메뉴 건너뛰기




Volumn 52, Issue 8, 2003, Pages 322-333

Some aspects of interindividual variations in the metabolism of xenobiotics

Author keywords

Cytochrome P450 gene; Inducers; Nuclear receptors; Polymorphism; Regulation

Indexed keywords

CELL NUCLEUS RECEPTOR; CYTOCHROME P450;

EID: 0041662013     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00011-003-1186-4     Document Type: Review
Times cited : (28)

References (94)
  • 1
    • 0028237729 scopus 로고
    • Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
    • Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians. J Pharmacol Exp Therap 1994; 270: 414-23.
    • (1994) J Pharmacol Exp Therap , vol.270 , pp. 414-423
    • Shimada, T.1    Yamazaki, H.2    Mimura, M.3    Inui, Y.4    Guengerich, F.P.5
  • 2
    • 0028289040 scopus 로고
    • Clinical implications of genetic polymorphism in drug metabolism
    • Tucker GT. Clinical implications of genetic polymorphism in drug metabolism. J Pharm Pharmacol. 1994; 46 (suppl. 1): 417-24.
    • (1994) J Pharm Pharmacol , vol.46 , Issue.1 SUPPL. , pp. 417-424
    • Tucker, G.T.1
  • 4
    • 85057305219 scopus 로고    scopus 로고
    • Cytochrome P450 nomenclature
    • Philips IR, Shephard EA, editors. Humana Press, Totowa New Jersey
    • Nelson DR. Cytochrome P450 nomenclature. In: Philips IR, Shephard EA, editors. Cytochrome P450 Protocols. Humana Press, Totowa New Jersey, 1998: 15-25.
    • (1998) Cytochrome P450 Protocols , pp. 15-25
    • Nelson, D.R.1
  • 6
    • 0035726732 scopus 로고    scopus 로고
    • Alteration of drug biotransformation and elimination during infection and inflammation
    • Renton KW. Alteration of drug biotransformation and elimination during infection and inflammation. Pharmacol Therap 2001; 92: 147-63.
    • (2001) Pharmacol Therap , vol.92 , pp. 147-163
    • Renton, K.W.1
  • 7
    • 0035119064 scopus 로고    scopus 로고
    • Regulation of cytochrome P450 by inflammatory mediators: Why and how?
    • Morgan ET. Regulation of cytochrome P450 by inflammatory mediators: why and how? Drug Metab Dispos 2001; 29: 207-12.
    • (2001) Drug Metab Dispos , vol.29 , pp. 207-212
    • Morgan, E.T.1
  • 8
    • 0034655747 scopus 로고    scopus 로고
    • Regulation of cytochrome P450 (CYP) genes by nuclear receptors
    • Honkakoski P, Negishi M. Regulation of cytochrome P450 (CYP) genes by nuclear receptors. Biochem J 2000; 347: 321-37.
    • (2000) Biochem J , vol.347 , pp. 321-337
    • Honkakoski, P.1    Negishi, M.2
  • 9
    • 0035136070 scopus 로고    scopus 로고
    • Organization of the CYP1A cluster on human chromosome 15: Implications for gene regulation
    • Corchero J, Pimprale S, Kimura S, Gonzalez FJ. Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation. Pharmacogenetics 2001; 11: 1-6.
    • (2001) Pharmacogenetics , vol.11 , pp. 1-6
    • Corchero, J.1    Pimprale, S.2    Kimura, S.3    Gonzalez, F.J.4
  • 10
    • 0032414615 scopus 로고    scopus 로고
    • Molecular genetics of the human cytochrome P450 monooxygenase superfamily
    • Smith G, Stubbins MJ, Harries LW, Wolf CR. Molecular genetics of the human cytochrome P450 monooxygenase superfamily. Xenobiotica 1998; 28: 1129-65.
    • (1998) Xenobiotica , vol.28 , pp. 1129-1165
    • Smith, G.1    Stubbins, M.J.2    Harries, L.W.3    Wolf, C.R.4
  • 11
    • 0023665615 scopus 로고
    • Characterization of xenobiotic responsive elements upstream from the drug-metabolizing cytochrome P-450c gene: A similarity to glucocorticoid regulatory elements
    • Fujisawa-Sehara A, Sogawa K, Yamane M., Fuji-Kurijama Y. Characterization of xenobiotic responsive elements upstream from the drug-metabolizing cytochrome P-450c gene: a similarity to glucocorticoid regulatory elements. Nucleic Acids Res 1987; 15: 4179-91.
