Effect of microcystin-LR and cyanobacterial extract from Polish reservoir of drinking water on cell cycle progression, mitotic spindle, and apoptosis in CHO-K1 cells

Toxicology and Applied Pharmacology

Volumn 189, Issue 3, 2003, Pages 204-213

  Lankoff, Anna ^a   Banasik, Anna ^a   Obe, Guenter ^b   Deperas, Marta ^a   Kuzminski, Konrad ^a   Tarczynska, Malgorzata ^c   Jurczak, Tomasz ^c   Wojcik, Andrzej ^a,d  

^a JAN KOCHANOWSKI UNIVERSITY   (Poland)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c UNIVERSITY OF LODZ   (Poland)

^d INSTITUTE OF NUCLEAR CHEMISTRY AND TECHNOLOGY   (Poland)

Author keywords

Apoptosis; CHO K1 cells; Microcystin LR; Mitotic spindle; Polyploid cells

Indexed keywords

CYANOGINOSIN LR; DRINKING WATER;

ANAPHASE; ANIMAL CELL; APOPTOSIS; ARTICLE; BACTERIUM; BIOACCUMULATION; CELL CYCLE; CELL DEATH; CELL STRAIN; CHINESE HAMSTER; CHROMOSOME SEGREGATION; CONTROLLED STUDY; CORRELATION ANALYSIS; GIEMSA STAIN; INCUBATION TIME; MITOSIS SPINDLE; NECROSIS; NONHUMAN; ONSET AGE; REGULATORY MECHANISM; RESERVOIR;

CRICETINAE; CRICETULUS GRISEUS; CYANOBACTERIA;

EID: 0037532605     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-008X(03)00094-2     Document Type: Article

References (46)

