Effective elimination of lung metastases induced by tumor cells treated with hydrostatic pressure and N-acetyl-L-cysteine

Cancer Research

Volumn 60, Issue 2, 2000, Pages 350-358

  Goldman, Yechiel ^b   Peled, Alpha ^a   Shinitzky, Meir ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ADENOSINE DIALDEHYDE; MEMBRANE PROTEIN; PROTEIN DISULFIDE REDUCTASE (GLUTATHIONE);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CROSS LINKING; FEMALE; HYDROSTATIC PRESSURE; IMMUNIZATION; IMMUNOGENICITY; LUNG METASTASIS; LUNG WEIGHT; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR CELL CULTURE;

ACETYLCYSTEINE; ADENOSINE; ANIMALS; ANTIGENS, CD4; ANTIGENS, CD8; FEMALE; HUMANS; HYDROSTATIC PRESSURE; HYPERSENSITIVITY, DELAYED; LUNG; LUNG NEOPLASMS; LYMPHOCYTE CULTURE TEST, MIXED; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEOPLASM METASTASIS; SPLEEN;

EID: 0034650884     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Ellem, K. A., Schmidt, C. W., Li, C. L., Misko, I., Kelso, A., Sing, G., Macdonald, G., and O'Rourke, M. G. The labyrinthine ways of cancer immunotherapy-T cell, tumor cell encounter: "How do I lose thee? Let me count the ways." Adv. Cancer Res., 75: 203-249, 1998.
2. Van den Eynde, B. J., and van der Bruggen, P. T cell defined tumor antigens. Curr. Opin. Immunol., 9: 684-693, 1997.
3. Henderson, R. A., and Finn, O. J. Human tumor antigens are ready to fly. Adv. Immunol., 62: 217-256, 1996.
4. Guo, Y. J., Che, X. Y., Shen, F., Xie, T. P., Ma, J., Wang, X. N., Wu, S. G., Anthony, D. D., and Wu, M. C. Effective tumor vaccines generated by in vitro modification of tumor cells with cytokines and bispecific monoclonal antibodies. Nat. Med., 3: 451-455, 1997.
5. Nestle, F. O., Alijagic, S., Gilliet, M., Sun, Y., Grabbe, S., Dummer, R., Burg, G., and Schadendorf, D. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells. Nat. Med., 4: 328-332, 1998.
6. Ridge, J. P., Di Rosa, F., and Matzinger, P. A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature (Lond.), 393: 474-478, 1998.
7. Wang, Q., Redovan, C., Tubbs, R., Olencki, T., Klein, E., Kudoh, S., Finke, J., and Bukowski, R. M. Selective cytokine gene expression in renal cell carcinoma tumor cells and tumor-infiltrating lymphocytes. Int. J. Cancer, 61: 780-785, 1995.
8. Bannerji, R., Arroyo, C. D., Cordon-Cardo, C., and Gilboa, E. The role of IL-2 secreted from genetically modified tumor cells in the establishment of antitumor immunity. J. Immunol., 152: 2324-2332, 1994.
9. Rosenberg, S. A., Yang, J. C., Schwartzentruber, D. J., Hwu, P., Marincola, F. M., Topalian, S. L., Restifo, N. P., Dudley, M. E., Schwarz, S. L., Spiess, P. J., Wunderlich, J. R., Parkhurst, M. R., Kawakami, Y., Seipp, C. A., Einhorn, J. H., and White, D. E. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma. Nat. Med., 4: 321-327, 1998.
10. Srivastava, P. K., Menoret, A., Basu, S., Binder, R. J., and McQuade, K. L. Heat shock proteins come of age: primitive functions acquire new roles in an adaptive world. Immunity, 8: 657-665, 1998.
11. Janetzki, S., Blachere, N. E., and Srivastava, P. K. Generation of tumor-specific cytotoxic T lymphocytes and memory T cells by immunization with tumor-derived heat shock protein gp96. J. Immunother., 21: 269-276, 1998.
12. Shinitzky, M., and Skornick, Y. Cancer immunotherapy with autologous and allogeneic vaccines: a practical overview. Prog. Clin. Biol. Res., 348: 95-125, 1990.
13. Ramakrishna, V., and Shinitzky, M. Potentiation of delayed-type hypersensitivity response to syngeneic tumors in mice prevaccinated with cells modified by hydrostatic pressure and crosslinking. Cancer Immunol. Immunother., 33: 1-8, 1991.
