Effects of chronic administration of tamoxifen and toremifene on DNA adducts in rat liver, kidney, and uterus

Cancer Research

Volumn 57, Issue 8, 1997, Pages 1438-1441

  Li, Donghui ^a   Dragan, Yvonne ^b   Jordan, V Craig ^c   Wang, Mianying ^a   Pitot, Henry C ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TAMOXIFEN; TOREMIFENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; DNA ADDUCT; DOSE TIME EFFECT RELATION; DRUG CARCINOGENICITY; DRUG DNA BINDING; FEMALE; KIDNEY CANCER; LIVER CANCER; NONHUMAN; PRIORITY JOURNAL; RAT; UTERUS CANCER;

ANIMALS; ANTICARCINOGENIC AGENTS; DNA ADDUCTS; FEMALE; KIDNEY; LIVER; RATS; RATS, INBRED F344; TAMOXIFEN; TOREMIFENE; UTERUS;

EID: 0030899189     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Jordan, V. C. Tamoxifen: toxicities and drug resistance during the treatment and prevention of breast cancer. Annu. Rev. Pharmacol. Toxicol., 35: 195-211, 1995.
2. Greaves, P., Goonetilleke, R., Nunn, G., Topham, J., and Orton, T. Two year carcinogenicity study of tamoxifen in Alderley Park Wistar-derived rats. Cancer Res., 53: 3919-3924, 1993.
3. Williams, G. M., Iatropoulos, M. J., Djordjevic, M. V., and Kaltenberg, O. P. The triphenylethylene drug tamoxifen is a strong liver carcinogen in the rat. Carcinogenesis (Lond.), 14: 315-317, 1993.
4. Fisher, B., Costantino, J. P., Redmond, C. K., Fisher, E. R., Wickerham, D. L., and Cronin, W. W. Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14. J. Natl. Cancer Inst., 86: 527-537, 1994.
5. Magriples, U., Naftolin, F., Schwartz, P., and Carcongium, M. High grade endometrial carcinoma in tamoxifen treated breast cancer patients. J. Clin. Oncol., 11: 485-490, 1993.
6. van Leuwen, F., Benraadt, J., Coeberg, J., Kiemeney, L., Gimbrere, C., Otter, R., Scheuten, L., Damhuis, R., Bontenbal, M., Diepenhorst, F., van den Belt-Dusebout, A., and van Tinteren, H. Risk of endometrial cancer after tamoxifen treatment of breast cancer. Lancet, 343: 448-452, 1994.
7. Jordan, V. C., and Assikis, V. Endometrial cancer and tamoxifen: clearing up a controversy. Clin. Cancer Res., 1: 467-472, 1995.
8. Valaara, R. Phase II trials with toremifene in advanced breast cancer: a review. Breast Cancer Res. Treat., 16: 31-35, 1990.
9. Vogel, C. L., Shemano, I., Schoenfelder, J., Gams, R. A., and Green, M. R. Multicenter phase II efficacy trial of toremifene in tamoxifen-refractory patients with advanced breast cancer. J. Clin. Oncol., 11: 345-350, 1993.
10. Phillips, D. H., Hewer, A., Grover, P. L., Poon, G. K., and Carmichael, P. L. Tamoxifen does not form delectable DNA adducts in white blood cells of breast cancer patients. Carcinogenesis (Lond.), 17: 1149-1152, 1996.
11. Han, X., and Liehn J. G. Induction of covalent DNA adducts in rodents by tamoxifen. Cancer Res., 52: 1360-1363, 1992.
12. White, I. N. H., de Matteis, F., Davies, A., Smith, L. L., Crofton-Sleigh, C., Venitt, S., Hewer, A., and Phillips, D. H. Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells. Carcinogenesis (Lond.), 12: 2197-2203, 1992.
13. Montandon, F., and Williams, G. M. Comparison of DNA reactivity of the polyphenylethylene hormonal agents diethylstilbestrol, tamoxifen and toremifene in rat and hamster liver. Arch. Toxicol., 68: 272-275, 1994.
14. 32P-postlabelled DNA adducts in liver obtained from women treated with tamoxifen. Carcinogenesis (Lond.), 16: 1651-1654, 1995.
15. Carmichael, P. L., Ugwumadu, H. N., Neven, P., Hewer, A. J., Poon, G. K., and Phillips, D. H. Lack of genotoxicity of tamoxifen in human endometrium. Cancer Res., 56: 1475-1479, 1996.
16. Hemminki, K., Rajaniemi, H., Lindahl, B., and Moberger, B. Tamoxifen-induced DNA adducts in endometrial samples from breast cancer patients. Cancer Res., 56: 4374-4377, 1996.
17. Pathak, D. N., Pongracz, K., and Bodell, W. J. Activation of 4-hydroxytamoxifen and the tamoxifen derivative metabolite E by uterine peroxidase to form DNA adducts: comparison with DNA adducts formed in the uterus of Sprague-Dawley rats treated with tamoxifen. Carcinogenesis (Lond.), 17: 1785-1790, 1996.
18. Carthew, P., Martin, E. A., White, I. N. H., Matteis, F., Edwards, R. E., Dorman, B. M., Heydon, R. T., and Smith, L. L. Tamoxifen induces short-term cumulative DNA damage and liver tumors in rats: promotion by phenobarbital. Cancer Res., 55: 544-547, 1995.
19. 32P-postlabeling test for structurally diverse DNA adducts. Carcinogenesis (Lond.), 7: 1543-1551, 1986.
20. Hard, G. C., Iatropoulos, M. J., Jordan, K., Radi, L., Kaltenberg, O. P., Imondi, A. R., and Williams, G. M. Major difference in the hepatocarcinogenicity and DNA adduct forming ability between toremifene and tamoxifen in female Crl:CD(BR) rats. Cancer Res., 53: 4534-4541, 1993.
21. Gradishar, W., and Jordan, V. C. Clinical potential of new antiestrogens. J. Clin. Oncol., in press, 1997.
22. Dragan, Y. P., Vaughan, J., Jordan, V. C., and Pilot, H. C. Comparison of the effects of tamoxifen and toremifene on liver and kidney tumor promotion in female rats. Carcinogenesis (Lond.), 16: 2733-2741, 1995.
23. White, I. N. H., Davies, A., Jukes, R., Phillips, D., and de Matteis, F. A comparison of the genotoxic potential of tamoxifen and toremifene in female F344 rats. Hum. Exp. Toxicol., 12: 569, 1993.
24. Sargent, L. M., Dragan, Y. P., Sattler, C., Bahnub, N., Sattler, G., Martin, P., Cisneros, A., Mann, J., Thorgeirsson, S., Jordan, V. C., and Pilot, H. C. Induction of hepatic aneuploidy in vivo by tamoxifen, toremifene and idoxifene in female Sprague-Dawley rats. Carcinogenesis (Lond.), 17: 1051-1056, 1996.
25. Randerath, K., Li, D., and Randerath, E. Age-related DNA modifications (I-compounds): modulation by physiological and pathological processes. Mutat. Res., 238: 245-253, 1990.
26. Nuwaysir, E. F., Dragan, Y. P., Jefcoate, C. R., Jordan, V. C., and Pilot, H. C. Effects of tamoxifen administration on the expression of xenobiotic metabolizing enzymes in rat liver. Cancer Res., 55: 1780-1786, 1995.