1. Amon H. The spindle checkpoint. Curr. Opin. Genet. Dev. 9:1999;69-75.
2. Carmichael W.W. Cyanobacteria secondary metabolites the cyanotoxins . J. Appl. Bacteriol. 72:1992;445-459.
3. Carmichael W.W. The cyanotoxins. Callow J.A. Advances in Botanical Research. 1997;211-256 Academic Press, London.
4. Carmichael W.W. Health effects of toxin-producing cyanobacteria the CyanoHABs″ Hum. Ecol. Risk Assess. 7:2001;1393-1407.
5. Casenghi M., Mangiacasale R., Tuynder M., Caillet-Fauquet P., Elhajouji A., Lavia P., Mousset S., Kirsch-Volders M., Cundari E. p-53-independent apoptosis and p-53-dependent block of DNA replication following mitotic spindle inhibition in human cells. Exp. Cell Res. 250:1999;339-350.
6. Codd G.A., Bell S.G., Kaya K., Ward C.J., Beattie K.A., Metcalf J.S. Cyanobacterial toxins, exposure routes and human health. Eur. J. Phycol. 34:1999;405-415.
7. Erenpreisa J., Cragg M.S. Mitotic death a mechanism of survival? Cancer Cell Int. 23:2001;1-7.
8. Fernandez A., Brautigan D.L., Lamb J.C. Protein phosphatase type 1 in mammalian cell mitosis chromosomal localization and involvement in mitotic exit . J. Cell Biol. 116:1992;1421-1430.
9. Ghosh S., Paweletz N., Schroter D. Failure of kinetochore development and mitotic spindle formation in okadaic acid-induced premature mitosis in HeLa cells. Exp. Cell Res. 201:1992;535-540.
10. Hamm-Alvarez S., Wei X., Berndt N., Runnegar M. Protein phosphatases independently regulate vesicle movement and microtubule subpopulations in hepatocytes. Am. J. Physiol. 271:1996;C929-C943.
11. Hernandez M., Macia M., Padilla C., Del Campo F. Modulation of human polymorphonuclear leukocyte adherence by cyanopeptide toxins. Environ. Res. Sci. 84:2000;64-68.
12. Honkanen R.E., Zwiller J., Moore R.E., Daily S.L., Khatra B.S., Dukelow M., Boynton A.L. Characterization of microcystin-LR, a potent inhibitor of type 1 and 2A protein phosphatases. J. Biol. Chem. 265:1990;19401-19404.
13. Humpage A.R., Falconer I.R. Microcystin-LR and liver tumor promotion effects on cytokinesis, ploidy and apoptosis in cultured hepatocytes . Environ. Toxicol. 14:1999;61-75.
14. Ito E., Kondo F., Terao K., Harada I. Neoplastic nodular formation in mouse liver induced by repeated intraperitoneal injections of microcystin-LR. Toxicon. 35(9):1997;1453-1457.
15. Janssens V., Goris J. Protein phosphatase 2A a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling . Biochem. J. 353:2001;417-439.
16. Jordan, M.A., Wilson, L., 1998. Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr. Opin. Cell Biol. 10(1), 123-130.
17. Kanduc, D., Mittelman, A., Serpico, R., Sinigaglia, E., Sinha, A.A., Natale, C., Santacroce, R., di Corcia, M.G., Lucchese, A., Dini, L., Pani, P., Santacroce, S., Simone, S., Bucci, Farber, E., 2002. Cell death: apoptosis versus necrosis (review). Int. J. Oncol. 21, 165-170.
18. Kato T., Kameoka S., Kimura T., Tanaka S., Nishikawa T., Kobayashi M. p53, mitosis, apoptosis and necrosis as prognostic indicators of long-term survival in breast cancer. Anticancer Res. 22:2002;1105-1112.
19. Khan S.A., Wickstrom M.L., Haschek W.M., Schaeffer D.J., Ghosh S., Beasley V.R. Microcystin-LR and kinetics of cytoskeletal reorganization in hepatocytes, kidney cells and fibroblasts. Nat. Toxins. 4:1996;206-214.
20. Klumpp S., Krieglstein J. Serine/threonine protein phosphatases in apoptosis. Curr.Opin. Pharmacol. 2:2002;458-462.
21. Lawton L.A., Edwords C., Beattie K.A., Pleasante S., Dear G.J., Codd G.A. Isolation and characterization of microcystins from laboratory cultures and environmental samples of Microcystis aeruginosa and from an associated animal toxicosis. Nat. Toxins, 3:1995;50-57.
22. Mankiewicz J., Tarczynska M., Fladmark K.E., Doskeland S.O., Walter Z., Zalewski M. Apoptotic effect of cyanobacterial extract on rat hepatocytes and human lymphocytes. Environ, Toxicol. 16:2001;225-233.
23. Mankiewicz J., Walter Z., Tarczyńska M., Zalewski M., Fladmark K.E., Doskeland S.O. Apoptotic effect of cyanobacterial blooms collected from Polish water reservoirs. Int. J. Occup. Med. Environ. Health. 13:2000;335-344.
24. Mayer-Jaekel R.E., Okhura H., Gomes R., Sunkel C.E., Baumgartner S., Hemmings B.A., Glover D.M. The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase. Cell. 72:1994;621-633.
