메뉴 건너뛰기




Volumn 58, Issue 2, 2000, Pages 388-398

Receptor density and recycling affect the rate of agonist-induced desensitization of μ-opioid receptor

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE CYCLASE; BETA FUNALTREXAMINE; BREFELDIN A; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ETORPHINE; METENKEPHALIN; MONENSIN; MORPHINE; MU OPIATE RECEPTOR; NALOXONE; SUCROSE;

EID: 0033930091     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.2.388     Document Type: Article
Times cited : (95)

References (45)
  • 1
    • 0028943362 scopus 로고
    • C-terminal truncation of the neurokinin-2 receptor causes enhanced and sustained agonist-induced signaling
    • Alblas J, Etten IV, Khanum A and Moolenaar WH (1995) C-terminal truncation of the neurokinin-2 receptor causes enhanced and sustained agonist-induced signaling. J Biol Chem 270:8944-8951.
    • (1995) J Biol Chem , vol.270 , pp. 8944-8951
    • Alblas, J.1    Etten, I.V.2    Khanum, A.3    Moolenaar, W.H.4
  • 2
    • 0030662153 scopus 로고    scopus 로고
    • Agonist-induced phosphorylation of the κ-opioid receptor
    • Appleyard SM, Patterson TA, Jin W and Chavkin C (1997) Agonist-induced phosphorylation of the κ-opioid receptor. J Neurochem 69:2405-2412.
    • (1997) J Neurochem , vol.69 , pp. 2405-2412
    • Appleyard, S.M.1    Patterson, T.A.2    Jin, W.3    Chavkin, C.4
  • 3
    • 0029130047 scopus 로고
    • Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged μ-opioid receptor expressed in HEK293 cells
    • Arden JR, Segredo V, Wang A, Lameh J and Sadee W (1995) Phosphorylation and agonist-specific intracellular trafficking of an epitope-tagged μ-opioid receptor expressed in HEK293 cells. J Neurochem 65:1636-1645.
    • (1995) J Neurochem , vol.65 , pp. 1636-1645
    • Arden, J.R.1    Segredo, V.2    Wang, A.3    Lameh, J.4    Sadee, W.5
  • 4
    • 0031024509 scopus 로고    scopus 로고
    • 4 subtype is essential for agonist-induced desensitization
    • 4 subtype is essential for agonist-induced desensitization. Mol Pharmacol 51:343-349.
    • (1996) Mol Pharmacol , vol.51 , pp. 343-349
    • Bastepe, M.1    Ashby, B.2
  • 5
    • 0032509023 scopus 로고    scopus 로고
    • Somatostatin receptor desensitization in NG10815 cells. A consequence of receptor sequestration
    • Beaumont V, Hepworth MB, Luty JS, Kelly E and Henderson G (1998) Somatostatin receptor desensitization in NG10815 cells. A consequence of receptor sequestration. J Biol Chem 273:33174-33183.
    • (1998) J Biol Chem , vol.273 , pp. 33174-33183
    • Beaumont, V.1    Hepworth, M.B.2    Luty, J.S.3    Kelly, E.4    Henderson, G.5
  • 6
    • 0031590309 scopus 로고    scopus 로고
    • Agonist-induced signaling and trafficking of the mu-opioid receptor: Role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain
    • Capeyrou R, Riond J, Corbani M, Lepage JF, Bertin B and Emorine LJ (1997) Agonist-induced signaling and trafficking of the mu-opioid receptor: Role of serine and threonine residues in the third cytoplasmic loop and C-terminal domain. FEBS Lett 415:200-205.
