메뉴 건너뛰기




Volumn 12, Issue 2, 2003, Pages 71-78

PTEN as a molecular marker to distinguish metastatic from primary synchronous endometrioid carcinomas of the ovary and uterus

Author keywords

Ovary; PTEN; Synchronous endometrioid carcinoma; Uterus

Indexed keywords

MOLECULAR MARKER; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

EID: 0038779338     PISSN: 10529551     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019606-200306000-00002     Document Type: Article
Times cited : (23)

References (47)
  • 1
    • 0002709042 scopus 로고    scopus 로고
    • Tumors of the ovary, maldeveloped gonads, fallopian tube and broad ligament
    • (AFIP, Atlas of Tumor Pathology No. 23). Washington, D.C., Am. Registry of Pathology
    • Scully RE. Tumors of the ovary, maldeveloped gonads, fallopian tube and broad ligament. Atlas of Tumor Pathology (AFIP, Atlas of Tumor Pathology No. 23). Washington, D.C., Am. Registry of Pathology, 1999:125-6.
    • (1999) Atlas of Tumor Pathology , pp. 125-126
    • Scully, R.E.1
  • 2
    • 0023853367 scopus 로고
    • Simultaneous endometrioid carcinoma of the uterine corpus and ovary: A clinicopathologic study of 15 cases
    • Jambhekar NA, Sampat MB. Simultaneous endometrioid carcinoma of the uterine corpus and ovary: a clinicopathologic study of 15 cases. J Surg Oncol 1988;37:20-3.
    • (1988) J Surg Oncol , vol.37 , pp. 20-23
    • Jambhekar, N.A.1    Sampat, M.B.2
  • 3
    • 0027761370 scopus 로고
    • Synchronous dual primary ovarian and endometrial carcinomas
    • Pearl ML, Johnston CM, Frank TS, et al. Synchronous dual primary ovarian and endometrial carcinomas. Int J Gynaecol Obstet 1993;43:305-12.
    • (1993) Int J Gynaecol Obstet , vol.43 , pp. 305-312
    • Pearl, M.L.1    Johnston, C.M.2    Frank, T.S.3
  • 4
    • 0034754947 scopus 로고    scopus 로고
    • Simultaneously detected endometrial and ovarian carcinomas - A prospective clinocipathologic of 74 cases: A gynecologic oncology group study
    • Zaino R, Whitney C, Brady MF, et al. Simultaneously detected endometrial and ovarian carcinomas - a prospective clinocipathologic of 74 cases: a gynecologic oncology group study. Gynecol Oncol 2001;83:355-62.
    • (2001) Gynecol Oncol , vol.83 , pp. 355-362
    • Zaino, R.1    Whitney, C.2    Brady, M.F.3
  • 5
    • 0031004088 scopus 로고    scopus 로고
    • Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
    • Liaw D, Marsh DJ, Li J, et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 1997;16:64-7.
    • (1997) Nat Genet , vol.16 , pp. 64-67
    • Liaw, D.1    Marsh, D.J.2    Li, J.3
  • 6
    • 0031203265 scopus 로고    scopus 로고
    • Germline mutations in PTEN are present in Bannayan-Zonana syndrome
    • Marsh DJ, Dahia PL, Zheng Z, et al. Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat Genet 1997;16:333-4.
    • (1997) Nat Genet , vol.16 , pp. 333-334
    • Marsh, D.J.1    Dahia, P.L.2    Zheng, Z.3
  • 7
    • 0035734381 scopus 로고    scopus 로고
    • PTEN regulates neuronal soma size: A mouse model of Lhermitte-Duclos disease
    • Kwon CH, Zhu X, Zhang J, et al. PTEN regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat Genet 2001; 29:404-11.
    • (2001) Nat Genet , vol.29 , pp. 404-411
    • Kwon, C.H.1    Zhu, X.2    Zhang, J.3
  • 8
    • 0035733762 scopus 로고    scopus 로고
    • Deletion of PTEN in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
    • Backman SA, Stambolic V, Suzuki A, et al. Deletion of PTEN in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet 2001;29:396-403.
