-
1
-
-
0021256125
-
Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. 1. Isolation, physicochemical characterization, and antitumor activity
-
Tokunaga, T., H. Yamamoto, S. Shimada, H. Abe, T. Fukuda, Y. Fujisawa, Y. Furutani, O. Yano, T. Kataoka, T. Sudo, et al. 1984. Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. 1. Isolation, physicochemical characterization, and antitumor activity. J. Natl. Cancer Inst. 72:955.
-
(1984)
J. Natl. Cancer Inst.
, vol.72
, pp. 955
-
-
Tokunaga, T.1
Yamamoto, H.2
Shimada, S.3
Abe, H.4
Fukuda, T.5
Fujisawa, Y.6
Furutani, Y.7
Yano, O.8
Kataoka, T.9
Sudo, T.10
-
2
-
-
0026556987
-
Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells
-
Tokunaga, T., O. Yano, E. Kuramoto, Y. Kimura, T. Yamamoto, T. Kataoka, and S. Yamamoto. 1992. Synthetic oligonucleotides with particular base sequences from the cDNA encoding proteins of Mycobacterium bovis BCG induce interferons and activate natural killer cells. Microbiol. Immunol. 36:55.
-
(1992)
Microbiol. Immunol.
, vol.36
, pp. 55
-
-
Tokunaga, T.1
Yano, O.2
Kuramoto, E.3
Kimura, Y.4
Yamamoto, T.5
Kataoka, T.6
Yamamoto, S.7
-
3
-
-
0029984358
-
CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon γ
-
Klinman, D. M., A. K. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and Interferon γ. Proc. Natl. Acad. Sci. USA 93:2879.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 2879
-
-
Klinman, D.M.1
Yi, A.K.2
Beaucage, S.L.3
Conover, J.4
Krieg, A.M.5
-
4
-
-
8944253295
-
Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
-
Sato, Y., M. Roman, H. Tighe, D. Lee, M. Corr, M. D. Nguyen, G. J. Silverman, M. Lotz, D. A. Carson, and E. Raz. 1996. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 273:352.
-
(1996)
Science
, vol.273
, pp. 352
-
-
Sato, Y.1
Roman, M.2
Tighe, H.3
Lee, D.4
Corr, M.5
Nguyen, M.D.6
Silverman, G.J.7
Lotz, M.8
Carson, D.A.9
Raz, E.10
-
5
-
-
0030239828
-
Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
-
Ballas, Z. K., W. L. Rasmussen, and A. M. Krieg. 1996. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J. Immunol. 157:1840.
-
(1996)
J. Immunol.
, vol.157
, pp. 1840
-
-
Ballas, Z.K.1
Rasmussen, W.L.2
Krieg, A.M.3
-
6
-
-
0031213914
-
Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12
-
Chace, J. H., N. A. Hooker, K. L. Mildenstein, A. M. Krieg, and J. S. Cowdery. 1997. Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12. Clin. Immunol. Immunopathol. 84:185.
-
(1997)
Clin. Immunol. Immunopathol.
, vol.84
, pp. 185
-
-
Chace, J.H.1
Hooker, N.A.2
Mildenstein, K.L.3
Krieg, A.M.4
Cowdery, J.S.5
-
7
-
-
0030816325
-
Macrophages sense pathogens via DNA motifs: Induction of tumor necrosis factor-α-mediated shock
-
Sparwasser, T., T. Miethke, G. Lipford, A. Erdmann, H. Hacker, K. Heeg, and H. Wagner. 1997. Macrophages sense pathogens via DNA motifs: induction of tumor necrosis factor-α-mediated shock. Eur. J. Immunol. 27:1671.
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 1671
-
-
Sparwasser, T.1
Miethke, T.2
Lipford, G.3
Erdmann, A.4
Hacker, H.5
Heeg, K.6
Wagner, H.7
-
8
-
-
0031867535
-
Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
-
Sparwasser, T., E. S. Koch, R. M. Vabulas, K. Heeg, G. B. Lipford, J. W. Ellwart, and H. Wagner. 1998. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28:2045.
