Histamine H3-receptor-mediated [35S]GTPγ[S] binding: Evidence for constitutive activity of the recombinant and native rat and human H3 receptors

British Journal of Pharmacology

Volumn 135, Issue 2, 2002, Pages 383-392

  Rouleau, A ^a   Ligneau, X ^a,b   Tardivel Lacombe, J ^a   Morisset, S ^a   Gbahou, F ^a   Schwartz, J C ^a   Arrang, J M ^a  

^a CENTRE PAUL BROCA   (France)

^b Bioprojet   (France)

Author keywords

Ciproxifan; Constitutive activity; G protein coupled receptors; Histamine; Native receptors; Rat brain; Recombinant receptors

Indexed keywords

ARACHIDONIC ACID; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HISTAMINE AGONIST; HISTAMINE H3 RECEPTOR; LIGAND; RECOMBINANT PROTEIN; SULFUR; ADENOSINE A1 RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; CIPROXIFAN; DOPAMINE 2 RECEPTOR; DOPAMINE 3 RECEPTOR; FUB 465; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR AGONIST; RECOMBINANT RECEPTOR; SIGMA OPIATE RECEPTOR; SULFUR 35; THIOPERAMIDE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; BIOSYNTHESIS; BRAIN; CHO CELL; DRUG EFFECT; GENETICS; HAMSTER; HUMAN; MALE; METABOLISM; PHYSIOLOGY; RAT; SECRETION; WISTAR RAT; ANIMAL CELL; BRAIN MEMBRANE; CELL ADHESION; CELL MEMBRANE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RECEPTOR BINDING; RECEPTOR DENSITY; RECEPTOR INTRINSIC ACTIVITY; SPECIES DIFFERENCE;

ANIMALS; ARACHIDONIC ACID; BRAIN; CHO CELLS; CRICETINAE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HISTAMINE AGONISTS; HUMANS; LIGANDS; MALE; RATS; RATS, WISTAR; RECEPTORS, HISTAMINE H3; RECOMBINANT PROTEINS; SULFUR RADIOISOTOPES;

EID: 0036008203     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0704490     Document Type: Article

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