Corticosterone delivery to the amygdala increases corticotropin-releasing factor mRNA in the central amygdaloid nucleus and anxiety-like behavior

Brain Research

Volumn 861, Issue 2, 2000, Pages 288-295

  Shepard, Jack D ^a   Barron, Kirk W ^a   Myers, Dean A ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Amygdala; Anxiety; Corticosterone; Corticotropin releasing factor; Elevated plus maze; Fear

Indexed keywords

CHOLESTEROL; CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DRUG EFFECT; FEAR; IN SITU HYBRIDIZATION; MALE; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; RAT; REARING; STEREOTAXIC SURGERY;

AMYGDALA; ANIMALS; ANTI-INFLAMMATORY AGENTS; ANXIETY; CHOLESTEROL; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; MALE; MOTOR ACTIVITY; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 0034646909     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02019-9     Document Type: Article

References (50)

1. Altemus M., Smith M.A., Diep V., Aulakh C.S., Murphy D.L. Increased mRNA for corticotrophin releasing hormone in the amygdala of fawn-hooded rats: a potential animal model of anxiety. Anxiety. 1:1994;251-257.
2. Andreae L.C., Herbert J. Expression of c-fos in restricted areas of the basal forebrain and brainstem following single or combined intraventricular infusions of vasopressin and corticotropin-releasing factor. Neuroscience. 53:1993;735-748.
3. Arnold F.J., De Lucas B., Shiers H., Hancock D.C., Evan G.I., Herbert J. Expression of c-fos in regions of the basal limbic forebrain following intracerebroventricular corticotropin-releasing factor in unstressed or stressed male rats. Neuroscience. 51:1992;377-390.
4. Beaulieu S., Di Paolo T., Barden N. Control of ACTH secretion by the central nucleus of the amygdala: implication of the serotoninergic systems and its relevance to the glucocorticoid delayed negative feedback mechanism. Neuroendocrine. 44:1986;247-254.
5. Bell M.E., Myers T.R., McDonald T.J., Myers D.A. Fetal sheep pituitary proopiomelanocortin in late gestation: effect of bilateral lesions of the paraventricular neurons on regional and cellular messenger ribonucleic acid levels. Endocrinology. 138:1997;3873-3880.
6. Bell M.E., Myers T.R., Myers D.A. Expression of proopiomelanocortin and prohormone convertase-1 and -2 in the late gestation fetal sheep pituitary. Endocrinology. 139:1998;5135-5143.
7. Calvo N., Martijena I.D., Molina V.A., Volosin M. Metyrapone pretreatment prevents the behavioral and neurochemical sequelae induced by stress. Brain Res. 800:1998;227-235.
8. Chapman W.P., Schroeder H.R., Geyer G., Brazier M.A.B., Fager C., Poppen J.L., Soloman H.C., Yakovlev P.I. Physiological evidence concerning importance of the amygdaloid nuclear region in the integration of circulatory function and emotion in man. Science. 120:1954;949-950.
9. Corodimas K.P., Ledoux J.E., Gold P.W., Schulkin J. Corticosterone potentiation of conditioned fear in rats. Ann. N. Y. Acad. Sci. 746:1994;392-393.
10. Cruz A.P.M., Frei F., Graeff F.G. Ethopharmacological analysis of rat behavior on the elevated plus-maze. Pharmacol. Biochem. Behav. 49:1994;171-176.
11. Davis M. Neurobiology of fear responses: the role of the amygdala. J. Neuropsychiatry Clin. Neurosci. 9:1997;382-402.
12. de Fonseca F.R., Carrera M.R.A., Navarro M., Koob G.F., Weiss F. Activation of corticotropin-releasing factor in the limbic system during cannabinoid withdrawal. Science. 276:1997;2050-2054.
13. Feldman S., Conforti N., Itzik A., Weidenfield J. Differential effect of amygdaloid lesions on CRF-41 ACTH and corticosterone responses following neural stimuli. Brain Res. 658:1994;21-26.
