Therapy with a combination of low doses of interleukin 12 and chloroquine completely cures blood-stage malaria, prevents severe anemia, and induces immunity to reinfection

Infection and Immunity

Volumn 67, Issue 2, 1999, Pages 513-519

  Mohan, Karkada ^a   Sam, Hakeem ^a   Stevenson, Mary M ^a  

^a MONTREAL GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; CHLOROQUINE; INTERLEUKIN 12; INTERLEUKIN 2 RECEPTOR; MESSENGER RNA;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ERYTHROCYTE COUNT; EXPERIMENTAL INFECTION; HEMATOCRIT; HOST RESISTANCE; IMMUNOREGULATION; INFECTION RESISTANCE; MALARIA; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PLASMODIUM CHABAUDI; PRIORITY JOURNAL; RETICULOCYTE;

EID: 0032962873     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.2.513-519.1999     Document Type: Article

References (35)

1. Allen, R. D., T. A. Stanley, and C. L. Sidman. 1993. Differential cytokine expression in acute and chronic murine graft-versus-host disease. Eur. J. Immunol. 23:333-339.
2. Butler, D. 1997. Time to put malaria control on the global agenda. Nature 386:535-541.
3. Chua, A. O., V. L. Willinson, D. H. Presky, and U. Gubler. 1995. Cloning and characterization of a mouse IL-12 receptor-beta component. J. Immunol. 155:4286-4294.
4. Doherty, T. M., and A. Sher. 1998. IL-12 promotes drug-induced clearance of Mycobacterium avium infection in mice. J. Immunol. 160:5428-5435.
5. Facer, C. A., and M. Tanner. 1997. Clinical trials of malaria vaccines: progress and prospects. Adv. Parasitol. 39:1-68.
6. Guler, M. L., N. G. Jacobson, U. Gubler, and K. M. Murphy. 1997. T cell genetic background determines maintenance of IL-12 signaling: effect on BALB/c and B10.D2 T helper cell type 1 phenotype development. J. Immunol. 159:1767-1774.
7. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505-1509.
8. Hoffman, S. L., J. M. Crutcher, S. K. Puri, A. A. Ansari, F. Villinger, E. D. Franks, P. P. Singh, F. Finkelman, M. K. Gately, G. P. Dutta, and M. Sedegah. 1997. Sterile protection of monkeys against malaria after administration of interleukin-12. Nat. Med. 3:80-83.
9. Jackson, J. D., Y. Yan, M. J. Brunda, L. S. Kelsey, and J. E. Talmadge. 1995. Interleukin-12 enhances peripheral hematopoiesis in vivo. Blood 85:2371-2376.
10. Jacobs, P., D. Radzioch, and M. M. Stevenson. 1996. A Th1-associated increase in tumor necrosis factor alpha expression in the spleen correlates with resistance to blood-stage malaria in mice. Infect. Immun. 64:535-541.
11. Kichian, K., F. P. Nestel, D. Kim, P. Ponka, and W. S. Lapp. 1996. IL-12 p40 messenger RNA expression in target organs during acute graft-versus-host disease. J. Immunol. 157:2851-2856.
12. Lackritz, E. M., C. C. Campbell, T. K. Ruebush, A. W. Hightower, W. Wakube, R. W. Steketee, and J. B. O. Were. 1989. Effect of blood transfusion on survival among children in a Kenyan hospital. Lancet 340:524-528.
13. + T cells in the immune response to Plasmodium chabaudi. Parasitol. Today 5:362-365.
14. Li, J., S. Sutterwala, and J. P. Farrell. 1997. Successful therapy of chronic, nonhealing murine cutaneous leishmaniasis with sodium stibogluconate and gamma interferon depends on continued interleukin-12 production. Infect. Immun. 65:3225-3230.
15. Locksley, R. M. 1993. Interleukin 12 in host defense against microbial pathogens. Proc. Natl. Acad. Sci. USA 90:5879-5880.
16. McGregor, I. A., and R. J. M. Wilson. 1988. Specific immunity: acquired in man, p. 559. In W. H. Wernsdorfer and I. A. McGregor (ed.), Malaria: principles and practice of malariology. Churchill Livingstone, Ltd., Edinburgh, United Kingdom.
