Boranophosphates support the RNase H cleavage of polyribonucleotides

Antisense and Nucleic Acid Drug Development

Volumn 9, Issue 1, 1999, Pages 53-60

  Rait, Vladimir K ^a   Shaw, Barbara Ramsay ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BORANE DERIVATIVE; PHOSPHOROTHIOIC ACID; POLYADENYLIC ACID; POLYRIBONUCLEOTIDE; RIBONUCLEASE H; THYMIDINE PHOSPHATE;

ARTICLE; ESCHERICHIA COLI; PRIORITY JOURNAL; THERMOSTABILITY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0032995076     PISSN: 10872906     EISSN: None     Source Type: Journal    
DOI: 10.1089/oli.1.1999.9.53     Document Type: Article

References (9)

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5. CROOKE, S.T., LEMONIDIS, K.M., NEILSON, L., GRIFFEY, R., LESNIK, E.A., and MONIA, B.P. (1995). Kinetic characteristics of Escherichia coli RNase H1: Cleavage of various antisense oligonucleotide-RNA duplexes. Biochem. J. 312, 599-608.
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8. WALDER, R.Y., and WALDER, J.A. (1988). Role of RNase H in hybrid-arrested translation by antisense oligonucleotides. Proc. Natl. Acad. Sci. USA 85, 5011-5015.
9. ZHANG, J., TERHORST, T., and MATTEUCCI, M.D. (1997). Synthesis and hybridization study of a boranophosphate-linked oligothymidine deoxynucleotide. Tetrahedron Lett. 38, 4957-4960.