Investigation of the induced-fit mechanism and catalytic activity of the human cytomegalovirus protease homodimer via molecular dynamics simulations

Proteins: Structure, Function and Genetics

Volumn 52, Issue 4, 2003, Pages 483-491

  Fernandes de Oliveira, César Augusto ^a   Werneck Guimarães, Cristiano Ruch ^a,b   Barreiro, Gabriela ^a,c   De Alencastro, Ricardo Bicca ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b YALE UNIVERSITY   (United States)

^c WESLEYAN UNIVERSITY   (United States)

Author keywords

Assemblin; B factors; Conformational changes; Enzyme dimer; HCMV protease; Induced fit mechanism; MD simulations; Oxyanion hole stabilization

Indexed keywords

ANION; ARGININE; ASSEMBLIN; CIDOFOVIR; DNA POLYMERASE; FOSCARNET; GANCICLOVIR; PROTEIN INHIBITOR; PROTEINASE; SERINE PROTEINASE; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS PROTEASE;

AMINO TERMINAL SEQUENCE; ARTICLE; BIOCHEMISTRY; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CYTOMEGALOVIRUS; DIMERIZATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE; INDUCED FIT MECHANISM; MOLECULAR DYNAMICS; MUTAGENESIS; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN STABILITY; SIMULATION; SPECIES DIFFERENCE; VIRUS GENE; VIRUS INFECTIVITY;

CYTOMEGALOVIRUS; DNA VIRUSES; HUMAN HERPESVIRUS 5;

EID: 0042420691     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/prot.10403     Document Type: Article

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