    • (1987) Nucleic Acids Res , vol.15 , pp. 4179-4191
    • Fujisawa-Sehara, A.1    Sogawa, K.2    Yamane, M.3    Fuji-Kurijama, Y.4
  • 13
    • 0025264720 scopus 로고
    • A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene
    • Yanagida A, Sogawa K, Yasumoto K-I, Fujii-Kurijama Y. A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene. Mol Cell Biol 1990; 10: 1470-75.
    • (1990) Mol Cell Biol , vol.10 , pp. 1470-1475
    • Yanagida, A.1    Sogawa, K.2    Yasumoto, K.-I.3    Fujii-Kurijama, Y.4
  • 15
    • 0026625037 scopus 로고
    • Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor
    • Reyes H, Reisz-Porszasz S, Hankinson O. Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science 1992; 256: 1193-95.
    • (1992) Science , vol.256 , pp. 1193-1195
    • Reyes, H.1    Reisz-Porszasz, S.2    Hankinson, O.3
  • 16
    • 0027403810 scopus 로고
    • Ligand-dependent recruitment of the Arnt coregulator determines DNA recognation by the dioxin receptor
    • Whitelaw M, Pongratz I, Wilhelmsson A, Gustafsson J-A, Poellinger L. Ligand-dependent recruitment of the Arnt coregulator determines DNA recognation by the dioxin receptor. Mol Cell Biol 1993; 13: 2504-14.
    • (1993) Mol Cell Biol , vol.13 , pp. 2504-2514
    • Whitelaw, M.1    Pongratz, I.2    Wilhelmsson, A.3    Gustafsson, J.-A.4    Poellinger, L.5
  • 17
    • 0027442864 scopus 로고
    • A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consist of at least two helix-loop-helix proteins, Ah receptor and Arnt
    • Matsushita N, Sogawa K, Ema M, Yashida A, Fujii-Kuriyama Y. A factor binding to the xenobiotic responsive element (XRE) of P-4501A1 gene consist of at least two helix-loop-helix proteins, Ah receptor and Arnt. J Biol Chem 1993; 268: 21002-6.
    • (1993) J Biol Chem , vol.268 , pp. 21002-21006
    • Matsushita, N.1    Sogawa, K.2    Ema, M.3    Yashida, A.4    Fujii-Kuriyama, Y.5
  • 18
    • 0029131399 scopus 로고
    • Partial characterization of the human CYP1A1 negatively acting transcription factor and mutational analysis of its cognate DNA recognition sequence
    • Boucher PD, Piechocki MP, Hines RN. Partial characterization of the human CYP1A1 negatively acting transcription factor and mutational analysis of its cognate DNA recognition sequence. Mol Cell Biol 1995; 15: 5144-51.
    • (1995) Mol Cell Biol , vol.15 , pp. 5144-5151
    • Boucher, P.D.1    Piechocki, M.P.2    Hines, R.N.3
  • 19
    • 0032970253 scopus 로고    scopus 로고
    • Role of canonical glucocorticoid responsive elements in modulating expression of genes regulated by the arylhydrocarbon receptor
    • Linder MW, Falkner KC, Sprinivasan G, Hines RN, Prough RA. Role of canonical glucocorticoid responsive elements in modulating expression of genes regulated by the arylhydrocarbon receptor. Drug Metab Rev 1999; 31: 247-71.
    • (1999) Drug Metab Rev , vol.31 , pp. 247-271
    • Linder, M.W.1    Falkner, K.C.2    Sprinivasan, G.3    Hines, R.N.4    Prough, R.A.5
  • 20
    • 12444308159 scopus 로고    scopus 로고
    • The effect of dexamethasone on in vitro induction of CYP1A1 by 3-methylcholantrene
    • Stresa, Italy. July 10-14
    • Monostory K, Vereczkey L. The effect of dexamethasone on in vitro induction of CYP1A1 by 3-methylcholantrene. Microsomes and Drug Oxidations, Stresa, Italy. July 10-14 2000; 104.
