Gene gun-mediated delivery of an interleukin-12 expression plasmid protects against infections with the intracellular protozoan parasites Leishmania major and Trypanosoma cruzi in mice

Immunology

Volumn 99, Issue 4, 2000, Pages 615-624

  Sakai, T ^a   Hisaeda, H ^a   Nakano, Y ^a   Ishikawa, H ^a   Maekawa, Y ^a   Ishii, K ^a   Nitta, Y ^b   Miyazaki, J ^b   Himeno, K ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; GANGLIOSIDE GM1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; GENE THERAPY; GENE TRANSFER; HELPER CELL; IMMUNITY; LEISHMANIA MAJOR; LEISHMANIASIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PLASMID; PRIORITY JOURNAL; SPLEEN CELL; TH1 CELL; TRYPANOSOMA CRUZI; TRYPANOSOMIASIS;

ANIMALS; BIOLISTICS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHAGAS DISEASE; FEMALE; GENE EXPRESSION; GENE THERAPY; INTERLEUKIN-12; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PLASMIDS; TH1 CELLS; TRYPANOSOMA CRUZI;

EID: 0034087102     PISSN: 00192805     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2567.2000.00989.x     Document Type: Article

References (44)

1. 1. YANG N.-S., BURKHOLDER J., ROBERTS B., MARTINELL B. & MCCABE D. (1990) In vivo and in vitro gene transfer to mammalian somatic cells by particle bombardment. Proc Natl Acad Sci USA 87, 9568.
2. 2. CHENG L., ZIEGELHOFFER R.P. & YANG N.-S. (1993) In vivo promoter activity and transgene expression in mammalian somatic tissues evaluated by using particle bombardment. Proc Natl Acad Sci USA 90, 4455.
3. 3. TIGHE H., CORR M., ROMAN M. & RAZ E. (1998) Gene vaccination: plasmid DNA is more than just a blueprint. Immunol Today 19, 89.
4. 4. DONNELLY J.J., ULMER J.B., SHIVER J.W. & LIU M.A. (1997) DNA vaccines. Annu Rev Immunol 15, 617.
5. 5. RAKHMILEVICH A.L., TURNER J., FORD M.J. et al. (1996) Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors. Proc Natl Acad Sci USA 93, 6291.
6. 6. RAKHMILEVICH A.L., JANSSE K., TURNER J., CULP J. & YANG N.-S. (1997) Cytokine gene therapy of cancer using gene gun technology: superior antitumor activity of interleukin-12. Hum Gene Ther 8, 1303.
7. 7. KOBAYASHI M., FITZ J., RYAN M. et al. (1989) Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biological effects on human lymphocytes. J Exp Med 170, 827.
8. 8. STERN A.S., PADLASKY F.J., HULMES J.D. et al. (1990) Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc Natl Acad Sci USA 87, 6808.
9. 9. VALIANTE N.M., RENGRAJU M. & TRINCHIERI G. (1992) Role of the production of natural killer cell stimulatory factor (NKSF/IL-12) in the ability of the B cell lines to stimulate T and NK proliferation. Cell Immunol 145, 187.
10. 10. GATELY M.K., DESAI B.B., WOLITZKY A.G., QUINN P.M., DWYER C.M. & PODLASKI F.J. (1991) Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J Immunol 147, 874.
11. + T cells. J Immunol 151, 1938.
12. + T cells from αβ-TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int Immunol 5, 1119.
13. 13. BLOOM E.T. & HORVATH J.A. (1994) Cellular and molecular mechanisms of the IL-12-induced increase in allospecific murine cytolytic T cell activity: implications for the age-related decline in CTL. J Immunol 152, 4242.
14. 14. O'GARRA A. (1998) Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity 8, 275.
15. 15. TRINCHIERI G. (1998) Interleukin-12: a cytokine at the interface of inflammation and immunity. Adv Immunol 70, 83.
16. 16. NIWA H., YAMAMURA K. & MIYAZAKI J. (1991) Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108, 193.
17. 17. HEINZEL F.P., SADICK M.D., HOLADAY B.J., COFFMAN R.L. & LOCKSLEY R.M. (1989) Reciprocal expression of interferon γ or IL-4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T cell subsets. J Exp Med 169, 59.
18. 18. SCOTT P. (1989) The role of Th1 and Th2 cells in experimental cutaneous leishmaniasis. Exp Parasitol 68, 369.
19. 19. SCOTT P., NATOVITZ P., COFFMAN R., PLARCE E. & SHER A. (1988) Immunoregulation of cutaneous leishmaniasis: T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med 168, 1675.
20. + lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc Natl Acad Sci USA 88, 7011.
21. 21. HOLADAY B.J., SADICK M.D., WANG Z. et al. (1991) Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines. J Immunol 147, 1653.
