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Volumn 10, Issue 3, 1998, Pages 353-359

The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

EID: 0031833431     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(98)80175-1     Document Type: Article
Times cited : (181)

References (49)
  • 1
    • 0028174061 scopus 로고
    • Function and activation of NF-κB in the immune system
    • Baeuerle PA, Henkel T. Function and activation of NF-κB in the immune system. Annu Rev Immunol. 12:1994;141-179.
    • (1994) Annu Rev Immunol , vol.12 , pp. 141-179
    • Baeuerle, P.A.1    Henkel, T.2
  • 3
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • Kontgen F, Grumont RJ, Strasser A, Metcalf D, Li R, Tarlinton D, Gerondakis S. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression. Genes Dev. 9:1995;1965-1977.
    • (1995) Genes Dev , vol.9 , pp. 1965-1977
    • Kontgen, F.1    Grumont, R.J.2    Strasser, A.3    Metcalf, D.4    Li, R.5    Tarlinton, D.6    Gerondakis, S.7
  • 4
    • 0030999057 scopus 로고    scopus 로고
    • NF-κB RelA-deficient lymphocytes: Normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses
    • Doi TS, Takahashi T, Taguchi O, Takachika A, Obata Y. NF-κB RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses. J Exp Med. 185:1997;953-961.
    • (1997) J Exp Med , vol.185 , pp. 953-961
    • Doi, T.S.1    Takahashi, T.2    Taguchi, O.3    Takachika, A.4    Obata, Y.5
  • 5
    • 0028804551 scopus 로고    scopus 로고
    • Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
    • Sha WC, Liou H-C, Toumanen EI, Baltimore D. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses. Cell. 80:1997;321-330.
    • (1997) Cell , vol.80 , pp. 321-330
    • Sha, W.C.1    Liou H-C2    Toumanen, E.I.3    Baltimore, D.4
  • 6
    • 0030763645 scopus 로고    scopus 로고
    • Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-κB2
    • Ishikawa H, Carrasco D, Claudio E, Ryseck R-P, Bravo R. Gastric hyperplasia and increased proliferative responses of lymphocytes in mice lacking the COOH-terminal ankyrin domain of NF-κB2. J Exp Med. 186:1997;999-1014.
    • (1997) J Exp Med , vol.186 , pp. 999-1014
    • Ishikawa, H.1    Carrasco, D.2    Claudio, E.3    Ryseck R-P4    Bravo, R.5
  • 7
    • 0031159205 scopus 로고    scopus 로고
    • Multifocal defects in immune responses in RelB-deficient mice
    • Weih F, Warr G, Yang H, Bravo R. Multifocal defects in immune responses in RelB-deficient mice. J Immunol. 158:1997;5211-5218.
    • (1997) J Immunol , vol.158 , pp. 5211-5218
    • Weih, F.1    Warr, G.2    Yang, H.3    Bravo, R.4
  • 9
    • 0030837598 scopus 로고    scopus 로고
    • Failure of lymphopoiesis after adoptive transfer of NF-κB-deficient fetal liver cells
    • Horwitz BH, Scott ML, Cherry SR, Bronson RT, Baltimore D. Failure of lymphopoiesis after adoptive transfer of NF-κB-deficient fetal liver cells. Immunity. 6:1997;765-772.
    • (1997) Immunity , vol.6 , pp. 765-772
    • Horwitz, B.H.1    Scott, M.L.2    Cherry, S.R.3    Bronson, R.T.4    Baltimore, D.5
  • 12
    • 0031159039 scopus 로고    scopus 로고
    • Abnormal T lymphocyte development induced by targeted overexpression of IκBα
    • Esslinger CW, Wilson A, Sardat B, Beermann F, Jongeneel CV. Abnormal T lymphocyte development induced by targeted overexpression of IκBα J Immunol. 158:1997;5075-5078.
