Simplified synthetic TMC-95A/B analogues retain the potency of proteasome inhibitory activity

ChemBioChem

Volumn 4, Issue 6, 2003, Pages 508-513

  Yang, Zhi Qiang ^a   Kwok, Benjamin H B ^c   Lin, Songnian ^a   Koldobskiy, Michael A ^c   Crews, Craig M ^c,d   Danishefsky, Samuel J ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Columbia University ^*  (United States)

^c YALE UNIVERSITY   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Inhibitors; Peptides; Proteasome; Structure activity relationships; Synthesis

Indexed keywords

AMIDE; CYCLOPEPTIDE; PROTEASOME INHIBITOR; TMA 95B; TMC 95A; UNCLASSIFIED DRUG;

ARTICLE; CANCER; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; INFLAMMATION; PRIORITY JOURNAL; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

ANIMALS; CATALYSIS; CATTLE; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; MOLECULAR STRUCTURE; MULTIENZYME COMPLEXES; PEPTIDES, CYCLIC; PROTEASOME ENDOPEPTIDASE COMPLEX; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0038575020     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200300560     Document Type: Article

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