The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers

Psychopharmacology

Volumn 145, Issue 3, 1999, Pages 260-266

  Young, A H ^d   Sahakian, B J ^a   Robbins, T W ^b   Cowen, P J ^c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UK   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d NONE

Author keywords

Frontal lobe; Frontal lobe dysfunction; Hydrocortisone; Learning; Memory; Normal volunteers

Indexed keywords

CORTICOSTEROID; HYDROCORTISONE; PLACEBO;

ADULT; ARTICLE; CLINICAL TRIAL; COGNITION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; FRONTAL LOBE; HUMAN; HUMAN EXPERIMENT; LEARNING; MALE; MEMORY; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TASK PERFORMANCE;

ADULT; ANTI-INFLAMMATORY AGENTS; COGNITION; COGNITION DISORDERS; CROSS-OVER STUDIES; FRONTAL LOBE; HUMANS; HYDROCORTISONE; LEARNING; MALE; MEMORY; MIDDLE AGED; MOVEMENT;

EID: 0032784243     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130051057     Document Type: Article

References (42)

1. Abas MA, Sahakian BJ, Levy R (1990) Neuropsychological deficits and CT scan changes in elderly depressives. Psychol Med 20: 507-520
2. Austin MP, Ross M, Murray C, O'Carroll RE, Ebmeier KP, Goodwin GM (1992) Cognitive function in major depression. J Affect Disord 25: 21-30
3. Baker SC, Rogers RD, Owen AM, Frith CD, Dolan RJ, Frackowiak RSJ, Robbins TW (1996) Neural systems engaged by planning: a PET study of the Tower of London task. Neuropsychologia 34: 515-526
4. Barden N, Reul JMHM, Holsboer F (1995) Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system? Trends Neurosci 18: 6-11
5. Beats BC, Sahakian BJ, Levy R (1996) Cognitive performance in tests sensitive to frontal lobe dysfunction in the elderly depressed. Psychol Med 26: 591-603
6. Bodnoff SR, Humphreys AG, Lehman JC, Diamond DM, Rose GM, Meaney MJ (1995) Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats. J Neurosci 15: 61-69
7. Carpenter WT, Gruen PH (1982) Cortisol's effect on human mental functioning. J Clin Psychopharmacol 2: 91-101
8. Diamond DM, Bennett MC, Fleschner M, Rose GM (1992) Inverted U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation. Hippocampus 2: 421-430
9. Elliott R, Baker SC, Rogers RD, O'Leary DA, Paykel ES, Frith CD, Dolan RJ, Sahakian BJ (1997) Prefrontal dysfunction in depressed patients performing a complex planning task: a study using positron emission tomography. Psychol Med 27: 931-942
10. Elliott R, McKenna PJ, Robbins TW, Sahakian BJ (1998) Specific neuropsychological deficits in schizophrenic patients with preserved intellectual function. Cognit Neuropsychiatr 3: 45-70
11. Elliott R, Sahakian BJ, McKay AP, Herrod JJ, Robbins TW, Paykel ES (1996) Neuropsychological impairments in unipolar depression: the influence of perceived failure on subsequent performance. Psychol Med 26: 975-989
12. Fowler KS, Saling MM, Conway EL, Semple JM, Louis WJ (1997) Computerised Neuropsychological tests in the early detection of dementia: prospective findings. J Int Neuropsychol Soc 3: 139-146
13. Hills M, Armitage P (1979) The two-period cross-over clinical trial. Br J Clin Pharmacol 8: 7-20
14. Kirschbaum C, Wolf OT, May M, Wippich W, Hellhammer DH (1996) Stress and treatment induced elevations of cortisol levels associated with impaired declarative memory in healthy adults. Life Sci 58: 1475-1483
15. Lange KW, Sahakian BJ, Quinn NP, Marsden CD, Robbins TW (1995) Comparison of executive and visuospatial memory function in Huntington's disease and dementia of Alzheimer type matched for degree of dementia. J Neurol Neurosurg Psychiatry 58: 598-606
16. Lupien S, de Leon M, de Santi S, Convit A, Tarshish C, Nair NPV, Thakur M, McEwen BS, Hauger RL, Meaney MJ (1998) Cortisol levels during human ageing predict hippocampal atrophy and memory deficits. Nature Neurosci 1: 69-73
17. Lupien S, Lecours AR, Lussier I, Schwartz G, Nair NPV, Meaney MJ (1994) Basal cortisol levels and cognitive deficits in human ageing. J Neurosci 14: 2893-2903
18. McAllister-Williams RH, Ferrier IN, Young AH (1998) Mood and neuropsychological function in depression: the role of corticosteroids and serotonin. Psychol Med 28: 573-584
