Potential drug targets: Small GTPases that regulate leukocyte function

Trends in Pharmacological Sciences

Volumn 20, Issue 9, 1999, Pages 365-370

  Benard, Valerie ^b   Bokoch, Gary M ^b   Diebold, Becky A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOTRANSFERASE; RECEPTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REGULATOR PROTEIN; RHO FACTOR;

APOPTOSIS; DRUG TARGETING; ENDOCYTOSIS; ENZYME ACTIVITY; GENE EXPRESSION; HOST RESISTANCE; HUMAN; INFLAMMATION; LEUKOCYTE FUNCTION; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; WISKOTT ALDRICH SYNDROME;

ANTI-INFLAMMATORY AGENTS; APOPTOSIS; GTP PHOSPHOHYDROLASES; HUMANS; LEUKOCYTES; NADPH OXIDASE; PHAGOCYTOSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038598472     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(99)01367-X     Document Type: Review

References (98)

1. Bokoch G.M. Blood. 86:1995;1649-1660.
2. Quinn M.T. J. Leukocyte Biol. 58:1995;263-276.
3. Cox A.D., Der C.J. Curr. Opin. Cell Biol. 4:1992;1008-1015.
4. Boguski M.S., McCormick F. Nature. 366:1993;643-654.
5. Clark R.A. J. Infect. Dis. 161:1990;1140-1147.
6. Smith J.A. J. Leukocyte Biol. 56:1994;672-686.
7. Gomez-Cambronero J., Keire P. Cell Signal. 10:1998;387-397.
8. Downey G.P.et al. J. Immunol. 160:1998;434-443.
9. Bokoch G.M. Trends Cell Biol. 5:1995;109-113.
10. Dorseuil O., Quinn M.T., Bokoch G.M. J. Leukocyte Biol. 58:1995;108-113.
11. Kim K-S.et al. J. Clin. Invest. 101:1998;1821-1826.
12. Voncken J.W.et al. Cell. 80:1995;719-728.
13. Diekmann D., Abo A., Johnston C., Segal A.W., Hall A. Science. 265:1994;531-533.
14. Xu X., Barry D.C., Settleman J., Schwartz M.A., Bokoch G.M. J. Biol. Chem. 269:1994;23569-23574.
15. Freeman J.L., Kreck M.L., Uhlinger D.J., Lambeth J.D. Biochemistry. 33:1994;13431-13435.
16. Diekmann D., Nobes C.D., Burbelo P.D., Abo A., Hall A. EMBO J. 14:1995;5297-5305.
17. Toporik A., Gorzalczany Y., Hirshberg M., Pick E., Lotan O. Biochemistry. 37:1998;7147-7156.
18. Nishimoto Y., Freeman J.L.R., Motalebi S.A., Hirshberg M., Lambeth J.D. J. Biol. Chem. 272:1997;18834-18841.
19. Dorseuil O., Reibel L., Bokoch G.M., Camonis J., Gacon G. J. Biol. Chem. 271:1996;83-88.
20. Ahmed S.et al. J. Biol. Chem. 273:1998;15693-15701.
21. Zigmond S.H. Curr. Opin. Cell Biol. 8:1996;66-73.
22. Hall A. Science. 279:1998;509-514.
23. Aepfelbacher M., Essler M., Huber E., Czech A., Weber P.C. J. Immunol. 157:1996;5070-5075.
24. Allen W.E., Jones G.E., Pollard J.W., Ridley A.J. J. Cell Sci. 110:1997;707-710.
25. Allen W.E., Zicha D., Ridley A.J., Jones G.E. J. Cell Biol. 141:1998;1147-1157.
26. Stasia M-J., Jovan A., Bourmeyster N., Boquet P., Vignais P. Biochem. Biophys. Res. Commun. 180:1991;615-622.
27. Laudanna C., Campbell J.J., Butcher E.C. Science. 271:1996;981-983.
28. Zigmond S.H., Joyce M., Borleis J., Bokoch G.M., Devreotes P.N. J. Cell Biol. 138:1997;363-374.
29. Cox D.et al. J. Exp. Med. 186:1997;1487-1494.
30. Massol P., Montcourrier P., Guillemot J.C., Chavrier P. EMBO J. 17:1998;6219-6229.
31. Prepens U., Just I., Eichel-Streiber C.V., Aktories K. J. Biol. Chem. 271:1996;7324-7329.
32. Caron E., Hall A. Science. 282:1998;1717-1721.
33. Dharmawardhane S., Bokoch G.M. Curr. Opin. Hem. 4:1997;12-18.
34. VanAelst L., D'Souza-Schorey C. Genes Dev. 11:1997;2295-2322.
35. Symons M.et al. Cell. 84:1996;723-734.
36. Machesky L.M., Insall R.H. Curr. Biol. 8:1998;1347-1356.
37. Rohatgi R.et al. Cell. 97:1999;221-231.
38. Mullins R.D., Pollard T.D. Curr. Biol. 9:1999;405-415.
39. Manser E., Leung T., Salihuddin H., Zhao Z-S., Lim L. Nature. 367:1994;40-46.
40. Knaus U.G., Morris S., Dong H-J., Chernoff J., Bokoch G.M. Science. 269:1995;221-223.
41. Jones S.L., Knaus U.G., Bokoch G.M., Brown E.J. J. Biol. Chem. 273:1998;10556-10566.
