Rho Is a Negative Regulator of Human Monocyte Spreading

Journal of Immunology

Volumn 157, Issue 11, 1996, Pages 5070-5075

  Aepfelbacher, Martin ^a,b   Essler, Markus ^a   Huber, Elisabeth ^a   Czech, Anja ^a   Weber, Peter C ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b Inst Prophylaxe Epidemiol K   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BOTULINUM TOXIN; EXOENZYME C3, CLOSTRIDIUM BOTULINUM; GUANINE NUCLEOTIDE BINDING PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; VINCULIN;

ARTICLE; CELL ADHESION; CELL LINE; CELL MEMBRANE; CELL MOTION; CLOSTRIDIUM BOTULINUM; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; MONOCYTE; PHYSIOLOGY;

ACTINS; ADP RIBOSE TRANSFERASES; BOTULINUM TOXINS; CELL ADHESION; CELL LINE; CELL MEMBRANE; CELL MOVEMENT; CLOSTRIDIUM BOTULINUM; GTP-BINDING PROTEINS; HUMANS; MONOCYTES; RHOA GTP-BINDING PROTEIN; VINCULIN;

EID: 0030459360     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Beekhuizen, H., and R. van Furth. 1993. Monocyte adherence to human vascular endothelium. J. Leukocyte Biol. 54:363.
2. Juliano, R. L., and S. Haskill. 1993. Signal transduction from the extracellular matrix. J. Cell Biol. 120:577.
3. 2-integrins. J. Cell Biol. 125:1417.
4. Carlos, T. M., and J. M. Harlan. 1992. Membrane proteins involved in phagocyte adherence to endothelium. Immunol. Rev. 114:5.
5. Giancotti, F. G., P. M. Comoglio, and G. Tarone. 1986. Fibronectin-plasma membrane interaction in the adhesion of hemopoietic cells. J. Cell Biol. 103:429.
6. Clark, E. A., and J. S. Brugge. 1995. Integrins and signal transduction pathways: the road taken. Science 268:233.
7. Amato, P. A., E. R. Unanue, and D. L. Taylor. 1983. Distribution of actin in spreading macrophages: a comparative study on living and fixed cells. J. Cell Biol. 96:750.
8. Gaidano, G., L. Bergui, M. Schena, M. Gaboli, O. Cremona, P. C. Marchisio, and F. Caligaris-Cappio. 1990. Integrin distribution and cytoskeleton organization in normal and malignant monocytes. Leukemia 4:682.
9. Hass, R., H. Bartels, N. Topley, M. Hadam, L. Köhler, M. Goppelt-Strübe, and K. Resch. 1989. TPA-induced differentiation and adhesion of U937 cells: changes in ultrastructure, cytoskelelal organisation and expression of cell surface antigens. Eur. J. Cell Biol. 48:282.
10. Vincent, S., P. Jeanteur, and P. Fort. 1992. Growth-regulated expression of rhoG. a new member of the ras homolog gene family. Mol. Cell. Biol. 12:3138.
11. Nobes, C. D., and A. Hall. 1995. Rho, Rac, and Cdc42 GTPase regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53.
12. Chant, J., and L. Stowers. 1995. GTPase cascades choreographing cellular behaviour: movement, morphogenesis and more. Cell 81:1.
13. Glomset, J. A., and C. C. Farnsworth. 1994. The role of protein modification reaction in programming interaction between Ras-related GTPases and cell membranes. Annu. Rev. Cell Biol. 10:181.
14. Boguski, M. S., and F. McCormick. 1993. Proteins regulating ras and its relatives. Nature 366:643.
15. Aktories, K., and I. Just. 1993. GTPases and actin as targets for bacterial toxins. In GTPases in Biology I. B. F. Dickey and L. Birnbaumer, eds. Springer Verlag, Berlin, p. 87.
16. Ridley, A. J., and A. Hall. 1992. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389.
17. Hotchin, N. A., and A. Hall. 1995. The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J. Cell Biol. 131:1857.
18. 1 integrin receptor. FEBS Lett. 363:78.
19. Smith, D. B., and K. S. Johnson. 1988. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 67:31.
20. 2+ mobilization and eicosanoid release in human Mono Mac 6 cells. J. Immunol. 148:2186.
21. Aepfelbacher, M., F. Vauti, P. C. Weber, and J. A. Glomset. 1994. Spreading of differentiating human monocytes is associated with a major increase in membrane-bound CDC42. Proc. Natl. Acad. Sci. USA 91:4263.
22. Aepfelbacher, M., M. Essler, K. Luber, and P. C. Weber. 1995. ADP-ribosylation of the GTP-binding protein RhoA blocks cytoplasmic division in human myelomonocytic cells. Biochem. J. 308:853.
23. Papadimitriou, J. M., and R. B. Ashman. 1989. Macrophages: current views on their differentiation, structure, and function. Ultrastruct. Pathol. 13:343.
24. Howard, T. H., and R. G. Watts. 1994. Actin polymerization and leukocyte function. Curr. Opin. Hematol. 1:61.
25. Cassimeris, L., H. McNeill, and S. H. Zigmond. 1990. Chemoattractant-stimulated polymorphonuclear leukocytes contain two populations of actin filaments that differ in their spatial distributions and relative stabilities. J. Cell Biol. 10: 1067.
26. Takaishi, K., T. Sasaki, T. Kameyama, S. Tsukita, and Y. Takai. 1995. Translocation of activated Rho from the cytoplasm to membrane ruffling area, cell-cell adhesion sites and cleavage furrows. Oncogene 11:39.
27. Jalink, K., E. J. van Corven, T. Hengeveld, N. Morii, S. Narumiya, and W. H. Moolenaar. 1994. Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP-ribosylation of the small GTP-binding protein Rho. J. Cell Biol. 126:801.
28. Chardin, P., P. Boquet, P. Madaule, M. R. Popoff, E. J. Rubin, and D. M. Gill. 1989. The mammalian G protein rho C is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells. EMBO J. 8:1087.
29. Paterson, H. F., A. J. Self, M. D. Garrett, I. Just, K. Aktories, and A. Hall. 1990. Microinjection of recombinant p21rho induces rapid changes in cell morphology. J. Cell Biol. 111:1001.
30. Cao, L.-G., and Y.-L. Wang. 1990. Mechanism of the formation of contractile ring in dividing cultured animal cells. II. Cortical movement of microinjected actin filaments. J. Cell Biol. 111:1905.
31. Koch, G., J. Norgauer, and K. Aktories. 1994. ADP-ribosylation of the GTP-binding protein Rho by Clostridium limosum exoenzyme affects basal, but not N-formyl-peptide-stimulated, actin polymerization in human myeloid leukaemic (HL60) cells. Biochem. J. 299:775.
32. Burridge, K., K. Fath, T. Kelly, G. Nuckolls, and C. Turner. 1988. Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton. Annu. Rev. Cell Biol. 4:487.
33. Dutartre, H., J. Davoust, J.-P. Gorvel, and P. Chavrier. 1996. Cytokinesis arrest and redistribution of actin-cytoskeleton regulatory components in cells expressing the Rho GTPase CDC42Hs. J. Cell Sci. 109:367.
34. Aktories, K., and I. Just. 1995. Monoglucosylation of low-molecular mass GTP-binding Rho proteins by clostridial cytotoxins. Trends Cell Biol. 5:441.
35. Cossart, P., P. Boquet, S. Normark, and R. Rappuoli. 1996. Cellular microbiology emerging. Science 271:315.