-
(1998)
Eur. J. Immunol.
, vol.28
, pp. 2045
-
-
Sparwasser, T.1
Koch, E.S.2
Vabulas, R.M.3
Heeg, K.4
Lipford, G.B.5
Ellwart, J.W.6
Wagner, H.7
-
9
-
-
0032531036
-
Activation of cutaneous dendritic cells by CpG-containing oligonucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
-
Jakob, T., P. S. Walker, A. M. Krieg, M. C. Udey, and J. C. Vogel. 1998. Activation of cutaneous dendritic cells by CpG-containing oligonucleotides: a role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA. J. Immunol. 161:3042.
-
(1998)
J. Immunol.
, vol.161
, pp. 3042
-
-
Jakob, T.1
Walker, P.S.2
Krieg, A.M.3
Udey, M.C.4
Vogel, J.C.5
-
10
-
-
0028931102
-
CpG motifs in bacterial DNA trigger direct B-cell activation
-
Krieg, A. M., A. K. Yi, S. Matson, T. J. Waldschmidt, G. A. Bishop, R. Teasdale, G. A. Koretzky, and D. M. Klinman. 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546.
-
(1995)
Nature
, vol.374
, pp. 546
-
-
Krieg, A.M.1
Yi, A.K.2
Matson, S.3
Waldschmidt, T.J.4
Bishop, G.A.5
Teasdale, R.6
Koretzky, G.A.7
Klinman, D.M.8
-
11
-
-
0027409793
-
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
-
Manetti, R., P. Parronchi, M. G. Giudizi, M. P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199.
-
(1993)
J. Exp. Med.
, vol.177
, pp. 1199
-
-
Manetti, R.1
Parronchi, P.2
Giudizi, M.G.3
Piccinni, M.P.4
Maggi, E.5
Trinchieri, G.6
Romagnani, S.7
-
12
-
-
0029670726
-
IFN-γ promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides
-
Yi, A. K., J. H. Chace, J. S. Cowdery, and A. M. Krieg. 1996. IFN-γ promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides. J. Immunol. 156:558.
-
(1996)
J. Immunol.
, vol.156
, pp. 558
-
-
Yi, A.K.1
Chace, J.H.2
Cowdery, J.S.3
Krieg, A.M.4
-
13
-
-
0030764558
-
Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants
-
Roman, M., E. Martin-Orozco, J. S. Goodman, M. D. Nguyen, Y. Sato, A. Ronaghy, R. S. Kornbluth, D. D. Richman, D. A. Carson, and E. Raz. 1997. Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants. Nat. Med. 3:849.
-
(1997)
Nat. Med.
, vol.3
, pp. 849
-
-
Roman, M.1
Martin-Orozco, E.2
Goodman, J.S.3
Nguyen, M.D.4
Sato, Y.5
Ronaghy, A.6
Kornbluth, R.S.7
Richman, D.D.8
Carson, D.A.9
Raz, E.10
-
14
-
-
0030613651
-
CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
-
Chu, R. S., O. S. Targoni, A. M. Krieg, P. V. Lehmann, and C. V. Harding. 1997. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity. J. Exp. Med. 186:1623.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1623
-
-
Chu, R.S.1
Targoni, O.S.2
Krieg, A.M.3
Lehmann, P.V.4
Harding, C.V.5
-
15
-
-
0028049247
-
The adjuvant effect of interleukin 12 in a vaccine against Leishmania major
-
Afonso, L. C. C., T. M. Scharton, L. Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1993. The adjuvant effect of interleukin 12 in a vaccine against Leishmania major. Science 263:235.
