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Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
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Sha, W.C.1
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Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-κB2
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Weih, F.1
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Expression of relB is required for development of thymic medulla and dendritic cells
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Horwitz, B.H.1
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Requirement for NF-κB in osteoclast and B-cell development
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Franzoso G, Carlson L, Xing L, Poljak L, Shores EW, Brown KD, Leonardi A, Tran T, Boyce BF, Siebenlist U. Requirement for NF-κB in osteoclast and B-cell development. Genes Dev. 11:1997;3482-3496.
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Esslinger, C.W.1
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13
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Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-κB
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Boothby MR, Mora AL, Scherer DC, Brockman JA, Ballard DW. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-κB. J Exp Med. 185:1997;1897-1907.
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Boothby, M.R.1
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14
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Corepression of RelA and c-Rel inhibits immunoglobulin κ gene transcription and rearrangement in precursor B lymphocytes
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Scherer DC, Brockman JA, Bendall HH, Zhang GM, Ballard DW, Oltz EM. Corepression of RelA and c-Rel inhibits immunoglobulin κ gene transcription and rearrangement in precursor B lymphocytes. Immunity. 5:1996;563-574.
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Scherer, D.C.1
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The subunit composition of NF-κB complexes changes during B-cell development
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Grumont RJ, Gerondakis S. The subunit composition of NF-κB complexes changes during B-cell development. Cell Growth Differ. 5:1994;1321-1331.
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Grumont, R.J.1
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16
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0032473405
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B lymphocytes diferentially use the Rel and NF-κB1 transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells
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of special interest. This study demonstrates for the first time that nuclear factor-κB1 (NF-κB1) and Rel differentially regulate B cell survival in quiescent and mitogen-activated B cells and are required for mitogen-dependent G1 progression.
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Grumont RJ, Rourke IJ, O'Reilly LA, Strasser A, Miyake K, Sha W, Gerondakis S. B lymphocytes diferentially use the Rel and NF-κB1 transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells. of special interest J Exp Med. 187:1998;1-12 This study demonstrates for the first time that nuclear factor-κB1 (NF-κB1) and Rel differentially regulate B cell survival in quiescent and mitogen-activated B cells and are required for mitogen-dependent G1 progression.
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J Exp Med
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Grumont, R.J.1
Rourke, I.J.2
O'Reilly, L.A.3
Strasser, A.4
Miyake, K.5
Sha, W.6
Gerondakis, S.7
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17
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0030614504
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Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator
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Perkins ND, Felzein LK, Betts JC, Leung K, Beech D, Nabel GL. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science. 275:1997;523-527.
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Perkins, N.D.1
Felzein, L.K.2
Betts, J.C.3
Leung, K.4
Beech, D.5
Nabel, G.L.6
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19
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0029814063
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Inhibition of NF-κB/Rel induces apoptosis of murine B cells
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Wu M, Lee H, Bellas R, Schauer S, Arsura M, Katz D, FitzGerald MJ, Rothstein TL, Sherr DH, Sonenshein GE. Inhibition of NF-κB/Rel induces apoptosis of murine B cells. EMBO J. 15:1996;4682-4690.
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Wu, M.1
Lee, H.2
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Fitzgerald, M.J.7
Rothstein, T.L.8
Sherr, D.H.9
Sonenshein, G.E.10
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20
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0029941255
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Maintenance of nuclear factor-κB/Rel and c-myc expression during CD40 ligand rescue of W231 early B cells from receptor-mediated apoptosis through modulation of IκB proteins
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Schauer SL, Wang Z, Sonenshein GE, Rothstein TL. Maintenance of nuclear factor-κB/Rel and c-myc expression during CD40 ligand rescue of W231 early B cells from receptor-mediated apoptosis through modulation of IκB proteins. J Immunol. 156:1996;81-86.
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Schauer, S.L.1
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0030933777
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The immunoglobulin class switch: Beyond "accessibility"
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Snapper CM, Marcu KB, Zelazowski P. The immunoglobulin class switch: beyond "accessibility" Immunity. 6:1997;217-223.