    • (2000) Microsomes and Drug Oxidations , vol.104
    • Monostory, K.1    Vereczkey, L.2
  • 21
    • 0026753655 scopus 로고
    • Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells
    • Fukuda Y, Ishida N, Noguchi T, Kappas A, Sassa S. Interleukin-6 down regulates the expression of transcripts encoding cytochrome P450 IA1, IA2 and IIIA3 in human hepatoma cells. Biochem Biophys Res Commun 1992; 184: 960-65.
    • (1992) Biochem Biophys Res Commun , vol.184 , pp. 960-965
    • Fukuda, Y.1    Ishida, N.2    Noguchi, T.3    Kappas, A.4    Sassa, S.5
  • 22
    • 0028348202 scopus 로고
    • Suppression of cytochrome P450IA1 by interleukin-6 in human HepG2 hepatoma cells
    • Fukuda Y, Sassa S. Suppression of cytochrome P450IA1 by interleukin-6 in human HepG2 hepatoma cells. Biochem Pharmacol 1994; 47: 1187-95.
    • (1994) Biochem Pharmacol , vol.47 , pp. 1187-1195
    • Fukuda, Y.1    Sassa, S.2
  • 23
    • 0028670237 scopus 로고
    • Transforming growth factor-β1 down-regulates basal and polycyclic aromatic hydrocarbon-induced cytochromes P-450 1A1 and 1A2 in adult human hepatocytes in primary culture
    • Abdel-Razzak Z, Corcos L, Fautrel A, Campion JP, Guillouzo A. Transforming growth factor-β1 down-regulates basal and polycyclic aromatic hydrocarbon-induced cytochromes P-450 1A1 and 1A2 in adult human hepatocytes in primary culture. Mol Pharmacol 1994; 46: 1100-10.
    • (1994) Mol Pharmacol , vol.46 , pp. 1100-1110
    • Abdel-Razzak, Z.1    Corcos, L.2    Fautrel, A.3    Campion, J.P.4    Guillouzo, A.5
  • 24
    • 0029126915 scopus 로고
    • Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2 and CYP3A4 in human hepatocytes in primary culture
    • Muntane-Relat J, Ourlin J-C, Domergue J, Maurel P. Differential effects of cytokines on the inducible expression of CYP1A1, CYP1A2 and CYP3A4 in human hepatocytes in primary culture. Hepatology 1995; 22: 1143-53.
    • (1995) Hepatology , vol.22 , pp. 1143-1153
    • Muntane-Relat, J.1    Ourlin, J.-C.2    Domergue, J.3    Maurel, P.4
  • 25
    • 0025236927 scopus 로고
    • Identification of genetically high risk individual to lung cancer by DNA polymorphisms of the cytochrome P4501A1 gene
    • Kawajari K, Nakachi K, Imai K, Yoshii A, Shonida N, Watanabe J. Identification of genetically high risk individual to lung cancer by DNA polymorphisms of the cytochrome P4501A1 gene. FEBS Lett 1990; 263: 131-3.
    • (1990) FEBS Lett , vol.263 , pp. 131-133
    • Kawajari, K.1    Nakachi, K.2    Imai, K.3    Yoshii, A.4    Shonida, N.5    Watanabe, J.6
  • 27
    • 0034890461 scopus 로고    scopus 로고
    • CYP1A1 levels in lung tissue of tobacco smokers and polymorphisms of CYP1A1 and aromatic hydrocarbon receptor
    • Anttila S, Tuominen P, Hirvonen A, Nurminen M, Karjalainen A, Hankinson O et al. CYP1A1 levels in lung tissue of tobacco smokers and polymorphisms of CYP1A1 and aromatic hydrocarbon receptor. Pharmacogenetics 2001; 11: 501-9.
    • (2001) Pharmacogenetics , vol.11 , pp. 501-509
    • Anttila, S.1    Tuominen, P.2    Hirvonen, A.3    Nurminen, M.4    Karjalainen, A.5    Hankinson, O.6
  • 28
    • 0025914145 scopus 로고
    • Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene
    • Hayashi S, Watanabe J, Nakachi K, Kawajiri K. Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene. J Biochem 1991; 110: 407-11.
    • (1991) J Biochem , vol.110 , pp. 407-411
    • Hayashi, S.1    Watanabe, J.2    Nakachi, K.3    Kawajiri, K.4
  • 30
    • 0029854529 scopus 로고    scopus 로고
    • A C4887A polymorphism in exon 7 of human CYP1A1: Population frequency, mutation linkages, and impact on lung cancer susceptibility
    • Cascorbi I, Brockmöller J, Roots I. A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility. Cancer Res 1996; 56: 4965-9.
