Uncoupling of virus-induced inflammation and anti-viral immunity in the brain parenchyma

Journal of General Virology

Volumn 83, Issue 7, 2002, Pages 1735-1743

  Stevenson, P G ^a   Austyn, J M ^a   Hawke, S ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; VIRUS ANTIGEN;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; BRAIN INFECTION; BRAIN TISSUE; CELL FUNCTION; CEREBROSPINAL FLUID; CONTROLLED STUDY; DENDRITIC CELL; IMMUNOGENICITY; INFLAMMATION; INFLUENZA VIRUS; INOCULATION; LATERAL BRAIN VENTRICLE; MAJOR HISTOCOMPATIBILITY COMPLEX; MICROENVIRONMENT; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; VIRUS IMMUNITY;

ANIMALIA; INFLUENZA VIRUS; RNA VIRUSES;

EID: 0036298188     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-83-7-1735     Document Type: Article

References (35)

1. + T cell priming and Th1/Th2 cell restimulation
2. Dendritic cells initiate a two-stage mechanism for T lymphocyte proliferation
3. Immunologically privileged sites
4. Mature microglia resemble immature antigen-presenting cells
5. 8 T cells into the central nervous system by professional antigen-presenting cells
6. Cervical lymphatics, the blood-brain barrier and the immunoreactivity of the brain: A new view
7. Brain dendritic cells and macrophages/microglia in central nervous system inflammation
8. Phenotype and functions of brain dendritic cells emerging during chronic infection of mice with Toxoplasma gondii
9. Microglia induce CD4 T lymphocyte final effector function and death
10. T cell apoptosis in autoimmune diseases: Termination of inflammation in the nervous system and other sites with specialized immune-defense mechanisms
11. Ovalbumin is more immunogenic when introduced into brain or cerebrospinal fluid than into extracerebral sites
12. Virus-specific antigen presentation by different subsets of cells from lung and mediastinal lymph node tissues of influenza virus-infected mice
13. Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain
14. Long-term persistence of activated cytotoxic T lymphocytes after viral infection of the central nervous system
15. Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo
16. Brain-derived gangliosides regulate the cytokine production and proliferation of activated T cells
17. Migration patterns of dendritic cells in the mouse. Traffic from the blood, and T cell-dependent and -independent entry to lymphoid tissues
18. A mouse model for immunization with ex vivo virus-infected dendritic cells
19. Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell responses in vitro
20. Bacillus Calmette-Guerin sequestered in the brain parenchyma escapes immune recognition
21. Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue and to the anterior chamber of the eye
22. Dendritic cells: Specialized and regulated antigen processing machines
23. Mechanisms of mouse spleen dendritic cell function in the generation of influenza-specific, cytolytic T lymphocytes
24. Pathogenesis of neurovirulent influenza A virus infection in mice. Route of entry of virus into brain determines infection of different populations of cells
25. Developmental plasticity of CNS microglia
26. Incomplete growth cycle of influenza virus in mouse brain
27. Intracerebral recruitment and maturation of dendritic cells in the onset and progression of experimental autoimmune encephalomyelitis
28. The dendritic cell system and its role in immunogenicity
29. The immunogenicity of intracerebral virus infection depends on anatomical site
30. Virus dissemination through the brain parenchyma without immunologic control
31. + memory T cells in an immunoprivileged site
32. Immune privilege as the result of local tissue barriers and immunosuppressive microenvironments
33. A neurotropic strain of human influenza virus
34. The substantia nigra is a major target for neurovirulent influenza A virus