    • (1997) FEBS Lett , vol.415 , pp. 200-205
    • Capeyrou, R.1    Riond, J.2    Corbani, M.3    Lepage, J.F.4    Bertin, B.5    Emorine, L.J.6
  • 7
    • 0028061556 scopus 로고
    • Influence of cell type upon the desensitization of the beta 3-adrenergic receptor
    • Chaudhry A and Granneman JG (1994) Influence of cell type upon the desensitization of the beta 3-adrenergic receptor. J Pharmacol Exp Ther 271:1253-1258.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 1253-1258
    • Chaudhry, A.1    Granneman, J.G.2
  • 9
    • 0032544337 scopus 로고    scopus 로고
    • Selective interference of β-arrestin 1 with κ- and δ-but not μ-opioid receptor/G protein coupling
    • Cheng ZJ, Yu QM, Wu YL, Ma L and Pei G(1998) Selective interference of β-arrestin 1 with κ- and δ-but not μ-opioid receptor/G protein coupling. J Biol Chem 273:24328-24333.
    • (1998) J Biol Chem , vol.273 , pp. 24328-24333
    • Cheng, Z.J.1    Yu, Q.M.2    Wu, Y.L.3    Ma, L.4    Pei, G.5
  • 10
    • 0030859482 scopus 로고    scopus 로고
    • Delta and κ-opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist
    • Chu P, Murray S, Lissin D and von Zastrow M (1997) Delta and κ-opioid receptors are differentially regulated by dynamin-dependent endocytosis when activated by the same alkaloid agonist. J Biol Chem 272:27124-27130.
    • (1997) J Biol Chem , vol.272 , pp. 27124-27130
    • Chu, P.1    Murray, S.2    Lissin, D.3    Von Zastrow, M.4
  • 11
    • 0026677375 scopus 로고
    • Brefeldin A inhibits Golgi membrane-catalyzed exchange of guanine nucleotide onto ARF protein
    • Donaldson JG, Finazzi D and Klausner RD (1992) Brefeldin A inhibits Golgi membrane-catalyzed exchange of guanine nucleotide onto ARF protein. Nature (Lond) 360:350-352.
    • (1992) Nature (Lond) , vol.360 , pp. 350-352
    • Donaldson, J.G.1    Finazzi, D.2    Klausner, R.D.3
  • 12
    • 0026034357 scopus 로고
    • Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the golgi complex, shows homology to beta-adaptin
    • Duden R, Griffiths G, Frank R, Argos P and Kreis TE (1991) Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin. Cell 64:649-665.
    • (1991) Cell , vol.64 , pp. 649-665
    • Duden, R.1    Griffiths, G.2    Frank, R.3    Argos, P.4    Kreis, T.E.5
  • 13
    • 0033515531 scopus 로고    scopus 로고
    • The absence of a direct correlation between the loss of DAMGO inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation
    • El-Kouhen R, El-Kouhen OM, Law PY and Loh HH (1999) The absence of a direct correlation between the loss of DAMGO inhibition of adenylyl cyclase activity and agonist-induced mu-opioid receptor phosphorylation. J Biol Chem 274:9207-9215.
    • (1999) J Biol Chem , vol.274 , pp. 9207-9215
    • El-Kouhen, R.1    El-Kouhen, O.M.2    Law, P.Y.3    Loh, H.H.4
  • 15
    • 0026746713 scopus 로고
    • Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF
    • Helms JB and Rothman JE (1992) Inhibition by brefeldin A of a Golgi membrane enzyme that catalyses exchange of guanine nucleotide bound to ARF. Nature (Lond) 360:352-354.
    • (1992) Nature (Lond) , vol.360 , pp. 352-354
    • Helms, J.B.1    Rothman, J.E.2
  • 16
    • 0030946790 scopus 로고    scopus 로고
    • Agonist-induced desensitization, internalization and phosphorylation of the sst2A somatostatin receptor
    • Hipkin RW, Friedman J, Clark RB, Eppler CM and Schonbrunn A (1997) Agonist-induced desensitization, internalization and phosphorylation of the sst2A somatostatin receptor. J Biol Chem 272:13869-13876.
    • (1997) J Biol Chem , vol.272 , pp. 13869-13876
    • Hipkin, R.W.1    Friedman, J.2    Clark, R.B.3    Eppler, C.M.4    Schonbrunn, A.5
  • 17
    • 0028785484 scopus 로고
    • Truncation of the C-terminal tail of the follitropin receptor does not impair the agonist-or phorbol ester-induced receptor phosphorylation and uncoupling
    • Hipkin RW, Xuebo L and Ascoli M (1995) Truncation of the C-terminal tail of the follitropin receptor does not impair the agonist-or phorbol ester-induced receptor phosphorylation and uncoupling. J Biol Chem 270:26683-26689.