    • (1996) Cancer Res , vol.56 , pp. 4965-4969
    • Cascorbi, I.1    Brockmöller, J.2    Roots, I.3
  • 31
  • 32
    • 0030977819 scopus 로고    scopus 로고
    • Human Ah receptor (AHR) gene: Localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility
    • Micka J, Milatovich A, Menon A, Grabowski AG, Puga A, Nebert DW. Human Ah receptor (AHR) gene: localization to 7p15 and suggestive correlation of polymorphism with CYP1A1 inducibility. Pharmacogenetics 1997; 7: 95-101.
    • (1997) Pharmacogenetics , vol.7 , pp. 95-101
    • Micka, J.1    Milatovich, A.2    Menon, A.3    Grabowski, A.G.4    Puga, A.5    Nebert, D.W.6
  • 33
    • 0034054613 scopus 로고    scopus 로고
    • Variation in induced CYP1A1 levels: Relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms
    • Smart J, Daly KA. Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms. Pharmacogenetics 2000; 10: 11-24.
    • (2000) Pharmacogenetics , vol.10 , pp. 11-24
    • Smart, J.1    Daly, K.A.2
  • 34
    • 0035834558 scopus 로고    scopus 로고
    • Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction
    • Wong JMY, Okey AB, Harper PA. Human aryl hydrocarbon receptor polymorphisms that result in loss of CYP1A1 induction. Biochem Biophys Res Commun 2001; 288: 990-6.
    • (2001) Biochem Biophys Res Commun , vol.288 , pp. 990-996
    • Wong, J.M.Y.1    Okey, A.B.2    Harper, P.A.3
  • 35
    • 0026879487 scopus 로고
    • Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites
    • Butler MA, Lang NP, Young JF, Caporaso NE, Vineis P, Hayes RB et al. Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. Pharmacogenetics 1992; 2: 116-27.
    • (1992) Pharmacogenetics , vol.2 , pp. 116-127
    • Butler, M.A.1    Lang, N.P.2    Young, J.F.3    Caporaso, N.E.4    Vineis, P.5    Hayes, R.B.6
  • 36
    • 0030834058 scopus 로고    scopus 로고
    • Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors
    • Rendic S, Di Carlo FJ. Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors. Drug Metab Rev 1997; 29: 413-580.
    • (1997) Drug Metab Rev , vol.29 , pp. 413-580
    • Rendic, S.1    Di Carlo, F.J.2
  • 39
    • 0034629105 scopus 로고    scopus 로고
    • Transcriptional regulation of the human CYP1B1 gene
    • Shehin SE, Stephenson RO, Greenlee WF. Transcriptional regulation of the human CYP1B1 gene. J Biol Chem 2000; 275: 6770-6.
    • (2000) J Biol Chem , vol.275 , pp. 6770-6776
    • Shehin, S.E.1    Stephenson, R.O.2    Greenlee, W.F.3
  • 40
    • 0029591606 scopus 로고
    • Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19
    • Hoffman SMG, Fernandez-Salguero P, Gonzales FJ, Mohrenweiser HW. Organization and evolution of the cytochrome P450 CYP2A-2B-2F subfamily gene cluster on human chromosome 19. J Mol Evol 1995; 41: 894-900.
    • (1995) J Mol Evol , vol.41 , pp. 894-900
    • Hoffman, S.M.G.1    Fernandez-Salguero, P.2    Gonzales, F.J.3    Mohrenweiser, H.W.4
  • 41
    • 0029099107 scopus 로고
    • A genetic polimorphism in coumarin 7-hydroxylation: Sequence of the human CYP2A genes and identification of variant CYP2A6 alleles
    • Fernandez-Salguero P, Hoffman SMG, Cholerton S, Mohrenweiser HW, Raunio H, Rautio A et al. A genetic polimorphism in coumarin 7-hydroxylation: sequence of the human CYP2A genes and identification of variant CYP2A6 alleles. Am J Hum Genet 1995; 57: 651-60.
