Inhibition of phosphatidylinositol-3′-kinase prevents induction of endotoxin tolerance in vitro

Journal of Surgical Research

Volumn 63, Issue 1, 1996, Pages 287-292

  Bowling, William M ^a   Flye, M Wayne ^a   Qiu, Yu Yu ^a   Callery, Mark P ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRITE; PHOSPHATIDYLINOSITOL 3 KINASE; TUMOR NECROSIS FACTOR ALPHA; WORTMANNIN;

ANIMAL CELL; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOLOGICAL TOLERANCE; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; RAT; SEPSIS; SHOCK; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMALS; CELL LINE; DRUG TOLERANCE; ENDOTOXINS; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; KINETICS; LEAST-SQUARES ANALYSIS; MACROPHAGES; MODELS, BIOLOGICAL; NITRITES; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RATS; REGRESSION ANALYSIS; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0029978925     PISSN: 00224804     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsre.1996.0262     Document Type: Article

References (43)

1. Beal, A. L., and Cerra, F. B. Multiple organ failure syndrome in the 1990s. JAMA 271: 226, 1994.
2. Morrison, D. C., and Ryan, J. L. Endotoxin and disease mechanisms. Ann. Rev. Med. 38: 417, 1987.
3. Nathan, C. F. Secretory products of macrophages. J. Clin. Invest. 79: 319, 1987.
4. van der Poll, T., and Lowry, S. F. Tumor necrosis factor in sepsis: Mediator of multiple organ failure or essential part of host defense? Shock 3: 1, 1995.
5. Legrand, E. K. An evolutionary perspective of endotoxin: A signal for a well-adapted defense system. Med. Hypotheses 33: 49, 1990.
6. Johnston, C. A., and Griesman, S. E. Mechanisms of endotoxin tolerance. In L. B. Hinshaw, (Ed.), Handbook of Endotoxin. New York: Elsevier Medical Publishers, 1986. Pp. 359-407.
7. Sanchez-Cantu, L., Rode, H. N., and Christou, N. V. Endotoxin tolerance is associated with reduced secretion of tumor necrosis factor. Arch. Surg. 124: 1432, 1989.
8. Fraker, D. L., Stovroff, M. C., Merino, M. J., and Norton, J. A. Tolerance to tumor necrosis in rats and the relationship to endotoxin tolerance and toxicity. J. Exp. Med. 168: 95, 1988.
9. Seatter, S. C., Bennet, T., Li, M. H., Bubrick, M. P., and West, M. A. Macrophage endotoxin tolerance. Arch. Surg. 129: 1263, 1994.
10. Bowling, W. M., Hafenrichter, D. G., Flye, M. W., and Callery, M. P. Endotoxin tolerance alters phospholipase C-γ1 and phosphatidylinositol-3′-kinase expression in peritoneal macrophages. J. Surg. Res. 58: 592, 1995.
11. Bansal, V. S., and Majerus, P. W. Phosphatidylinositol-derived precursors and signals. Annu. Rev. Cell Biol. 6: 41, 1990.
12. Arcaro, A., and Wymann, M. P. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-triphosphate in neutrophil responses. Biochem. J. 296: 297, 1993.
13. Powis, G., Bonjouklian, R., Berggren, M. M., Gallegos, A., Abraham, R., Ashendel, C., Zalkow, L., Matter, W. F., Dodge, J., Grindley, G., and Valhos, C. J. Wortmannin, a potent and selective inhibitor of phosphatidylinositol-3-kinase. Cancer Res. 54: 2419, 1994.
14. Virca, G. D., Kim, S. Y., Glaser, K. B., and Ulevitch, R. J. Lipopolysaccharide induces hyporesponsiveness to its own action in RAW 264.7 cells. J. Bio. Chem. 264: 21951, 1989.
15. 15N]nitrate in biological fluids. Anal. Biochem. 126: 131, 1982.
16. Sefton, B. M., and Campbell, M. A. The role of tyrosine protein phosphorylation in lymphocyte activation. Annu. Rev. Cell Biol. 7: 257, 1991.
17. Bolen, J. B. Signal transduction of the SRC family of tyrosine protein kinases in hemopoietic cells. Cell Growth & Differ. 2: 409, 1991.
18. Koch, C. A., Anderson, D., Moran, M. F., Ellis, C., and Pawson, T. SH2 and SH3 domains: Elements that control interactions of cytoplasmic signaling proteins. Science 252: 668, 1991.
19. Cooper, J. A., and Howell, B. The when and now of Src regulation. Cell 73: 1051, 1993.
20. Raetz, C. R. H., Ulevitch, R. J., Wright, S. D., Sibley, C. H., Ding, A., and Nathan, C. F. Gram-negative endotoxin: An extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J. 5: 2652, 1991.
