Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major

Infection and Immunity

Volumn 67, Issue 8, 1999, Pages 3719-3726

  Stacey, Katryn J ^a,b   Blackwell, Jenefer M ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

LEISHMANIA VACCINE; OLIGODEOXYNUCLEOTIDE;

ADJUVANT THERAPY; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIGEN SPECIFICITY; ARTICLE; COST EFFECTIVENESS ANALYSIS; CYTOTOXIC T LYMPHOCYTE; DNA SEQUENCE; HELPER CELL; IMMUNOSTIMULATION; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMASTIGOTE; SURVIVAL; VACCINATION;

EID: 0032768534     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.8.3719-3726.1999     Document Type: Article

References (53)

1. Aebischer, T., L. Morris, and E. Handman. 1994. Intravenous injection of irradiated Leishmania major into susceptible BALB/c mice: immunization or protective tolerance. Int. Immunol. 6:1535-1543.
2. Afonso, L. C., T. M. Scharton, L. Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235-237.
3. Armijos, R. X., M. M. Weigel, H. Aviles, R. Maldonado, and J. Racines. 1998. Field trial of a vaccine against New World cutaneous leishmaniasis in an at-risk child population: safely, immunogenicity, and efficacy during the first 12 months of follow-up. J. Infect. Dis. 177:1352-1357.
4. Bretscher, P. A., G. Wei, J. N. Menon, and H. Bielefeldt-Ohmann. 1992. Establishment of stable, cell-mediated immunity that makes "susceptible" mice resistant to Leishmania major. Science 257:539-542.
5. Chace, J. H., N. A. Hooker, K. L. Mildenstein, A. M. Krieg, and J. S. Cowdery. 1997. Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12. Clin. Immunol. Immunopathol. 84:185-193.
6. Chace, M. W. 1967. Production of antiserum. Methods Immunol. Immunochem. 1:197-209.
7. Chu, R. S., O. S. Targoni, A. M. Krieg, P. V. Lehmann, and C. V. Harding. 1997. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 186:1623-1631.
8. Connell, N. D., E. Medina-Acosta, W. R. McMaster, B. R. Bloom, and D. G. Russell. 1993. Effective immunization against cutaneous leishmaniasis with recombinant bacille Calmette-Guerin expressing the Leishmania surface proteinase gp63. Proc. Natl. Acad. Sci. USA 90:11473-11477.
9. Cooper, A. M., H. Rosen, and J. M. Blackwell. 1988. Monoclonal antibodies that recognise distinct epitopes of the macrophage type three complement receptor differ in their ability to inhibit binding of Leishmania promastigotes harvested at different phases of their growth cycle. Immunology 65:511-514.
10. Da Silva, R. P., B. F. Hall, K. A. Joiner, and D. L. Sacks. 1989. CR1, the C3b receptor, mediates binding of infective Leishmania major metacyclic promastigotes to human macrophages. J. Immunol. 143:617-622.
11. Davis, H. L., R. Weeranta, T. J. Waldshmidt, L. Tygrett, J. Schorr, and A. M. Krieg. 1998. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J. Immunol. 160: 870-876.
12. H1 cell development. Science 271:984-986.
13. Gurunathan, S., D. L. Sacks, D. R. Brown, S. L. Reiner, H. Charest, N. Glaichenhaus, and R. A. Seder. 1997. Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J. Exp. Med. 186:1137-1147.
14. Halpern, M. D., R. J. Kurlander, and D. S. Pisetsky. 1996. Bacterial DNA induces mutine interferon-γ production by stimulation of interleukin-12 and tumour necrosis factor-α. Cell. Immunol. 167:72-78.
15. Handman, E., F. M. Symons, T. M. Baldwin, J. M. Curtis, and J. P. Scheerlinck. 1995. Protective vaccination with promastigote surface antigen 2 from Leishmania major is mediated by a TH1 type of immune response. Infect. Immun. 63:4261-4267.
