Rel/NF-κB transcription factors: Key mediators of B-cell activation

Immunological Reviews

Volumn 176, Issue , 2000, Pages 134-140

  Gugasyan, R ^a   Grumont, R ^a   Grossmann, M ^a   Nakamura, Y ^a   Pohl, T ^a   Nesic, D ^a   Gerondakis, S ^a  

^a ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR; IMMUNOGLOBULIN CLASS; TRANSCRIPTION FACTOR REL;

ANIMAL CELL; B LYMPHOCYTE; CELL CYCLE; CELL DIVISION; CELL SURVIVAL; FETUS; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; GENE EXPRESSION REGULATION; HUMAN; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PROTO ONCOGENE;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL DIVISION; GENE EXPRESSION REGULATION; GENES, REL; HUMANS; IMMUNOGLOBULIN ISOTYPES; LYMPHOCYTE ACTIVATION; MICE; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-REL;

EID: 0033626350     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2000.00615.x     Document Type: Review

References (36)

1. Inducibility of κ immunoglobulin enhancer-binding protein Nf-κB by a posttranslational mechanism
2. Function and activation of NF-κB in the immune system
3. The NF-κB and IκB proteins: New discoveries and insights
4. Genetic approaches in mice to understand Rel/NF-κB and IκB function: Transgenics and knockouts
5. Mechanistic aspects of NF-κB regulation: The emerging role of phosphorylation and proteolysis
6. Rel/NF-κB/I κB family: Intimate tales of association and dissociation
7. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation
8. The subunit composition of NF-κB complexes changes during B-cell development
9. Sequential induction of NF-κB/Rel family proteins during B-cell terminal differentiation
10. The regulation and roles of Rel/NF-κB transcription factors during lymphocyte activation
11. Requirement for NF-κB in osteoclast and B-cell development
12. Failure of lymphopoiesis after adoptive transfer of NF-κB-deficient fetal liver cells
13. Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
14. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB
15. Life and death during lymphocyte development and function: Evidence for two distinct killing mechanisms
16. Long-lived B cells are distinguished by elevated expression of A1
17. Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis
18. B lymphocytes differentially use the Rel and nuclear factor κB1 (NF-κB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells
19. Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene
20. Role of bcl-2 in the development of lymphoid cells from the hematopoietic stem cell
21. Demonstration of B-cell maturation in X-linked immunodeficient mice by simultaneous three-colour immunofluorescence
22. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
23. Syk tyrosine kinase is required for the positive selection of immature B cells into the recirculating B cell pool
24. The complexity of signaling pathways activated by the BCR
25. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death
26. NF-κB RelA-deficient lymphocytes: Normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses
27. Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses
28. The immunoglobulin class switch: Beyond 'accessibility'
29. B cells from p50/NF-κB knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching
30. Molecular cloning of LSIRF, a lymphoid-specific member of the interferon regulatory factor family that binds the interferon-stimulated response element (ISRE)
31. Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function
32. Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma
33. The growing family of interferon regulatory factors
34. IRF-1: The transcription factor linking the interferon response and oncogenesis
35. Rel induces interferon regulatory factor 4 (IRF-4) expression in lymphocytes: Modulation of interferon-regulated gene expression by Rel/nuclear factor κB
36. A novel interferon regulatory factor family transcription factor, ICSAT/Pip/LSIRF, that negatively regulates the activity of interferon-regulated genes