14. Eisenthal, A., Ramakrishna, V., Skornick, Y., and Shinitzky, M. Induction of cell-mediated immunity against B16-BL6 melanoma in mice vaccinated with cells modified by hydrostatic pressure and chemical crosslinking. Cancer Immunol. Immunother., 36: 300-306, 1993.
15. Ramakrishna, V., Eisenthal, A., Skornick, Y., and Shinilzky, M. Increased projection of MHC and tumor antigens in murine B16-BL6 melanoma induced by hydrostatic pressure and chemical crosslinking. Cancer Immunol. Immunother, 36: 293-299, 1993.
16. Eisenthal, A., Matsaev, A., Gelfand, A., Kahn, P., Lifschitz-Mercer, B., Skornick. Y., and Shinitzky, M. Surface projection of murine major histocompatibility determinants induced by hydrostatic pressure and cytokines. Pathobiology, 64: 142-149, 1996.
17. Eisenthal, A., Goldman, Y., Skornick, Y., Gelfand, A., Buyaner, D., Kaver, I., Yellin, A., Yehoshua, H., Lifschitz-Mercer, B., Gonnene, A., and Shinitzky, M. Human tumor cells, modified by a novel pressure/crosslinking methodology, promote autologous lymphocyte proliferation and modulate cytokine secretion. Cancer Immunol. Immunother., 46: 304-310, 1998.
18. Haskin, C., and Cameron, I. Physiological levels of hydrostatic pressure alter morphology and organization of cytoskeletal and adhesion proteins in MG-63 osteosarcoma cells. Biochem. Cell Biol., 71: 27-35, 1993.
19. Bourns, B., Franklin, S., Cassimeris, L., and Salmon, E. D. High hydrostatic pressure effects in vivo: changes in cell morphology, microtubule assembly, and actin organization. Cell Motil. Cytoskeleton, 10: 380-390, 1988.
20. Welch, T. J., Farewell, A., Neidhardt, F. C., and Bartlett, D. H. Stress response of Escherichia coli to elevated hydrostatic pressure. J. Bacteriol., 175: 7170-7177, 1993.
21. Rhodes, J., Chen, H., Hall, S. R., Beesley, J. E., Jenkins, D. C., Collins, P., and Zheng, B. Therapeutic potentiation of the immune system by costimulatory Schiff-base-forming drugs. Nature (Lond.), 377: 71-75, 1995.
22. Schirrmacher, V., Ahlert, T., Probstle, T., Steiner, H. H., Herold-Mende, C., Gerhards, R., and Hagmuller, E. Immunization with virus-modified tumor cells. Semin. Oncol., 25; 677-696, 1998.
23. Reynolds, J. E. F. Martindale-The Extra Encyclopedia, 31st ed., pp. 1060-1062. London: Royal Pharmaceutical Society of Great Britain, 1996.
24. Droge, W., Kinscherf, R., Mihm, S., Galter, D., Roth, S., Gmunder, H., Fischbach, T., and Bockstette, M. Thiols and the immune system: effect of N-acetylcysteine on T cell system in human subjects. Methods Enzymol., 251: 255-270, 1995.
25. Droge, W., Eck, H. P., Gmunder, H., and Mihm, S. Modulation of lymphocyte functions and immune responses by cysteine and cysteine derivatives. Am. J. Med., 91: 140S-144S, 1991.
26. Eisenbach, L., Hollander, N., Greenfeld, L., Yakor, H., Segal, S., and Feldman, M. The differential expression of H-2K versus H-2D antigens, distinguishing high-metastatic from low-metastatic clones, is correlated with the immunogenic properties of the tumor cells. Int. J. Cancer, 34: 567-573, 1984.
27. Lappin, G. R., and Clark, L. C. Colorimetric method for determination of traces of carbonyl compounds. Anal. Chem., 23: 541-542, 1951.
28. Ceppellini, R., Curtoni, E. S., Leigheb, G., Mattiuz, P. L., Miggiano, V. C., and Visetti, M. An experimental approach to genetic analysis of histocompatibility in man. Histocompatibility testing. Ser. Haematol., 11: 13, 1965.
29. Porgador, A., Bannerji, R., Watanabe, Y., Feldman, M., Gilboa, E., and Eisenbach, L. Antimetastatic vaccination of tumor-bearing mice with two types of IFN-γ gene-inserted tumor cells. J. Immunol., 150: 1458-1470, 1993.
