Evidence of a conformational change in the human cytomegalovirus protease upon binding of peptidyl-activated carbonyl inhibitors

Biochemistry

Volumn 36, Issue 41, 1997, Pages 12644-12652

  Bonneau, Pierre R ^a   Grand Maître, Chantal ^a   Greenwood, Daniel J ^b   Lagacé, Lisette ^a   LaPlante, Steven R ^a   Massariol, Marie Josée ^a   Ogilvie, William W ^a   O'Meara, Jeff A ^a   Kawai, Stephen H ^a  

^a BOEHRINGER INGELHEIM CANADA LTD   (Canada)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; ALPHA KETOAMIDE; CARBONYL DERIVATIVE; KETONE DERIVATIVE; PENTAFLUOROETHYLKETONE; PROTEINASE; PROTEINASE INHIBITOR; TRIFLUOROMETHYLKETONE; TRYPTOPHAN; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; BINDING KINETICS; CONFORMATIONAL TRANSITION; FLUORESCENCE; HUMAN CYTOMEGALOVIRUS; NONHUMAN; PRIORITY JOURNAL;

CYTOMEGALOVIRUS; ENDOPEPTIDASES; HUMANS; KETONES; MAGNETIC RESONANCE SPECTROSCOPY; PROTEASE INHIBITORS; PROTEIN CONFORMATION; SERINE ENDOPEPTIDASES;

HUMAN HERPESVIRUS 5;

EID: 0343035589     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi970366x     Document Type: Article

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