Non-imidazole histamine H3 ligands. Part I. Synthesis of 2-(1-piperazinyl)- and 2-(hexahydro-1H-1,4-diazepin-1-yl)benzothiazole derivatives as H3-antagonists with H1 blocking activities

Farmaco

Volumn 54, Issue 10, 1999, Pages 684-694

  Walczyński, Krzysztof ^a   Guryn, Roman ^a   Zuiderveld, Obbe P ^b   Timmerman, Henk ^b  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

2 Piperazinyl and 2 (hexahydro 1H 1,4 diazepin 1 yl)benzothiazoles; H1 and H3 antagonists; Histamine H1 and H3 receptors

Indexed keywords

BENZOTHIAZOLE DERIVATIVE; HISTAMINE H1 RECEPTOR; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR ANTAGONIST;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; GUINEA PIG; JEJUNUM; MALE; NONHUMAN; PHYSICAL CHEMISTRY; SMOOTH MUSCLE RELAXATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; GUINEA PIGS; HISTAMINE ANTAGONISTS; HISTAMINE H1 ANTAGONISTS; MALE; RECEPTORS, HISTAMINE H3; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 0345062210     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(99)00081-6     Document Type: Article

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