    • (1995) Am J Hum Genet , vol.57 , pp. 651-660
    • Fernandez-Salguero, P.1    Hoffman, S.M.G.2    Cholerton, S.3    Mohrenweiser, H.W.4    Raunio, H.5    Rautio, A.6
  • 44
    • 0025022689 scopus 로고
    • The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes
    • Yamano S, Tatsuno J, Gonzalez FJ. The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. Biochemistry 1990; 29: 1322-29.
    • (1990) Biochemistry , vol.29 , pp. 1322-1329
    • Yamano, S.1    Tatsuno, J.2    Gonzalez, F.J.3
  • 45
    • 0035038008 scopus 로고    scopus 로고
    • Phenobarbital response elements of cytochrome P450 genes and nuclear receptors
    • Sueyoshi T, Negishi M. Phenobarbital response elements of cytochrome P450 genes and nuclear receptors. Annu Rev Pharmacol Toxicol 2001; 41: 123-43.
    • (2001) Annu Rev Pharmacol Toxicol , vol.41 , pp. 123-143
    • Sueyoshi, T.1    Negishi, M.2
  • 46
    • 0036142429 scopus 로고    scopus 로고
    • Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital
    • Ueda A, Hamadeh HK, Webb HK, Yamamoto Y, Sueyoshi T, Afshari CA et al. Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol Pharmacol 2002; 61: 1-6.
    • (2002) Mol Pharmacol , vol.61 , pp. 1-6
    • Ueda, A.1    Hamadeh, H.K.2    Webb, H.K.3    Yamamoto, Y.4    Sueyoshi, T.5    Afshari, C.A.6
  • 47
    • 0034649218 scopus 로고    scopus 로고
    • Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes
    • Zelko I, Negishi M. Phenobarbital-elicited activation of nuclear receptor CAR in induction of cytochrome P450 genes. Biochem Biophys Res Commun 2000; 277: 1-6.
    • (2000) Biochem Biophys Res Commun , vol.277 , pp. 1-6
    • Zelko, I.1    Negishi, M.2
  • 48
    • 0033664347 scopus 로고    scopus 로고
    • Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: Consequences on cytochrome P450 gene regulation
    • Pascussi J-M, Gerbal-Chaloin S, Fabre J-M, Maurel P, Vilarem M-J. Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation. Mol Pharmacol 2000; 58: 1441-50.
    • (2000) Mol Pharmacol , vol.58 , pp. 1441-1450
    • Pascussi, J.-M.1    Gerbal-Chaloin, S.2    Fabre, J.-M.3    Maurel, P.4    Vilarem, M.-J.5
  • 50
    • 0037067665 scopus 로고    scopus 로고
    • Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes
    • Drocourt L, Ourlin J-C, Pascussi J-M, Maurel P, Vilarem M-J. Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes. J Biol Chem 2002; 277: 25125-32.
    • (2002) J Biol Chem , vol.277 , pp. 25125-25132
    • Drocourt, L.1    Ourlin, J.-C.2    Pascussi, J.-M.3    Maurel, P.4    Vilarem, M.-J.5
  • 51
    • 0034637122 scopus 로고    scopus 로고
    • Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes
    • Pascussi J-M, Gerbal-Chaloin S, Pichard-Garcia L, Daujat M, Fabre J-M, Maurel P et al. Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes. Biochem Biophys Res Commun 2000; 274: 707-13.
    • (2000) Biochem Biophys Res Commun , vol.274 , pp. 707-713
    • Pascussi, J.-M.1    Gerbal-Chaloin, S.2    Pichard-Garcia, L.3    Daujat, M.4    Fabre, J.-M.5    Maurel, P.6
  • 52
    • 0029122980 scopus 로고
    • A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24
    • Gray IC, Nobile C, Muresu R, Ford S, Spurr NK. A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24. Genomics 1995; 28: 328-32.
    • (1995) Genomics , vol.28 , pp. 328-332
    • Gray, I.C.1    Nobile, C.2    Muresu, R.3    Ford, S.4    Spurr, N.K.5
  • 54
    • 0029035904 scopus 로고
    • Transcriptional regulation of human CYP2C genes: Functional comparison of CYP2C9 and CYP2C18 promoter regions
    • Ibeanu GC, Goldstein J. Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions. Biochemistry 1995; 34: 8028-36.
