Noninvasive imaging of myocardial reperfusion injury using leukocyte-targeted contrast echocardiography

Circulation

Volumn 105, Issue 15, 2002, Pages 1764-1767

  Christiansen, Jonathan P ^a   Leong Poi, Howard ^a   Klibanov, Alexander L ^a   Kaul, Sanjiv ^a   Lindner, Jonathan R ^a  

^a UNIVERSITY OF VIRGINIA MEDICAL CENTER   (United States)

Author keywords

Echocardiography; Inflammation; Schemia

Indexed keywords

MYELOPEROXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTRAST ECHOCARDIOGRAPHY; CONTROLLED STUDY; CORONARY ARTERY CIRCUMFLEX BRANCH; CORRELATION ANALYSIS; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DISEASE SEVERITY; DOG; ENZYME ACTIVITY; HEART INFARCTION; HEART PERFUSION; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LEUKOCYTE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REPERFUSION INJURY; SCINTISCANNING;

ANIMALS; DOGS; ECHOCARDIOGRAPHY; INFLAMMATION; KINETICS; LEUKOCYTES; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PEROXIDASE;

EID: 0037117659     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000015466.89771.E2     Document Type: Article

References (11)

1. Role of leukocytes in response to acute myocardial ischemia and reflow in dogs
2. Quantification of neutrophil migration following myocardial ischemia and reperfusion in cats and dogs
3. Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog
4. Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation: Integrin- and complement-mediated adherence to activated leukocytes
5. Noninvasive imaging of inflammation by ultrasound detection of phagocytosed microbubbles
6. Noninvasive ultrasound imaging of inflammation using microbubbles targeted to activated leukocytes
7. Noninvasive prediction of ultimate infarct size at the time of coronary occlusion based on the extent and magnitude of collateral-derived myocardial blood flow
8. 99mTc-RP517, a new imaging agent that targets activated neutrophils in vivo
9. Role of leukocytes in acute myocardial infarction in anesthetized dogs: Relationship to myocardial salvage by anti-inflammatory drugs
10. Neutrophil accumulation in ischemic myocardium: Insights into time course, distribution, and mechanism of localization during early reperfusion
11. Coronary reserve abnormalities in the infarcted myocardium: Assessment of myocardial viability immediately versus late after reflow by contrast echocardiography