Interleukin-12 as an adjuvant for an antischistosome vaccine consisting of adult worm antigens: Protection of rats from cercarial challenge

Infection and Immunity

Volumn 67, Issue 5, 1999, Pages 2340-2348

  Bungiro Jr , Richard D ^a   Goldberg, Miriam ^a   Suri, Parmjeet K ^a   Knopf, Paul M ^a  

^a BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DETERGENT; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOLOGICAL ADJUVANT; PARASITE ANTIGEN; RECOMBINANT INTERLEUKIN 12; SCHISTOSOMA VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIBODY TITER; ANTIGEN RECOGNITION; ARTICLE; CERCARIA; CONTROLLED STUDY; FEMALE; HELPER CELL; IMMUNOMODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS;

EID: 0344780824     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.5.2340-2348.1999     Document Type: Article

References (61)

1. Barker, R. H., Jr., B. S. Srivastava, P. Suri, M. Goldberg, and P. M. Knopf. 1985. Immunoprecipitation analysis of radiolabelled protein antigens biosynthesized in vitro by S. mansoni. I. Identification of antigens uniquely recognized by protective antibodies. J. Immunol. 134:1192-1201.
2. Bergman, I., and R. Loxley. 1963. Two improved and simplified methods for the spectrophotometric determination of hydroxyproline. Anal. Chem. 35: 1961-1965.
3. Bergquist, N. R., and D. G. Colley. 1998. Schistosomiasis vaccines: research to development. Parasitol. Today 14:99-104.
4. Bliss, J., C. V. Van, K. Murray, A. Wiencis, M. Ketchum, R. Maylor, T. Haire, C. Resmini, A. K. Abbas, and S. F. Wolf. 1996. IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response. J. Immunol. 156:887-894.
5. Brunda, M. J. 1994. Interleukin-12. J. Leukoc. Biol. 55:280-288.
6. Buchanan, J. M., L. A. Vogel, V. H. Van Cleave, and D. W. Metzger. 1995. Interleukin 12 alters the isotype-restricted antibody response of mice to hen eggwhite lysozyme. Int. Immunol. 7:1519-1528.
7. Burstein, H. J., R. I. Tepper, P. Leder, and A. K. Abbas. 1991. Humoral immune functions in IL-4 transgenic mice. J. Immunol. 147:2950-2956.
8. Capron, A., J. P. Dessaint, M. Capron, M. Joseph, and J. Pestel. 1980. Role of anaphylactic antibodies in immunity to schistosomes. Am. J. Trop. Med. Hyg. 29:849-857.
9. Capron, A. R. 1992. Immunity to schistosomes. Curr. Opin. Immunol. 4:419-424.
10. Cetre, C., C. Cocude, C. Pierrot, C. Godin, A. Capron, M. Capron, and J. Khalife. 1998. In vivo expression of cytokine mRNA in rats infected with Schistosoma mansoni. Parasite Immunol. 20:135-142.
11. Cioli, D., P. M. Knopf, and A. W. Senft. 1977. A study of Schistosoma mansoni transferred into permissive and nonpermissive hosts. Int. J. Parasitol. 7:293-297.
12. Cutts, L., and R. A. Wilson. 1997. Elimination of a primary schistosome infection from rats coincides with elevated IgE titres and mast cell degranulation. Parasite Immunol. 19:91-102.
13. Finkelman, F. D., J. Holmes, I. M. Katona, J. J. Urban, M. P. Beckmann, L. S. Park, K. A. Schooley, R. L. Coffman, T. R. Mosmann, and W. E. Paul. 1990. Lymphokine control of in vivo immunoglobulin isotype selection. Annu. Rev. Immunol. 8:303-333.
14. Ford, M. J., C. Dissous, R. J. Pierce, M. G. Taylor, Q. D. Bickle, and A. Capron. 1987. The isotypes of antibody responsible for the 'late' passive transfer of immunity in rats vaccinated with highly irradiated cercariae. Parasitology 94:509-522.
15. Gately, M. K., R. R. Warrier, S. Honasoge, D. M. Carvajal, D. A. Faherty, S. E. Connaughton, T. D. Anderson, U. Sarmiento, B. R. Hubbard, and M. Murphy. 1994. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo. Int. Immunol. 6:157-167.
16. Germann, T., M. Bongartz, H. Dlugonska, H. Hess, E. Schmitt, L. Kolbe, E. Kolsch, F. J. Podlaski, M. K. Gately, and E. Rude. 1995. Interleukin-12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b and IgG3 antibody subclasses in vivo. Eur. J. Immunol. 25: 823-829.
17. Gracie, J. A., and J. A. Bradley. 1996. Interleukin-12 induces interferon-gamma-dependent switching of IgG alloantibody subclass. Eur. J. Immunol. 26:1217-1221.
18. James, S. L., and E. J. Pearce. 1988. The influence of adjuvant on induction of protective immunity by a non-living vaccine against schistosomiasis. J. Immunol. 140:2753-2759.
