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Volumn 90, Issue SUPPL. 2, 2003, Pages S97-S104

Concepts of immunostimulation to increase antiparasitic drug action

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPARASITIC AGENT; CYTOKINE; GAMMA INTERFERON; IMIQUIMOD; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G2A; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; LEISHMANIA VACCINE; LYMPHOTOXIN; MESSENGER RNA; MURAMYL DIPEPTIDE; OLIGODEOXYNUCLEOTIDE DERIVATIVE; PARASITE ANTIGEN; RESIQUIMOD; STAT4 PROTEIN; TRYPANOSOMA CRUZI VACCINE;

EID: 0037963683     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-002-0774-5     Document Type: Review
Times cited : (6)

References (59)
  • 1
    • 0033214404 scopus 로고    scopus 로고
    • Dendritic cell (DC)-based anti-infective strategies: DCs engineered to secrete IL-12 are a potent vaccine in a murine model of an intracellular infection
    • Ahuja SS, Reddick RL, Sato N, Montalbo E, Kostecki V, Zhao W, Dolan MJ, Melby PC, Ahuja SK (1999) Dendritic cell (DC)-based anti-infective strategies: DCs engineered to secrete IL-12 are a potent vaccine in a murine model of an intracellular infection. J Immunol 163:3890-3897
    • (1999) J Immunol , vol.163 , pp. 3890-3897
    • Ahuja, S.S.1    Reddick, R.L.2    Sato, N.3    Montalbo, E.4    Kostecki, V.5    Zhao, W.6    Dolan, M.J.7    Melby, P.C.8    Ahuja, S.K.9
  • 2
    • 0034001713 scopus 로고    scopus 로고
    • IFN-gamma, IL-4, IL-10 and IL-12 gene expression in BCG-Leishmania vaccination of Trypanosoma cruzi-infected mice
    • Araujo Z, Heremans H, Stordeur P, Wissing M, Goldman M, Castes M, Carlier Y (2000) IFN-gamma, IL-4, IL-10 and IL-12 gene expression in BCG-Leishmania vaccination of Trypanosoma cruzi-infected mice. Vaccine 18:1822-1829
    • (2000) Vaccine , vol.18 , pp. 1822-1829
    • Araujo, Z.1    Heremans, H.2    Stordeur, P.3    Wissing, M.4    Goldman, M.5    Castes, M.6    Carlier, Y.7
  • 3
    • 0032055579 scopus 로고    scopus 로고
    • A critical role for IL-13 in resistance to intestinal nematode infection
    • Bancroft AJ, McKenzie ANJ, Grencis RK (1998) A critical role for IL-13 in resistance to intestinal nematode infection. J Immunol 160:3453-3461
    • (1998) J Immunol , vol.160 , pp. 3453-3461
    • Bancroft, A.J.1    McKenzie, A.N.J.2    Grencis, R.K.3
  • 6
    • 0033715826 scopus 로고    scopus 로고
    • Lower hookworm incidence, prevalence, and intensity of infection in children with a Bacillus Calmette-Guerin vaccination scar
    • Barreto ML, Rodrigues LC, Silva RC, Assis AM, Reis MG, Santos CA, Blanton RE (2000) Lower hookworm incidence, prevalence, and intensity of infection in children with a Bacillus Calmette-Guerin vaccination scar. J Infect Dis 182:1800-1803
    • (2000) J Infect Dis , vol.182 , pp. 1800-1803
    • Barreto, M.L.1    Rodrigues, L.C.2    Silva, R.C.3    Assis, A.M.4    Reis, M.G.5    Santos, C.A.6    Blanton, R.E.7
  • 7
    • 0027378498 scopus 로고
    • Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors
    • Bermudez LE, Covaro G, Remington J (1993) Infection of murine macrophages with Toxoplasma gondii is associated with release of transforming growth factor beta and downregulation of expression of tumor necrosis factor receptors. Infect Immun 61:4126-4130
    • (1993) Infect Immun , vol.61 , pp. 4126-4130
    • Bermudez, L.E.1    Covaro, G.2    Remington, J.3
  • 8
    • 0034668049 scopus 로고    scopus 로고
    • Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection
    • Bliss SK, Butcher BA, Denkers EY (2000) Rapid recruitment of neutrophils containing prestored IL-12 during microbial infection. J Immunol 165:4515-4521
    • (2000) J Immunol , vol.165 , pp. 4515-4521
    • Bliss, S.K.1    Butcher, B.A.2    Denkers, E.Y.3
  • 9
    • 0035720557 scopus 로고    scopus 로고
    • Unresponsiveness of specific T cells to IL-12 is associated with active cutaneous leishmaniasis owing to Leishmania guyanensis
    • Bourreau E, Prevot G, Pradinaud R, Launois P (2001) Unresponsiveness of specific T cells to IL-12 is associated with active cutaneous leishmaniasis owing to Leishmania guyanensis. Scand J Immunol 54:335-339
    • (2001) Scand J Immunol , vol.54 , pp. 335-339
    • Bourreau, E.1    Prevot, G.2    Pradinaud, R.3    Launois, P.4
  • 10
    • 0033057209 scopus 로고    scopus 로고
    • Treatment of experimental leishmaniasis with the immunomodulators imiquimod and S-28463: Efficacy and mode of action
    • Buates S, Matlashewski G (1999) Treatment of experimental leishmaniasis with the immunomodulators imiquimod and S-28463: efficacy and mode of action. J Infect Dis 179:1485-1494
    • (1999) J Infect Dis , vol.179 , pp. 1485-1494
    • Buates, S.1    Matlashewski, G.2
  • 11
    • 0344780824 scopus 로고    scopus 로고
    • Interleukin-12 as an adjuvant for an antischistosome vaccine consisting of adult worm antigens: Protection of rats from cercarial challenge
    • Bungiro RD Jr, Goldberg M, Suri PK, Knopf PM (1999) Interleukin-12 as an adjuvant for an antischistosome vaccine consisting of adult worm antigens: protection of rats from cercarial challenge. Infect Immun 67:2340-2348
    • (1999) Infect Immun , vol.67 , pp. 2340-2348
    • Bungiro R.D., Jr.1    Goldberg, M.2    Suri, P.K.3    Knopf, P.M.4
  • 12
  • 13
    • 0035060828 scopus 로고    scopus 로고
    • Vaccination against the intracellular pathogens Leishmania major and L. amazonensis by directing CD40 ligand to macrophages
    • Chen G, Darrah PA, Mosser DM (2001) Vaccination against the intracellular pathogens Leishmania major and L. amazonensis by directing CD40 ligand to macrophages. Infect Immun 69:3255-3263
    • (2001) Infect Immun , vol.69 , pp. 3255-3263
    • Chen, G.1    Darrah, P.A.2    Mosser, D.M.3
  • 14
    • 0034650433 scopus 로고    scopus 로고
    • CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism
    • Chiaramonte MG, Hesse M, Cheever AW, Wynn TA (2000) CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism. J Immunol 164:973-985
    • (2000) J Immunol , vol.164 , pp. 973-985
    • Chiaramonte, M.G.1    Hesse, M.2    Cheever, A.W.3    Wynn, T.A.4
  • 15
    • 0034666740 scopus 로고    scopus 로고
    • CpG DNA as aTh1-promoting adjuvant immunization against Trypanosoma cruzi
    • Corral RS, Petray PB (2000) CpG DNA as aTh1-promoting adjuvant immunization against Trypanosoma cruzi. Vaccine 19:234-242
    • (2000) Vaccine , vol.19 , pp. 234-242
    • Corral, R.S.1    Petray, P.B.2
  • 16
    • 0033028503 scopus 로고    scopus 로고
    • Ability of macrophage subsets to transfer resistance to routine leishmaniasis is dependent on IL-12 production
    • Doherty TM, Coffman RL (1999) Ability of macrophage subsets to transfer resistance to routine leishmaniasis is dependent on IL-12 production. Eur Immunol 29:522-529
    • (1999) Eur Immunol , vol.29 , pp. 522-529
    • Doherty, T.M.1    Coffman, R.L.2
  • 18
    • 0030271361 scopus 로고    scopus 로고