-
(1993)
Science
, vol.263
, pp. 235
-
-
Afonso, L.C.C.1
Scharton, T.M.2
Vieira, L.Q.3
Wysocka, M.4
Trinchieri, G.5
Scott, P.6
-
16
-
-
0030955249
-
Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
-
Weiner, G. J., H. M. Liu, J. E. Wooldridge, C. E. Dahle, and A. M. Krieg. 1997. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc. Natl. Acad. Sci. USA 94:10833.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 10833
-
-
Weiner, G.J.1
Liu, H.M.2
Wooldridge, J.E.3
Dahle, C.E.4
Krieg, A.M.5
-
17
-
-
0032168355
-
CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeriu monocytogenes challenge
-
Krieg, A. M., L. Love-Homan, A. K. Yi, and J. T. Harty. 1998. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeriu monocytogenes challenge. J. Immunol. 161:2428.
-
(1998)
J. Immunol.
, vol.161
, pp. 2428
-
-
Krieg, A.M.1
Love-Homan, L.2
Yi, A.K.3
Harty, J.T.4
-
18
-
-
0031800888
-
CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
-
Moldoveanu, Z., L. Love-Homan, W. Q. Huang, and A. M. Krieg. 1998. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine 16:1216.
-
(1998)
Vaccine
, vol.16
, pp. 1216
-
-
Moldoveanu, Z.1
Love-Homan, L.2
Huang, W.Q.3
Krieg, A.M.4
-
19
-
-
0031964257
-
CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
-
Davis, H. L., R. Weeranta, T. J. Waldschmidt, L. Tygrett, J. Schorr, and A. M. Krieg. 1998. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen. J. Immunol. 160:870.
-
(1998)
J. Immunol.
, vol.160
, pp. 870
-
-
Davis, H.L.1
Weeranta, R.2
Waldschmidt, T.J.3
Tygrett, L.4
Schorr, J.5
Krieg, A.M.6
-
20
-
-
0032521881
-
CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leistimaniasis
-
Zimmermann, S., O. Egeter, S. Hausmann, G. B. Lipford, M. Rocken, H. Wagner, and K. Heeg. 1998. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leistimaniasis. J. Immunol. 160:3627.
-
(1998)
J. Immunol.
, vol.160
, pp. 3627
-
-
Zimmermann, S.1
Egeter, O.2
Hausmann, S.3
Lipford, G.B.4
Rocken, M.5
Wagner, H.6
Heeg, K.7
-
21
-
-
0025924547
-
Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni
-
Grzych, J. M., E. J. Pearce, A. Cheever, Z. A. Caulada, P. Caspar, S. Heiny, F. Lewis, and A. Sher. 1991. Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni. J. Immunol. 146:1322.
-
(1991)
J. Immunol.
, vol.146
, pp. 1322
-
-
Grzych, J.M.1
Pearce, E.J.2
Cheever, A.3
Caulada, Z.A.4
Caspar, P.5
Heiny, S.6
Lewis, F.7
Sher, A.8
-
22
-
-
0026060650
-
Down-regulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni
-
Pearce, E. J., P. Caspar, J. M. Grzych, F. A. Lewis, and A. Sher. 1992. Down-regulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. J. Exp. Med. 173:159.
-
(1992)
J. Exp. Med.
, vol.173
, pp. 159
-
-
Pearce, E.J.1
Caspar, P.2
Grzych, J.M.3
Lewis, F.A.4
Sher, A.5
-
23
-
-
0030588570
-
The granulomatous response in murine schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice
-
Metwali, A., D. Elliott, A. M. Blum, J. Li, M. Sandor, R. Lynch, N. Noben-Trauth, and J. V. Weinstock. 1996. The granulomatous response in murine schistosomiasis mansoni does not switch to Th1 in IL-4-deficient C57BL/6 mice. J. Immunol. 157:4546.
-
(1996)
J. Immunol.
, vol.157
, pp. 4546
-
-
Metwali, A.1
Elliott, D.2
Blum, A.M.3
Li, J.4
Sandor, M.5
Lynch, R.6
Noben-Trauth, N.7
Weinstock, J.V.8
-
24
-
-
0032519993
-
Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response
-
Kaplan, M. H., J. R. Whitfield, D. L. Boros, and M. J. Grusby. 1998. Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response. J. Immunol. 160:1850.