42. Sells M.A.et al. Curr. Biol. 7:1997;202-210.
43. Dharmawardhane S., Brownson D., Lennarts M., Bokoch G.M. J. Leukocyte Biol. (in press).
44. Sells M.A., Boyd J.T., Chernoff J. J. Cell Biol. 145:1999;837-849.
45. Barkalow K., Witke W., Kwiatkowski D.J., Hartwig J.H. J. Cell Biol. 134:1996;389-399.
46. Tolias K., Cantley L.C., Carpenter C.L. J. Biol. Chem. 270:1995;17656-17659.
47. Hartwig J.H.et al. Cell. 82:1995;643-653.
48. Chong L., Traynor-Kaplan A., Bokoch G.M., Schwartz M.A. Cell. 79:1994;507-513.
49. Illenberger D.et al. EMBO J. 17:1998;6241-6249.
50. Vlahos C.J.et al. J. Immunol. 154:1995;2413-2422.
51. Zheng Y., Glaven J.A., Wu W.J., Cerione R.A. J. Biol. Chem. 271:1996;23815-23819.
52. Missy K.et al. J. Biol. Chem. 273:1998;30279-30286.
53. Cerione R.A., Zheng Y. Curr. Opin. Cell Biol. 8:1996;216-222.
54. Leung T., Chen X.Q., Manser E., Lim L. Mol. Cell. Biol. 16:1996;5313-5327.
55. Amano M.et al. Science. 275:1997;1308-1311.
56. Kimura K.et al. Science. 273:1996;245-248.
57. Amano M.et al. J. Biol. Chem. 271:1996;20246-20249.
58. Saito H.et al. J. Immunol. 161:1998;1533-1540.
59. Nuoffer C., Balch W.E. Annu. Rev. Biochem. 63:1994;949-990.
60. Moss J., Vaughan M. J. Biol. Chem. 270:1995;12327-12330.
61. Kahn R.A., Yucel J.K., Malhotra V. Cell. 75:1993;1045-1048.
62. Squier M.K.T., Sehnert A.J., Cohen J.J. J. Leukocyte Biol. 57:1995;2-10.
63. Liles W.C., Klebanoff S.J. J. Immunol. 155:1995;3289-3291.
64. Na S.et al. J. Biol. Chem. 271:1996;11209-11213.
65. Danley D.E., Chuang T-H., Bokoch G.M. J. Immunol. 157:1996;500-503.
66. Mills J.C., Stone N.L., Erhardt J., Pittman R.N. J. Cell Biol. 140:1998;627-636.
67. Subauste M.C.et al. J. Biol. Chem. (in press).
68. Billadeau D.D.et al. J. Exp. Med. 188:1998;549-559.
69. Rudel T., Bokoch G.M. Science. 276:1997;1571-1574.
70. Cardone M.H., Salvesen G.S., Widmann C., Johnson G., Frisch S.M. Cell. 90:1997;315-323.
71. Chuang T-H., Hahn K.M., Lee J-D., Danley D.E., Bokoch G.M. Mol. Biol. Cell. 8:1997;1687-1698.
72. Lores P., Morin L., Luna R., Gacon G. Oncogene. 15:1997;601-605.
73. Ward C.et al. J. Biol. Chem. 274:1999;4309-4318.
74. Sulciner D.J.et al. Mol. Cell. Biol. 16:1996;7115-7121.
75. Perona R.et al. Genes Dev. 11:1997;463-475.
76. Hirshberg M., Stockley R.W., Dodson G., Webb M.R. Nat. Struct. Biol. 4:1997;147-152.
77. Krengel U.et al. Cell. 62:1990;539-548.
78. Ihara K.et al. J. Biol. Chem. 273:1998;9656-9666.
79. Abdul-Manan N.et al. Nature. 399:1999;379-383.
80. Mott H.R.et al. Nature. 399:1999;384-388.
81. Wu W.J., Leonard D.A., Cerione R.A., Manor D. J. Biol. Chem. 272:1997;26153-26158.
82. Fujisawa K.et al. J. Biol. Chem. 273:1998;18943-18949.
83. Scheffzek K.et al. Science. 277:1997;333-338.
84. Scheffzek K., Ahmadian M.R., Wittinghofer A. Trends Biochem. Sci. 23:1998;257-262.
85. Sprang S.R., Coleman D.E. Cell. 95:1998;155-158.
86. Boriack-Sjodin P.A., Margarit S.M., Bar-Sagi D., Kuriyan J. Nature. 394:1998;337-343.
87. Peyroche A.et al. Mol. Cell. 3:1999;275-285.
88. Chardin P., McCormick F. Cell. 97:1999;153-155.
89. Gibbs J., Oliff A., Kohl N.E. Cell. 77:1994;175-178.
90. Uehata M.et al. Nature. 389:1997;990-994.
91. Kumar C.C.et al. Cancer Res. 55:1995;5106-5117.
92. Walsh A.B., Dhanasekaran M., Bar-Sagi D., Kumar C.C. Oncogene. 15:1997;2553-2560.
93. Morozov I., Lotan O., Joseph G., Gorzalczany Y., Pick E. J. Biol. Chem. 273:1998;15435-15444.
94. Kreck M.L., Uhlinger D.J., Tyagi S.R., Inge K.L., Lambeth J.D. J. Biol. Chem. 269:1994;4161-4168.
95. Heyworth P.G., Knaus U.G., Settleman J., Curnutte J.T., Bokoch G.M. Mol. Biol. Cell. 4:1993;1217-1223.
96. Reif K., Nobes C.D., Thomas G., Hall A., Cantrell D.A. Curr. Biol. 6:1996;1445-1455.
97. Zhou K.et al. J. Biol. Chem. 273:1998;16782-16786.
98. Manser E.et al. Mol. Cell. 1:1998;183-192.