    • (2001) Nat Genet , vol.29 , pp. 396-403
    • Backman, S.A.1    Stambolic, V.2    Suzuki, A.3
  • 9
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci U S A 1999;96:4240-5.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 10
    • 17144436629 scopus 로고    scopus 로고
    • Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
    • Steck PA, Pershouse MA, Jasser SA, et al. Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat Genet 1997;15:356-62.
    • (1997) Nat Genet , vol.15 , pp. 356-362
    • Steck, P.A.1    Pershouse, M.A.2    Jasser, S.A.3
  • 11
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997;275:1943-7.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 12
    • 0030799909 scopus 로고    scopus 로고
    • Somatic mutations of PTEN in glioblastoma multiforme
    • Wang SI, Puc J, Li J, et al. Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res 1997;57:4183-6.
    • (1997) Cancer Res , vol.57 , pp. 4183-4186
    • Wang, S.I.1    Puc, J.2    Li, J.3
  • 13
    • 0034746302 scopus 로고    scopus 로고
    • PTEN and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse
    • Di Cristofano A, De Acetis M, Koff A, et al. PTEN and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse. Nat Genet 2001;27:222-4.
    • (2001) Nat Genet , vol.27 , pp. 222-224
    • Di Cristofano, A.1    De Acetis, M.2    Koff, A.3
  • 14
    • 0032473921 scopus 로고    scopus 로고
    • Analysis of PTEN and the 10q23 region in primary prostate carcinomas
    • Feilotter HE, Nagai MA, Boag AH, et al. Analysis of PTEN and the 10q23 region in primary prostate carcinomas. Oncogene 1998; 16:1743-8.
    • (1998) Oncogene , vol.16 , pp. 1743-1748
    • Feilotter, H.E.1    Nagai, M.A.2    Boag, A.H.3
  • 15
    • 0033587014 scopus 로고    scopus 로고
    • PTEN/MMAC1 mutations in hepatocellular carcinomas
    • Yao YJ, Ping XL, Zhang H, et al. PTEN/MMAC1 mutations in hepatocellular carcinomas. Oncogene 1999;18:3181-5.
    • (1999) Oncogene , vol.18 , pp. 3181-3185
    • Yao, Y.J.1    Ping, X.L.2    Zhang, H.3
  • 16
    • 7344227886 scopus 로고    scopus 로고
    • Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers
    • Cairns P, Evron E, Okami K, et al. Point mutation and homozygous deletion of PTEN/MMAC1 in primary bladder cancers. Oncogene 1998;16:3215-8.
    • (1998) Oncogene , vol.16 , pp. 3215-3218
    • Cairns, P.1    Evron, E.2    Okami, K.3
  • 17
    • 0030777104 scopus 로고    scopus 로고
    • Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
    • Guldberg P, thor Straten P, Birck A, et al. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 1997;57:3660-3.
    • (1997) Cancer Res , vol.57 , pp. 3660-3663
    • Guldberg, P.1    Thor Straten, P.2    Birck, A.3
  • 18
    • 0030801275 scopus 로고    scopus 로고
    • Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas
    • Rhei E, Kang L, Bogomolniy F, et al. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas. Cancer Res 1997;57:3657-9.
    • (1997) Cancer Res , vol.57 , pp. 3657-3659
    • Rhei, E.1    Kang, L.2    Bogomolniy, F.3
  • 19
    • 0032857217 scopus 로고    scopus 로고
    • Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
    • Perren A, Weng LP, Boag AH, et al. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. Am J Pathol 1999;155:1253-60.
    • (1999) Am J Pathol , vol.155 , pp. 1253-1260
    • Perren, A.1    Weng, L.P.2    Boag, A.H.3
  • 20
    • 0030761409 scopus 로고    scopus 로고
    • Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecologic malignancies
    • Tashiro H, Blazes MS, Wu R, et al. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecologic malignancies. Cancer Res 1997;57:3935-40.