-
(1998)
J. Immunol.
, vol.160
, pp. 1850
-
-
Kaplan, M.H.1
Whitfield, J.R.2
Boros, D.L.3
Grusby, M.J.4
-
25
-
-
0031573220
-
Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo
-
Wynn, T. A., R. Morawetz, T. Scharton-Kersten, S. Hieny, H. C. r. Morse, R. Kuhn, W. Muller, A. W. Cheever, and A. Sher. 1997. Analysis of granuloma formation in double cytokine-deficient mice reveals a central role for IL-10 in polarizing both T helper cell 1- and T helper cell 2-type cytokine responses in vivo. J. Immunol. 159:5014.
-
(1997)
J. Immunol.
, vol.159
, pp. 5014
-
-
Wynn, T.A.1
Morawetz, R.2
Scharton-Kersten, T.3
Hieny, S.4
Morse, H.C.R.5
Kuhn, R.6
Muller, W.7
Cheever, A.W.8
Sher, A.9
-
26
-
-
0033555809
-
IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs
-
Chiaramonte, M. G., L. R. Schopf, T. Y. Neben, A. W. Cheever, D. D. Donaldson, and T. A. Wynn. 1999. IL-13 is a key regulatory cytokine for Th2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs. J. Immunol. 162:920.
-
(1999)
J. Immunol.
, vol.162
, pp. 920
-
-
Chiaramonte, M.G.1
Schopf, L.R.2
Neben, T.Y.3
Cheever, A.W.4
Donaldson, D.D.5
Wynn, T.A.6
-
27
-
-
0028231754
-
Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology
-
Wynn, T. A., I. Eltoum, I. P. Oswald, A. W. Cheever, and A. Sher. 1994. Endogenous interleukin 12 (IL-12) regulates granuloma formation induced by eggs of Schistosoma mansoni and exogenous IL-12 both inhibits and prophylactically immunizes against egg pathology. J. Exp. Med. 179:1551.
-
(1994)
J. Exp. Med.
, vol.179
, pp. 1551
-
-
Wynn, T.A.1
Eltoum, I.2
Oswald, I.P.3
Cheever, A.W.4
Sher, A.5
-
28
-
-
0029142790
-
An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection
-
Wynn, T. A., A. W. Cheever, D. Jankovic, R. W. Poindexter, P. Caspar, F. A. Lewis, and A. Sher. 1995. An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection. Nature 376:594.
-
(1995)
Nature
, vol.376
, pp. 594
-
-
Wynn, T.A.1
Cheever, A.W.2
Jankovic, D.3
Poindexter, R.W.4
Caspar, P.5
Lewis, F.A.6
Sher, A.7
-
29
-
-
0032696176
-
Immune deviation as a strategy for schistosomiasis vaccines designed to prevent infection and egg-induced immunopathology
-
Wynn, T. A. 1999. Immune deviation as a strategy for schistosomiasis vaccines designed to prevent infection and egg-induced immunopathology. Microbes Infect. 1:525.
-
(1999)
Microbes Infect.
, vol.1
, pp. 525
-
-
Wynn, T.A.1
-
30
-
-
0029882942
-
Induction of Th1 cell-mediated protective immunity to Schistosoma mansoni by co-administration of larval antigens and IL-12 as an adjuvant
-
Mountford, A. P., S. Anderson, and R. A. Wilson. 1996. Induction of Th1 cell-mediated protective immunity to Schistosoma mansoni by co-administration of larval antigens and IL-12 as an adjuvant. J. Immunol. 156:4739.
-
(1996)
J. Immunol.
, vol.156
, pp. 4739
-
-
Mountford, A.P.1
Anderson, S.2
Wilson, R.A.3
-
31
-
-
0026441372
-
+ T lymphocytes, and NK cells
-
+ T lymphocytes, and NK cells. J. Immunol. 149:3495.