16. Howard, J. G., F. Y. Liew, C. Hale, and S. Nicklin. 1984. Prophylactic immunization against experimental leishmaniasis. II. Further characterization of the protective immunity against fatal Leishmania tropica infection induced by irradiated promastigotes. J. Immunol. 132:450-455.
17. Howard, J. G., S. Nicklin, C. Hale, and F. Y. Liew. 1982. Prophylactic immunization against experimental leishmaniasis. I. Protection induced in mice genetically vulnerable to fatal Leishmania tropica infection. J. Immunol. 129:2206-2212.
18. Julia, V., M. Rassoulzadegan, and N. Glaichenhaus. 1996. Resistance to Leishmania major induced by tolerance to a single antigen. Science 274:421-423.
19. Kemp, M., T. Theander, and A. Kharazmi. 1996. The contrasting roles of CD4+ T cells in intracellular infections in humans: leishmaniasis as an example. Immunol. Today 17:13-16.
20. Klinman, D. M., G. Yamshchikov, and Y. Ishigatsubo. 1997. Contribution of CpG motifs to the immunogenicity of DNA vaccines. J. Immunol. 158:3635-3639.
21. Kopf, M., F. Brombacher, G. Köhler, G. Kienzle, K.-H. Widmann, K. Lefrang, C. Humborg, B. Ledermann, and W. Solbach. 1996. IL-4-deficient Balb/c mice resist infection with Leishmania major. J. Exp. Med. 184:1127-1136.
22. Krieg, A. M., A.-K. Yi, S. Matson, T. J. Waldschmidt, G. A. Bishop, R. Teasdale, G. A. Koretzky, and D. M. Klinman. 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546-549.
23. Launois, P., F. Conceiçao-Silva, H. Himmerlich, C. Parra-Lopez, F. Tacchilli-Cottier, and J. A. Louis. 1998. Setting in motion the immune mechanisms underlying genetically determined resistance and susceptibility to infection with Leishmania major. Parasite Immunol. 20:223-230.
24. + T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity 6:541-549.
25. Leclerc, C., E. Dériaud, M. Rojas, and R. G. Whalen. 1997. The preferential induction of a Th1 immune response by DNA-based immunization is mediated by the immunostimulatory effect of plasmid DNA. Cell. Immunol. 179:97-106.
26. Liew, F. Y., C. Hale, and J. G. Howard. 1985. Prophylactic immunization against experimental leishmaniasis. IV. Subcutaneous immunization prevents induction of protective immunity against fatal Leishmania major infection. J. Immunol. 135:2095-2101.
27. Liew, F. Y., and C. A. O'Donnell. 1993. Immunology of leishmaniasis. Adv. Parasitol. 32:161-259.
28. Lipford, G. B., M. Bauer, C. Blank, R. Reiter, H. Wagner, and K. Heeg. 1997. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur. J. Immunol. 27:2340-2344.
29. Lipford, G. B., T. Sparwasser, M. Bauer, S. Zimmerman, E.-S. Koch, K. Heeg, and H. Wagner. 1997. Immunostimulatory DNA: sequence-dependent production of potentially harmful or useful cytokines. Eur. J. Immunol. 27:3420-3426.
30. McSorley, S. J., D. Xu, and F. Y. Liew. 1997. Vaccine efficacy of Salmonella strains expressing glycoprotein 63 with different promoters. Infect. Immun. 65:171-178.
31. Messina, J. P., G. S. Gilkeson, and D. A. Pisetsky. 1991. Stimulation of in vitro murine lymphocyte proliferation by bacterial DNA. J. Immunol. 147: 1759-1764.
32. Monteith, D. K., S. P. Henry, R. B. Howard, S. Flournoy, A. A. Levin, C. F. Bennett, and S. T. Crooke. 1997. Immune stimulation: a class effect of phosphorothioate oligodeoxynucleotides in rodents. Anticancer Drug Des. 12:421-432.
33. Mougneau, E., F. Altare, A. E. Wakil, S. Zheng, T. Coppola, Z. E. Wang, R. Waldmann, R. M. Locksley, and N. Glaichenhaus. 1995. Expression cloning of a protective Leishmania antigen. Science 268:563-566.
34. Noben-Trauth, N., P. Kropf, and I. Müller. 1996. Susceptibility to Leishmania major infection in interleukin-4-deficient mice. Science 271:987-990.