    • (1997) Cancer Res , vol.57 , pp. 3935-3940
    • Tashiro, H.1    Blazes, M.S.2    Wu, R.3
  • 21
    • 84984777123 scopus 로고    scopus 로고
    • PTEN1 is frequently mutated in primary endometrial carcinomas
    • Kong D, Suzuki A, Zou TT, et al. PTEN1 is frequently mutated in primary endometrial carcinomas. Nat Genet 1997;17:143-4.
    • (1997) Nat Genet , vol.17 , pp. 143-144
    • Kong, D.1    Suzuki, A.2    Zou, T.T.3
  • 22
    • 0030781053 scopus 로고    scopus 로고
    • PTEN/MMAC1 mutations in endometrial cancers
    • Risinger JI, Hayes AK, Berchuck A, et al. PTEN/MMAC1 mutations in endometrial cancers. Cancer Res 1997;57:4736-8.
    • (1997) Cancer Res , vol.57 , pp. 4736-4738
    • Risinger, J.I.1    Hayes, A.K.2    Berchuck, A.3
  • 23
    • 0034019805 scopus 로고    scopus 로고
    • PTEN mutations in endometrial carcinomas: A molecular and clinicopathologic analysis of 38 cases
    • Bussaglia E, del Rio E, Matias-Guiu X, et al. PTEN mutations in endometrial carcinomas: a molecular and clinicopathologic analysis of 38 cases. Hum Pathol 2000;31:312-7.
    • (2000) Hum Pathol , vol.31 , pp. 312-317
    • Bussaglia, E.1    Del Rio, E.2    Matias-Guiu, X.3
  • 24
    • 0032410253 scopus 로고    scopus 로고
    • PTEN mutations in endometrial cancers with 10q LOH: Additional evidence for the involvement of multiple tumor suppressors
    • Simpkins SB, Peiffer-Schneider S, Mutch DG, et al. PTEN mutations in endometrial cancers with 10q LOH: additional evidence for the involvement of multiple tumor suppressors. Gynecol Oncol 1998;71:391-5.
    • (1998) Gynecol Oncol , vol.71 , pp. 391-395
    • Simpkins, S.B.1    Peiffer-Schneider, S.2    Mutch, D.G.3
  • 25
    • 0035220843 scopus 로고    scopus 로고
    • Mutational analysis of the PTEN gene in endometrial carcinoma and hyperplasia
    • Sun H, Enomoto T, Fujita M, et al. Mutational analysis of the PTEN gene in endometrial carcinoma and hyperplasia. Am J Clin Pathol 2001;115:32-8.
    • (2001) Am J Clin Pathol , vol.115 , pp. 32-38
    • Sun, H.1    Enomoto, T.2    Fujita, M.3
  • 26
    • 0034616634 scopus 로고    scopus 로고
    • Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers
    • Mutter GL, Lin MC, Fitzgerald JT, et al. Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers. J Natl Cancer Inst 2000;92:924-30.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 924-930
    • Mutter, G.L.1    Lin, M.C.2    Fitzgerald, J.T.3
  • 27
    • 0032146038 scopus 로고    scopus 로고
    • PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma
    • Levine RL, Cargile CB, Blazes MS, et al. PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma. Cancer Res 1998; 58:3254-8.
    • (1998) Cancer Res , vol.58 , pp. 3254-3258
    • Levine, R.L.1    Cargile, C.B.2    Blazes, M.S.3
  • 28
    • 0036890870 scopus 로고    scopus 로고
    • Clonal analysis and mutations in the PTEN and in K-ras genes in endometrial hyperplasias
    • Sun H, Enomoto T, Shroyer KR, et al. Clonal analysis and mutations in the PTEN and in K-ras genes in endometrial hyperplasias. Diagn Mol Pathol 2002;11:204-11.