    • Synergism of IL-2-stimulated splenocytes and Pentostam enhances the killing of Leishmania donovani in vitro
    • Eslami Z, Gaucher D, Tanner CE (1996) Synergism of IL-2-stimulated splenocytes and Pentostam enhances the killing of Leishmania donovani in vitro. Clin Immunol Immunopathol 81:74-81
    • (1996) Clin Immunol Immunopathol , vol.81 , pp. 74-81
    • Eslami, Z.1    Gaucher, D.2    Tanner, C.E.3
  • 19
    • 0034163317 scopus 로고    scopus 로고
    • Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent
    • Fallon PG, Richardson EJ, McKenzie GJ, McKenzie AN (2000) Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent. J Immunol 164:2585-2591
    • (2000) J Immunol , vol.164 , pp. 2585-2591
    • Fallon, P.G.1    Richardson, E.J.2    McKenzie, G.J.3    McKenzie, A.N.4
  • 20
  • 21
    • 0033178829 scopus 로고    scopus 로고
    • The role of IL-13 in helminth-induced inflammation and protective immunity against nematode infections
    • Finkelman FD, Wynn TA, Donaldson DD, Urban JF (1999) The role of IL-13 in helminth-induced inflammation and protective immunity against nematode infections. Curr Opin Immunol 11:420-426
    • (1999) Curr Opin Immunol , vol.11 , pp. 420-426
    • Finkelman, F.D.1    Wynn, T.A.2    Donaldson, D.D.3    Urban, J.F.4
  • 22
    • 0037203803 scopus 로고    scopus 로고
    • Immune responses to an inactive vaccine against American cutaneous leishmaniasis together with granulocyte-macrophage colony-stimulating factor
    • Follador I, Araujo C, Orge G, Cheng LH, Carvalho LP de, Bacellar O, Almeida RP, Carvalho EM (2002) Immune responses to an inactive vaccine against American cutaneous leishmaniasis together with granulocyte-macrophage colony-stimulating factor. Vaccine 20:1365-1368
    • (2002) Vaccine , vol.20 , pp. 1365-1368
    • Follador, I.1    Araujo, C.2    Orge, G.3    Cheng, L.H.4    De Carvalho, L.P.5    Bacellar, O.6    Almeida, R.P.7    Carvalho, E.M.8
  • 23
    • 0345222527 scopus 로고    scopus 로고
    • A single intramuscular injection with an adenovirus-expressing IL-12 protects BALB/c mice against Leishmania major infection, while treatment with an IL-4 expressing vector increases disease susceptibility in B10.D2 mice
    • Gabaglia CR, Pedersen B, Hitt M, Burdin N, Sercarz EE, Graham FL, Gauldie J, Braciak TA (1999) A single intramuscular injection with an adenovirus-expressing IL-12 protects BALB/c mice against Leishmania major infection, while treatment with an IL-4 expressing vector increases disease susceptibility in B10.D2 mice. J Immunol 162:753-760
    • (1999) J Immunol , vol.162 , pp. 753-760
    • Gabaglia, C.R.1    Pedersen, B.2    Hitt, M.3    Burdin, N.4    Sercarz, E.E.5    Graham, F.L.6    Gauldie, J.7    Braciak, T.A.8
  • 25
    • 0034234710 scopus 로고    scopus 로고
    • IL-4-independent inhibition of IL-12 responsiveness during Leishmania amazonensis infection
    • Jones DE, Buxbaum LU, Scott P (2000) IL-4-independent inhibition of IL-12 responsiveness during Leishmania amazonensis infection. J Immunol 165:364-372
    • (2000) J Immunol , vol.165 , pp. 364-372
    • Jones, D.E.1    Buxbaum, L.U.2    Scott, P.3
  • 26
    • 0032864099 scopus 로고    scopus 로고
    • Protective immunity using recombinant human IL-12 and alum as adjuvants in a primate model of cutaneous leishmaniasis
    • Kenney RT, Sacks DL, Sypek JP, Vilela L, Garn AA, Evans-Davis K (1999) Protective immunity using recombinant human IL-12 and alum as adjuvants in a primate model of cutaneous leishmaniasis. J Immunol 163:4481-4488
