High antagonist potency of GT-2227 and GT-2331, new histamine H3 receptor antagonists, in two functional models

European Journal of Pharmacology

Volumn 351, Issue 3, 1998, Pages 307-311

  Tedford, Clark E ^a   Hoffmann, Marcel ^b   Seyedi, Nahid ^c   Maruyama, Ryushi ^c   Levi, Roberto ^c   Yates, Stephen L ^a   Ali, Syed M ^a   Phillips, James G ^a  

^a GUILFORD PHARMACEUTICALS INC   (United States)

^b LEIDEN UNIVERSITY   (Netherlands)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

GT 2227; GT 2331; Heart; Histamine H3 receptor; Jejunum; Norepinephrine

Indexed keywords

4 (2 (5,5 DIMETHYLHEX 1 YNYL)CYCLOPROPYL)IMIDAZOLE; 4 (6 CYCLOHEXYLHEX 3 ENYL)IMIDAZOLE; ACETYLCHOLINE; ALPHA METHYLHISTAMINE; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR ANTAGONIST; TRIPROLIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GUINEA PIG; HEART MUSCLE CELL; INTESTINE CONTRACTION; JEJUNUM; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; SYNAPTOSOME;

ANIMALS; ELECTRIC STIMULATION; GUINEA PIGS; HISTAMINE AGONISTS; HISTAMINE ANTAGONISTS; IMIDAZOLES; JEJUNUM; MALE; METHYLHISTAMINES; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MYOCARDIUM; NOREPINEPHRINE; RECEPTORS, HISTAMINE H3; SYNAPTOSOMES;

EID: 0031854957     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00396-3     Document Type: Article

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