Not just research tools - Proteasome inhibitors offer therapeutic promise

Nature Medicine

Volumn 8, Issue 4, 2002, Pages 338-340

  Goldberg, Alfred L ^a   Rock, Kenneth ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTACYSTIN; LACTACYSTIN BETA LACTONE; PROTEASOME INHIBITOR; PS 541; PS 551; UBIQUITIN; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; CANCER; CLINICAL TRIAL; CYTOLOGY; DRUG EFFICACY; DRUG MECHANISM; HUMAN; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PSORIASIS; SHORT SURVEY;

NON-PROGRAMMATIC;

ANIMALS; CELL DIVISION; CYSTEINE ENDOPEPTIDASES; HUMANS; INFLAMMATION; MICE; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; NEOPLASMS; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN CONFORMATION; PSORIASIS;

ANIMALIA; EUKARYOTA;

EID: 0036104603     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0402-338     Document Type: Short Survey

References (16)

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4. Proteasome inhibitors: From research tools to drug candidates
5. Proteasome inhibition reduces superantigen-mediated T cell activation and the severity of psoriasis in a SCID-hu model
6. Proteasome inhibition in cancer: Development of PS-341
7. Inhibitors of the proteasome block nonlysosomal protein degradation and the generation of peptides presented on MHC-class I molecules
8. The ubiquitin-proteasome pathway is required for processing the NF-κB precursor protein and the activation of NF-κB
9. Degradation of cell proteins and the generation of MHC class I - Presented peptides
10. Nuclear factor-κB: A pivotal transcription factor in chronic inflammatory diseases
11. NF-κB signaling pathways in mammalian and insect innate immunity
12. Role of the proteasome and NF-κB in streptococcal cell wall-induced polyarthritis
13. Proteasome inhibition: A novel mechanism to combat asthma
14. Treatment of established relapsing experimental autoimmune encephalomyelitis with the proteasome inhibitor PS-519
15. Proteasome inhibitor PS519 reduces infarction and attenuates leukocyte infiltration in a rat model of focal cerebral ischemia
16. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells