메뉴 건너뛰기




Volumn 36, Issue 12, 1998, Pages 1981-1996

The cyanobacterial toxin, microcystin-LR, can induce apoptosis in a variety of cell types

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CYANOGINOSIN LR; CYTOSKELETON PROTEIN; DNA FRAGMENT; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A;

EID: 0032400774     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0041-0101(98)00128-7     Document Type: Article
Times cited : (144)

References (40)
  • 1
    • 0025823502 scopus 로고
    • The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells
    • Boe, R., Gjertsen, B. T., Vintermyr, O. K., Houge, G., Lanotte, M. and Doskeland, S. O. (1991) The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp. Cell Res. 195, 237-246.
    • (1991) Exp. Cell Res. , vol.195 , pp. 237-246
    • Boe, R.1    Gjertsen, B.T.2    Vintermyr, O.K.3    Houge, G.4    Lanotte, M.5    Doskeland, S.O.6
  • 2
    • 0026651340 scopus 로고
    • Cyanobacterial secondary metabolites - The cyanotoxins
    • Carmichael, W. W. (1992) Cyanobacterial secondary metabolites - the cyanotoxins. J. Appl. Bacteriol. 72, 445-459.
    • (1992) J. Appl. Bacteriol. , vol.72 , pp. 445-459
    • Carmichael, W.W.1
  • 3
    • 0024792262 scopus 로고
    • Protein phosphatases come of age
    • Cohen, P. and Cohen, P. T. W. (1989) Protein phosphatases come of age. J. Biol. Chem. 264, 435-438.
    • (1989) J. Biol. Chem. , vol.264 , pp. 435-438
    • Cohen, P.1    Cohen, P.T.W.2
  • 4
    • 0026766118 scopus 로고
    • The role of the nucleus and other components in toxic cell death produced by alkylating hepatotoxicants
    • Corcoran, G. B. and Ray, S. D. (1992) The role of the nucleus and other components in toxic cell death produced by alkylating hepatotoxicants. Toxicol. Appl. Pharmacol. 113, 167-183.
    • (1992) Toxicol. Appl. Pharmacol. , vol.113 , pp. 167-183
    • Corcoran, G.B.1    Ray, S.D.2
  • 5
    • 0023105617 scopus 로고
    • Ultrastructural changes in the mouse liver induced by hepatotoxin from the freshwater cyanobacterium Microcystis aeruginosa strain 7820
    • Dabholkar, A. S. and Carmichael, W. W. (1987) Ultrastructural changes in the mouse liver induced by hepatotoxin from the freshwater cyanobacterium Microcystis aeruginosa strain 7820. Toxicon 25, 285-292.
    • (1987) Toxicon , vol.25 , pp. 285-292
    • Dabholkar, A.S.1    Carmichael, W.W.2
  • 7
    • 84970582448 scopus 로고
    • Liver pathology in mice in poisoning by the blue-green alga Microcystis aeruginosa
    • Falconer, I. R., Jackson, A. R. B., Langley, J. and Runnegar, M. T. (1981) Liver pathology in mice in poisoning by the blue-green alga Microcystis aeruginosa. Aust. J. Biol. Sci. 34, 179-187.
    • (1981) Aust. J. Biol. Sci. , vol.34 , pp. 179-187
    • Falconer, I.R.1    Jackson, A.R.B.2    Langley, J.3    Runnegar, M.T.4
  • 8
    • 0023628234 scopus 로고
    • Effects of the peptide toxin from microcystis aeruginosa on intracellular calcium, pH and membrane integrity in mammalian cells
    • Falconer, I. R. and Runnegar, T. C. (1987) Effects of the peptide toxin from microcystis aeruginosa on intracellular calcium, pH and membrane integrity in mammalian cells. Chem.-Biol. Interactions 63, 215-225.
    • (1987) Chem.-Biol. Interactions , vol.63 , pp. 215-225
    • Falconer, I.R.1    Runnegar, T.C.2
  • 9
    • 0026544023 scopus 로고
    • Cytoskeletal changes in hepatocytes induced by Microcystis toxins and their relation to hyperphosphorylation of cell proteins
    • Falconer, I. R. and Yeung, D. S. K. (1992) Cytoskeletal changes in hepatocytes induced by Microcystis toxins and their relation to hyperphosphorylation of cell proteins. Chem.-Biol. Interactions 81, 181-196.
    • (1992) Chem.-Biol. Interactions , vol.81 , pp. 181-196
    • Falconer, I.R.1    Yeung, D.S.K.2
  • 10
    • 0025311008 scopus 로고
    • Phosphorylation of Tau proteins: A major event during the process of neurofibrillary degeneration. A comparative study between Alzheimer's disease and Down's syndrome
    • Flament, S., Delacourte, A. and Mann, D. M. A. (1990) Phosphorylation of Tau proteins: a major event during the process of neurofibrillary degeneration. A comparative study between Alzheimer's disease and Down's syndrome. Brain Res. 516, 15-19.
    • (1990) Brain Res. , vol.516 , pp. 15-19
    • Flament, S.1    Delacourte, A.2    Mann, D.M.A.3
  • 13
    • 0027178335 scopus 로고
    • Cell death and the cell cycle: A relationship between transformation and neurodegeneration?
    • Heintz, N. (1993) Cell death and the cell cycle: a relationship between transformation and neurodegeneration? TIBS 18, 157-159.
    • (1993) TIBS , vol.18 , pp. 157-159
    • Heintz, N.1
  • 14
    • 0025201229 scopus 로고
    • Characterization of microcystin-LR, a potent inhibitor of Type 1 and Type 2A protein phosphatases
    • Honkanen, R. E., Zwillers, J., Moore, R. E., Daily, S. L., Khatra, B. S., Dukelow, M. and Boynton, A. L. (1990) Characterization of microcystin-LR, a potent inhibitor of Type 1 and Type 2A protein phosphatases. J. Biol. Chem. 265, 19401-19404.
    • (1990) J. Biol. Chem. , vol.265 , pp. 19401-19404
    • Honkanen, R.E.1    Zwillers, J.2    Moore, R.E.3    Daily, S.L.4    Khatra, B.S.5    Dukelow, M.6    Boynton, A.L.7
  • 15
    • 0021344304 scopus 로고
    • Clinical and pathological changes in sheep experimentally poisoned by the blue - Green alga Microcystis aeruginosa
    • Jackson, A. R. B., McInnes, A., Falconer, I. R. and Runnegar, M. T. C. (1993) Clinical and pathological changes in sheep experimentally poisoned by the blue - green alga Microcystis aeruginosa. Vet. Pathol. 21, 102-113.
    • (1993) Vet. Pathol. , vol.21 , pp. 102-113
    • Jackson, A.R.B.1    McInnes, A.2    Falconer, I.R.3    Runnegar, M.T.C.4
  • 16
    • 0027255417 scopus 로고
    • Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis
    • Kaufmann, S. H., Desnoyers, S., Ottaviano, Y., Davidson, N. E. and Poirier, G. G. (1993) Specific proteolytic cleavage of poly(ADP-ribose) polymerase: An early marker of chemotherapy-induced apoptosis. Cancer Res. 53, 3976-3985.
    • (1993) Cancer Res. , vol.53 , pp. 3976-3985
    • Kaufmann, S.H.1    Desnoyers, S.2    Ottaviano, Y.3    Davidson, N.E.4    Poirier, G.G.5
  • 17
    • 0001082853 scopus 로고
    • The liver and biliary system
    • ed. K. V. F. Jubb, P. C. Kennedy and N. Palmer, 3rd ed., Academic Press, New York
    • Kelly, W. R. (1985) The liver and biliary system. In Pathology of Domestic Animals, ed. K. V. F. Jubb, P. C. Kennedy and N. Palmer, 3rd ed., pp. 239-312. Academic Press, New York.
    • (1985) Pathology of Domestic Animals , pp. 239-312
    • Kelly, W.R.1
  • 18
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J. F. R., Wyllie, A. H. and Currie, A. R. (1972) Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.R.1    Wyllie, A.H.2    Currie, A.R.3
  • 19
    • 0028102478 scopus 로고
    • Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
    • Lazebnik, Y., Kaufmann, S., Desnoyers, S., Poirier, G. and Earnshaw, W. (1994) Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature (London) 371, 346-347.
    • (1994) Nature (London) , vol.371 , pp. 346-347
    • Lazebnik, Y.1    Kaufmann, S.2    Desnoyers, S.3    Poirier, G.4    Earnshaw, W.5
  • 20
    • 85008014440 scopus 로고
    • Identification of okadaic acid as a toxic component of a marine dinonagellate
    • Murakami, Y., Oshima, Y. and Yasumoto, T. (1982) Identification of okadaic acid as a toxic component of a marine dinonagellate. Bull. Jpn. Soc. Sci. Fish 48, 69-72.
    • (1982) Bull. Jpn. Soc. Sci. Fish , vol.48 , pp. 69-72
    • Murakami, Y.1    Oshima, Y.2    Yasumoto, T.3
  • 21
    • 0027057360 scopus 로고
    • Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes
    • Ohta, T., Nishiwaki, R., Yatsunami, J., Komori, A., Suganuma, M. and Fujiki, H. (1992) Hyperphosphorylation of cytokeratins 8 and 18 by microcystin-LR, a new liver tumor promoter, in primary cultured rat hepatocytes. Carcinogenesis 13, 2443-2447.
    • (1992) Carcinogenesis , vol.13 , pp. 2443-2447
    • Ohta, T.1    Nishiwaki, R.2    Yatsunami, J.3    Komori, A.4    Suganuma, M.5    Fujiki, H.6
  • 22
    • 0030434801 scopus 로고    scopus 로고
    • Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment
    • Ray, S. D., Mumaw, V. R., Raje, R. R. and Fariss, M. W. (1996) Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J. Pharmacol. Exp. Ther. 279, 1470-1483.
    • (1996) J. Pharmacol. Exp. Ther. , vol.279 , pp. 1470-1483
    • Ray, S.D.1    Mumaw, V.R.2    Raje, R.R.3    Fariss, M.W.4
  • 23
    • 0028072225 scopus 로고
    • Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells
    • Re, F., Zanetti, A., Sironi, M., Polentarutti, N., Lanfrancone, L., Dejana, E. and Colotta, F. (1994) Inhibition of anchorage-dependent cell spreading triggers apoptosis in cultured human endothelial cells. J. Cell Biol. 127, 537-546.
    • (1994) J. Cell Biol. , vol.127 , pp. 537-546
    • Re, F.1    Zanetti, A.2    Sironi, M.3    Polentarutti, N.4    Lanfrancone, L.5    Dejana, E.6    Colotta, F.7
  • 24
    • 0028065199 scopus 로고
    • Molecular structure of the cyanobaterial tumor-promoting microcystins
    • Rudolph-Bohner, S., Mierke, D. F. and Moroder, L. (1994) Molecular structure of the cyanobaterial tumor-promoting microcystins. FEBS Letters 349, 319-323.
    • (1994) FEBS Letters , vol.349 , pp. 319-323
    • Rudolph-Bohner, S.1    Mierke, D.F.2    Moroder, L.3
  • 25
    • 0028806986 scopus 로고
    • Microcystin uptake and inhibition of protein phosphatases: Effects of chemoprotectants and self-inhibition in relation to known hepatic transporters
    • Runnegar, M., Berndt, N. and Kaplowitz, N. (1995) Microcystin uptake and inhibition of protein phosphatases: Effects of chemoprotectants and self-inhibition in relation to known hepatic transporters. Toxicol. Appl. Pharmacol. 134, 264-272.