    • (1999) J Immunol , vol.163 , pp. 4481-4488
    • Kenney, R.T.1    Sacks, D.L.2    Sypek, J.P.3    Vilela, L.4    Garn, A.A.5    Evans-Davis, K.6
  • 27
    • 0032853312 scopus 로고    scopus 로고
    • IL-15 prolongs the duration of CD8+ T cell-mediated immunity in mice infected with a vaccine strain of Toxoplasma gondii
    • Khan IA, Casciotti L (1999) IL-15 prolongs the duration of CD8+ T cell-mediated immunity in mice infected with a vaccine strain of Toxoplasma gondii. J Immunol 163:4503-4509
    • (1999) J Immunol , vol.163 , pp. 4503-4509
    • Khan, I.A.1    Casciotti, L.2
  • 28
    • 0032825554 scopus 로고    scopus 로고
    • Synergistic effect of interferon-gamma and mannosylated liposome-incorporated doxorubicin in the therapy of experimental visceral leishmaniasis
    • Kole L, Das L, Das PK(1999) Synergistic effect of interferon-gamma and mannosylated liposome-incorporated doxorubicin in the therapy of experimental visceral leishmaniasis. J Infect Dis 180:811-820
    • (1999) J Infect Dis , vol.180 , pp. 811-820
    • Kole, L.1    Das, L.2    Das, P.K.3
  • 29
    • 0035139931 scopus 로고    scopus 로고
    • Pretreatment with recombinant Flt3 ligand partially protects against progressive cutaneous leishmaniasis in susceptible BALB/c mice
    • Kremer IB, Gould MP, Cooper KD, Heinzel FP (2001) Pretreatment with recombinant Flt3 ligand partially protects against progressive cutaneous leishmaniasis in susceptible BALB/c mice. Infect Immun 69:673-680
    • (2001) Infect Immun , vol.69 , pp. 673-680
    • Kremer, I.B.1    Gould, M.P.2    Cooper, K.D.3    Heinzel, F.P.4
  • 30
    • 0033974189 scopus 로고    scopus 로고
    • The capacity to produce IFN-gamma rather than the presence of interleukin-4 determines the resistance and the degree of susceptibility to Leishmania donovani infection in mice
    • Lehmann J, Enssle KH, Lehmann I, Emmendorfer A, Lohmann-Matthes ML (2000) The capacity to produce IFN-gamma rather than the presence of interleukin-4 determines the resistance and the degree of susceptibility to Leishmania donovani infection in mice. J Interferon Cytokine Res 20:63-77
    • (2000) J Interferon Cytokine Res , vol.20 , pp. 63-77
    • Lehmann, J.1    Enssle, K.H.2    Lehmann, I.3    Emmendorfer, A.4    Lohmann-Matthes, M.L.5
  • 31
    • 0033555789 scopus 로고    scopus 로고
    • Anti-TGF-beta treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production
    • Li J, Hunter CA, Farrell JP (1999) Anti-TGF-beta treatment promotes rapid healing of Leishmania major infection in mice by enhancing in vivo nitric oxide production. J Immunol 162:974-979
    • (1999) J Immunol , vol.162 , pp. 974-979
    • Li, J.1    Hunter, C.A.2    Farrell, J.P.3
  • 34
    • 0034535361 scopus 로고    scopus 로고
    • Immunomodulators in infectious diseases: Panoply of possibilities
    • Masihi KN (2000) Immunomodulators in infectious diseases: panoply of possibilities. Int J Immunopharmacol 22:1083-1091
    • (2000) Int J Immunopharmacol , vol.22 , pp. 1083-1091
    • Masihi, K.N.1
  • 35
    • 0035407515 scopus 로고    scopus 로고
    • Fighting infection using immunomodulatory agents
    • Masihi KN (2001) Fighting infection using immunomodulatory agents. Expert Opin Biol Ther 1:641-653
    • (2001) Expert Opin Biol Ther , vol.1 , pp. 641-653
    • Masihi, K.N.1
  • 36
    • 0034703810 scopus 로고    scopus 로고
