The influence of dietary folate and methionine on the metabolic disposition of endotoxic homocysteine

Biochemical and Molecular Medicine

Volumn 59, Issue 2, 1996, Pages 104-111

  Lucock, M D ^a   Daskalakis, I G ^a   Wild, J ^a   Anderson, A ^b   Schorah, C J ^a   Lean, M E J ^b   Levene, M I ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b GLASGOW ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTATHIONINE BETA SYNTHASE; FOLIC ACID; HOMOCYSTEINE; METHIONINE;

ADOLESCENT; ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; DIET; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERTENSION; MALE; METHYLATION; NEURAL TUBE DEFECT; PROTEIN METABOLISM; SPONTANEOUS ABORTION; VASCULAR DISEASE;

EID: 0030465229     PISSN: 10773150     EISSN: None     Source Type: Journal    
DOI: 10.1006/bmme.1996.0074     Document Type: Article

References (33)

1. 1. Ueland PM, Refsum H, Brattstrom L. Plasma homocysteine and cardiovascular disease. In Atherosclerotic Cardiovascular Disease, Hemostasis, and Endothelial Function (Francis RB, Ed.), Dekker, New York, 1992, p. 183.
2. 2. Clarke RJ, Daly L, Robinson K, Naughten E, Cahalane S, Fowler B, Graham I. Hyperhomocysteinemia: An independent risk factor for vascular disease. N Eng J Med 324:1149-1155, 1991.
3. 3. Stampfer MJ, Malinow MR, Willett WC, Newcomer LM, Upson B, Ullmann D, Tishler PV, Hennekens H. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians. J Am Med Assoc 268:877-881, 1992.
4. 4. Brattstrom LE, Lindgren A, Israelsson B, Malinow MR, Norrving B, Upson B, Hamfelt A. Hyperhomocysteinaemia in stroke: Prevalence, cause, and relationships to type of stroke and stroke risk factors. Eur J Clin Invest 22:214-221, 1992.
5. 5. Steegers-Theunissen RPM, Boers GHJ, Blom HJ, Trijbels JMF, Eskes TKAB. Hyperhomocysteinaemia and recurrent spontaneous abortion or abruptio placentae. Lancet 339:1122-1123, 1992.
6. 6. Mills JL, Scott JM, Kirke PN, McPartlin JM, Conley MR, Weir D, Molloy AM, Lee YJ. Homocysteine and neural tube defects. J Nutr 126:7565-7605, 1996.
7. 7. Brattstrom LE, Israelsson B, Jeppsson JO, Hultberg BL. Folic acid: An innocuous means to reduce plasma homocysteine. Scand J Clin Lab Invest 48:215-221, 1988.
8. 8. Finkelstein JD. Methionine metabolism in mammals: The biochemical basis for homocystinuria. Metabolism 23:387-398, 1974.
9. 9. Finkelstein JD, Martin JJ. Methionine metabolism in mammals. Adaptation to methionine excess. J Biol Chem 261:1582-1587, 1986.
10. 10. Stipanuk MH. Metabolism of sulphur containing amino acids. Annu Rev Nutr 6:179-209, 1986.
11. 11. Jencks DA, Matthews RG. Allosteric inhibition of methylenetetrahydrofolate reductase by adenosylmethionine. J Biol Chem 262:2485-2493, 1987.
12. 12. Kutzback C, Stokstad ELR. Mammalian methylenetetrahy-drofolatereductase: Partial purification, properties, and inhibition by S-adenosylmethionine. Biochim Biophys Acta 250:459-477, 1971.
13. 13. Kutzbach C, Stokstad ELR. Feedback inhibition of methylenetetrahydrofolate reductase in rat liver by S-adenosylmethionine. Biochim Biophys Acta 139:217-220, 1967.
14. 14. Finkelstein JD, Kyle WE, Martin JJ, Pick AM. Activation of cystathionine synthase by adenosylmethionine and adenosylethionine. Biochem Biophys Res Commun 66:81-87, 1975.
15. 15. Koracevic D, Djordjevic V. Effect of trypsin, S-adenosylmethionine and ethionine on L-serine sulfhydrase activity. Experientia 33:1010-1011, 1977.