-
(1992)
J. Immunol.
, vol.149
, pp. 3495
-
-
Perussia, B.1
Chan, S.H.2
D'Andrea, A.3
Tsuji, K.4
Santoli, D.5
Pospisil, M.6
Young, D.7
Wolf, S.F.8
Trinchieri, G.9
-
32
-
-
0028970060
-
Interleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity
-
Trinchieri, G. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu. Rev. Immunol. 13:251.
-
(1995)
Annu. Rev. Immunol.
, vol.13
, pp. 251
-
-
Trinchieri, G.1
-
33
-
-
0032782399
-
IL-12 can directly induce T-helper 1 responses in IFN-γ receptor-deficient mice, but requires IFN-γ signalling to downregulate T-helper 2 responses
-
Mountford, A. P., P. S. Coulson, A. W. Cheever, A. Sher, R. A. Wilson, and T. A. Wynn. 1999. IL-12 can directly induce T-helper 1 responses in IFN-γ receptor-deficient mice, but requires IFN-γ signalling to downregulate T-helper 2 responses. Immunology 97:588.
-
(1999)
Immunology
, vol.97
, pp. 588
-
-
Mountford, A.P.1
Coulson, P.S.2
Cheever, A.W.3
Sher, A.4
Wilson, R.A.5
Wynn, T.A.6
-
34
-
-
0032521274
-
Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
-
Kline, J. N., T. J. Waldschmidt, T. R. Businga, J. E. Lemish, J. V. Weinstock, P. S. Thorne, and A. M. Krieg. 1998. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. J. Immunol. 160:2555.
-
(1998)
J. Immunol.
, vol.160
, pp. 2555
-
-
Kline, J.N.1
Waldschmidt, T.J.2
Businga, T.R.3
Lemish, J.E.4
Weinstock, J.V.5
Thorne, P.S.6
Krieg, A.M.7
-
35
-
-
0033563211
-
Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides
-
Sur, S., J. S. Wild, B. K. Choudhury, N. Sur, R. Alam, and D. M. Klinman. 1999. Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. J. Immunol. 162:6284.
-
(1999)
J. Immunol.
, vol.162
, pp. 6284
-
-
Sur, S.1
Wild, J.S.2
Choudhury, B.K.3
Sur, N.4
Alam, R.5
Klinman, D.M.6
-
36
-
-
0027260963
-
Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni
-
Wynn, T. A., I. Eltoum, A. W. Cheever, F. A. Lewis, W. C. Cause, and A. Sher. 1993. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni. J. Immunol. 151:1430.
-
(1993)
J. Immunol.
, vol.151
, pp. 1430
-
-
Wynn, T.A.1
Eltoum, I.2
Cheever, A.W.3
Lewis, F.A.4
Cause, W.C.5
Sher, A.6
-
37
-
-
0033566010
-
Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni
-
Hoffmann, K. F., S. L. James, A. W. Cheever, and T. A. Wynn. 1999. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. J. Immunol. 163:927.
-
(1999)
J. Immunol.
, vol.163
, pp. 927
-
-
Hoffmann, K.F.1
James, S.L.2
Cheever, A.W.3
Wynn, T.A.4
-
38
-
-
0026002789
-
Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody
-
Svetic, A., F. D. Finkelman, Y. C. Jian, C. W. Dieffenbach, D. E. Scott, K. F. McCarthy, A. D. Steinberg, and W. C. Gause. 1991. Cytokine gene expression after in vivo primary immunization with goat antibody to mouse IgD antibody. J. Immunol. 147:2391.
-
(1991)
J. Immunol.
, vol.147
, pp. 2391
-
-
Svetic, A.1
Finkelman, F.D.2
Jian, Y.C.3
Dieffenbach, C.W.4
Scott, D.E.5
McCarthy, K.F.6
Steinberg, A.D.7
Gause, W.C.8
-
39
-
-
0343746835
-
An interleukin-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
-
Chiaramonte, M. G., D. D. Donaldson, A. W. Cheever, and T. A. Wynn. 1999. An interleukin-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J. Clin. Invest. 104:1.