    • Mycobacterium bovis bacillus Calmette-Guerin induces protective immunity against infection by Plasmosdium yoelii at blood-stage depending on shifting immunity toward Th1 type and inducing protective IgG2a after the parasite infection
    • Matsumoto S, Yukitake H, Kanbara H, Yarnada H, Kitamura A, Yamada T (2000) Mycobacterium bovis bacillus Calmette-Guerin induces protective immunity against infection by Plasmosdium yoelii at blood-stage depending on shifting immunity toward Th1 type and inducing protective IgG2a after the parasite infection. Vaccine 19:779-787
    • (2000) Vaccine , vol.19 , pp. 779-787
    • Matsumoto, S.1    Yukitake, H.2    Kanbara, H.3    Yarnada, H.4    Kitamura, A.5    Yamada, T.6
  • 38
    • 0033178799 scopus 로고    scopus 로고
    • Inhibition of host cell signal transduction by Leishmania: Observations relevant to the selective impairment of IL-12 responses
    • McDowell MA, Sacks DL (1999) Inhibition of host cell signal transduction by Leishmania: observations relevant to the selective impairment of IL-12 responses. Curr Opin Microbiol 2:438-443
    • (1999) Curr Opin Microbiol , vol.2 , pp. 438-443
    • McDowell, M.A.1    Sacks, D.L.2
  • 39
    • 0032510452 scopus 로고    scopus 로고
    • A distinct role for interleukin-13 in Th2 cell-mediated immune responses
    • McKenzie GJ, Bancroft A, Grencis RK, McKenzie AN (1998) A distinct role for interleukin-13 in Th2 cell-mediated immune responses. Curr Biol 8:339-342
    • (1998) Curr Biol , vol.8 , pp. 339-342
    • McKenzie, G.J.1    Bancroft, A.2    Grencis, R.K.3    McKenzie, A.N.4
  • 40
    • 0032962873 scopus 로고    scopus 로고
    • Therapy with a combination of low doses of interleukin 12 and chloroquine completely cures blood-stage malaria, prevents severe anemia, and induces immunity to reinfection
    • Mohan K, Sam H, Stevenson MM (1999) Therapy with a combination of low doses of interleukin 12 and chloroquine completely cures blood-stage malaria, prevents severe anemia, and induces immunity to reinfection. Infect Immun 67:513-519
    • (1999) Infect Immun , vol.67 , pp. 513-519
    • Mohan, K.1    Sam, H.2    Stevenson, M.M.3
  • 41
    • 0033783387 scopus 로고    scopus 로고
    • Interleukin-12 regulates the response to chemotherapy, in experimental visceral leishmaniasis
    • Murray HW, Montelibano C, Peterson R, Sypek JP (2000) Interleukin-12 regulates the response to chemotherapy, in experimental visceral leishmaniasis. J Infect Dis 182:1497-1502
    • (2000) J Infect Dis , vol.182 , pp. 1497-1502
    • Murray, H.W.1    Montelibano, C.2    Peterson, R.3    Sypek, J.P.4
  • 42
    • 0035140009 scopus 로고    scopus 로고
    • Counter-protective role for interleukin-5 during acute Toxoplasma gondii infection
    • Nickdel MB, Roberts F, Brombacher F, Alexander J, Roberts CW (2001) Counter-protective role for interleukin-5 during acute Toxoplasma gondii infection. Infect Immun 69:1044-1052
    • (2001) Infect Immun , vol.69 , pp. 1044-1052
    • Nickdel, M.B.1    Roberts, F.2    Brombacher, F.3    Alexander, J.4    Roberts, C.W.5
  • 43
    • 0035725122 scopus 로고    scopus 로고
    • In vitro indomethacin administration upregulates interleukin-12 production and polarizes the immune response towards a Th1 type in susceptible BALB/c mice infected with Leishmania mexicana
    • Perez-Santos JL, Talamas-Rohana P (2001) In vitro indomethacin administration upregulates interleukin-12 production and polarizes the immune response towards a Th1 type in susceptible BALB/c mice infected with Leishmania mexicana. Parasite Immunol 23:599-606