19. James, S. L., E. J. Pearce, and A. Sher. 1985. Induction of protective immunity against Schistosoma mansoni by a non-living vaccine. I. Partial characterization of antigens recognized by antibodies from mice immunized with soluble schistosome extracts. J. Immunol. 134:3432-3438.
20. Jankovic, D., P. Caspar, M. Zweig, M. M. Garcia, S. D. Showalter, F. R. Vogel, and A. Sher. 1997. Adsorption to aluminum hydroxide promotes the activity of IL-12 as an adjuvant for antibody as well as type 1 cytokine responses to HIV-1 gp120. J. Immunol. 159:2409-2417.
21. Jelinek, D. F., and J. K. Braaten. 1995. Role of IL-12 in human B lymphocyte proliferation and differentiation. J. Immunol. 154:1606-1613.
22. Kelly, E. A., and D. G. Colley. 1988. In vivo effects of monoclonal anti-L3T4 antibody on immune responsiveness of mice infected with Schistosoma mansoni. Reduction of irradiated cercariae-induced resistance. J. Immunol. 140: 2737-2745.
23. Khalife, J., C. Pierrot, C. Cocude, C. Cetre, C. Godin, and A. Capron. 1998. Molecular cloning and sequencing of the rat interleukin-12 p40 gene. Eur. Cytokine Netw. 9:69-73.
24. Knopf, P. M. 1979. Schistosoma mansoni: peripheral and tissue eosinophilia in infected rats. Exp. Parasitol. 47:232-245.
25. Knopf, P. M., and D. Cioli. 1980. Schistosoma mansoni: resistance to an infection with cercariae induced by the transfer of live adult worms in the rat. Int. J. Parasitol. 10:13-19.
26. Knopf, P. M., M. G. Goldberg, C. A. Grossi, M. Cappello, and S. T. Coulter. 1988. Induction of resistance to Schistosoma mansoni by immunization with subfractions of worms. Am. J. Trop. Med. Hyg. 38:515-528.
27. Knopf, P. M., B. L. Mangold, and G. J. Makari. 1983. Recovery of parasites at different stages of migration following infection of rats with Schistosoma mansoni. Parasitology 86:37-49.
28. Knopf, P. M., T. B. Nutman, and J. A. Reasoner. 1977. Schistosoma mansoni: resistance to reinfection in the rat. Exp. Parasitol. 41:461-482.
29. Knopf, P. M., and P. K. Suri. 1992. Modern approaches to development of vaccines against schistosomes. R. I. Med. 75:200-207.
30. Kopf, M., G. Le Gros, M. Bachmann, M. C. Lamers, H. Bluethmann, and G. Kohler. 1993. Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 362:245-248.
31. Leonard, J. P., K. E. Waldburger, R. G. Schaub, T. Smith, A. K. Hewson, M. L. Cuzner, and S. J. Goldman. 1997. Regulation of the inflammatory response in animal models of multiple sclerosis by interleukin-12. Crit. Rev. Immunol. 17:545-553.
32. Mangold, B. L., and P. M. Knopf. 1981. Host protective humoral immune responses to Schistosoma mansoni infections in the rat. Kinetics of hyper-immune serum-dependent sensitivity and elimination of schistosomes in a passive transfer system. Parasitology 83:559-574.
33. Mathieson, P. W., and K. M. Gillespie. 1996. Cloning of a partial cDNA for rat interleukin-12 (IL-12) and analysis of IL-12 expression in vivo. Scand. J. Immunol. 44:11-14.
34. McKnight, A. J., G. J. Zimmer, I. Fogelman, S. F. Wolf, and A. K. Abbas. 1994. Effects of IL-12 on helper T cell-dependent immune responses in vivo. J. Immunol. 152:2172-2179.
35. McLaren, D. J., and S. R. Smithers. 1987. The immune response to schistosomes in experimental hosts, p. 233-263. In D. Rollinson and A. Simpson (ed.), The biology of schistosomes. Harcourt Brace Jovanovich, San Diego, Calif.
36. Metzger, D. W., R. M. McNutt, J. T. Collins, J. M. Buchanan, C. V. Van, and W. A. Dunnick. 1997. Interleukin-12 acts as an adjuvant for humoral immunity through interferon-gamma-dependent and -independent mechanisms. Eur. J. Immunol. 27:1958-1965.
37. Miller, H. R., G. F. Newlands, A. McKellar, L. Inglis, P. S. Coulson, and R. A. Wilson. 1994. Hepatic recruitment of mast cells occurs in rats but not mice infected with Schistosoma mansoni. Parasite Immunol. 16:145-155.
38. Morris, S. C., K. B. Madden, J. J. Adamovicz, W. C. Gause, B. R. Hubbard, M. K. Gately, and F. D. Finkelman. 1994. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J. Immunol. 152:1047-1056.