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 1
-
-
Chiaramonte, M.G.1
Donaldson, D.D.2
Cheever, A.W.3
Wynn, T.A.4
-
40
-
-
0033060455
-
CpG DNA: A novel immunomodulator
-
Krieg, A. M. 1999. CpG DNA: a novel immunomodulator. Trends Microbiol. 7:64.
-
(1999)
Trends Microbiol.
, vol.7
, pp. 64
-
-
Krieg, A.M.1
-
41
-
-
0028931469
-
IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ
-
Wynn, T. A., D. Jankovic, S. Hieny, K. Zioncheck, P. Jardieu, A. W. Cheever, and A. Sher. 1995. IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ. J. Immunol. 154:3999.
-
(1995)
J. Immunol.
, vol.154
, pp. 3999
-
-
Wynn, T.A.1
Jankovic, D.2
Hieny, S.3
Zioncheck, K.4
Jardieu, P.5
Cheever, A.W.6
Sher, A.7
-
42
-
-
0029091255
-
Successful T cell priming in B cell-deficient mice
-
Epstein, M. M., F. Di Rosa, D. Jankovic, A. Sher, and P. Matzinger. 1995. Successful T cell priming in B cell-deficient mice. J. Exp. Med. 182:915.
-
(1995)
J. Exp. Med.
, vol.182
, pp. 915
-
-
Epstein, M.M.1
Di Rosa, F.2
Jankovic, D.3
Sher, A.4
Matzinger, P.5
-
43
-
-
0032983440
-
Interleukin 5 (IL-5) is not required for expression of a Th2 response or host resistance mechanisms during murine schistosomiasis mansoni but does play a role in development of IL-4-producing non-T, non-B cells
-
Brunet, L. R., E. A. Sabin, A. W. Cheever, M. A. Kopf, and E. J. Pearce. 1999. Interleukin 5 (IL-5) is not required for expression of a Th2 response or host resistance mechanisms during murine schistosomiasis mansoni but does play a role in development of IL-4-producing non-T, non-B cells. Infect. Immun. 67:3014.
-
(1999)
Infect. Immun.
, vol.67
, pp. 3014
-
-
Brunet, L.R.1
Sabin, E.A.2
Cheever, A.W.3
Kopf, M.A.4
Pearce, E.J.5
-
44
-
-
0028207191
-
Effects of interluekin-12 on in vivo cytokine gene expression and Ig isotype selection
-
Morris, S. C., K. B. Madden, J. J. Adamovicz, W. C. Gause, B. R. Hubbard, M. K. Gately, and F. D. Finkelman. 1994. Effects of interluekin-12 on in vivo cytokine gene expression and Ig isotype selection. J. Immunol. 152:1047.
-
(1994)
J. Immunol.
, vol.152
, pp. 1047
-
-
Morris, S.C.1
Madden, K.B.2
Adamovicz, J.J.3
Gause, W.C.4
Hubbard, B.R.5
Gately, M.K.6
Finkelman, F.D.7
-
45
-
-
0029959459
-
+ T cells and accompanied by overproduction of IL-12. IFN-γ and TNF-α
-
+ T cells and accompanied by overproduction of IL-12. IFN-γ and TNF-α. J. Immunol. 157:798.
