Somatic mutations of the PTEN/MMAC1 gene in fifteen Japanese endometrial cancers: Evidence for inactivation of both alleles

Japanese Journal of Cancer Research

Volumn 89, Issue 8, 1998, Pages 842-848

  Kurose, Keisuke ^a,b   Bando, Koichi ^a   Fukino, Koichi ^a   Sugisaki, Yuichi ^b   Araki, Tsutomu ^b   Emi, Mitsuru ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b NIPPON MEDICAL SCHOOL HOSPITAL   (Japan)

Author keywords

Chromosome 10q; Endometrial cancer; PTEN MMAC1; Tumor suppressor gene

Indexed keywords

ALLELE; ARTICLE; CHROMOSOME 10Q; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOMETRIUM CANCER; FEMALE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; PRIORITY JOURNAL; SOMATIC MUTATION; TUMOR SUPPRESSOR GENE;

EID: 0031681438     PISSN: 09105050     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1349-7006.1998.tb00638.x     Document Type: Article

References (36)

1. Parker, S. L., Tong, T., Bolden, S. and Wingo, P. A. Cancer statistics. CA Cancer J. Clin., 46, 5-27 (1996).
2. Weinberg, R. A. Tumor suppressor genes. Science, 254, 1138-1146 (1991).
3. Nakamura, Y. Multi-step carcinogenesis of colorectal cancer. Jpn. J. Hum. Genet., 38, 23 (1993).
4. Knudson, A. G. Antioncogenes and human cancer. Proc. Natl. Acad. Sci. USA, 90, 10914-10921 (1993).
5. Nakamura, Y. Application of DNA markers to clinical genetics. Jpn. J. Hum. Genet., 41, 1-10 (1996).
6. Yanase, T. Human genetics: past, present, and future. Jpn. J. Hum. Genet., 42, 265-316 (1997).
7. Peltomaki, P., Lothe, R. A., Aaltonen, L. A.. Pylkkanen, L., Nystrom-Lahti, M., Seruca, R., David, L., Holm, R., Ryberg, D., Haugen, A., Brogger, A., Borresen, A.-L. and de la Chapelle, A. Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome. Cancer Res., 53, 5853-5855 (1993).
8. Burks, R. T., Kessis, T. D., Cho. K. R. and Hedrick, L. Microsatellite instability in endometrial carcinoma. Oncogene, 9, 1163-1166 (1994).
9. Risinger, J. I., Berchuck, A., Kohler, M. F., Watson, P., Lynch, H. T. and Boyd, J. Genetic instability of microsatellites in endometrial carcinoma. Cancer Res., 53, 5100-5103 (1993).
10. Enomoto, T., Fujita, M., Inoue, M., Nomura, T. and Shroyer, K. R. Alteration of the p53 tumor suppressor gene and activation of c-K-ras-2 protooncogene in endometrial adenocarcinoma from Colorado. Am. J. Clin. Pathol. 103, 224-230 (1995).
11. Jones, M. H., Koi, S., Fujimoto, I., Hasumi, K., Kato, K. and Nakamura, Y. Allelotype of uterine cancer by analysis of RFLP and microsatellite polymorphisms: frequent loss of heterozygosity on chromosome arms 3p, 9q, 10q, and 17p. Genes Chromosom. Cancer. 9, 119-123 (1994).
12. Peiffer, S. L., Herzog, T. J., Tribune, D. J., Mutch, D. G., Gersell, D. J. and Goodfellow, P. J. Allelic loss of sequences from the long arm of chromosome 10 and replication errors in endometrial cancers. Cancer Res., 55, 1922-1926 (1995).
13. Nagase, S., Sato, S., Tezuka, F., Wada, Y., Yajima, A. and Horii, A. Deletion mapping on chromosome 10q25-q26 in human endometrial cancer. Br. J. Cancer. 74, 1979-1983 (1996).
14. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Pue, J., Miliaresis, C., Rodgers, L., McCombie, R., Bigner, S. H., Giovanella, B. C., Ittmann, M., Tycko, B., Hibshoosh, H., Wigler, M. H. and Parsons, R. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science, 275, 1943-1947 (1997).
15. Steck, P. A., Pershouse, M. A., Jasser, S. A., Yung, W. K., Lin, H., Ligon, A. H., Langford, L. A., Baumgard, M. L., Hattier, T., Davis, T., Frye, C., Hu, R., Swedlund, B., Teng, D. H. and Tavtigian, S. V. Identification of a candidate tumour suppressor gene. MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15, 356-362 (1997).
16. Liaw, D., Marsh, D. J., Li, J., Dahia, P. L., Wang, S. I., Zheng, Z., Bose, S., Call, K. M., Tsou, H. C., Peacocke, M., Eng, C. and Parsons, R. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat. Genet., 16, 64-67 (1997).