14. Feldman S., Weidenfeld J. Glucocorticoid receptor antagonists in the hippocampus modify the negative feedback following neural stimuli. Brain Res. 821:1999;33-37.
15. Fernandes de Molina A., Hunsperger R.W. Central representation of affective reactions in forebrain and brainstem: electrical stimulation of amygdala, stria terminalis, and adjacent structures. J. Physiol. 145:1959;251-265.
16. File S.E., Zangrossi H. Jr., Sanders F.L., Mabbutt P.S. Raised corticosterone in the rat after exposure to the elevated plus-maze. Psychopharmacology. 113:1994;543-546.
17. Gray T.S. Amygdaloid CRF pathways: role in autonomic, neuroendocrine, and behavioral responses to stress. Ann. N. Y. Acad. Sci. 697:1993;53-60.
18. Gray T.S., Bingaman E.W. The amygdala: corticotropin-releasing factor, steroids, and stress. Crit. Rev. Neurobiol. 10:1996;155-168.
19. Heilig M., Koob G.F., Ekman R., Britton K.T. Corticotropin-releasing factor and neuropeptide Y: role in emotional integration. Trends Neurosci. 17:1994;80-85.
20. Heinrichs S.C., Menzaghi F., Merlo P.E., Britton K.T., Koob G.F. The role of CRF in behavioral aspects of stress. Ann. N. Y. Acad. Sci. 771:1995;92-104.
21. Heinrichs S.C., Pich E.M., Miczek K.A., Britton K.T., Koob G.F. Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotopic action. Brain Res. 581:1992;190-197.
22. Hilton S.M., Zbrozyna A.W. Amygdaloid region for defense reactions and its efferent pathway to the brainstem. J. Physiol. 165:1963;160-173.
23. Honkaniemi J., Pelto-Huikko M., Rechardt L., Isola J., Lammi A., Fuxe K., Gustafsson J., Wikstrom A., Hokfelt T. Colocalization of peptide and glucocorticoid receptor immunoreactivities in rat central amygdaloid nucleus. Neuroendocrinology. 55:1992;451-459.
24. Hsu D.T., Chen F.-L., Takahashi L.K., Kalin N.H. Rapid stress-induced elevations in corticotropin-releasing hormone mRNA in rat central amygdala nucleus and hypothalamic paraventricular nucleus: an in situ hybridization analysis. Brain Res. 788:1998;305-310.
25. Kalin N.K., Takahashi L.K., Chen F.L. Restraint stress increases corticotropin-releasing hormone mRNA content in the amygdala and paraventricular nucleus. Brain Res. 656:1994;182-186.
26. Kaskow J.W., Regmi A., Gill P.S., Parkes D.G., Geracioti T.D. Regulation of corticotropin-releasing factor (CRF) messenger ribonucleic acid and CRF peptide in the amygdala: studies in primary amygdalar cultures. Endocrinology. 138:1997;4774-4782.
27. Kopchia K.L., Altman H.J., Commissaris R.L. Effects of lesions of the central nucleus of the amygdala on anxiety-like behaviors in the rat. Pharmacol. Biochem. Behav. 43:1992;453-461.
28. LeDoux J. Fear and the brain: where have we been, and where are we going? Biol. Psychiatry. 44:1998;1229-1238.
29. Lee Y., Davis M. Role of the hippocampus, the bed nucleus of the stria terminalis, and the amygdala in the excitatory effects of corticotropin-releasing hormone on the acoustic startle reflex. J. Neurosci. 17:1997;6434-6446.
30. Lee Y., Schulkin J., Davis M. Effect of corticosterone on the enhancement of the acoustic startle reflex by corticotropin releasing factor (CRF). Brain Res. 666:1994;93-98.
31. Lehnert H., Schulz C., Dieterich K. Physiological and neurochemical aspects of corticotropin-releasing factor actions in the brain: the role of the locus coeruleus. Neurochem. Res. 23:1998;1039-1052.
32. Liebsch G., Landgraf R., Gerstberger R., Probst J.C., Wotjak C.T., Engelmann M., Holsboer F., Montkowski A. Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats. Regul. Pept. 59:1995;229-239.