16. 16. Wagner C. Biochemical role of folate in cellular metabolism. In Folate in Health and Disease (Bailey L, Ed.), Dekker, New York, 1995, pp. 23-42.
17. 17. Lucock MD, Wild J, Levene MI. Enzyme defect as risk factor for spina bifida. Lancet 346:1495-1496, 1995.
18. 18. Selhub J, Miller JW. The pathogenesis of homocysteinemia: Interruption of the coordinate regulation of S-adenosylmethionine of the remethylation and transsulphuration of homocysteine. Am J Clin Nutr 55:131-138, 1992.
19. 19. Kang SS, Wang PWK, Zhou J. Thermolabile methylenetetrahydrofolate reductase in patients with coronary artery disease. Metabolism 37:611-613, 1989.
20. 20. Kang SS, Zhou J, Wang PWK, Kowalisyn J, Strokosch G. Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase. Am J Hum Genet 43:414-421, 1988.
21. 21. Ueland PM, Refsum H. Plasma homocysteine a risk factor for vascular disease: Plasma levels in health, disease and drug therapy. J Lab Clin Med 144:473-501, 1989.
22. 22. Daskalakis I, Lucock MD, Anderson A, Wild J, Schorah CJ, Levene MI. Determination of plasma total homocysteine and cysteine using hplc with fluorescence detection and an ammonium 7-fluoro-2,1,3-benzoxadiazole-4-sulphonate (SBD-F) derivatization protocol optimised for antioxidant concentration, derivatisation reagent concentration, temperature and matrix pH. Biomed Chromatogr 1996, in press.
23. 23. Wild J, Schorah CJ, Sheldon TA, Smithells RW. Investigation of factors influencing folate status in women who have had a neural tube defect affected infant. Br J Obstet Gynecol 100:546-549, 1993.
24. 24. Holland B, Welch AA, Unwin ID, Boss DH, Paul AA, Southgate DAT. McCance and Widdowson's The Composition of Foods (Paul AA, Southgate DA, Eds.), 5th ed., The Royal Society of Chemistry and Ministry of Agriculture, Fisheries and Food, 1991.
25. 25. Brattstrom LE, Israelsson B, Jeppsson JO, Hultberg BL. Folic acid: An innocuous means to reduce plasma homocysteine. Scand J Clin Lab Invest 48:215-221, 1988.
26. 26. Selhub J, Jacques PF, Wilson PWF, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. J Am Med Assoc 270:2693-2698, 1993.
27. 27. Mudd SH, Levy HL, Skovby F. Disorders of Transsulphuration in: The metabolic basis of inherited disease (Scriver CR, Beaudet AL, Sly WS, Valle D, Eds.), 6th ed., McGraw-Hill, New York, 1989, pp. 693-734.
28. 28. MRC Vitamin Study Group. Prevention of neural tube defects. Results of the Medical Research Council Vitamin study. Lancet 338:131-137, 1991.
29. 29. Motulsky AG. Nutritional ecogenetics: Homocysteine related arteriosclerotic vascular disease, neural tube defects, and folic acid. Am J Hum Genet 58:17-20, 1996.
30. 30. Jacob RA, Wu MM, Henning SM, Swendseid ME. Homocysteine increases as folate decreased in plasma of healthy men during short-term dietary folate and methyl group restriction. J Nutr 124:1072-1080, 1994.
31. 31. Steegers-Theunissen RPM, Boers GHJ, Trijbels FJM, Eskes TKAB. Neural tube defects and derangement of homocysteine metabolism. New Eng J Med 324:199-200, 1991.
32. 32. Kirke PN, Molloy AM, Daly LE, Burke H, Weir DG, Scott JM. Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. Q J Med 86:703-708, 1993.
33. 33. Van der Put NMJ, Steegers-Theunissen RPM, Frosst P, Trijbels FJM, Eskes TKAB, Van der Heuvel LP, Mariman ECM, Den Heyer M, Roger R, Blom HJ. Lancet 346:1070, 1995.