    • (1995) J Biol Chem , vol.270 , pp. 26683-26689
    • Hipkin, R.W.1    Xuebo, L.2    Ascoli, M.3
  • 18
    • 0029790078 scopus 로고    scopus 로고
    • Role of receptor phosphorylation in desensitization and internalizaton of the secretin receptor
    • Holtmann MH, Roettger BF, Pinon DI and Miller LJ (1996) Role of receptor phosphorylation in desensitization and internalizaton of the secretin receptor. J Biol Chem 271:23566-23571.
    • (1996) J Biol Chem , vol.271 , pp. 23566-23571
    • Holtmann, M.H.1    Roettger, B.F.2    Pinon, D.I.3    Miller, L.J.4
  • 21
    • 0032577554 scopus 로고    scopus 로고
    • Carboxyl-terminal splicing of the rat μ-opioid receptor modulates agonist-mediated internalization and receptor resensitization
    • Koch T, Schulz S, Schroder H, Wolf R, Raulf E and Hollt V (1998) Carboxyl-terminal splicing of the rat μ-opioid receptor modulates agonist-mediated internalization and receptor resensitization. J Biol Chem 273:13652-13657.
    • (1998) J Biol Chem , vol.273 , pp. 13652-13657
    • Koch, T.1    Schulz, S.2    Schroder, H.3    Wolf, R.4    Raulf, E.5    Hollt, V.6
  • 22
    • 0031726194 scopus 로고    scopus 로고
    • Agonist induced homologous desensitization of μ-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy
    • Koover A, Celver JP, Wu A and Chavkin C (1998) Agonist induced homologous desensitization of μ-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy. Mol Pharmacol 54:704-711.
    • (1998) Mol Pharmacol , vol.54 , pp. 704-711
    • Koover, A.1    Celver, J.P.2    Wu, A.3    Chavkin, C.4
  • 23
    • 0030736086 scopus 로고    scopus 로고
    • Mu and δ-opioid receptors are differentially desensitized by the coexpression of β-adrenergic receptor kinase 2 and β-arrestin 2 in Xenopus oocytes
    • Koover A, Nappey V, Kieffer BL and Chavkin C (1997) Mu and δ-opioid receptors are differentially desensitized by the coexpression of β-adrenergic receptor kinase 2 and β-arrestin 2 in Xenopus oocytes. J Biol Chem 272:27605-27611.
    • (1997) J Biol Chem , vol.272 , pp. 27605-27611
    • Koover, A.1    Nappey, V.2    Kieffer, B.L.3    Chavkin, C.4
  • 24
    • 0032563291 scopus 로고    scopus 로고
    • G-protein coupled receptors III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization
    • Lefkowitz RJ (1998) G-protein coupled receptors III. New roles for receptor kinases and β-arrestins in receptor signaling and desensitization. J Biol Chem 273:18677-18680.
    • (1998) J Biol Chem , vol.273 , pp. 18677-18680
    • Lefkowitz, R.J.1
  • 25
    • 0027418423 scopus 로고
    • Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor
    • Liggett SB, Freedman NJ, Schwinn DA and Lefkowitz RJ (1993) Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor. Proc Natl Acad Sci USA 90:3665-3669.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 3665-3669
    • Liggett, S.B.1    Freedman, N.J.2    Schwinn, D.A.3    Lefkowitz, R.J.4
  • 26
    • 0025240867 scopus 로고
    • Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity
    • Mollenhauer HH, Morre DJ and Rowe LD (1990) Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochim Biophys Acta 1031:225-246.
    • (1990) Biochim Biophys Acta , vol.1031 , pp. 225-246
    • Mollenhauer, H.H.1    Morre, D.J.2    Rowe, L.D.3
  • 28
    • 0029804995 scopus 로고    scopus 로고
    • Agonist-induced functional desensitization of the μ-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from g protein
    • Pak Y, Kouvelas A, Scheideler MA, Rasmussen J, O'Dowd BF and George SR (1996) Agonist-induced functional desensitization of the μ-opioid receptor is mediated by loss of membrane receptors rather than uncoupling from G protein. Mol Pharmacol 50:1214-1222.