    • (1995) Biochemistry , vol.34 , pp. 8028-8036
    • Ibeanu, G.C.1    Goldstein, J.2
  • 55
    • 0036206152 scopus 로고    scopus 로고
    • Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: Effect on atypical kinetic metabolism profiles
    • Tracy TS, Hutzler JM, Haining RL, Rettie AE, Hummel MA, Dickmaun LJ. Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles. Drug Metab Dispos 2002; 30: 385-90.
    • (2002) Drug Metab Dispos , vol.30 , pp. 385-390
    • Tracy, T.S.1    Hutzler, J.M.2    Haining, R.L.3    Rettie, A.E.4    Hummel, M.A.5    Dickmaun, L.J.6
  • 59
    • 0032797302 scopus 로고    scopus 로고
    • A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin
    • Ibeanu GC, Blaisdell J, Ferguson RJ, Ghanayem BI, Brosen K, Benhamou S et al. A novel transversion in the intron 5 donor splice junction of CYP2C19 and a sequence polymorphism in exon 3 contribute to the poor metabolizer phenotype for the anticonvulsant drug S-mephenytoin. J Pharmacol Exp Therap 1999, 290: 635-40.
    • (1999) J Pharmacol Exp Therap , vol.290 , pp. 635-640
    • Ibeanu, G.C.1    Blaisdell, J.2    Ferguson, R.J.3    Ghanayem, B.I.4    Brosen, K.5    Benhamou, S.6
  • 60
    • 0024796958 scopus 로고
    • The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and pseudogene
    • Kimura S, Umeno M, Skoda RC, Meyer UA, Gonzalez FJ. The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and pseudogene. Am J Hum Genet 1989; 45: 889-904.
    • (1989) Am J Hum Genet , vol.45 , pp. 889-904
    • Kimura, S.1    Umeno, M.2    Skoda, R.C.3    Meyer, U.A.4    Gonzalez, F.J.5
  • 63
    • 0027276869 scopus 로고
    • Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotype in Black Americans
    • Evans WE, Relling MV, Rahman A, McLeod HL, Scott EP, Lin JS. Genetic basis for a lower prevalence of deficient CYP2D6 oxidative drug metabolism phenotype in Black Americans. J Clin Invest. 1993; 91:2150-4.
    • (1993) J Clin Invest , vol.91 , pp. 2150-2154
    • Evans, W.E.1    Relling, M.V.2    Rahman, A.3    McLeod, H.L.4    Scott, E.P.5    Lin, J.S.6
  • 64
    • 84920227522 scopus 로고
    • Low frequency of slow debrisoquine hydroxylation in a native Chinese population
    • Lou YC, Ying L, Bertilsson L, Sjoqvist F. Low frequency of slow debrisoquine hydroxylation in a native Chinese population. Lancet 1987; 2: 852-3.
    • (1987) Lancet , vol.2 , pp. 852-853
    • Lou, Y.C.1    Ying, L.2    Bertilsson, L.3    Sjoqvist, F.4
  • 65
    • 0032540934 scopus 로고    scopus 로고
    • Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells
    • Jover R, Bort R, Gomez-Lechon MJ, Castell JV. Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells. FEBS Lett 1998; 431: 227-30.
    • (1998) FEBS Lett , vol.431 , pp. 227-230
    • Jover, R.1    Bort, R.2    Gomez-Lechon, M.J.3    Castell, J.V.4
  • 67
    • 0035029635 scopus 로고    scopus 로고
    • Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: Mechanisms involving endogenous factors
    • Hines RN, Luo Z, Cresteil T, Ding X, Prough RA, Fitzpatrick JL et al. Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: mechanisms involving endogenous factors. Drug Metab Dispos 2001; 29: 623-33.
    • (2001) Drug Metab Dispos , vol.29 , pp. 623-633
    • Hines, R.N.1    Luo, Z.2    Cresteil, T.3    Ding, X.4    Prough, R.A.5    Fitzpatrick, J.L.6
  • 68
    • 0026567713 scopus 로고
    • Oxidative and reductive metabolism by cytochrome P450 2E1
    • Koop DR. Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J 1992; 6: 724-30.
    • (1992) FASEB J , vol.6 , pp. 724-730
    • Koop, D.R.1
  • 69
    • 0025073482 scopus 로고
    • Transcriptional control of the rat hepatic CYP2E1 gene
    • Ueno T, Gonzalez FJ. Transcriptional control of the rat hepatic CYP2E1 gene. Mol Cell Biol 1990; 10: 4495-505.