    • (1997) J Immunol , vol.158 , pp. 5075-5078
    • Esslinger, C.W.1    Wilson, A.2    Sardat, B.3    Beermann, F.4    Jongeneel, C.V.5
  • 13
    • 0030925372 scopus 로고    scopus 로고
    • Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-κB
    • Boothby MR, Mora AL, Scherer DC, Brockman JA, Ballard DW. Perturbation of the T lymphocyte lineage in transgenic mice expressing a constitutive repressor of nuclear factor (NF)-κB. J Exp Med. 185:1997;1897-1907.
    • (1997) J Exp Med , vol.185 , pp. 1897-1907
    • Boothby, M.R.1    Mora, A.L.2    Scherer, D.C.3    Brockman, J.A.4    Ballard, D.W.5
  • 14
    • 0030299799 scopus 로고    scopus 로고
    • Corepression of RelA and c-Rel inhibits immunoglobulin κ gene transcription and rearrangement in precursor B lymphocytes
    • Scherer DC, Brockman JA, Bendall HH, Zhang GM, Ballard DW, Oltz EM. Corepression of RelA and c-Rel inhibits immunoglobulin κ gene transcription and rearrangement in precursor B lymphocytes. Immunity. 5:1996;563-574.
    • (1996) Immunity , vol.5 , pp. 563-574
    • Scherer, D.C.1    Brockman, J.A.2    Bendall, H.H.3    Zhang, G.M.4    Ballard, D.W.5    Oltz, E.M.6
  • 15
    • 0028154853 scopus 로고
    • The subunit composition of NF-κB complexes changes during B-cell development
    • Grumont RJ, Gerondakis S. The subunit composition of NF-κB complexes changes during B-cell development. Cell Growth Differ. 5:1994;1321-1331.
    • (1994) Cell Growth Differ , vol.5 , pp. 1321-1331
    • Grumont, R.J.1    Gerondakis, S.2
  • 16
    • 0032473405 scopus 로고    scopus 로고
    • B lymphocytes diferentially use the Rel and NF-κB1 transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells
    • of special interest. This study demonstrates for the first time that nuclear factor-κB1 (NF-κB1) and Rel differentially regulate B cell survival in quiescent and mitogen-activated B cells and are required for mitogen-dependent G1 progression.
    • Grumont RJ, Rourke IJ, O'Reilly LA, Strasser A, Miyake K, Sha W, Gerondakis S. B lymphocytes diferentially use the Rel and NF-κB1 transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells. of special interest J Exp Med. 187:1998;1-12 This study demonstrates for the first time that nuclear factor-κB1 (NF-κB1) and Rel differentially regulate B cell survival in quiescent and mitogen-activated B cells and are required for mitogen-dependent G1 progression.
    • (1998) J Exp Med , vol.187 , pp. 1-12
    • Grumont, R.J.1    Rourke, I.J.2    O'Reilly, L.A.3    Strasser, A.4    Miyake, K.5    Sha, W.6    Gerondakis, S.7
  • 17
    • 0030614504 scopus 로고    scopus 로고
    • Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator
    • Perkins ND, Felzein LK, Betts JC, Leung K, Beech D, Nabel GL. Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science. 275:1997;523-527.
    • (1997) Science , vol.275 , pp. 523-527
    • Perkins, N.D.1    Felzein, L.K.2    Betts, J.C.3    Leung, K.4    Beech, D.5    Nabel, G.L.6
  • 20
    • 0029941255 scopus 로고    scopus 로고
    • Maintenance of nuclear factor-κB/Rel and c-myc expression during CD40 ligand rescue of W231 early B cells from receptor-mediated apoptosis through modulation of IκB proteins
    • Schauer SL, Wang Z, Sonenshein GE, Rothstein TL. Maintenance of nuclear factor-κB/Rel and c-myc expression during CD40 ligand rescue of W231 early B cells from receptor-mediated apoptosis through modulation of IκB proteins. J Immunol. 156:1996;81-86.
    • (1996) J Immunol , vol.156 , pp. 81-86
    • Schauer, S.L.1    Wang, Z.2    Sonenshein, G.E.3    Rothstein, T.L.4
  • 21
    • 0030933777 scopus 로고    scopus 로고
    • The immunoglobulin class switch: Beyond "accessibility"
    • Snapper CM, Marcu KB, Zelazowski P. The immunoglobulin class switch: beyond "accessibility" Immunity. 6:1997;217-223.
