Adenovirus binding to the coxsackievirus and adenovirus receptor or integrins is not required to elicit brain inflammation but is necessary to transduce specific neural cell types

Journal of Virology

Volumn 76, Issue 7, 2002, Pages 3452-3460

  Thomas, Clare E ^a   Edwards, Penny ^a   Wickham, Thomas J ^a   Castro, Maria G ^a   Lowenstein, Pedro R ^a  

^a Gene Therapeutics Research Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; VIRUS RECEPTOR; VIRUS VECTOR;

ADENOVIRUS; ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COXSACKIE VIRUS; ENCEPHALITIS; GENE MUTATION; GENETIC TRANSDUCTION; NERVE CELL; NEUROTROPISM; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; VIRUS CAPSID;

ADENOVIRIDAE; ADENOVIRIDAE INFECTIONS; ANIMALS; CAPSID; CAPSID PROTEINS; ENCEPHALITIS; ENTEROVIRUS; GENE THERAPY; GENETIC VECTORS; IMMUNOHISTOCHEMISTRY; INTEGRINS; MUTATION; NEUROGLIA; NEURONS; OLIGODENDROGLIA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, VIRUS; TRANSDUCTION, GENETIC;

EID: 0036118869     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.7.3452-3460.2002     Document Type: Article

References (29)

1. Isolation of a common receptor for coxsackie B viruses and adenoviruses 2 and 5
2. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses
3. Adenovirus vector-induced expression of the C-X-C chemokine IP-10 is mediated through capsid-dependent activation of NF-κB
4. Adenovirus infection stimulates the Raf/MAPK signaling pathway and induces interleukin-8 expression
5. Adenovirus gene transfer causes inflammation in the brain
6. Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain
7. High adenoviral loads stimulate NFκB-dependent gene expression in human vascular smooth muscle cells
8. Construction of a pseudoreceptor that mediates transduction by adenoviruses expressing a ligand in fiber or penton base
9. Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions
10. CAR-dependent and CAR-independent pathways of adenovirus vector-mediated gene transfer and expression in human fibroblasts
11. Cytotoxic T-lymphocyte target proteins and their major histocompatibility complex class I restriction in response to adenovirus vectors delivered to mouse liver
12. Mutations in the DG loop of adenovirus type 5 fiber knob protein abolish high-affinity binding to its cellular receptor CAR
13. Type-specific induction of interleukin-8 by adenovirus
14. The role of Kupffer cell activation and viral gene expression in early liver toxicity after infusion of recombinant adenovirus vectors
15. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy
16. Immune response to recombinant adenovirus in humans: Capsid components from viral input are targets for vector-specific cytotoxic T lymphocytes
17. Cytokine production by cultured human bronchial epithelial cells infected with a replication-deficient adenoviral gene transfer vector or wild-type adenovirus type 5
18. Toxicity associated with repeated administration of first-generation adenovirus vectors does not occur with a helper-dependent vector
19. Microglia and macrophages
20. Identification of a conserved receptor-binding site on the fiber proteins of CAR-recognizing adenoviridae
21. Genomic DNA transfer with a high-capacity adenovirus vector results in improved in vivo gene expression and decreased toxicity
22. Gene transfer to the brain using adenovirus vectors
23. Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain
24. Peripheral infection with adenovirus causes unexpected long-term brain inflammation in animals injected intracranially with first-generation, but not with high-capacity, adenovirus vectors: Toward realistic long-term neurological gene therapy for chronic diseases
25. Preexisting antiadenoviral immunity is not a barrier to efficient and stable transduction of the brain, mediated by novel high-capacity adenovirus vectors
26. Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment
27. Adenovirus targeted to heparan-containing receptors increases its gene delivery efficiency to multiple cell types
28. Targeting of adenovirus penton base to new receptors through replacement of its RGD motif with other receptor-specific peptide motifs
29. Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infection