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Immunity
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Snapper, C.M.1
Marcu, K.B.2
Zelazowski, P.3
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22
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CD40 cross-linking induces IgE germline transcripts in B cells via activation of NF-κB
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Iciek LA, Delphin SA, Stavnezer J. CD40 cross-linking induces IgE germline transcripts in B cells via activation of NF-κB. J Immunol. 158:1997;4769-4779.
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Iciek, L.A.1
Delphin, S.A.2
Stavnezer, J.3
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23
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Regulation of 3′ IgH enhancers by a common set of factors, including κb-binding proteins
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Michaelson JS, Singh M, Snapper CM, Sha WC, Baltimore D, Birshtein BK. Regulation of 3′ IgH enhancers by a common set of factors, including κB-binding proteins. J Immunol. 156:1996;2828-2839.
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Michaelson, J.S.1
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Snapper, C.M.3
Sha, W.C.4
Baltimore, D.5
Birshtein, B.K.6
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24
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0030048332
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B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germline CH transcription, and Ig class switching
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Snapper CM, Zelazowski P, Rosas FR, Kehry MR, Tian M, Baltimore D, Sha WC. B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germline CH transcription, and Ig class switching. J Immunol. 156:1996;183-191.
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Snapper, C.M.1
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Rosas, F.R.3
Kehry, M.R.4
Tian, M.5
Baltimore, D.6
Sha, W.C.7
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26
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0028233142
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A class switch control region at the 3′ end of the immunoglobulin heavy chain locus
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Cogne M, Lansford R, Bottaro A, Zhang J, Gorman J, Young F, Cheng H-L, Alt FW. A class switch control region at the 3′ end of the immunoglobulin heavy chain locus. Cell. 77:1994;737-747.
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Cogne, M.1
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Alt, F.W.8
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0026061865
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Regulation of interleukin-2 gene enhancer activity by the T-cell accessory molecule CD28
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Fraser JD, Irving BA, Crabtree GR, Weiss A. Regulation of interleukin-2 gene enhancer activity by the T-cell accessory molecule CD28. Science. 251:1991;313-316.
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Fraser, J.D.1
Irving, B.A.2
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Weiss, A.4
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28
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0030958177
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Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-κB/Rel transcription factors
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Maggirwar SB, Harhaj E, Sun S-C. Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-κB/Rel transcription factors. Mol Cell Biol. 17:1997;2605-2614.
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Maggirwar, S.B.1
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Sun S-C3
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29
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0030294284
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High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters
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of special interest. This work provides a mechanism for explaining the selective binding of Rel to the CD28 response element.
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Himes SR, Coles LS, Reeves R, Shannon MF. High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters. of special interest Immunity. 5:1996;479-489 This work provides a mechanism for explaining the selective binding of Rel to the CD28 response element.
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(1996)
Immunity
, vol.5
, pp. 479-489
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Himes, S.R.1
Coles, L.S.2
Reeves, R.3
Shannon, M.F.4
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30
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0029866670
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Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor
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Gerondakis S, Strasser A, Metcalf D, Grigoriadis G, Scheerlinck J-PY, Grumont RJ. Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci USA. 93:1996;3405-3409.
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Gerondakis, S.1
Strasser, A.2
Metcalf, D.3
Grigoriadis, G.4
Scheerlinck J-Py5
Grumont, R.J.6
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31
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0030481581
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The Rel subunit of NF-κB-like transcription factors is a positive and negative regulator of macrophage gene expression: Distinct roles for Rel in different macrophage populations
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Grigoriadis G, Zhan Y, Grumont RJ, Metcalf D, Handman E, Cheers C, Gerondakis S. The Rel subunit of NF-κB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations. EMBO J. 15:1996;7099-7107.
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Grigoriadis, G.1
Zhan, Y.2
Grumont, R.J.3
Metcalf, D.4
Handman, E.5
Cheers, C.6
Gerondakis, S.7
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Mutual regulation of the transcriptional activator NF-κB and its inhibitor, IκBα
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Brown K, Park S, Kanno T, Granzoso G, Seibenlist U. Mutual regulation of the transcriptional activator NF-κB and its inhibitor, IκBα Proc Natl Acad Sci USA. 90:1993;2532-2536.
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Brown, K.1
Park, S.2
Kanno, T.3
Granzoso, G.4
Seibenlist, U.5
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33
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0029977948
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CD28 mediates a potent costimulatory signal for rapid degradation of IκBβ which is associated with accelerated activation of various NF-κB/Rel heterodimers
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of special interest. This demonstrates the differential phosphorylation and degradation of the inhibitor of NF-κBα (IκBα) and IκBβ in response to TCR and CD28 signals and illustrates the basis by which Rel/NF-κB is regulated in a transient or sustained fashion.
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Harhaj EW, Maggirwar SB, Good L, Sun S-C. CD28 mediates a potent costimulatory signal for rapid degradation of IκBβ which is associated with accelerated activation of various NF-κB/Rel heterodimers. of special interest Mol Cell Biol. 16:1996;6736-6743 This demonstrates the differential phosphorylation and degradation of the inhibitor of NF-κBα (IκBα) and IκBβ in response to TCR and CD28 signals and illustrates the basis by which Rel/NF-κB is regulated in a transient or sustained fashion.
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(1996)
Mol Cell Biol
, vol.16
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Harhaj, E.W.1
Maggirwar, S.B.2
Good, L.3
Sun S-C4
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34
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0028986194
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IκBβ regulates the persistent response in a biphasic activation of NF-κB
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Thompson JE, Phillips RJ, Erdjument-Bromage H, Tempst P, Ghosh S. IκBβ regulates the persistent response in a biphasic activation of NF-κB. Cell. 80:1995;573-582.
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Thompson, J.E.1
Phillips, R.J.2
Erdjument-Bromage, H.3
Tempst, P.4
Ghosh, S.5
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35
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0028971291
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Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in IκBα-deficient mice
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Beg AA, Sha WC, Bronson RT, Baltimore D. Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in IκBα-deficient mice. Genes Dev. 9:1995;2736-2746.
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Beg, A.A.1
Sha, W.C.2
Bronson, R.T.3
Baltimore, D.4
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36
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0028978626
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TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40
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Rothe M, Sarma V, Dixit VM, Goeddel DV. TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science. 269:1995;1424-1427.
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Science
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Rothe, M.1
Sarma, V.2
Dixit, V.M.3
Goeddel, D.V.4
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37
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0008206988
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TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival
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of special interest. These studies indicate for the first time that tumor necrosis factor receptor associated factor 2 (TRAF2) is not essential for nuclear factor (NF)-κB activation in B cells by CD40.
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Lee SY, Reichlin A, Santana A, Sokol KA, Nussenzwieg MC, Choi Y. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival. of special interest Immunity. 7:1997;703-713 These studies indicate for the first time that tumor necrosis factor receptor associated factor 2 (TRAF2) is not essential for nuclear factor (NF)-κB activation in B cells by CD40.
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(1997)
Immunity
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Lee, S.Y.1
Reichlin, A.2
Santana, A.3
Sokol, K.A.4
Nussenzwieg, M.C.5
Choi, Y.6
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38
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0029847814
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TRAF5, a novel TNF receptor associated factor family protein, mediates CD40 signalling
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Ishida T, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J-I. TRAF5, a novel TNF receptor associated factor family protein, mediates CD40 signalling. Proc Natl Acad Sci USA. 93:1995;9437-9442.
