Immunological instability of persistent adenovirus vectors in the brain: Peripheral exposure to vector leads to renewed inflammation, reduced gene expression, and demyelination

Journal of Neuroscience

Volumn 16, Issue 9, 1996, Pages 3045-3055

  Byrnes, Andrew P ^a   MacLaren, Robert E ^a   Chariton, Harry M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

adenovirus; caudate; demyelination; gene therapy; microglia; neuroimmunology; viral vector

Indexed keywords

BETA GALACTOSIDASE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN; VIRUS ANTIGEN; VIRUS VECTOR;

ADENOVIRUS; ARTICLE; BRAIN; CONTROLLED STUDY; DEMYELINATION; GENE; GENE EXPRESSION; IMMUNE RESPONSE; INFLAMMATION; MICROGLIA; NEUROIMMUNOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; T LYMPHOCYTE;

EID: 0029876694     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.16-09-03045.1996     Document Type: Article

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