Functional mapping of conserved, surface-exposed charges of antibody variable domains

Journal of Molecular Recognition

Volumn 15, Issue 2, 2002, Pages 94-103

  Weidenhaupt, Marianne ^a   Khalifa, Myriam Ben ^a   Hugo, Nicolas ^b   Choulier, Laurence ^c   Altschuh, Danièle ^c   Vernet, Thierry ^a  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b UNIVERSITÉ DE LYON   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Antibody engineering; Antibody variable domains; Biacore ; Charged surface residues; Kinetic interaction parameters; Site directed mutagenesis

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; PEPTIDE FRAGMENT; VIRUS ANTIBODY;

ANIMAL; ANTIBODY COMBINING SITE; ANTIGEN ANTIBODY REACTION; ARTICLE; CHEMISTRY; GENETICS; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGY; KINETICS; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PEPTIDE MAPPING; PROTEIN SECONDARY STRUCTURE; SITE DIRECTED MUTAGENESIS; TOBACCO MOSAIC VIRUS;

ANIMALS; ANTIBODIES, VIRAL; ANTIGEN-ANTIBODY REACTIONS; BINDING SITES, ANTIBODY; CONSERVED SEQUENCE; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; IMMUNOGLOBULIN VARIABLE REGION; KINETICS; MICE; MUTAGENESIS, SITE-DIRECTED; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; PROTEIN STRUCTURE, SECONDARY; TOBACCO MOSAIC VIRUS;

EID: 0036227998     PISSN: 09523499     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmr.562     Document Type: Article

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