17. Metzger, D. W., R. M. McNutt, J. T. Collins, J. M. Buchanan, V. H. Van Cleave, and W. A. Dunnick. 1997. Interleukin-12 acts as an adjuvant for humoral immunity through interferon-γ-dependent and -independent mechanisms. Eur. J. Immunol. 27:1958-1965.
18. Mohan, K., P. Moulin, and M. M. Stevenson. 1997. NK cell cytokine production not cytotoxicity contribute to resistance against blood-stage Plasmodium chabaudi AS infection. J. Immunol. 159:4990-4998.
19. Mohan, K., and M. M. Stevenson. 1998. Interleukin 12 corrects severe anemia during blood-stage Plasmodium chabaudi AS in susceptible A/J mice. Exp. Hematol. 26:45-52.
20. Murphy, G. S., H. Basri, Purnomo, E. M. Andersen, M. J. Bangs, D. L. Mount, J. Gorden, A. A. Lal, A. K. Purwokusumo, S. Harjosuwarno, K. Sorensen, and S. L. Hoffman. 1993. Vivax malaria resistant to treatment and prophylaxis with chloroquine. Lancet 341:96-100.
21. Nabors, G. S., L. C. C. Afonso, J. P. Farrell, and P. Scott. 1995. Switch from a type 2 to type 1 T helper cell response and cure of established Leishmania major infection in mice is induced by combined therapy with interleukin 12 and Pentostam. Proc. Natl. Acad. Sci. USA 92:3142-3146.
22. Orange, J. A., T. P. Salazar-Mather, S. M. Opal, R. L. Spencer, A. H. Miller, B. S. McEwen, and C. A. Biron. 1995. Mechanisms of interleukin 12-mediated toxicities during experimental viral infections: Role of tumor necrosis factor and glucocorticoides. J. Exp. Med. 181:901-914.
23. Presky, D. H., H. Yang, L. J. Minetti, A. O. Chua, N. Nabavi, C. Y. Wu, M. K. Gately, and U. Gubler. 1996. A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 93:14002-14007.
24. Sedegah, M., F. Finkelman, and S. L. Hoffman. 1994. Interleukin 12 induction of interferon γ-dependent protection against malaria. Proc. Natl. Acad. Sci. USA 91:10700-10702.
25. Stevenson, M. M., and M. F. Tam. 1993. Differential induction of helper T cell subsets during blood-stage Plasmodium chabaudi AS infection in resistant and susceptible mice. Clin. Exp. Immunol. 92:77-83.
26. Stevenson, M. M., M. F. Tam, S. F. Wolf, and A. Sher. 1995. IL-12-induced protection against blood-stage Plasmodium chabaudi AS requires IFN-γ and TNF-α and occurs via a nitric oxide-dependent mechanism. J. Immunol. 155:2545-2556.
27. Trinchieri, G., and P. Scott. 1994. The role of interleukin 12 in the immune response, disease and therapy. Immunol. Today 15:460-463.
28. White, N. J. 1992. Antimalarial drug resistance: the pace quickens. J. Antimicrob. Chemother. 30:571-585.
29. White, N. J. 1996. Treatment of malaria. N. Engl. J. Med. 335:801-806.
30. Wickramasinghe, S. N., S. Abdalla, and D. J. Weatherall. 1982. Cell cycle distribution of erythroblasts in P. falciparum malaria. Scand. J. Hematol. 29:83-87.
31. World Health Organization. 1990. Practical chemotherapy of malaria. W. H. O. Tech. Rep. Ser. 805:1-124.
32. Wu, C. Y., J. Ferrante, M. K. Gately, and J. Magram. 1997. Characterization of IL-12 receptor β1 chain (IL-12Rβ1)-deficient mice: IL-12Rβ1 is an essential component of the functional mouse IL-12 receptor. J. Immunol. 159:1658-1665.
33. Yap, G. S., and M. M. Stevenson. 1992. Plasmodium chabaudi AS: erythropoietic responses in resistant and susceptible mice. Exp. Parasitol. 75:340-352.
34. Yap, G. S., and M. M. Stevenson. 1994. Blood transfusion alters the course and outcome of Plasmodium chabaudi AS infection in mice. Infect. Immun. 62:3761-3765.
35. Zhou, P., M. C. Sieve, R. P. Tewari, and R. A. Seder. 1997. Interleukin-12 modulates the protective immune response in SCID mice infected with Histoplasma capsulatum. Infect. Immun. 65:936-942.