30. Vadas, M. A., Miller, J. F., Gamble, J., and Whitelaw. A. A radioisotopic method to measure delayed type hypersensitivity in the mouse. I. Studies in sensitized and normal mice. Int. Arch. Allergy Appl. Immunol., 49: 670-692, 1975.
31. Miller, J. F., Vadas, M. A., Whitelaw, A., and Gamble, J. A radioisotopic method to measure delayed type hypersensitivity in the mouse. II. Cell transfer studies. Int. Arch. Allergy Appl. Immunol., 49: 693-708, 1975.
32. Mandelboim, O., Feldman, M., and Eisenbach, L. H-2K double transfectants of tumor cells as antimetastatic cellular vaccines in heterozygous recipients. Implications for the T cell repertoire. J. Immunol., 148: 3666-3673, 1992.
33. Zitvogel, L., Regnault, A., Lozier, A., Wolfers, J., Flament, C., Tenza, D., Ricciardi-Castagnoli, P., Raposo, G., and Amigorena, S. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat. Med., 4: 594-600, 1998.
34. Ji, H., Chang, E. Y., Lin, K. Y., Kurman, R. J., Pardoll, D. M., and Wu, T. C. Antigen-specific immunotherapy for murine lung metastatic tumors expressing human papillomavirus type 16 E7 oncoprotein. Int. J. Cancer, 78: 41-45, 1998.
35. Hardy, B., Kovjazin, R., Raiter, A., Ganor, N., and Novogrodsky, A. A lymphocyte-activating monoclonal antibody induces regression of human tumors in severe combined immunodeficient mice. Proc. Natl. Acad. Sci. USA. 94: 5756-5760, 1997.
36. Nair, S. K., Snyder, D., Rouse, B. T., and Gilboa, E. Regression of tumors in mice vaccinated with professional antigen- presenting cells pulsed with tumor extracts. Int. J. Cancer, 70: 706-715, 1997.
37. Broome, J. D., and Jeng, M. W. Promotion of replication in lymphoid cells by specific thiols and disulfides in vitro. Effects on mouse lymphoma cells in comparison with splenic lymphocytes. J. Exp. Med., 138: 574-592, 1973.
38. Wolpe, S. D. In vitro immunization and growth of hybridomas in serum-free medium. In: J. P. Mather (ed.), Mammalian Cell Culture, pp. 103-128. New York: Plenum Press, 1984.
39. Eylar, E., Rivera-Quinones, C., Molina, C., Baez, I., Molina, F., and Mercado, C. M. N-Acetylcysteine enhances T cell functions and T cell growth in culture. Int. Immunol., 5: 97-101, 1993.
40. Droge, W., Mihm, S., Bockstette, M., and Roth, S. Effect of reactive oxygen intermediates and antioxidants on proliferation and function of T lymphocytes. Methods Enzymol., 234: 135-151, 1994.
41. Schenk, H., Vogt, M., Droge, W., and Schulze-Osthoff, K. Thioredoxin as a potent costimulus of cytokine expression. J. Immunol., 156: 765-771, 1996.
42. Droge, W., Schulze-Osthoff, K., Mihm, S., Galter, D., Schenk, H., Eck, H. P., Roth, S., and Gmunder, H. Functions of glutathione and glutathione disulfide in immunology and immunopathology. FASEB J., 8: 1131-1138, 1994.
43. Lanzavecchia, A., Iezzi, G., and Viola, A. From TCR engagement to T cell activation: a kinetic view of T cell behavior. Cell, 96: 1-4, 1999.
44. Davis, M. M., Boniface, J. J., Reich, Z., Lyons, D., Hampl, J., Arden, B., and Chien, Y. Ligand recognition by α and β T cell receptors. Annu. Rev. Immunol., 16: 523-544, 1998.
45. McKeithan, T. W. Kinetic proofreading in T-cell receptor signal transduction. Proc. Natl. Acad. Sci. USA. 92: 5042-5046, 1995.
46. Ishii, T., Udono, H., Yamano, T., Ohta, H., Uenaka, A., Ono, T., Hizuta, A., Tanaka, N., Srivastava, P. K., and Nakayama, E. Isolation of MHC class I-restricted tumor antigen peptide and its precursors associated with heat shock proteins HSP70, HSP90, and GP96. J. Immunol., 162: 1303-1309, 1999.
47. Matzinger, P. An innate sense of danger. Semin. Immunol., 10: 399-415, 1998.