Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-Dihydroxytamoxifen-o-quinone

Chemical Research in Toxicology

Volumn 13, Issue 1, 2000, Pages 53-62

  Zhang, Fagen ^a   Fan, Peter W ^a   Liu, Xuemei ^a   Shen, Lixin ^a   Van Breemen, Richard B ^a   Bolton, Judy L ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDROXYTAMOXIFEN; 4 HYDROXYTAMOXIFEN; BENZOPHENONE DERIVATIVE; DEOXYGUANOSINE DERIVATIVE; GLUTATHIONE; MONOPHENOL MONOOXYGENASE; PROPIOPHENONE; QUINONE DERIVATIVE; TAMOXIFEN; TAMOXIFEN DERIVATIVE; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CANCER RISK; CARCINOGENESIS; CONTROLLED STUDY; DRUG CARCINOGENICITY; DRUG CYTOTOXICITY; DRUG HALF LIFE; DRUG METABOLISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOMETRIUM CANCER; HUMAN; HUMAN CELL;

ANIMALS; BREAST NEOPLASMS; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEOXYGUANOSINE; GLUTATHIONE; HUMANS; MASS SPECTROMETRY; MICROSOMES, LIVER; MONOPHENOL MONOOXYGENASE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OXIDATION-REDUCTION; QUINONES; RATS; TAMOXIFEN; THYMIDINE; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0033970909     PISSN: 0893228X     EISSN: None     Source Type: Journal    
DOI: 10.1021/tx990145n     Document Type: Article

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