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Volumn 41, Issue 5, 2002, Pages 780-783
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The core structure of TMC-95A is a promising lead for reversible proteasome inhibition
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Author keywords
Inhibitors; Natural products; NMR spectroscopy; Structure activity relationships; Total synthesis
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Indexed keywords
ENZYME INHIBITION;
MOLECULAR STRUCTURE;
X RAYS;
CORE STRUCTURE;
ENZYMES;
PROTEASOME INHIBITOR;
TMC 95A;
UNCLASSIFIED DRUG;
CYCLOPEPTIDE;
CYSTEINE PROTEINASE;
MULTIENZYME COMPLEX;
PROTEASOME;
PROTEINASE;
PROTEINASE INHIBITOR;
TMC-95A;
ARTICLE;
CHEMICAL REACTION;
COVALENT BOND;
CYCLIZATION;
DRUG CONFORMATION;
DRUG PROTEIN BINDING;
DRUG STRUCTURE;
DRUG SYNTHESIS;
ENZYME INHIBITION;
IC 50;
REACTION ANALYSIS;
STRUCTURE ANALYSIS;
CHEMISTRY;
CONFORMATION;
DRUG ANTAGONISM;
ENZYMOLOGY;
SYNTHESIS;
YEAST;
CYSTEINE ENDOPEPTIDASES;
ENDOPEPTIDASES;
INHIBITORY CONCENTRATION 50;
MOLECULAR CONFORMATION;
MULTIENZYME COMPLEXES;
PEPTIDES, CYCLIC;
PROTEASE INHIBITORS;
PROTEASOME ENDOPEPTIDASE COMPLEX;
YEASTS;
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EID: 0036494798
PISSN: 14337851
EISSN: None
Source Type: Journal
DOI: 10.1002/1521-3773(20020301)41:5<780::AID-ANIE780>3.0.CO;2-V Document Type: Article |
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Times cited : (93)
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References (35)
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