    • (1997) Immunity , vol.6 , pp. 217-223
    • Snapper, C.M.1    Marcu, K.B.2    Zelazowski, P.3
  • 22
    • 0031570029 scopus 로고    scopus 로고
    • CD40 cross-linking induces IgE germline transcripts in B cells via activation of NF-κB
    • Iciek LA, Delphin SA, Stavnezer J. CD40 cross-linking induces IgE germline transcripts in B cells via activation of NF-κB. J Immunol. 158:1997;4769-4779.
    • (1997) J Immunol , vol.158 , pp. 4769-4779
    • Iciek, L.A.1    Delphin, S.A.2    Stavnezer, J.3
  • 23
    • 0030584725 scopus 로고    scopus 로고
    • Regulation of 3′ IgH enhancers by a common set of factors, including κb-binding proteins
    • Michaelson JS, Singh M, Snapper CM, Sha WC, Baltimore D, Birshtein BK. Regulation of 3′ IgH enhancers by a common set of factors, including κB-binding proteins. J Immunol. 156:1996;2828-2839.
    • (1996) J Immunol , vol.156 , pp. 2828-2839
    • Michaelson, J.S.1    Singh, M.2    Snapper, C.M.3    Sha, W.C.4    Baltimore, D.5    Birshtein, B.K.6
  • 24
    • 0030048332 scopus 로고    scopus 로고
    • B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germline CH transcription, and Ig class switching
    • Snapper CM, Zelazowski P, Rosas FR, Kehry MR, Tian M, Baltimore D, Sha WC. B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germline CH transcription, and Ig class switching. J Immunol. 156:1996;183-191.
    • (1996) J Immunol , vol.156 , pp. 183-191
    • Snapper, C.M.1    Zelazowski, P.2    Rosas, F.R.3    Kehry, M.R.4    Tian, M.5    Baltimore, D.6    Sha, W.C.7
  • 27
    • 0026061865 scopus 로고
    • Regulation of interleukin-2 gene enhancer activity by the T-cell accessory molecule CD28
    • Fraser JD, Irving BA, Crabtree GR, Weiss A. Regulation of interleukin-2 gene enhancer activity by the T-cell accessory molecule CD28. Science. 251:1991;313-316.
    • (1991) Science , vol.251 , pp. 313-316
    • Fraser, J.D.1    Irving, B.A.2    Crabtree, G.R.3    Weiss, A.4
  • 28
    • 0030958177 scopus 로고    scopus 로고
    • Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-κB/Rel transcription factors
    • Maggirwar SB, Harhaj E, Sun S-C. Regulation of the interleukin-2 CD28-responsive element by NF-ATp and various NF-κB/Rel transcription factors. Mol Cell Biol. 17:1997;2605-2614.
    • (1997) Mol Cell Biol , vol.17 , pp. 2605-2614
    • Maggirwar, S.B.1    Harhaj, E.2    Sun S-C3
  • 29
    • 0030294284 scopus 로고    scopus 로고
    • High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters
    • of special interest. This work provides a mechanism for explaining the selective binding of Rel to the CD28 response element.
    • Himes SR, Coles LS, Reeves R, Shannon MF. High mobility group protein I(Y) is required for function and for c-Rel binding to CD28 response elements within the GM-CSF and IL-2 promoters. of special interest Immunity. 5:1996;479-489 This work provides a mechanism for explaining the selective binding of Rel to the CD28 response element.