    • (2001) Parasite Immunol , vol.23 , pp. 599-606
    • Perez-Santos, J.L.1    Talamas-Rohana, P.2
  • 44
    • 0034698826 scopus 로고    scopus 로고
    • Preformed membrane-associated stores of interleukin (IL)-12 are a previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact with an intracellular parasite
    • Quinones M, Ahuja SK, Melby PC, Pate L, Reddick RL, Ahuja SS (2000) Preformed membrane-associated stores of interleukin (IL)-12 are a previously unrecognized source of bioactive IL-12 that is mobilized within minutes of contact with an intracellular parasite. J Exp Med 192:507-516
    • (2000) J Exp Med , vol.192 , pp. 507-516
    • Quinones, M.1    Ahuja, S.K.2    Melby, P.C.3    Pate, L.4    Reddick, R.L.5    Ahuja, S.S.6
  • 46
    • 0032778357 scopus 로고    scopus 로고
    • Vaccination against Leishmania major in a CBA mouse model of infection: Role of adjuvants and mechanism of protection
    • Rivier D, Bovay P, Shah R, Didisheim S, Mauel J (1999) Vaccination against Leishmania major in a CBA mouse model of infection: role of adjuvants and mechanism of protection. Parasite Immunol 21:461-473
    • (1999) Parasite Immunol , vol.21 , pp. 461-473
    • Rivier, D.1    Bovay, P.2    Shah, R.3    Didisheim, S.4    Mauel, J.5
  • 47
    • 0033067374 scopus 로고    scopus 로고
    • Susceptibility or resistance to Leishmania infection is dictated by the macrophages evolved under the influence of IL-3 or GM-CSF
    • Saha B, Saini A, Germond R, Perrin PJ, Harlan DM, Davis TA (1999) Susceptibility or resistance to Leishmania infection is dictated by the macrophages evolved under the influence of IL-3 or GM-CSF. Eur J Immunol 29:2319-2329
    • (1999) Eur J Immunol , vol.29 , pp. 2319-2329
    • Saha, B.1    Saini, A.2    Germond, R.3    Perrin, P.J.4    Harlan, D.M.5    Davis, T.A.6
  • 48
    • 0034087102 scopus 로고    scopus 로고
    • Gene gun-mediated delivery of an interleukin-12 expression plasmid protects against infections with the intracellular protozoan parasites Leishmania major and Trypanosoma cruzi in mice
    • Sakai T, Hisaeda H, Nakano Y, Ishikawa H, Maekawa Y, Ishii K, Nitta Y, Miyazaki J, Himeno K (2000) Gene gun-mediated delivery of an interleukin-12 expression plasmid protects against infections with the intracellular protozoan parasites Leishmania major and Trypanosoma cruzi in mice. Immunology 99:615-624
    • (2000) Immunology , vol.99 , pp. 615-624
    • Sakai, T.1    Hisaeda, H.2    Nakano, Y.3    Ishikawa, H.4    Maekawa, Y.5    Ishii, K.6    Nitta, Y.7    Miyazaki, J.8    Himeno, K.9
  • 50
    • 0033937767 scopus 로고    scopus 로고
    • Immunomodulatory and pharmacologic properties of imiquimod
    • Sauder DN (2000) Immunomodulatory and pharmacologic properties of imiquimod. J Am Acad Dermatol 43:S6-S11
    • (2000) J Am Acad Dermatol , vol.43
    • Sauder, D.N.1
  • 51
    • 0025741792 scopus 로고
    • Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta)
    • Silva JS, Twrdzik DR, Reed SG (1991) Regulation of Trypanosoma cruzi infections in vitro and in vivo by transforming growth factor beta (TGF-beta). J Exp Med 174:539-545
    • (1991) J Exp Med , vol.174 , pp. 539-545
    • Silva, J.S.1    Twrdzik, D.R.2    Reed, S.G.3
  • 52
    • 0032768534 scopus 로고    scopus 로고
    • Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major
