VL position 34 is a key determinant for the engineering of stable antibodies with fast dissociation rates

Protein Engineering

Volumn 16, Issue 5, 2003, Pages 381-386

  Hugo, N ^a   Weidenhaupt, M ^b   Beukes, M ^a   Xu, B ^c   Janson, J C ^c   Vernet, T ^b   Altschuh, D ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Antibody engineering; Binding kinetics; Covariance; Expression level; Thermostability

Indexed keywords

COAT PROTEIN; IMMUNOGLOBULIN F(AB) FRAGMENT; ONCOPROTEIN; SERINE; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; THREONINE;

AFFINITY CHROMATOGRAPHY; ANTIBODY ENGINEERING; ANTIGEN BINDING; ARTICLE; BINDING KINETICS; BIOTECHNOLOGY; COVARIANCE; DEFECTIVE VIRUS; DISSOCIATION; MOLECULAR RECOGNITION; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; THERMOSTABILITY;

ESCHERICHIA COLI; MURINAE; NICOTIANA TABACUM; TOBACCO MOSAIC VIRUS;

EID: 0038451345     PISSN: 02692139     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/gzg042     Document Type: Article

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