    • (1996) Immunity , vol.5 , pp. 479-489
    • Himes, S.R.1    Coles, L.S.2    Reeves, R.3    Shannon, M.F.4
  • 30
    • 0029866670 scopus 로고    scopus 로고
    • Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor
    • Gerondakis S, Strasser A, Metcalf D, Grigoriadis G, Scheerlinck J-PY, Grumont RJ. Rel-deficient T cells exhibit defects in production of interleukin 3 and granulocyte-macrophage colony-stimulating factor. Proc Natl Acad Sci USA. 93:1996;3405-3409.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3405-3409
    • Gerondakis, S.1    Strasser, A.2    Metcalf, D.3    Grigoriadis, G.4    Scheerlinck J-Py5    Grumont, R.J.6
  • 31
    • 0030481581 scopus 로고    scopus 로고
    • The Rel subunit of NF-κB-like transcription factors is a positive and negative regulator of macrophage gene expression: Distinct roles for Rel in different macrophage populations
    • Grigoriadis G, Zhan Y, Grumont RJ, Metcalf D, Handman E, Cheers C, Gerondakis S. The Rel subunit of NF-κB-like transcription factors is a positive and negative regulator of macrophage gene expression: distinct roles for Rel in different macrophage populations. EMBO J. 15:1996;7099-7107.
    • (1996) EMBO J , vol.15 , pp. 7099-7107
    • Grigoriadis, G.1    Zhan, Y.2    Grumont, R.J.3    Metcalf, D.4    Handman, E.5    Cheers, C.6    Gerondakis, S.7
  • 32
    • 0027462682 scopus 로고
    • Mutual regulation of the transcriptional activator NF-κB and its inhibitor, IκBα
    • Brown K, Park S, Kanno T, Granzoso G, Seibenlist U. Mutual regulation of the transcriptional activator NF-κB and its inhibitor, IκBα Proc Natl Acad Sci USA. 90:1993;2532-2536.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 2532-2536
    • Brown, K.1    Park, S.2    Kanno, T.3    Granzoso, G.4    Seibenlist, U.5
  • 33
    • 0029977948 scopus 로고    scopus 로고
    • CD28 mediates a potent costimulatory signal for rapid degradation of IκBβ which is associated with accelerated activation of various NF-κB/Rel heterodimers
    • of special interest. This demonstrates the differential phosphorylation and degradation of the inhibitor of NF-κBα (IκBα) and IκBβ in response to TCR and CD28 signals and illustrates the basis by which Rel/NF-κB is regulated in a transient or sustained fashion.
    • Harhaj EW, Maggirwar SB, Good L, Sun S-C. CD28 mediates a potent costimulatory signal for rapid degradation of IκBβ which is associated with accelerated activation of various NF-κB/Rel heterodimers. of special interest Mol Cell Biol. 16:1996;6736-6743 This demonstrates the differential phosphorylation and degradation of the inhibitor of NF-κBα (IκBα) and IκBβ in response to TCR and CD28 signals and illustrates the basis by which Rel/NF-κB is regulated in a transient or sustained fashion.
    • (1996) Mol Cell Biol , vol.16 , pp. 6736-6743
    • Harhaj, E.W.1    Maggirwar, S.B.2    Good, L.3    Sun S-C4
  • 34
  • 35
    • 0028971291 scopus 로고
    • Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in IκBα-deficient mice
    • Beg AA, Sha WC, Bronson RT, Baltimore D. Constitutive NF-κB activation, enhanced granulopoiesis, and neonatal lethality in IκBα-deficient mice. Genes Dev. 9:1995;2736-2746.
    • (1995) Genes Dev , vol.9 , pp. 2736-2746
    • Beg, A.A.1    Sha, W.C.2    Bronson, R.T.3    Baltimore, D.4
  • 36
    • 0028978626 scopus 로고
    • TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40
    • Rothe M, Sarma V, Dixit VM, Goeddel DV. TRAF2-mediated activation of NF-κB by TNF receptor 2 and CD40. Science. 269:1995;1424-1427.
    • (1995) Science , vol.269 , pp. 1424-1427
    • Rothe, M.1    Sarma, V.2    Dixit, V.M.3    Goeddel, D.V.4
  • 37
    • 0008206988 scopus 로고    scopus 로고
    • TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival
    • of special interest. These studies indicate for the first time that tumor necrosis factor receptor associated factor 2 (TRAF2) is not essential for nuclear factor (NF)-κB activation in B cells by CD40.