35. Papadopoulou, G., E. Karagouni, and E. Dotsika. 1998. ISCOMs vaccine against experimental leishmaniasis. Vaccine 16:885-892.
36. Reiner, S. L., and R. M. Locksley. 1995. The regulation of immunity to Leishmania major. Annu. Rev. Immunol. 13:151-177.
37. Roman, M., E. Martin-Orozco, J. S. Goodman, M.-D. Nguyen, Y. Sato, A. Ronaghy, R. S. Kornbluth, D. D. Richman, D. A. Carson, and E. Raz. 1997. Immunostimulatory DNA sequences function as T helper-1 promoting adjuvants. Nat. Med. 3:849-854.
38. Russell, D. G., and J. Alexander. 1988. Effective immunization against cutaneous leishmaniasis with defined membrane antigens reconstituted into liposomes. J. Immunol. 140:1274-1279.
39. Scott, P., E. Pearce, P. Natovitz, and A. Sher. 1987. Vaccination against cutaneous leishmaniasis in a murine model. II. Immunologic properties of protective and nonprotective subfractions of a soluble promastigote extract. J. Immunol. 139:3118-3125.
40. Scott, P., E. Pearce, P. Natovitz, and A. Sher. 1987. Vaccination against cutaneous leishmaniasis in a murine model. I. Induction of protective immunity with a soluble extract of promastigotes. J. Immunol. 139:221-227.
41. Scott, P., and G. Trinchieri. 1997. IL-12 as an adjuvant for cell-mediated immunity. Semin. Immunol. 9:285-291.
42. Seppala, I. J. T., and O. Makela. 1996. Quantification of antibodies, p. 44.1-44.5. In L. A. Herzenberg, D. M. Weir, L. A. Herzenberg, and C. Blackwell (ed.), Weir's handbook of experimental immunology, 5th ed. Blackwell Science Inc., Malden, Mass.
43. Sjölander, A., T. M. Baldwin, J. M. Curtis, and E. Handman. 1998. Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response are required for generation of immunity to leishmaniasis. J. Immunol. 160:3949-3957.
44. Sparwasser, T., E. S. Koch, R. M. Vabulas, K. Heeg, G. B. Lipford, J. W. Ellwart, and H. Wagner. 1998. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28:2045-2054.
45. Sparwasser, T., T. Miethke, G. Lipford, A. Erdmann, H. Häcker, K. Heeg, and H. Wagner. 1997. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor. Eur. J. Immunol. 27:1671-1679.
46. Stacey, K. J., M. Sweet, and D. A. Hume. 1996. Macrophages ingest and are activated by bacterial DNA. J. Immunol. 157:2116-2122.
47. Sun, S., H. Kishimoto, and J. Sprent. 1998. DNA as an adjuvant: capacity of insect DNA and synthetic oligodeoxynucleotides to augment T cell responses to specific antigen. J. Exp. Med. 187:1145-1150.
48. Sweet, M. J., K. J. Stacey, D. K. Kakuda, D. Markovich, and D. A. Hume. 1998. IFN-γ primes macrophage responses to bacterial DNA. J. Interferon Cytokine Res. 18:263-271.
49. Walker, P. S., T. Scharton-Kersten, E. D. Rowton, U. Hengge, A. Bouloc, M. C. Udey, and J. C. Vogel. 1998. Genetic immunization with glycoprotein 63 cDNA results in a helper T cell type 1 immune response and protection in a murine model of leishmaniasis. Hum. Gene Ther. 9:1899-1907.
50. Weiner, G. J., H.-M. Liu, J. E. Wooldridge, C. E. Dahle, and A. M. Krieg. 1997. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc. Natl. Acad. Sci. USA 94:10833-10837.
51. Xu, D., and F. Y. Liew. 1995. Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp63. of L. major. Immunology 84:173-176.
52. Yamamoto, S., E. Kuramoto, S. Shimada, and T. Tokunaga. 1988. In vitro augmentation of natural killer cell activity and production of interferon-α/β and -γ with deoxyribonucleic acid fraction from Mycobacterium bovis BCG. Jpn. J. Cancer Res. 79:866-873.
53. Zimmermann, S., O. Egeter, S. Hausmann, G. B. Lipford, M. Röcken, H. Wagner, and K. Heeg, 1998. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J. Immunol. 160:3627-3630.