25. McDermot C.M., Nho C.W., Howard W., Holton B. The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types. Toxicon. 39:1998;1981-1996.
26. Merrick S.E., Trojanowski J.Q., Lee V.M.Y. Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons (NT2N cell). J. Neurosci. 17:1997;5726-5737.
27. Millward T.A., Zolnierowicz S., Hemmings B.A. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem. Sci. 24:1999;186-191.
28. Mistry S.J., Li H., Atweh G.F. Role of protein phosphatases in the cell-cycle-regulated phosphorylation of stathmin. Biochem. J. 334:1998;23-29.
29. Pereira G., Tanaka T.U., Nasmyth K., Schiebel E. Modes of spindle pole body inheritance and segregation of the Bfa 1p-Bub2p checkpoint protein complex. EMBO J. 15:1997;6359-6370.
30. Rieder C.L., Khodjakow A. Mitosis and check-points that control progression through mitosis in vertebrate somatic cells. Prog. Cell Cycle Res. 3:1997;301-312.
31. Sanchez C., Tompa P., Szucs K., Friedrich P., Avila J. Phosphorylation and dephosphorylation in the proline-rich C-terminal domain of microtubule-associated protein 2. Eur. J. Biochem. 241:1996;765-771.
32. Sassoon I., Severin F.F., Andrews P.D., Taba M.R., Kaplan K.B., Ashford A.J., Stark M.J., Sorger P.K., Hyman A.A. Regulation of Saccharomyces cervisiae kinetochores by the type 1 phosphatase Glc7p. Genes Dev. 13:1999;545-555.
33. Snaith H.A., Armstrong C.G., Guo Y., Kaiser K., Cohen P.T.W. Deficiency of protein phosphatase 2A uncouples the nuclear and ceentrosome cycles microtubule star (mts) embryos. J. Cell Sci. 109:1996;3001-3012.
34. Sontag, E., Nunbhakdi-Craig, V., Lee, G., Brandt, R., Kamibayashi, C., Kuret, J., White, C.L., III. Bloom, G.S., Mumby, M.C., 1999. Molecular interactions among protein phosphatase 2A, tau and microtubules: Implications for the regulation of tau phosphorylation and the development of tauopathies. J. Biol. Chem. 274, 25490-25498.
35. Sorger P.K., Dobles M., Tournebize R., Hymann A.A. Coupling cell division and cell death to microtubule dynamics. Curr. Opin. Cell. Biol. 9:1997;807-814.
36. Tournebize R., Andersen S.S., Verde F., Doree M., Karsenti E., Hyman A.A. Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis. EMBO J. 16:1997;5537-5549.
37. Trielli M.O., Andreassen P.R., Lacroix F.B., Margolis R.L. Differential Taxol-dependent arrest of transformed and nontransformed cells in the G1 phase of the cell cycle and specific-related mortality of transformed cells. J. Cell Biol. 135:1996;689-700.
38. Tsujimoto Y., Shimizu S., Eguchi Y., Kamiike W., Matsuda H. Bcl-2 and Bcl-xL block apoptosis as well as necrosis possible involvement of common mediators in apoptotic and necrotic signal transduction pathways . Leukemia Suppl. 3:1997;380-382.
39. Uemura T., Shiomi K., Togashi S., Takeichi M. Mutation of twins encoding a regulator of protein phosphatase 2A leads to pattern duplication in Drosophila imaginal discs. Genes Dev. 7:1993;429-440.
40. Wahl A.F., Donaldson K.L., Fairchild C., Lee F.Y.F., Foster S.A., Demers G.W., Galloway D.A. Loss of normal p53 function confers sensitization to taxol by increasing G2/M arrest and apoptosis. Nat. Med. 2:1996;72-79.
41. Wang B.D., Kuo T.T. Induction of a mitosis delay and cell lysis by high-level secretion of mouse alpha-amylase from Saccharomyces cerevisiae. Appl. Environ. Microbiol. 67:2001;3693-3701.
42. Waters J.C., Chen R.H., Murray A.W., Salmon E.D. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J. Cell Biol. 141:1997;1181-1191.
43. Wera S., Hemmings B. Serine/threonine protein phosphatases. Biochem. J. 311:1995;17-29.
44. Wickstrom M.L., Khan S.A., Haschek W.M., Wyman J.F., Eriksson J.E., Schaeffer D.J., Beasley V.R.1995. Alterations in microtubules, rmediate filaments and microfilaments induced by microcystin-LR in cultured cells. Toxicol. Pathol. 23:1995;326-337.
45. Yan Y., Shay J.W., Wright W.E., Mumby M.C. Inhibition of protein phosphatase activity induces p53-dependent apoptosis in absence of p53 transactivation. J. Biol. Chem. 272:1997;15220-15226.
46. Zheng B., Woo C.F., Kuo J.F. Mitotic arrest and enhanced nuclear protein phosphorylation in human leukemia K562 cells by okadaic acid, a potent protein phosphatase inhibitor and tumor promoter. J. Biol. Chem. 266:1991;10031-10034.