    • (1990) Mol Cell Biol , vol.10 , pp. 4495-4505
    • Ueno, T.1    Gonzalez, F.J.2
  • 71
    • 0025492528 scopus 로고
    • Multiple mechanisms in the regulation of ethanol inducible cytochrome P450IIE1
    • Koop DR, Tierney DJ. Multiple mechanisms in the regulation of ethanol inducible cytochrome P450IIE1. BioEssays 1990; 12: 429-35.
    • (1990) BioEssays , vol.12 , pp. 429-435
    • Koop, D.R.1    Tierney, D.J.2
  • 72
    • 0027443904 scopus 로고
    • Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture
    • Abdel-Razzak Z, Loyer P, Fautrel A, Gautier J-C, Corcos L, Turlin B et al. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol Pharmacol 1993; 44: 707-15.
    • (1993) Mol Pharmacol , vol.44 , pp. 707-715
    • Abdel-Razzak, Z.1    Loyer, P.2    Fautrel, A.3    Gautier, J.-C.4    Corcos, L.5    Turlin, B.6
  • 75
    • 0032702726 scopus 로고    scopus 로고
    • The orphan human pregnane X receptor mediates the transcripcional activation of CYP3A4 by rifampicin through a distal enchancer module
    • Goodwin B, Hodgson E, Liddle C. The orphan human pregnane X receptor mediates the transcripcional activation of CYP3A4 by rifampicin through a distal enchancer module. Mol Pharmacol 1999; 56: 1329-39.
    • (1999) Mol Pharmacol , vol.56 , pp. 1329-1339
    • Goodwin, B.1    Hodgson, E.2    Liddle, C.3
  • 76
    • 0035042684 scopus 로고    scopus 로고
    • CYP3A regulation: From pharmacology to nuclear receptors
    • Quatrochi LC, Guzelian PS. CYP3A regulation: from pharmacology to nuclear receptors. Drug Metab Dispos 2001; 29: 615-22.
    • (2001) Drug Metab Dispos , vol.29 , pp. 615-622
    • Quatrochi, L.C.1    Guzelian, P.S.2
  • 77
    • 0030059885 scopus 로고    scopus 로고
    • Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells
    • Schuetz JD, Schuetz EG, Thottassery JV, Guzelian PS, Strom S, Sun D. Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. Mol Pharmacol 1996; 49: 63-72.
    • (1996) Mol Pharmacol , vol.49 , pp. 63-72
    • Schuetz, J.D.1    Schuetz, E.G.2    Thottassery, J.V.3    Guzelian, P.S.4    Strom, S.5    Sun, D.6
  • 78
    • 0033931266 scopus 로고    scopus 로고
    • Dexamethasone induces pregnane X receptor and retinoid X receptor-α expression in human hepatocytes; synergistic increase of CYP3A4 induction by pregnane X receptor activators
    • Pascussi J-M, Drocourt L, Fabre J-M, Maurel P, Vilarem MJ. Dexamethasone induces pregnane X receptor and retinoid X receptor-α expression in human hepatocytes; synergistic increase of CYP3A4 induction by pregnane X receptor activators. Mol Pharmacol 2000; 58: 361-72.
    • (2000) Mol Pharmacol , vol.58 , pp. 361-372
    • Pascussi, J.-M.1    Drocourt, L.2    Fabre, J.-M.3    Maurel, P.4    Vilarem, M.J.5
  • 83
    • 0034782509 scopus 로고    scopus 로고
    • Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor
    • Staudinger JL, Liu Y, Madan A, Habeebu S, Klaassen CD. Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor. Drug Metab Dispos 2001; 29: 1467-72.
    • (2001) Drug Metab Dispos , vol.29 , pp. 1467-1472
    • Staudinger, J.L.1    Liu, Y.2    Madan, A.3    Habeebu, S.4    Klaassen, C.D.5
  • 84
    • 0036209248 scopus 로고    scopus 로고
    • Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor
    • Kliewer SA, Willson TM. Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor. J Lipid Res 2002; 43: 359-64.