    • Lee SY, Reichlin A, Santana A, Sokol KA, Nussenzwieg MC, Choi Y. TRAF2 is essential for JNK but not NF-κB activation and regulates lymphocyte proliferation and survival. of special interest Immunity. 7:1997;703-713 These studies indicate for the first time that tumor necrosis factor receptor associated factor 2 (TRAF2) is not essential for nuclear factor (NF)-κB activation in B cells by CD40.
    • (1997) Immunity , vol.7 , pp. 703-713
    • Lee, S.Y.1    Reichlin, A.2    Santana, A.3    Sokol, K.A.4    Nussenzwieg, M.C.5    Choi, Y.6
  • 39
    • 0030888186 scopus 로고    scopus 로고
    • 2+ response amplitude and duration
    • of special interest. This paper provides a mechanism to explain how calcium regulated transcription factors are differentially regulated by the amplitude and duration of a calcium flux. Nuclear factor (NF)-κB is specifically activated by a large transient increase in intracellular calcium.
    • 2+ response amplitude and duration. of special interest Nature. 386:1997;855-858 This paper provides a mechanism to explain how calcium regulated transcription factors are differentially regulated by the amplitude and duration of a calcium flux. Nuclear factor (NF)-κB is specifically activated by a large transient increase in intracellular calcium.
    • (1997) Nature , vol.386 , pp. 855-858
    • Dolmetsch, I.1    Lewis, R.S.2    Goodnow, C.C.3    Healy, J.I.4
  • 41
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
    • of outstanding interest. References by Didonato et al. and by Mercurio et al., 1997 [42], Regnier et al., 1997 [43], Woronicz et al., 1997 [45] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
    • Didonato JA, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. of outstanding interest Nature. 388:1997;548-554 References by Didonato et al. and by Mercurio et al., 1997 [42], Regnier et al., 1997 [43], Woronicz et al., 1997 [45] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
    • (1997) Nature , vol.388 , pp. 548-554
    • Didonato, J.A.1    Rothwarf, D.M.2    Zandi, E.3    Karin, M.4
  • 42
    • 0030685825 scopus 로고    scopus 로고
    • IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation
    • of outstanding interest. References by Mercurio et al. and by Didonato et al., 1997 [41], Regnier et al., 1997 [43], Woronicz et al., 1997 [45] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
    • Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BI, Li JW, Young DB, Barbosa M, Mann M, Manning A, Rao A. IKK-1 and IKK-2: Cytokine-activated IκB kinases essential for NF-κB activation. of outstanding interest Science. 278:1997;860-866 References by Mercurio et al. and by Didonato et al., 1997 [41], Regnier et al., 1997 [43], Woronicz et al., 1997 [45] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
    • (1997) Science , vol.278 , pp. 860-866
    • Mercurio, F.1    Zhu, H.2    Murray, B.W.3    Shevchenko, A.4    Bennett, B.I.5    Li, J.W.6    Young, D.B.7    Barbosa, M.8    Mann, M.9    Manning, A.10    Rao, A.11
  • 43
    • 0031586174 scopus 로고    scopus 로고
    • Identification and characterization of an IκB kinase
    • of outstanding interest. References by Regnier et al. and by Didonato et al., 1997 [41], Mercurio et al., 1997 [42], Woronicz et al., 1997 [45] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
    • Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M. Identification and characterization of an IκB kinase. of outstanding interest Cell. 90:1997;373-383 References by Regnier et al. and by Didonato et al., 1997 [41], Mercurio et al., 1997 [42], Woronicz et al., 1997 [45] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
    • (1997) Cell , vol.90 , pp. 373-383
    • Regnier, C.H.1    Song, H.Y.2    Gao, X.3    Goeddel, D.V.4    Cao, Z.5    Rothe, M.6
  • 44
    • 0029554095 scopus 로고
    • CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain
    • Connelly MA, Marcu KB. CHUK, a new member of the helix-loop-helix and leucine zipper families of interacting proteins, contains a serine-threonine kinase catalytic domain. Cell Mol Biol Res. 41:1995;537-549.