21. Weinstein, S. L., Sanghera, J. S., Lemke, K., DeFranco, A. L., and Pelech, S. L. Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J. Biol. Chem. 267: 14955, 1992.
22. Geppert, T. D., Whitehurst, C. E., Thompson, P., and Beutler, B. Lipopolysaccharide signals activation of tumor necrosis factor biosynthesis through the Ras/Raf-1 MEK/MAPK pathway. Mol. Med. 1: 93, 1995.
23. Reimann, T., Buscher, D., Hipskind, R. A., Krautwald, S., Lohmann-Matthes, M.-L., and Baccarini, M. Lipopolysaccharide induces activation of the Raf-1/MAPKinase pathway. J. Immunol. 153: 5741, 1994.
24. Liu, M. K., Herrera-Velit, P., Brownsey, R. W., and Reiner, N. E. CD14-dependent activation of protein kinase C and mitogen-activated protein kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide. J. Immunol. 153: 26422, 1994.
25. Rhee, S. G., Suh, P. G., Ruy, S. H., and Lee, S. Y. Studies of inositol phospholipid-specific phospholipase C. Science 244:546, 1989.
26. Lin, T.-A., Kong, X., Haystead, T. A. J., Pause, A., Belsham, G., Sonenberg, N., and Lawrence, J. C. Jr. PHAS-1 as a link between mitogen-activated protein kinase and translation initiation. Science 266: 653, 1994.
27. Chen, R.-H., Tung, R., Abate, C., and Blenis, J. Cytoplasmic to nuclear signal transduction by mitogen-activated protein kinase and 90 kDa ribosomal S6 kinase. Biochem. Soc. Trans. 21: 895, 1993.
28. Beutler, B., Krochin, N., Milsark, I. W., Luedke, C., and Cerami. A, Control of cachectic (tumor necrosis factor) synthesis: Mechanisms of endotoxin resistance. Science 232: 977, 1986.
29. Zingarelli, B., Halushka, P. V., Caputi, A. P., and Cook, J. A. Increased nitric oxide synthesis during the development of endotoxin tolerance. Shock 3: 102, 1995.
30. Knopf, H.-P., Otto, F., Engelhardt, R., Freudenberg, M. A., Galanos, C., Herrmann, F., and Schumann, R. R. Discordant adaptation of human peritoneal macrophages to stimulation by lipopolysaccharide and the synthetic lipid A analogue SDZ MRL 953. J. Immunol. 153: 287, 1994.
31. Han, J., Thompson, P., and Beutler, B. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectic/tumor necrosis factor synthesis at separate points in the signaling pathway. J. Exp. Med. 172: 391, 1990.
32. Zuckerman, S. H., Evans, G. F., and Guthrie, L. Transcriptional and post-translational mechanisms involved in the differential expression of LPS-induced IL-1 and TNF mRNA. Immunology 73: 460, 1991.
33. Kapeller, R., and Cantley, L. C. Phosphatidylinositol 3-kinase. BioEssays 16: 565, 1994.
34. Whitman, M., Downes, P. C., Keeler, M., Keller, T., and Cantley, L. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3′ phosphate. Nature 332: 644, 1988.
35. Parker, P. J., and Waterfield, M. D. Phosphatidylinositol 3-kinase: A novel effector. Cell Growth & Diff. 3: 747, 1992.
36. Cheatham, B., Vlahos, C. J., Cheatham, L., Wang, L., Blenis, J., and Kahn, C. R. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol. Cell. Biol. 14: 4902, 1994.
37. Coughlin, S. R., Escobede, J. A., and Williams, T. Role of phosphatidylinositol kinase in PDGF receptor signal transduction. Science 243: 1191, 1989.
38. Remillard, B., Petrillo, R., Maslinski, W., Tsudo, M., Strom, T. B., Cantley, L., and Varticovski, L. Interleukin-2 receptor regulates activation of phosphatidylinositol 3-kinase. J. Biol. Chem. 266: 14167, 1991.
39. Prpic, V., Weiel, J. E., and Sommers, S. D. Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol 4,5-bisphosphate in murine peritoneal macrophages. J. Immunol. 139: 526, 1987.
40. Chang, Z. L., Novotney, M., and Suzkuki, T. Phospholipase C and A-2 in tumoricidal activation of murine macrophage-like cell lines. FASEB J. 4: A1082, 1989.
41. Yano, H., Nakanishi, S., Kimura, K., Hanni, N., Saithoh, Y., Fukui, Y., Nonomura, Y., and Matsuola, Y. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J. Biol. Chem. 268: 25846, 1993.
42. Okada, T., Sakuma, L., Fukui, Y., Hazeki, O., and Ui, M. Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as result of selective inhibition of phosphatidylinositol 3′-kinase. J. Biol. Chem. 269: 3563, 1994.
43. rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis. Cell Growth & Diff. 2: 279, 1991.