    • (2002) Diagn Mol Pathol , vol.11 , pp. 204-211
    • Sun, H.1    Enomoto, T.2    Shroyer, K.R.3
  • 29
    • 0032523808 scopus 로고    scopus 로고
    • Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors
    • Obata K, Morland SJ, Watson RH, et al. Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors. Cancer Res 1998;58:2095-7.
    • (1998) Cancer Res , vol.58 , pp. 2095-2097
    • Obata, K.1    Morland, S.J.2    Watson, R.H.3
  • 30
    • 0034650817 scopus 로고    scopus 로고
    • Allelic imbalance and mutations of the PTEN gene in ovarian cancer
    • Saito M, Okamoto A, Kohno T, et al. Allelic imbalance and mutations of the PTEN gene in ovarian cancer. Int J Cancer 2000; 85:160-5.
    • (2000) Int J Cancer , vol.85 , pp. 160-165
    • Saito, M.1    Okamoto, A.2    Kohno, T.3
  • 31
    • 0034671218 scopus 로고    scopus 로고
    • Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: Possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clearq cell carcinoma of the ovary
    • Sato N, Tsunoda H, Nishida M, et al. Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clearq cell carcinoma of the ovary. Cancer Res 2000;60:7052-6.
    • (2000) Cancer Res , vol.60 , pp. 7052-7056
    • Sato, N.1    Tsunoda, H.2    Nishida, M.3
  • 32
    • 0031724674 scopus 로고    scopus 로고
    • Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas
    • Lin WM, Forgacs E, Warshal DP, et al. Loss of heterozygosity and mutational analysis of the PTEN/MMAC1 gene in synchronous endometrial and ovarian carcinomas. Clin Cancer Res 1998;4:2577-83.
    • (1998) Clin Cancer Res , vol.4 , pp. 2577-2583
    • Lin, W.M.1    Forgacs, E.2    Warshal, D.P.3
  • 33
    • 0034234268 scopus 로고    scopus 로고
    • High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/-mice
    • Stambolic V, Tsao MS, Macpherson D, et al. High incidence of breast and endometrial neoplasia resembling human Cowden syndrome in pten+/- mice. Cancer Res 2000;60:3605-11.
    • (2000) Cancer Res , vol.60 , pp. 3605-3611
    • Stambolic, V.1    Tsao, M.S.2    Macpherson, D.3
  • 34
    • 0032843540 scopus 로고    scopus 로고
    • Impaired Fas response and autoimmunity in Pten+/-mice
    • Di Cristofano A, Kotsi P, Peng YF, et al. Impaired Fas response and autoimmunity in Pten+/- mice. Science 1999;285:2122-5.
    • (1999) Science , vol.285 , pp. 2122-2125
    • Di Cristofano, A.1    Kotsi, P.2    Peng, Y.F.3
  • 35
    • 0036112627 scopus 로고    scopus 로고
    • DNA mismatch repair deficiency accelerates endometrial tumorigenesis in PTEN heterozygous mice
    • Wang H, Douglas, W, Lia M, et al. DNA mismatch repair deficiency accelerates endometrial tumorigenesis in PTEN heterozygous mice. Am J Pathol 2002;160:1481-6.
    • (2002) Am J Pathol , vol.160 , pp. 1481-1486
    • Wang, H.1    Douglas, W.2    Lia, M.3
  • 36
    • 0034681264 scopus 로고    scopus 로고
    • The multiple roles of PTEN in tumor suppression
    • Di Cristofano A, Pandolfi PP. The multiple roles of PTEN in tumor suppression. Cell 2000;100:387-90.
    • (2000) Cell , vol.100 , pp. 387-390
    • Di Cristofano, A.1    Pandolfi, P.P.2
  • 39
    • 0032412859 scopus 로고    scopus 로고
    • Clonal analysis of sporadic pancreatic endocrine tumors
    • Perren A, Roth J, Muletta-Feurer S, et al. Clonal analysis of sporadic pancreatic endocrine tumors. J Pathol 1998;186:363-71.