39. Mountford, A. P., S. Anderson, and R. A. Wilson. 1996. Induction of Th1 cell-mediated protective immunity to Schistosoma mansoni by co-administration of larval antigens and IL-12 as an adjuvant. J. Immunol. 156:4739-4745.
40. Mountford, A. P., and R. Harrop. 1998. Vaccination against schistosomiasis: the case for lung-stage antigens. Parasitol. Today 14:109-114.
41. Newport, G. R., and D. G. Colley. 1992. Schistosomiasis, p. 387-437. In K. S. Warren (ed.), Immunology and molecular biology of parasitic infections, 3rd ed. Blackwell Scientific Publications Ltd., Oxford, England.
42. Okuno, K., H. Jinnai, Y. S. Lee, K. Kaneda, and M. Yasutomi. 1996. Interleukin 12 augments the liver-associated immunity and reduces liver metastases. Hepatogastroenterobgy 43:1196-1202.
43. Okura, Y., K. Takeda, S. Honda, H. Hanawa, H. Watanabe, M. Kodama, T. Izumi, Y. Aizawa, S. Seki, and T. Abo. 1998. Recombinant murine interleukin-12 facilitates induction of cardiac myosin-specific type 1 helper T cells in rats. Circ. Res. 82:1035-1042.
44. Orange, J. S., S. F. Wolf, and C. A. Biron. 1994. Effects of IL-12 on the response and susceptibility to experimental viral infections. J. Immunol. 152:1253-1264.
45. Pearce, E. J., S. L. James, S. Hieny, D. E. Lanar, and A. Sher. 1988. Induction of protective immunity against Schistosoma mansoni by vaccination with schistosome paramyosin (Sm97), a nonsurface parasite antigen. Proc. Natl. Acad. Sci. USA 85:5678-5682.
46. Piper, K. P., and D. J. McLaren. 1993. The role of T cells in vaccine immunity in the murine model of schistosomiasis mansoni. Int. J. Parasitol. 23:245-256.
47. Sher, A. 1992. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu. Rev. Immunol. 10:385-409.
48. Sher, A., R. L. Coffman, S. Hieny, and A. W. Cheever. 1990. Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. J. Immunol. 145:3740-3746.
49. Sher, A., R. Gazzinelli, F. Hakim, V. F. de la Cruz, C. K. Stover, S. L. James, and E. Pearce. 1991. Immunization against parasites: bridging the gap between attenuated and non-living vaccines. Behring Inst. Mitt. 88:244-248.
50. Smythies, L. E., P. S. Coulson, and R. A. Wilson. 1992. Monoclonal antibody to IFN-γ modifies pulmonary inflammatory responses and abrogates immunity to Schistosoma mansoni in mice vaccinated with attenuated cercariae. J. Immunol. 149:3654-3658.
51. Snapper, C. M., and W. E. Paul. 1987. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236:944-947.
52. Stevens, T. L., A. Bossie, V. M. Sanders, R. Fernandez-Botran, R. L. Coffman, T. R. Mosmann, and E. S. Vitetta. 1988. Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells. Nature 334:255-258.
53. Taylor, M. G. 1994. Schistosomiasis vaccines: farewell to the god of plague? J. Trop. Med. Hyg. 97:257-268.
54. Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251-276.
55. Verwaerde, C., M. Joseph, M. Capron, R. J. Pierce, M. Damonneville, F. Velge, C. Auriault, and A. Capron. 1987. Functional properties of a rat monoclonal IgE antibody specific for Schistosoma mansoni. J. Immunol. 138:4441-4446.
56. Vignali, D. A., P. Crocker, Q. D. Bickle, S. Cobbold, H. Waldmann, and M. G. Taylor. 1989. A role for CD4+ but not CD8+ T cells in immunity to Schistosoma mansoni induced by 20 krad-irradiated and Ro 11-3128-terminated infections. Immunology 67:466-472.
57. Vogel, L. A., L. C. Showe, T. L. Lester, R. M. McNutt, C. V. Van, and D. W. Metzger. 1996. Direct binding of IL-12 to human and murine B lymphocytes. Int. Immunol. 8:1955-1962.
58. Wolf, S. F., D. Sieburth, and J. Sypek. 1994. Interleukin 12: a key modulator of immune function. Stem Cells 12:154-168.
59. Wynn, T. A., A. W. Cheever, D. Jankovic, R. W. Poindexter, P. Caspar, F. A. Lewis, and A. Sher. 1995. An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature 376:594-596.
60. Wynn, T. A., D. Jankovic, S. Hieny, A. W. Cheever, and A. Sher. 1995. IL-12 enhances vaccine-induced immunity to Schistosoma mansoni in mice and decreases T helper 2 cytokine expression, IgE production, and tissue eosinophilia. J. Immunol. 154:4701-4709.
61. Wynn, T. A., A. Reynolds, S. James, A. W. Cheever, P. Caspar, S. Hieny, D. Jankovic, M. Strand, and A. Sher. 1996. IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite. J. Immunol. 157:4068-4078.