-
(1996)
J. Immunol.
, vol.157
, pp. 798
-
-
Gazzinelli, R.T.1
Wysocka, M.2
Hieny, S.3
Scharton-Kersten, T.4
Cheever, A.5
Kuhn, R.6
Muller, W.7
Trinchieri, G.8
Sher, A.9
-
46
-
-
0027530129
-
Interleukin 12 and tumor necrosis factor α are costimulators of interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist
-
Tripp, C. S., S. F. Wolf, and E. R. Unanue. 1993. Interleukin 12 and tumor necrosis factor α are costimulators of Interferon γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic antagonist. Proc. Natl. Acad. Sci. USA 90:3725.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 3725
-
-
Tripp, C.S.1
Wolf, S.F.2
Unanue, E.R.3
-
47
-
-
0026562075
-
+ Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0-like stage
-
+ Th2 response induced by Schistosoma mansoni eggs develops rapidly, through an early, transient, Th0-like stage. J. Immunol. 148:2283.
-
(1992)
J. Immunol.
, vol.148
, pp. 2283
-
-
Vella, A.T.1
Pearce, E.J.2
-
48
-
-
0030850462
-
CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
-
Lipford, G. B., M. Bauer, C. Blank, R. Reiter, H. Wagner, and K. Heeg. 1997. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: a new class of vaccine adjuvants. Eur. J. Immunol. 27:2340.
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 2340
-
-
Lipford, G.B.1
Bauer, M.2
Blank, C.3
Reiter, R.4
Wagner, H.5
Heeg, K.6
-
49
-
-
0033168959
-
Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway
-
Schwartz, D. A., C. L. Wohlford-Lenane, T. J. Quinn, and A. M. Krieg. 1999. Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway. J. Immunol. 163:224.
-
(1999)
J. Immunol.
, vol.163
, pp. 224
-
-
Schwartz, D.A.1
Wohlford-Lenane, C.L.2
Quinn, T.J.3
Krieg, A.M.4
-
50
-
-
0033536013
-
Immunostimulatory oligonucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12-and IFN-γ-dependent mechanisms
-
Walker, P. S., T. Scharton-Kersten, A. M. Krieg, L. Love-Homan, E. D. Rowton, M. C. Udey, and J. C. Vogel. 1999. Immunostimulatory oligonucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12-and IFN-γ-dependent mechanisms. Prof. Natl. Acad. Sci. USA 96:6970.
-
(1999)
Prof. Natl. Acad. Sci. USA
, vol.96
, pp. 6970
-
-
Walker, P.S.1
Scharton-Kersten, T.2
Krieg, A.M.3
Love-Homan, L.4
Rowton, E.D.5
Udey, M.C.6
Vogel, J.C.7
-
51
-
-
0028949152
-
B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy
-
Kuchroo, V. K., M. P. Das, J. A. Brown, A. M. Ranger, S. S. Zamvil, R. A. Sobel, H. L. Weiner, N. Nabavi, and L. H. Glimcher. 1995. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 80:707.
-
(1995)
Cell
, vol.80
, pp. 707
-
-
Kuchroo, V.K.1
Das, M.P.2
Brown, J.A.3
Ranger, A.M.4
Zamvil, S.S.5
Sobel, R.A.6
Weiner, H.L.7
Nabavi, N.8
Glimcher, L.H.9
-
52
-
-
0030826374
-
CD40L blockade prevents autoimmune encephalomyelitis and hampers TH1 but not TH2 pathway of T cell differentiation
-
Samoilova, E. B., J. L. Horton, H. Zhang, and Y. Chen. 1997. CD40L blockade prevents autoimmune encephalomyelitis and hampers TH1 but not TH2 pathway of T cell differentiation. J. Mol. Med. 75:603.
-
(1997)
J. Mol. Med.
, vol.75
, pp. 603
-
-
Samoilova, E.B.1
Horton, J.L.2
Zhang, H.3
Chen, Y.4
-
53
-
-
0030293445
-
IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite
-
Wynn, T. A., A. Reynolds, S. James, A. W. Cheever, P. Caspar, S. Hieny, D. Jankovic, M. Strand, and A. Sher. 1996. IL-12 enhances vaccine-induced immunity to schistosomes by augmenting both humoral and cell-mediated immune responses against the parasite. J. Immunol. 157:4068.