17. Marsh, D. J., Dahia, P. L., Zheng, Z., Liaw, D., Parsons. R., Gorlin, R. J. and Eng, C. Germline mutations in PTEN are present in Bannayan-Zonana syndrome. Nat. Genet., 16, 333-334 (1997).
18. Myers, M. P., Stolarov, J. P., Eng, C., Li, J., Wang, S. I., Wigler, M. H., Parsons, R. and Tonks, N. K. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proc. Natl. Acad. Sci. USA, 94, 9052-9057 (1997).
19. Sato, T., Tanigami, A., Yamakawa, K., Akiyama, F., Kasumi, F., Sakamoto, G. and Nakamura, Y. Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer. Cancer Res., 50, 7184-7189 (1990).
20. Scully, R. E., Poulson, H. and Sobin, L. H. "International Histological Classification and Histologic Typing of Female Genital Tract Tumors" (1994). Springer-Verlag, Berlin.
21. Internationa] Federation of Gynecology and Obstetrics. FIGO Stages, 1988 Revision. Gvnecol. Oncol., 35, 125-127 (1989).
22. Iida, A., Isobe, R., Yoshimoto, M., Kasumi, F., Nakamura, Y. and Emi, M. Localization of a breast cancer tumour-suppressor gene to a 3-cM interval within chromosomal region 16q22. Br. J. Cancer, 75, 264-267 (1997).
23. Orita, M., Suzuki, Y., Sekiya, T. and Hayashi, K. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics, 5, 874-879 (1989).
24. Tashiro, H., Blazes, M. S., Wu, R., Cho, K. R., Bose, S., Wang, S. I., Li, J., Parsons, R. and Ellenson, L. H. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res., 57, 3935-3940 (1997).
25. Risinger, J. I., Haves, A. K., Berchuck, A. and Barrett, J. C. PTEN|MMAC1 mutations in endometrial cancers. Cancer Res., 57, 4736-4738 (1997).
26. Rasheed, B. K., Stenzel, T. T., McLendon, R. E., Parsons, R., Friedman, A. H., Friedman, H. S., Bigner, D. D. and Bigner, S. H. PTEN gene mutations are seen in high-grade but not in low-grade gliomas. Cancer Res., 57, 4187-4190 (1997).
27. Wang, S. I., Puc, J., Li, J., Bruce, J. N., Cairns, P., Sidransky, D. and Parsons, R. Somatic mutations of PTEN in glioblastoma multiforme. Cancer Res., 57, 4183-4186 (1997).
28. Marsh, D. J., Coulon, V., Lunetta, K. L., Rocca-Serra, P., Dahia, P. L., Zheng, Z., Liaw, D., Caron, S., Duboue, B., Lin, A. Y., Richardson, A. L., Bonnetblanc, J. M., Bressieux, J. M., Cabarrot-Moreau, A., Chompret, A., Demange, L., Eeles, R. A., Yahanda, A. M., Fearon, F. R., Fricker, J. P., Gorlin, R. J., Hodgson, S. V., Huson, S., Lacombe, D., LePrat, F., Odent, S., Toulouse, C., Olopade, O. I., Sobol, H., Tishler, S., Woods, C. G., Robinson, B. G., Weber, H. C., Parsons, R., Peacocke, M., Longy, M. and Eng, C. Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation. Hum. Mol. Genet., 7, 507-515 (1998).
29. Knudson, A. G. Mutation and cancer: statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA, 68, 820-823 (1971).
30. Hashimoto, T., Takahashi, R., Yandell, D. W., Xu, H. J., Hu, S. X., Gunnell, S. and Benedict, W. F. Characterization of intragenic deletions in two sporadic germinal mutation cases of retinoblastoma resulting in abnormal gene expression. Oncogene, 6, 463-469 (1991).
31. Zbar, B. Von Hippel-Lindau disease and sporadic renal cell carcinoma. Cancer Surv., 25, 219-232 (1995).
32. Little, M. and Wells, C. A clinical overview of WT1 gene mutations. Hum. Mutat., 9, 209-225 (1997).
33. Rhei, E., Kang, L., Bogomolniy, F., Federici, M. G., Borgen, P. I. and Boyd, J. Mutation analysis of the putative tumor suppressor gene PTEN|MMAC1 in primary breast carcinomas. Cancer Res., 57, 3657-3659 (1997).
34. Dahia, P. L., Marsh, D. J., Zheng, Z., Zedenius, J., Komminoth, P., Frisk, T., Wallin, G., Parsons, R., Longy, M., Larsson, C. and Eng, C. Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors. Cancer Res., 57, 4710-4713 (1997).
35. Ueda, K., Nishijima, M., Inui, H., Watatani, M., Yayoi, E., Okamura, J., Yasutomi, M., Nakamura, Y. and Miyoshi, Y. Infrequent mutations in the PTEN|MMAC1 gene among primary breast cancers. Jpn. J. Cancer Res., 89, 17-21 (1998).
36. Beaudet, A. L. and Tsui, L. A suggested nomenclature for designating mutations. Hum. Mutat., 2, 245-248 (1993).