    • (1995) Cell Mol Biol Res , vol.41 , pp. 537-549
    • Connelly, M.A.1    Marcu, K.B.2
  • 45
    • 0030611595 scopus 로고    scopus 로고
    • IκB kinase β: NF-κB activation and complex formation with IκB kinase-α And NIK
    • of outstanding interest. References by Woronicz et al. and by Didonato et al., 1997 [41], Mercurio et al., 1997 [42], Regnier et al., 1997 [43] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
    • Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel. IκB kinase β: NF-κB activation and complex formation with IκB kinase-α and NIK. of outstanding interest Science. 278:1997;866-869 References by Woronicz et al. and by Didonato et al., 1997 [41], Mercurio et al., 1997 [42], Regnier et al., 1997 [43] and Zandi et al., 1997 [46] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
    • (1997) Science , vol.278 , pp. 866-869
    • Woronicz, J.D.1    Gao, X.2    Cao, Z.3    Rothe, M.4    Goeddel5
  • 46
    • 0030613551 scopus 로고    scopus 로고
    • The IκB kinase complex(IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
    • of outstanding interest. References by Zandi et al. and by Didonato et al., 1997 [41], Mercurio et al., 1997 [42], Regnier et al., 1997 [43] and Woronicz et al., 1997 [45] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
    • Zandi E, Rothwarf DM, Delhase M, Hyakawa M, Karin M. The IκB kinase complex(IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. of outstanding interest Cell. 91:1997;243-252 References by Zandi et al. and by Didonato et al., 1997 [41], Mercurio et al., 1997 [42], Regnier et al., 1997 [43] and Woronicz et al., 1997 [45] collectively describe the identification, molecular cloning and characterization of the inhibitor of NF-κB (IκB) kinases IKK-1 and IKK-2.
    • (1997) Cell , vol.91 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3    Hyakawa, M.4    Karin, M.5
  • 47
    • 0030004897 scopus 로고    scopus 로고
    • Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity
    • Chen ZJ, Parent L, Maniatis T. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell. 84:1996;853-862.
    • (1996) Cell , vol.84 , pp. 853-862
    • Chen, Z.J.1    Parent, L.2    Maniatis, T.3
  • 48
    • 0031007867 scopus 로고    scopus 로고
    • IκBα is a target for the mitogen-activated 90 kDa ribosomal S6 kinase
    • of special interest. Data presented here show that p90 ribosomal S6 kinase is also able to activate nuclear factor (NF)-κB by specifically phosphorylating the inhibitor of NF-κB (IκB)α in response to phorbol ester. This is strong biochemical evidence that the IκB kinases IKK-1 and IKK-2 are not the sole IκB kinases.
    • Schouten GL, Vertegaal ACO, Whiteside ST, Israel A, Toebes M, Dorsman JC, van der Eb AJ, Zantema A. IκBα is a target for the mitogen-activated 90 kDa ribosomal S6 kinase. of special interest EMBO J. 16:1997;3133-3144 Data presented here show that p90 ribosomal S6 kinase is also able to activate nuclear factor (NF)-κB by specifically phosphorylating the inhibitor of NF-κB (IκB)α in response to phorbol ester. This is strong biochemical evidence that the IκB kinases IKK-1 and IKK-2 are not the sole IκB kinases.
    • (1997) EMBO J , vol.16 , pp. 3133-3144
    • Schouten, G.L.1    Vertegaal, A.C.O.2    Whiteside, S.T.3    Israel, A.4    Toebes, M.5    Dorsman, J.C.6    Van Der Eb, A.J.7    Zantema, A.8
  • 49
    • 0031159205 scopus 로고    scopus 로고
    • Multifocal defects in immune responses in RelB-deficient mice
    • Weih F, Warr G, Yang H, Bravo R. Multifocal defects in immune responses in RelB-deficient mice. J Immunol. 158:1997;5211-5218.
    • (1997) J Immunol , vol.158 , pp. 5211-5218
    • Weih, F.1    Warr, G.2    Yang, H.3    Bravo, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.