    • (1996) Mol Pharmacol , vol.50 , pp. 1214-1222
    • Pak, Y.1    Kouvelas, A.2    Scheideler, M.A.3    Rasmussen, J.4    O'Dowd, B.F.5    George, S.R.6
  • 29
    • 0030875721 scopus 로고    scopus 로고
    • Agonist-induced desensitization of the μ-opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail
    • Pak Y, O'Dowd BF and George SR (1997) Agonist-induced desensitization of the μ-opioid receptor is determined by threonine 394 preceded by acidic amino acids in the COOH-terminal tail. J Biol Chem 272:24961-24965.
    • (1997) J Biol Chem , vol.272 , pp. 24961-24965
    • Pak, Y.1    O'Dowd, B.F.2    George, S.R.3
  • 31
    • 0030614357 scopus 로고    scopus 로고
    • Identification of an A2a adenosine receptor domain specifically responsible for mediating short-term desensitization
    • Palmer TM and Stiles GL (1997) Identification of an A2a adenosine receptor domain specifically responsible for mediating short-term desensitization. Biochemistry 36:832-837.
    • (1997) Biochemistry , vol.36 , pp. 832-837
    • Palmer, T.M.1    Stiles, G.L.2
  • 32
    • 0028829471 scopus 로고
    • Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms
    • Pals-Rylaarsdam R, Xu Y, Witt-Enderby P, Benovic JL and Hosey MM (1995) Desensitization and internalization of the m2 muscarinic acetylcholine receptor are directed by independent mechanisms. J Biol Chem 270:29004-29011.
    • (1995) J Biol Chem , vol.270 , pp. 29004-29011
    • Pals-Rylaarsdam, R.1    Xu, Y.2    Witt-Enderby, P.3    Benovic, J.L.4    Hosey, M.M.5
  • 33
    • 0029085874 scopus 로고
    • Agonist-dependent phosphorylation of the mouse δ-opioid receptor: Involvement of G protein-coupled receptor kinases but not protein kinase C
    • Pei G, Kieffer BL, Lefkowitz RJ and Freedman NJ (1995) Agonist-dependent phosphorylation of the mouse δ-opioid receptor: Involvement of G protein-coupled receptor kinases but not protein kinase C. Mol Pharmacol 48:173-177.
    • (1995) Mol Pharmacol , vol.48 , pp. 173-177
    • Pei, G.1    Kieffer, B.L.2    Lefkowitz, R.J.3    Freedman, N.J.4
  • 34
    • 0030789693 scopus 로고    scopus 로고
    • Ligand-induced internalization of cholecystokinin receptors. Demonstration of the importance of the carboxyl terminus for ligand-induced internalization of rat cholecystokinin type B receptor but not the type A receptor
    • Pohl M, Silvente-Poirot S, Pisegna JR, Tarasova NI and Wank SA (1997) Ligand-induced internalization of cholecystokinin receptors. Demonstration of the importance of the carboxyl terminus for ligand-induced internalization of rat cholecystokinin type B receptor but not the type A receptor. J Biol Chem 272:18179-18184.
    • (1997) J Biol Chem , vol.272 , pp. 18179-18184
    • Pohl, M.1    Silvente-Poirot, S.2    Pisegna, J.R.3    Tarasova, N.I.4    Wank, S.A.5
  • 35
    • 0028365926 scopus 로고
    • Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells
    • Prather PL, Tsai AW and Law P-Y (1994) Mu and delta opioid receptor desensitization in undifferentiated human neuroblastoma SHSY5Y cells. J Pharmacol Exp Ther 270:177-184.
    • (1994) J Pharmacol Exp Ther , vol.270 , pp. 177-184
    • Prather, P.L.1    Tsai, A.W.2    Law, P.-Y.3
  • 36
    • 0030816392 scopus 로고    scopus 로고
    • Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor sytype 3 is crucial for its desensitization and internalization
    • Roth A, Kreienkamp HJ, Meyerhof W and Richter D (1997) Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor sytype 3 is crucial for its desensitization and internalization. J Biol Chem 272: 23769-23774.