33. Makino S., Gold P.W., Schulkin J. Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus. Brain Res. 640:1994;105-112.
34. Makino S., Gold P.W., Schulkin J. Effects of corticosterone on CRH mRNA and content in the bed nucleus of stria terminalis; comparison with the effects in the central nucleus of the amygdala and the paraventricular nucleus of the hypothalamus. Brain Res. 657:1994;141-149.
35. McDonald T.J., Hoffmann G.E., Myers D.A., Nathanielsz P.W. Hypothalamic glucocorticoid implants prevent fetal ovine adrenocorticotropin secretion in response to stress. Endocrinology. 127:1990;2862-2868.
36. Myers D.A., Bell M.E., McDonald T.J., Myers T.R. Corticotropin-releasing factor receptor expression in the pituitary of fetal sheep after lesions of the hypothalamic paraventricular nucleus. Endocrinology. 140:1999;4292-4299.
37. Myers D.A., McDonald T.J., Dunn T.G., Moss G.E., Nathanielsz P.W. Effect of implantation of dexamethasone adjacent to the paraventricular nucleus on messenger ribonucleic acid for corticotropin-releasing hormone and proopiomelanocortin during late gestation in fetal sheep. Endocrinology. 130:1992;2167-2172.
38. Myers D.A., McDonald T.J., Nathanielsz P.W. Effect of placement of dexamethasone adjacent to the ovine fetal paraventricular nucleus on adrenocortical steroid hydroxylase messenger ribonucleic acid. Endocrinology. 131:1992;1329-1335.
39. Pellow S., Chopin P., File S.E., Briley M. Validation of open-closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J. Neurosci. Methods. 14:1985;149-167.
40. Pich E.M., Lorang M., Yeganeh M., de Fonseca F.R., Raber J., Koob G.F., Weiss F. Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis. J. Neurosci. 15:1995;5439-5447.
41. Rassnick S., Heinrichs S.C., Britton K.T., Koob G.F. Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal. Brain Res. 605:1993;25-32.
42. Reul J.M.H.M., de Kloet E.R. Two receptor systems for corticosterone in rat brain: microdistribution and differential occupation. Endocrinology. 117:1985;2505-2511.
43. Roozendaal B., Bohus B., McGaugh J.L. Dose-dependent suppression of adrenocortical activity with metyrapone: effects on emotion and memory. Psychoneuroendocrinology. 21:1996;681-693.
44. Sakanaka M., Shibasaki T., Lederis K. Distribution and efferent projections of corticotropin-releasing factor-like immunoreactivity in the rat amygdaloid complex. Brain Res. 382:1986;213-238.
45. Schulkin J., Gold P.W., McEwen B.S. Induction of corticotropin-releasing hormone gene expression by glucocorticoids: implication for understanding the states of fear and anxiety and allostatic load. Psychoneuroendocrinology. 23:1998;219-243.
46. Schulkin J., McEwen B.S., Gold P.W. Allostasis, amygdala, and anticipatory angst. Neurosci. Biobehav. Rev. 18:1994;385-396.
47. Swanson L.W., Simmons D.M. Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the paraventricular nucleus: a hybridization histochemical study in the rat. J. Comp. Neurol. 285:1989;413-435.
48. Swiergiel A.H., Takahashi L.K., Kalin N.H. Attenuation of stress-induced behavior by antagonism of corticotropin-releasing factor receptors in the central amygdala in the rat. Brain Res. 623:1993;229-234.
49. C. Watson, G.T. Paxinos, The Rat Brain in Stereotaxic Coordinates, Academic Press, New York, 1997.
50. Watts A.G., Sanchez-Watts G. Region-specific regulation of neuropeptide mRNAs in rat limbic forebrain neurones by aldosterone and corticosterone. J. Physiol. 484:1995;721-736.