    • (1998) J Pathol , vol.186 , pp. 363-371
    • Perren, A.1    Roth, J.2    Muletta-Feurer, S.3
  • 40
    • 51249162117 scopus 로고
    • Molecular diagnosis of multiple endocrine neoplasia (MEN) in paraffin-embedded specimens
    • Komminoth P, Muletta-Feurer A, Saremaslani P, et al. Molecular diagnosis of multiple endocrine neoplasia (MEN) in paraffin-embedded specimens. Endocr Pathol 1995;79:267-78.
    • (1995) Endocr Pathol , vol.79 , pp. 267-278
    • Komminoth, P.1    Muletta-Feurer, A.2    Saremaslani, P.3
  • 41
    • 0031681438 scopus 로고    scopus 로고
    • Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: Evidence for inactivation of both alleles
    • Kurose K, Bando K, Fukino K, et al. Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: evidence for inactivation of both alleles. Jpn J Cancer Res 1998;89:842-8.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 842-848
    • Kurose, K.1    Bando, K.2    Fukino, K.3
  • 42
    • 0030837555 scopus 로고    scopus 로고
    • P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase
    • Myers MP, Stolarov JP, Eng C, et al. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc Natl Acad Sci U S A 1997;94:9052-7.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 9052-9057
    • Myers, M.P.1    Stolarov, J.P.2    Eng, C.3
  • 43
    • 0032506011 scopus 로고    scopus 로고
    • The lipid phosphatase activity of PTEN is critical for its tumor supressor function
    • Myers MP, Pass I, Batty IH, et al. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proc Natl Acad Sci U S A 1998;95:13513-8.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 13513-13518
    • Myers, M.P.1    Pass, I.2    Batty, I.H.3
  • 44
    • 0031884184 scopus 로고    scopus 로고
    • Comparative analysis of histologic homologues of endometrial and ovarian carcinomas
    • Caduff RF, Svoboda-Newman SM, Bartos RE, et al. Comparative analysis of histologic homologues of endometrial and ovarian carcinomas. Am J Surg Pathol 1998;22:319-26.
    • (1998) Am J Surg Pathol , vol.22 , pp. 319-326
    • Caduff, R.F.1    Svoboda-Newman, S.M.2    Bartos, R.E.3
  • 45
    • 0034993763 scopus 로고    scopus 로고
    • Beta -Catenin expression pattern, beta-catenin gene mutations, and microsatellite instability in endometrioid ovarian carcinomas and synchronous endometrial carcinomas
    • Moreno-Bueno G, Gamallo C, Perez-Gallego L et al. Beta -Catenin expression pattern, beta-catenin gene mutations, and microsatellite instability in endometrioid ovarian carcinomas and synchronous endometrial carcinomas. Diagn Mol Pathol 2001;10:116-22.
    • (2001) Diagn Mol Pathol , vol.10 , pp. 116-122
    • Moreno-Bueno, G.1    Gamallo, C.2    Perez-Gallego, L.3
  • 46
    • 0035890615 scopus 로고    scopus 로고
    • Diverse mechanisms of betacatenin deregulation in ovarian endometrioid andeocarcinomas
    • Wu R, Zhai Y, Fearon ER, et al. Diverse mechanisms of betacatenin deregulation in ovarian endometrioid andeocarcinomas. Cancer Res 2001;61:8247-55.
    • (2001) Cancer Res , vol.61 , pp. 8247-8255
    • Wu, R.1    Zhai, Y.2    Fearon, E.R.3
  • 47
    • 0033784576 scopus 로고    scopus 로고
    • Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma
    • Schlosshauer PW, Pirog EC, Levine RL, et al. Mutational analysis of the CTNNB1 and APC genes in uterine endometrioid carcinoma. Mod Pathol 2000;13:1066-71.
    • (2000) Mod Pathol , vol.13 , pp. 1066-1071
    • Schlosshauer, P.W.1    Pirog, E.C.2    Levine, R.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.