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Ishida, T.1
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Kobayashi, N.4
Ohishi, T.5
Watanabe, T.6
Yamamoto, T.7
Inoue J-I8
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39
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0030888186
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2+ response amplitude and duration
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of special interest. This paper provides a mechanism to explain how calcium regulated transcription factors are differentially regulated by the amplitude and duration of a calcium flux. Nuclear factor (NF)-κB is specifically activated by a large transient increase in intracellular calcium.
-
2+ response amplitude and duration. of special interest Nature. 386:1997;855-858 This paper provides a mechanism to explain how calcium regulated transcription factors are differentially regulated by the amplitude and duration of a calcium flux. Nuclear factor (NF)-κB is specifically activated by a large transient increase in intracellular calcium.
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(1997)
Nature
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Dolmetsch, I.1
Lewis, R.S.2
Goodnow, C.C.3
Healy, J.I.4
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40
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0030966218
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Different nuclear signals are activated by the B cell receptor during positive versus negative selection
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Healy JI, Dolmetsch RE, Timmerman LA, Cyster JG, Thaomas ML, Crabtree GR, Lewis RS, Goodnow CC. Different nuclear signals are activated by the B cell receptor during positive versus negative selection. Immunity. 6:1997;419-428.
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(1997)
Immunity
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Healy, J.I.1
Dolmetsch, R.E.2
Timmerman, L.A.3
Cyster, J.G.4
Thaomas, M.L.5
Crabtree, G.R.6
Lewis, R.S.7
Goodnow, C.C.8
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41
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0030610362
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A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
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of outstanding interest. References by Didonato et al. and by Mercurio et al., 1997 [42], Regnier et al., 1997 [43], Woronicz et al., 1997 [45] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
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Didonato JA, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. of outstanding interest Nature. 388:1997;548-554 References by Didonato et al. and by Mercurio et al., 1997 [42], Regnier et al., 1997 [43], Woronicz et al., 1997 [45] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
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(1997)
Nature
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Didonato, J.A.1
Rothwarf, D.M.2
Zandi, E.3
Karin, M.4
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42
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0030685825
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IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation
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of outstanding interest. References by Mercurio et al. and by Didonato et al., 1997 [41], Regnier et al., 1997 [43], Woronicz et al., 1997 [45] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
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Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BI, Li JW, Young DB, Barbosa M, Mann M, Manning A, Rao A. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation. of outstanding interest Science. 278:1997;860-866 References by Mercurio et al. and by Didonato et al., 1997 [41], Regnier et al., 1997 [43], Woronicz et al., 1997 [45] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
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(1997)
Science
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Mercurio, F.1
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of outstanding interest. References by Woronicz et al. and by Didonato et al., 1997 [41], Mercurio et al., 1997 [42], Regnier et al., 1997 [43] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
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Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel. IκB kinase β: NF-κB activation and complex formation with IκB kinase-α and NIK. of outstanding interest Science. 278:1997;866-869 References by Woronicz et al. and by Didonato et al., 1997 [41], Mercurio et al., 1997 [42], Regnier et al., 1997 [43] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
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of outstanding interest. References by Zandi et al. and by Didonato et al., 1997 [41], Mercurio et al., 1997 [42], Regnier et al., 1997 [43] and Woronicz et al., 1997 [45] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
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of special interest. Data presented here show that p90 ribosomal S6 kinase is also able to activate nuclear factor (NF)-κB by specifically phosphorylating the inhibitor of NF-κB (IκB)α in response to phorbol ester. This is strong biochemical evidence that the IκB kinases IKK-1 and IKK-2 are not the sole IκB kinases.
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Schouten GL, Vertegaal ACO, Whiteside ST, Israel A, Toebes M, Dorsman JC, van der Eb AJ, Zantema A. IκBα is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. of special interest EMBO J. 16:1997;3133-3144 Data presented here show that p90 ribosomal S6 kinase is also able to activate nuclear factor (NF)-κB by specifically phosphorylating the inhibitor of NF-κB (IκB)α in response to phorbol ester. This is strong biochemical evidence that the IκB kinases IKK-1 and IKK-2 are not the sole IκB kinases.
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