Tamoxifen: Is it safe? comparison of activation and detoxication mechanisms in rodents and in humans

Current Drug Metabolism

Volumn 4, Issue 3, 2003, Pages 223-239

  White, I N H ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Accelerator mass spectrometry; CYP; Glucuronyltransferase; Idoxifene; Sulfotransferase; Tamoxifen; Toremifene

Indexed keywords

ANASTROZOLE; ANTIESTROGEN; AROMATASE INHIBITOR; CARBON 14; CYTOCHROME P450; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; DROLOXIFENE; GLUCURONIDE; HYDROXYTAMOXIFEN; IDOXIFENE; NORTAMOXIFEN; PHOSPHORUS 32; RALOXIFENE; SULFATE; TAMOXIFEN; TOREMIFENE;

BREAST CANCER; CANCER INCIDENCE; CANCER RISK; CARCINOGENESIS; CATALYSIS; DRUG ACTIVATION; DRUG DETOXIFICATION; DRUG DNA BINDING; DRUG EXPOSURE; DRUG HALF LIFE; DRUG MEGADOSE; DRUG STRUCTURE; DRUG USE; ENDOMETRIUM CANCER; ESTROGEN ACTIVITY; GENOTOXICITY; HUMAN; ISOTOPE LABELING; LIFESPAN; LIVER CANCER; LIVER TUMOR; LOW DRUG DOSE; MASS SPECTROMETRY; NONHUMAN; REVIEW; SULFATION; UTERUS TUMOR;

ANIMALS; BIOTRANSFORMATION; ESTROGEN ANTAGONISTS; FEMALE; HUMANS; METABOLIC DETOXICATION, DRUG; MUTAGENS; TAMOXIFEN;

EID: 0038147559     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200033489451     Document Type: Review

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