    • Stacey KJ, Blackwell JM (1999) Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major. Infect Immun 67:3719-3726
    • (1999) Infect Immun , vol.67 , pp. 3719-3726
    • Stacey, K.J.1    Blackwell, J.M.2
  • 53
    • 0032785433 scopus 로고    scopus 로고
    • STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis
    • Stamm LM, Satoskar AA, Ghosh SK, David JR, Satoskar AR (1999) STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis. Eur J Immunol 29:2524-2529
    • (1999) Eur J Immunol , vol.29 , pp. 2524-2529
    • Stamm, L.M.1    Satoskar, A.A.2    Ghosh, S.K.3    David, J.R.4    Satoskar, A.R.5
  • 54
    • 0035110493 scopus 로고    scopus 로고
    • Modulation of host responses to blood-stage malaria by interleukin-12: From therapy to adjuvant activity
    • Stevenson MM, Su Z, Sam H, Mohan K (2001) Modulation of host responses to blood-stage malaria by interleukin-12: from therapy to adjuvant activity. Microbes Infect 2001:49-59
    • (2001) Microbes Infect , vol.2001 , pp. 49-59
    • Stevenson, M.M.1    Su, Z.2    Sam, H.3    Mohan, K.4
  • 55
    • 0033536013 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms
    • Walker PS, Scharton-Kersten T, Krieg AM, Love-Homan L, Rowton ED, Udey MC, Vogel JC (1999) Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12- and IFN-gamma-dependent mechanisms. Proc Natl Acad Sci USA 96:6970-6975
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 6970-6975
    • Walker, P.S.1    Scharton-Kersten, T.2    Krieg, A.M.3    Love-Homan, L.4    Rowton, E.D.5    Udey, M.C.6    Vogel, J.C.7
  • 56
    • 0034955683 scopus 로고    scopus 로고
    • A single intradermal administration of soluble leishmanial antigen and plasmid expressing interleukin-12 protects BALB/c mice from Leishmania major infection
    • Yamakami K, Akao S, Sato M, Nitta Y, Miyazaki J, Tadakuma T (2001) A single intradermal administration of soluble leishmanial antigen and plasmid expressing interleukin-12 protects BALB/c mice from Leishmania major infection. Parasitol Int 50:81-91
    • (2001) Parasitol Int , vol.50 , pp. 81-91
    • Yamakami, K.1    Akao, S.2    Sato, M.3    Nitta, Y.4    Miyazaki, J.5    Tadakuma, T.6
  • 57
    • 0034662258 scopus 로고    scopus 로고
    • Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii
    • Yap G, Pesin M, Sher A (2000) Cutting edge: IL-12 is required for the maintenance of IFN-gamma production in T cells mediating chronic resistance to the intracellular pathogen, Toxoplasma gondii. J Immunol 165:628-631
    • (2000) J Immunol , vol.165 , pp. 628-631
    • Yap, G.1    Pesin, M.2    Sher, A.3
  • 58
    • 0032786614 scopus 로고    scopus 로고
    • Protective role for interleukin-5 during chronic Toxoplasma gondii infection
    • Zhang Y, Denkers EY (1999) Protective role for interleukin-5 during chronic Toxoplasma gondii infection. Infect Immun 67:4383-4392
    • (1999) Infect Immun , vol.67 , pp. 4383-4392
    • Zhang, Y.1    Denkers, E.Y.2
  • 59
    • 0032521881 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal routine leishmaniasis
    • Zimmermann S, Egeter O, Hausmann S, Lipford GB, Rocken M, Wagner H, Heeg K (1998) CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal routine leishmaniasis. J Immunol 160:3627-3630
    • (1998) J Immunol , vol.160 , pp. 3627-3630
    • Zimmermann, S.1    Egeter, O.2    Hausmann, S.3    Lipford, G.B.4    Rocken, M.5    Wagner, H.6    Heeg, K.7


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