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Volumn 272, Issue , 1996, Pages 152-163

Tamoxifen metabolism by microsomal cytochrome P450 and flavin-containing monooxygenase

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; DIMETHYLANILINE MONOOXYGENASE; FLAVOPROTEIN; TAMOXIFEN; TAMOXIFEN DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0029758139     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0076-6879(96)72019-0     Document Type: Article
Times cited : (23)

References (54)
  • 33
    • 85030276438 scopus 로고    scopus 로고
    • note
    • Because of heat lability of FMO, preincubation in the absence of NADPH should be avoided when FMO catalysis is desired.
  • 37
    • 85030273354 scopus 로고    scopus 로고
    • note
    • Although an ethanolic solution of tamoxifen stored at 0-4° is essentially stable, a small amount of N-oxide is generated with time because of air exposure. It is, therefore, advisable that the stock of tamoxifen be monitored and, if necessary, purified on TLC.
  • 38
    • 85030274118 scopus 로고    scopus 로고
    • personal communication
    • The low level of N-oxidation of tamoxifen by chicken liver microsomes, despite the presence of considerable amount of FMO, is attributed to its restrictive active site (Dr. Daniel Ziegler, personal communication).
    • Ziegler, D.1
  • 39
    • 85030278930 scopus 로고    scopus 로고
    • note
    • Initially, 25 IU of COMT was included in incubations; however, we later observed that there is no necessity for exogenous COMT since there is sufficient COMT in the microsomes.
  • 44
    • 85088845394 scopus 로고    scopus 로고
    • note
    • 45
  • 46
    • 85088845537 scopus 로고    scopus 로고
    • note
    • 14,47


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.