-
(1996)
J. Immunol.
, vol.157
, pp. 4068
-
-
Wynn, T.A.1
Reynolds, A.2
James, S.3
Cheever, A.W.4
Caspar, P.5
Hieny, S.6
Jankovic, D.7
Strand, M.8
Sher, A.9
-
54
-
-
0025061069
-
Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni
-
Sher, A., R. L. Coffman, S. Heiny, P. Scott, and A. W. Cheever. 1990. Interleukin 5 is required for the blood and tissue eosinophilia but not granuloma formation induced by infection with Schistosoma mansoni. Proc. Natl. Acad. Sci. USA 87:61.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 61
-
-
Sher, A.1
Coffman, R.L.2
Heiny, S.3
Scott, P.4
Cheever, A.W.5
-
55
-
-
0030028722
-
Bacterial DNA induces murine interferon-γ production by stimulation of interleukin-12 and tumor necrosis factor-α
-
Halpern, M. D., R. J. Kurlander, and D. S. Pisetsky. 1996. Bacterial DNA induces murine interferon-γ production by stimulation of interleukin-12 and tumor necrosis factor-α. Cell. Immunol. 167:72.
-
(1996)
Cell. Immunol.
, vol.167
, pp. 72
-
-
Halpern, M.D.1
Kurlander, R.J.2
Pisetsky, D.S.3
-
57
-
-
0028940974
-
The role of the innate immune response in Th1 cell development following Leishmania major infection
-
Scharton-Kersten, T., and P. Scott. 1995. The role of the innate immune response in Th1 cell development following Leishmania major infection. J. Leukocyte Biol. 57:515.
-
(1995)
J. Leukocyte Biol.
, vol.57
, pp. 515
-
-
Scharton-Kersten, T.1
Scott, P.2
-
58
-
-
0032519939
-
CD40 ligand/CD40 stimulation regulates the production of IFN-γ from human peripheral blood mononuclear cells in an IL-12- and/or CD28-dependent manner
-
McDyer, J. F., T. J. Goletz, E. Thomas, C. H. June, and R. A. Seder. 1998. CD40 ligand/CD40 stimulation regulates the production of IFN-γ from human peripheral blood mononuclear cells in an IL-12- and/or CD28-dependent manner. J. Immunol. 160:1701.
-
(1998)
J. Immunol.
, vol.160
, pp. 1701
-
-
McDyer, J.F.1
Goletz, T.J.2
Thomas, E.3
June, C.H.4
Seder, R.A.5
-
59
-
-
0028230984
-
B7 and interleukin 12 cooperate for proliferation and inteiferon γ production by mouse T helper clones that are unresponsive to B7 costimulation
-
Murphy, E. E., G. Terres, S. E. Macatonia, C. S. Hsieh, J. Mattson, L. Lanier, M. Wysocka, G. Trinchieri, K. Murphy, and A. O'Garra. 1994. B7 and interleukin 12 cooperate for proliferation and inteiferon γ production by mouse T helper clones that are unresponsive to B7 costimulation. J. Exp. Med. 180:223.
-
(1994)
J. Exp. Med.
, vol.180
, pp. 223
-
-
Murphy, E.E.1
Terres, G.2
Macatonia, S.E.3
Hsieh, C.S.4
Mattson, J.5
Lanier, L.6
Wysocka, M.7
Trinchieri, G.8
Murphy, K.9
O'Garra, A.10
-
60
-
-
0029780119
-
CD40 ligand-dependent T cell activation: Requirement of B7-CD28 signaling through CD40
-
Yang, Y., and J. M. Wilson. 1996. CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. Science 273:1862.
-
(1996)
Science
, vol.273
, pp. 1862
-
-
Yang, Y.1
Wilson, J.M.2
-
61
-
-
0030152162
-
CD40 and its ligand in host defense
-
Noelle, R. J. 1996. CD40 and its ligand in host defense. Immunity 4:415.
-
(1996)
Immunity
, vol.4
, pp. 415
-
-
Noelle, R.J.1
|