    • (1997) J Biol Chem , vol.272 , pp. 23769-23774
    • Roth, A.1    Kreienkamp, H.J.2    Meyerhof, W.3    Richter, D.4
  • 37
    • 0019427430 scopus 로고
    • The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone
    • Takemori AE, Larson DL and Portoghese P (1981) The irreversible narcotic antagonistic and reversible agonistic properties of the fumaramate methyl ester derivative of naltrexone. Eur J Pharmacol 70:445-451.
    • (1981) Eur J Pharmacol , vol.70 , pp. 445-451
    • Takemori, A.E.1    Larson, D.L.2    Portoghese, P.3
  • 39
    • 0032544061 scopus 로고    scopus 로고
    • Morphine-activated opioid receptors elude desensitization by β-arrestin
    • Whistler JL and von Zastrow M (1998) Morphine-activated opioid receptors elude desensitization by β-arrestin. Proc Natl Acad Sci USA 95:9914-9919.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9914-9919
    • Whistler, J.L.1    Von Zastrow, M.2
  • 40
    • 0032981172 scopus 로고    scopus 로고
    • Replacement of threonine 394 by alanine facilitates internalization and resensitization of the rat μ-opioid receptor
    • Wolf R, Koch T, Schulz S, Hutzny M, Schroder H, Raulf E, Buhling F and Hollt V (1999) Replacement of threonine 394 by alanine facilitates internalization and resensitization of the rat μ-opioid receptor. Mol Pharmacol 55:263-268.
    • (1999) Mol Pharmacol , vol.55 , pp. 263-268
    • Wolf, R.1    Koch, T.2    Schulz, S.3    Hutzny, M.4    Schroder, H.5    Raulf, E.6    Buhling, F.7    Hollt, V.8
  • 41
    • 0030691760 scopus 로고    scopus 로고
    • Mu opioid receptor phosphorylation, desensitization and ligand efficacy
    • Yu Y, Zhang L, Yin X, Sun H, Uhl GR and Wang JB (1997) Mu opioid receptor phosphorylation, desensitization and ligand efficacy. J Biol Chem 272:28869-28874.
    • (1997) J Biol Chem , vol.272 , pp. 28869-28874
    • Yu, Y.1    Zhang, L.2    Yin, X.3    Sun, H.4    Uhl, G.R.5    Wang, J.B.6
  • 42
    • 0030766471 scopus 로고    scopus 로고
    • 2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types
    • 2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types. J Biol Chem 272:27005-27014.
    • (1997) J Biol Chem , vol.272 , pp. 27005-27014
    • Zhang, J.1    Barak, L.S.2    Winkler, K.E.3    Caron, M.G.4    Ferguson, S.S.G.5
  • 44
    • 15844416295 scopus 로고    scopus 로고
    • Differential mu opiate receptor phosphorylation and desensitization induced by agonists and phorbal ester
    • Zhang L, Yu Y, Mackin S, Weight FF, Uhl GR and Wang JB (1996) Differential mu opiate receptor phosphorylation and desensitization induced by agonists and phorbal ester. J Biol Chem 271:11449-11454.
    • (1996) J Biol Chem , vol.271 , pp. 11449-11454
    • Zhang, L.1    Yu, Y.2    Mackin, S.3    Weight, F.F.4    Uhl, G.R.5    Wang, J.B.6
  • 45
    • 0028847941 scopus 로고
    • Cloning and expression of an isoform of the rat μ-opioid receptor (rMOR1B) which differs in agonist induced desensitization from rMOR1
    • Zimprich A, Simon T and Hollt V (1995) Cloning and expression of an isoform of the rat μ-opioid receptor (rMOR1B) which differs in agonist induced desensitization from rMOR1. FEBS Lett 359:142-146.
    • (1995) FEBS Lett , vol.359 , pp. 142-146
    • Zimprich, A.1    Simon, T.2    Hollt, V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.