19. Moffoot APR, O'Carroll RE, Bennie J, Carroll S, Dick H, Ebmeier KP, Goodwin GM (1994) Diurnal variation of mood and neuropsychological function in major depression with melancholia. J Affect Disord 32: 257-269
20. Newcomer JW, Craft S, Hershey T, Askins K, Bardgett ME (1994) Glucocorticoid-induced impairment in declarative memory performance in adult humans. J Neurosci 14: 2047-2053
21. O'Brien JT, Sahakian BJ, Checkley SA (1993) Cognitive impairment in patients with seasonal affective disorder. Br J Psychiatry 163: 338-395
22. Owen AM, Downes JJ, Sahakian BJ, Polkey CE, Robbins TW (1990) Planning and spatial working memory following frontal lobe lesions in man. Neuropsychologia 28: 1021-1034
23. Owen AM, James M, Leigh PN, Summers BA, Marsden CD, Quinn NP, Lange KW, Robbins TW (1992) Fronto-striatal deficits at different stages of Parkinson's disease. Brain 115: 1727-1751
24. Owen AM, Sahakian BJ, Semple J, Polkey CE, Robbins TW (1995) Visuo-spatial short-term recognition memory and executive functions after temporal lobe excision, frontal lobe excision or amygdalo-hippocampectomy in man. Neuropsychologia 33: 1-24
25. Owen AM, Evans AC, Petrides M (1996a) Evidence for a two-stage model of spatial working memory processing within the lateral frontal cortex: a positron emission tomography study. Cereb Cortex 6: 31-38
26. Owen AM, Doyon J, Petrides M, Evans AC (1996b) Planning and spatial working: a positron emission tomography study in humans. Eur J Neurosci 8: 353-364
27. Owen AM, Morris RG, Sahakian BJ, Polkey CE, Robbins TW (1996c) Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man. Brain 119: 1597-1615
28. Owen AM, Iddon JL, Hodges JR, Summers BA, Robbins TW (1997) Spatial and non-spatial working memory at different stages of Parkinson's disease. Neuropsychologia 35: 519-532
29. Pantelis C, Barnes TR, Nelson HE, Tanner S, Weatherley L, Owen AM, Robbins TW (1997) Frontal-striatal cognitive deficits in patients with chronic schizophrenia. Brain 120: 1823-1843
30. Park SB, Coull JT, McShane RH, Young AH, Sahakian BJ, Robbins TW, Cowen PJ (1994) Tryptophan depletion in normal volunteers produces selective impairments in learning and memory. Neuropharmacology 33: 575-588
31. Pavlides C, Watanabe Y, Magarinos AM, McEwen BS (1995) Opposing role of adrenal steroid type 1 and type 11 receptors on hippocampal long-term potentiation. Neuroscience 68: 387-394
32. Reus VI (1984) Hormonal mediation of the memory disorder in depression. Drug Dev Res 4: 489-500
33. Robbins TW, James M, Owen AM, Sahakian BJ, McInnes L, Rabbitt P (1994) The Cambridge Neuropsychological Test Automated Battery CANTAB; a factor analytical study in a large number of normal elderly volunteers. Dementia 5: 266-281
34. Robbins TW, Elliott R, Sahakian BJ (1996) Neuropsychology-dementia and affective disorders. Br Med Bull 52: 627-643
35. Rubinow DR, Post RM, Savard R, Gold PW (1984) Cortisol hypersecretion and cognitve impairment in depression. Arch Gen Psychiatry 41: 279-283
36. Sahakian BJ, Morris RG, Evenden JL, Heald A, Levy R, Philpot M, Robbins TW (1988) A comparative study of visuospatial memory and learning in Alzheimer-type dementia and Parkinson's disease. Brain 111: 695-718
37. Sapolsky R (1992) Stress, the ageing brain and mechanisms of neuron death. MIT Press, Boston
38. Shallice T (1982) Specific impairments in planning. Philos Trans R Soc Lond B2948: 199-209
39. Winer BJ (1974) Statistical principles in experimental design. McGraw-Hill, New York
40. Wolkowitz OM, Reus VI, Weingartner H, Thompson K, Brier A, Doran A, Rubinow D, Pickar D (1990) Cognitive effects of corticosteroids in man. Am J Psychiatry 147: 1297-1303
41. Young AH, Sharpley AL, Campling GM, Hockney RA, Cowen PJ (1994) Effects of hydrocortisone on brain 5-HT function and sleep. J Affect Disord 32: 139-146
42. Young AH, Rue J, Odontiadis J, Cowen PJ (1998) Lack of effect of hydrocortisone treatment on d-fenfluramine-mediated prolactin release. Psychopharmacology 136: 198-200