Two novel and selective nonimidazole histamine H3 receptor antagonists A-304121 and A-317920: I. In vitro pharmacological effects

Journal of Pharmacology and Experimental Therapeutics

Volumn 305, Issue 3, 2003, Pages 887-896

  Esbenshade, Timothy A ^a   Krueger, Kathleen M ^a   Miller, Thomas R ^a   Hee Kang, Chae ^a   Denny, Lynne I ^b   Witte, David G ^a   Yao, Betty B ^a   Fox, Gerard B ^a   Faghih, Ramin ^a   Bennani, Youssef L ^c   Williams, Michael ^d   Hancock, Arthur A ^a  

^a ABBOTT LABORATORIES   (United States)

^b PFIZER INC   (United States)

^c ATHERSYS INC   (United States)

^d NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL 3 INDAZOLECARBOXYLIC ACID N TROPANYLAMIDE; 2 AMINO 1 [4 [3 (4 CYCLOPROPANECARBONYLPHENOXY)PROPYL] 1 PIPERAZINYL] 1 PROPANONE; A 317920; ALPHA METHYLHISTAMINE; CIPROXIFAN; CLOBENPROPIT; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HISTAMINE H3 RECEPTOR ANTAGONIST; MEPYRAMINE; N [2 [4 [3 [4 (CYCLOPROPYLCARBONYL)PHENOXY]PROPYL] 1 PIPERAZINYL] 1 METHYL 2 OXOETHYL] 2 FURAMIDE; PHENTOLAMINE; PRAZOSIN; RAUWOLSCINE; SEROTONIN; THIOPERAMIDE; TIOTIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG SPECIFICITY; DRUG STRUCTURE; GUINEA PIG; HUMAN; HUMAN CELL; ILEUM; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING;

ANIMALS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HISTAMINE ANTAGONISTS; HUMANS; MALE; NEUROTRANSMITTER AGENTS; PIPERAZINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, HISTAMINE H3; RECOMBINANT PROTEINS; SULFUR RADIOISOTOPES;

EID: 0037648479     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.047183     Document Type: Article

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