local drug and gene delivery through microbubbles. Prog Cardiovasc Dis 2001;44:45-54.
93. Greenleaf WJ, Bolander ME, Sarkar G, Goldring MB, Greenleaf JF. Artificial cavitation nuclei significantly enhance acoustically induced cell transfection. Ultrasound Med Biol 1998;24:587-95.
94. Vannan M, McCreery T, Li P, Han Z, Unger E, Kuersten B, et al. Ultrasound-mediated transfections of canine myocardium by intravenous administration of cationic microbubble-linked plasmid DNA. J Am Soc Echocardiogr 2002;15:214-8.
95. Shohet RV, Chen S, Zhou Y-T, Wang Z, Meidell RS, Unger RH, et al. Echocardiographic destruction of albumin microbubbles directs gene delivery to the myocardium. Circulation 2000;101:2554-6.
96. Lawrie A, Brisken AF, Francis SE, Cumberland DC, Crossman DC, Newman CM. Microbubble-enhanced ultrasound for vascular gene delivery. Gene Therapy 2000;7:2023-7.
97. Endoh M, Koibucchi N, Sato M, Morishita R, Kanzaki T, Murata Y, et al. Fetal gene transfer by intrauterine injection with microbubble-enhanced ultrasound. Mol Therapy 2002;5:501-8.
98. Frenkel PA, Chen S, Thai T, Shohet RV, Grayburn PA. DNA-loaded albumin microbubbles enhance ultrasound-mediated transfection in vitro. Ultrasound Med Biol 2002;28;817-22.
99. Beeri R, Guerrero JL, Supple G, Sullivan S, Levine RA, Hajjar RJ. New efficient catheter-based system for myocardial gene delivery. Circulation 2002;106:1756-9.
100. Tachibana K, Uchida T, Ogawa K, Yamashita N, Tamura K. Induction of cell-membrane porosity by ultrasound. Lancet 1999;353:1409.
101. Koch S, Pohl P, Cobet U, Rainov NG. Ultrasound enhancement of liposome-mediated cell transfection is caused by cavitation effects. Ultrasound Med Biol 2000;26:897-903.
102. Shaw LJ, Monaghan MJ, Nihoyannopoulos P. Clinical and economic outcomes assessment with myocardial contrast echocardiography. Heart 1999;82(suppl. III):III16-III21.