    • (2002) J Lipid Res , vol.43 , pp. 359-364
    • Kliewer, S.A.1    Willson, T.M.2
  • 85
    • 0001313948 scopus 로고
    • Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase
    • Beaune PH, Umbenhauer DR, Bork RW, Lloyd RS, Guengerich FP. Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase. Proc Natl Acad Sci USA 1986; 83: 8064-68.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 8064-8068
    • Beaune, P.H.1    Umbenhauer, D.R.2    Bork, R.W.3    Lloyd, R.S.4    Guengerich, F.P.5
  • 86
    • 0024588897 scopus 로고
    • Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity
    • Bork RW, Muto T, Beaune PH, Srivastava PK, Lloyd RS, Guengerich FP. Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity. J Biol Chem 1989; 264: 910-19.
    • (1989) J Biol Chem , vol.264 , pp. 910-919
    • Bork, R.W.1    Muto, T.2    Beaune, P.H.3    Srivastava, P.K.4    Lloyd, R.S.5    Guengerich, F.P.6
  • 87
    • 0023858226 scopus 로고
    • Human P450PCN1: Sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase
    • Gonzalez FJ, Schmid BJ, Umeno M, McBridge OW, Hardwick JP, Meyer UA et al. Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase. DNA 1988; 7: 79-86.
    • (1988) DNA , vol.7 , pp. 79-86
    • Gonzalez, F.J.1    Schmid, B.J.2    Umeno, M.3    McBridge, O.W.4    Hardwick, J.P.5    Meyer, U.A.6
  • 88
    • 17744397194 scopus 로고    scopus 로고
    • Genomic organisation of the human CYP3A locus: Identification of a new, inducible CYP3A gene
    • Gellner K, Eiselt R, Huster E, Arnold H, Koch I, Haberl M et al. Genomic organisation of the human CYP3A locus: identification of a new, inducible CYP3A gene. Pharmacogenetics 2001; 11: 111-21.
    • (2001) Pharmacogenetics , vol.11 , pp. 111-121
    • Gellner, K.1    Eiselt, R.2    Huster, E.3    Arnold, H.4    Koch, I.5    Haberl, M.6
  • 89
    • 0036786382 scopus 로고    scopus 로고
    • Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA
    • Koch I, Weil R, Wolbold R, Brockmoller J, Hustert E, Burk O et al. Interindividual variability and tissue-specificity in the expression of cytochrome P450 3A mRNA. Drug Metab Dispos 2002; 30: 1108-14.
    • (2002) Drug Metab Dispos , vol.30 , pp. 1108-1114
    • Koch, I.1    Weil, R.2    Wolbold, R.3    Brockmoller, J.4    Hustert, E.5    Burk, O.6
  • 90
    • 0342468270 scopus 로고    scopus 로고
    • Detection of a CYP3A5 allelic variant: A candidate for the polymorphic expression of the protein?
    • Jounaidi Y, Hyrailles V, Gervot L, Maurel P. Detection of a CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein? Biochem Biophys Res Commun 1996; 221: 466-70.
    • (1996) Biochem Biophys Res Commun , vol.221 , pp. 466-470
    • Jounaidi, Y.1    Hyrailles, V.2    Gervot, L.3    Maurel, P.4
  • 91
    • 0035071598 scopus 로고    scopus 로고
    • Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression
    • Kuehl P, Zhang J, Lin Y, Lamba J, Assem M, Schuetz J et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet 2001; 27: 383-91.
    • (2001) Nat Genet , vol.27 , pp. 383-391
    • Kuehl, P.1    Zhang, J.2    Lin, Y.3    Lamba, J.4    Assem, M.5    Schuetz, J.6
  • 92
    • 0036156595 scopus 로고    scopus 로고
    • The ontogeny of human drug-metabolizing enzymes: Phase I oxidative enzymes
    • Hines RN, McCarver DG. The ontogeny of human drug-metabolizing enzymes: phase I oxidative enzymes. J Pharmacol Exp Therap 2002; 300: 355-60.
    • (2002) J Pharmacol Exp Therap , vol.300 , pp. 355-360
    • Hines, R.N.1    McCarver, D.G.2
  • 93
    • 0038347333 scopus 로고    scopus 로고
    • Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during menstrual cycle
    • Sarkar MA, Vadlamuri V, Ghosh S, Glover DG. Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during menstrual cycle. Drug Metab Dispos 2003; 31: 1-6.
    • (2003) Drug Metab Dispos , vol.31 , pp. 1-6
    • Sarkar, M.A.1    Vadlamuri, V.2    Ghosh, S.3    Glover, D.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.