-
3
-
-
0025721850
-
-
3. Welsh, A. R.; Woods, A. S.; McNally, L. M.; Cotter, R. J.; Gibson, W., Proc. Natl. Acad. Sci. USA, 1991, 88, 10792
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 10792
-
-
Welsh, A.R.1
Woods, A.S.2
McNally, L.M.3
Cotter, R.J.4
Gibson, W.5
-
4
-
-
0028229066
-
-
4. Sardana, C. L.; Wolfgang, J. A.; Veloski, C. A.; Long, W. J.; LeGrow, K.; Wolinski, B.; Emini, E. A.; LaFemina, R. L., J. Biol. Chem. 1994, 269, 14337.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 14337
-
-
Sardana, C.L.1
Wolfgang, J.A.2
Veloski, C.A.3
Long, W.J.4
LeGrow, K.5
Wolinski, B.6
Emini, E.A.7
LaFemina, R.L.8
-
5
-
-
0011952961
-
-
5. Jones, T. R.; Sun, L.; Bebernitz, G. A.; Muzithras, V. P.; Kim, H-J.; Johnson, S. M.; Baum, E. Z., J. Virol. 1994, 68, 2742.
-
(1994)
J. Virol.
, vol.68
, pp. 2742
-
-
Jones, T.R.1
Sun, L.2
Bebernitz, G.A.3
Muzithras, V.P.4
Kim, H.-J.5
Johnson, S.M.6
Baum, E.Z.7
-
6
-
-
0028318401
-
-
6. Dilanni, C. L.; Stevens, J. T.; Bolger, M.; O'Boyle, D. R.; Weinheimer, S. P.; Colonno, R. J., J. Biol Chem. 1994, 269, 12672.
-
(1994)
J. Biol Chem.
, vol.269
, pp. 12672
-
-
Dilanni, C.L.1
Stevens, J.T.2
Bolger, M.3
O'Boyle, D.R.4
Weinheimer, S.P.5
Colonno, R.J.6
-
7
-
-
85030277095
-
-
note
-
16,17 or HCMV protease catalytic domain for 15 min in 25 uL buffer (50 mM sodium phosphate, 150 mM sodium chloride, 0.001mM EDTA, 0.01% PEG 3400; pH 8.0) then adding 250 μM R-site 14-mer peptide substrate, Ac-HTYLQASEKFKMWG and incubating at 27°C for 60 mins. The reaction was quenched with 40 μL 5% trifluoroacetic acid solution and the extent of proteolysis examined by quantifying the amounts of the substrate peptide and of the N-terminal and C-terminal cleavage fragments by HPLC analysis. The percentage cleavage was calculated and expressed as a fraction of the value obtained for an uninhibited control sample. Compounds 16-19 were assayed in a quenched fluorescence peptidolytic assay (A. Patel, unpublished results).
-
-
-
-
8
-
-
85030276747
-
-
note
-
8. Mass spectra analysis was carried out by reverse phase HPLC electrospray on a Finnigan TSQ700 and post source decay MS/MS on a Micromass TOF Spec E.
-
-
-
-
9
-
-
0000335094
-
-
9. Cativiela, C.; Diaz de Villegas, M. D.; Mayoral, J. A.; Melendez, E., J. Org. Chem. 1984, 49, 1436.
-
(1984)
J. Org. Chem.
, vol.49
, pp. 1436
-
-
Cativiela, C.1
Diaz De Villegas, M.D.2
Mayoral, J.A.3
Melendez, E.4
-
11
-
-
85030267937
-
-
note
-
11. All compounds are racemic and gave satisfactory spectroscopic and analytical date.
-
-
-
-
12
-
-
0011951737
-
-
12. Badr, M. Z.; El-Sherief, H. A. H.; Tadros, M. E., Bull. Chem. Soc. Jpn. 1982, 55, 2267.
-
(1982)
Bull. Chem. Soc. Jpn.
, vol.55
, pp. 2267
-
-
Badr, M.Z.1
El-Sherief, H.A.H.2
Tadros, M.E.3
-
13
-
-
85030272176
-
-
note
-
3):-δ 3.5 (s, 3H); 7.3 (s, 1H); 7.5 (m, 6H); 8.2 (dd, J = 7 & 2 Hz, 2H); 8.25 (dd, J = 7 & 2 Hz, 2H).
-
-
-
-
14
-
-
0024333382
-
-
14. Groutas, W. C.; Brubaker, M. J.; Stanga, M. A.; Castrisos, J. C.; Crowley, J. P.; Schatz, E. J., J. Med. Chem. 1989, 32, 1607.
-
(1989)
J. Med. Chem.
, vol.32
, pp. 1607
-
-
Groutas, W.C.1
Brubaker, M.J.2
Stanga, M.A.3
Castrisos, J.C.4
Crowley, J.P.5
Schatz, E.J.6
-
15
-
-
0001537510
-
-
15. Groutas, W. C.; Stanga, M. A.; Brubaker, M. J., J. Am. Chem. Soc. 1989, 111, 1931.
-
(1989)
J. Am. Chem. Soc.
, vol.111
, pp. 1931
-
-
Groutas, W.C.1
Stanga, M.A.2
Brubaker, M.J.3
-
16
-
-
0028926286
-
-
16. Steffy, K. R.; Scheon, S.; Chen, C-M., J. Gen. Virol. 1995, 76, 1069.
-
(1995)
J. Gen. Virol.
, vol.76
, pp. 1069
-
-
Steffy, K.R.1
Scheon, S.2
Chen, C.-M.3
-
17
-
-
85030280325
-
-
WO Patent Application 95/06055 ( to SmithKline Beecham), 1995
-
17. DiLella, A. G.; Debouck, C. M., WO Patent Application 95/06055 ( to SmithKline Beecham), 1995.
-
-
-
DiLella, A.G.1
Debouck, C.M.2
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