22. 22. TORRICO F., HERFMANS H., RIVERA M.T., VAN MARCK E., BILLIAU A. & CARLIER Y. (1991) Endogenous IFN-γ is required for resistance to acute Trypanosoma cruzi infection in mice. J Immunol 146, 3626.
23. 23. MINOPRIO P., CHEIKH M.C.E., MURPHY E. et al. (1993) Xid-associated resistance to experimental Chagas' disease is IFN-γ dependent. J Immunol 151, 4200.
24. 24. SILVA J., MORRISSEY P.J., GRABSTEIN K.H., MOHLER K.M., ANDERSON D. & REED S.G. (1992) Interleukin-10 and interferon-γ regulation of experimental Trypanosoma cruzi infection. J Exp Med 175, 169.
25. 25. REED S.G., BROWNELL C.E., RUSSO D.M., SILVA J.S., GRABSTEIN K.H. & MORRISSEY P.J. (1994) IL-10 mediates susceptibility to Trypanosoma cruzi infection. J Immunol 153, 3135.
26. 26. ROTTENBERG M.E., RIARTE A., SPORRONG L. et al. (1995) Outcome of infection with different strains of Trypanosoma cruzi in mice lacking CD4 and/or CD8. Immunol Lett 45, 53.
27. 27. ROTTENBERG M.E., BAKHIET M., OLSSON T. et al. (1993) Differential susceptibilities of mice genomically deleted of CD4 and CD8 to infections with Trypanosoma cruzi or Trypanosoma brucei. Infect Immun 61, 5129.
28. 28. TARLETON R.L., GRUSBY M.J., POSTAN M. & GLIMCHER L.H. (1996) Trypanosoma cruzi infection: further evidence for the role of both class I-and class II-restricted T cells in immune resistance and disease. Int Immunol 8, 13.
29. 29. TARLETON R.L., KOLLER B.H., LATOUR A. & POSTAN M. (1992) Susceptibility of β2-microglobulin-deficient mice to Trypanosoma cruzi infection. Nature 356, 338.
30. 30. ROTTENBERG M., CARDONI R.L., ANDERSSON R., SEGURA E.L. & ORN A. (1988) Role of T helper/inducer cells as well as natural killer cells in resistance to Trypanomoma cruzi infection. Scand J Immunol 28, 573.
31. 31. CARDILLO F., VOLTARELLI J.C., REED S.G. & SILVA J. (1996) Regulation of Trypanosoma cruzi infection and interleukin 10: role of NK cells. Infect Immun 64, 128.
32. 32. HEINZEL F.P., SCHOENHAUT D.S., RERKO R.M., ROSSER L.E. & GATELY M.K. (1993) Recombinant interleukin 12 cures mice infected with Leishmania major. J Exp Med 177, 1505.
33. 33. SYPEK J.P., CHUNG C.L., MAYOR S.E.H. et al. (1993) Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med 177, 1797.
34. 34. MATTNER F., PADOVA K.D. & ALBER G. (1997) Interleukin-12 is indispensable for protective immunity against Leishmania major. Infect Immun 65, 4378.
35. 35. ALIBERTI J.C.S., CARDOSO M.A.G., MARTINS G.A., GAZZINELLI R.T., VIEIRA L.Q. & SILVA J.S. (1996) Interleukin-12 mediated resistance to Trypanosoma cruzi in mice is produced by murine macrophages in response to live trypomastigotes. Infect Immun 64, 1961.
36. 36. HUNTER C.A., SLIFER T. & ARAUJO F. (1996) Interleukin-12-mediated resistance to Trypanosoma cruzi is dependent on tumor necrosis factor alpha and gamma interferon. Infect Immun 64, 2381.
37. 37. ORANGE J.S., SALAZAR-MATHER T.P., OPAL S.M. et al. (1995) Mechanism of interleukin 12-mediated toxicities during experimental viral infections: role of tumor necrosis factor and glucocorticoids. J Exp Med 181, 901.
38. 38. SUN W.H., BURKHOLDER J.K., SUN J. et al. (1995) In vivo cytokine transfer by gene gun reduces tumor growth in mice. Proc Natl Acad Sci USA 92, 2889.
39. 39. CONDON C., WATKINS S.C., CELLUZZI C.M., THOMPSON K. & FALO L.D. (1996) DNA-based immunization by in vivo transfection of dendritic cells. Nature Med 2, 1122.
40. + T cells after gene gun immunization. J Exp Med 188, 1075.
41. 41. TAN J., NEWTON C.A., DJEU J.Y. et al. (1996) Injection of complementary DNA encoding interleukin-12 inhibits tumor establishment at a distant site in a murine renal carcinoma model. Cancer Res 56, 3399.
42. 42. NITTA Y., TASHIRO F., TOKUI M. et al. (1998) Systemic delivery of interleukin 10 by intramuscular injection of expression plasmid DNA prevents autoimmune diabetes in nonobese diabetic mice. Hum Gen Ther 10, 1701.
43. 43. DAHESHIA M., KUKLIN N., KANANGAT S., MANICKAN E. & ROUSE B.T. (1997) Suppression of ongoing ocular inflammatory disease by topical administration of plasmid DNA encoding IL-10. J Immunol 159, 1945.
44. 44. MANICKAN E., DAHESHIA M., KUKLIN N., CHUN S. & ROUSE B.T. (1998) Modulation of virus-induced delayed-type hypersensitivity by plasmid DNA encoding the cytokine interleukin-10. Immunology 94, 129.