    • (1995) Toxicol. Appl. Pharmacol. , vol.134 , pp. 264-272
    • Runnegar, M.1    Berndt, N.2    Kaplowitz, N.3
  • 26
    • 0027225797 scopus 로고
    • Protein phosphatase inhibition and in-vivo hepatotoxicity of microcystins
    • Runnegar, M. T., Kong, S. and Berndt, N. (1993) Protein phosphatase inhibition and in-vivo hepatotoxicity of microcystins. Am. Physiol. Soc. 265, G224-G231.
    • (1993) Am. Physiol. Soc. , vol.265
    • Runnegar, M.T.1    Kong, S.2    Berndt, N.3
  • 27
    • 0023465354 scopus 로고
    • Injury to hepatocytes induced by a peptide toxin from the cyanobacterium Microcystis aeruginosa
    • Runnegar, M. T. C., Andrews, J., Gerdes, R. G. and Falconer, I. R. (1987) Injury to hepatocytes induced by a peptide toxin from the cyanobacterium Microcystis aeruginosa. Toxicon 25, 1235-1239.
    • (1987) Toxicon , vol.25 , pp. 1235-1239
    • Runnegar, M.T.C.1    Andrews, J.2    Gerdes, R.G.3    Falconer, I.R.4
  • 28
    • 0022633143 scopus 로고
    • Effect of toxin from the cyanobacterium microcystis aeruginosa on ultrastructural morphology and actin polymerization in isolated hepatocytes
    • Runnegar, M. T. C. and Falconer, I. R. (1986) Effect of toxin from the cyanobacterium microcystis aeruginosa on ultrastructural morphology and actin polymerization in isolated hepatocytes. Toxicon 24, 109-115.
    • (1986) Toxicon , vol.24 , pp. 109-115
    • Runnegar, M.T.C.1    Falconer, I.R.2
  • 29
    • 0027994239 scopus 로고
    • Cell nucleus and DNA fragmentation are not required for apoptosis
    • Schulze-Osthoff, K. H., Walczak, W., Droge, W. and Krammer, P. H. (1994) Cell nucleus and DNA fragmentation are not required for apoptosis. J. Cell Biol. 127, 15-20.
    • (1994) J. Cell Biol. , vol.127 , pp. 15-20
    • Schulze-Osthoff, K.H.1    Walczak, W.2    Droge, W.3    Krammer, P.H.4
  • 30
    • 0027479977 scopus 로고
    • Apoptosis: The biochemistry and molecular biology of programmed cell death
    • Schwartzman, R. A. and Cidlowski, J. A. (1993) Apoptosis: The biochemistry and molecular biology of programmed cell death. Endocrine Rev. 14, 133-151.
    • (1993) Endocrine Rev. , vol.14 , pp. 133-151
    • Schwartzman, R.A.1    Cidlowski, J.A.2
  • 31
    • 0017101039 scopus 로고
    • Preparation of isolated rat liver cells
    • Academic Press, New York
    • Seglen, P. O. (1976) Preparation of isolated rat liver cells. In Methods in Cell Biology, pp. 29-83. Academic Press, New York.
    • (1976) Methods in Cell Biology , pp. 29-83
    • Seglen, P.O.1
  • 33
    • 0026599593 scopus 로고
    • Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: Effects of Ca(2+)-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death
    • Shen, W., Kamendulis, L. M., Ray, S. D. and Corcoran, G. B. (1992) Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: effects of Ca(2+)-endonuclease, DNA repair, and glutathione depletion inhibitors on DNA fragmentation and cell death. Toxicol. Appl. Pharmacol. 112, 32-40.
    • (1992) Toxicol. Appl. Pharmacol. , vol.112 , pp. 32-40
    • Shen, W.1    Kamendulis, L.M.2    Ray, S.D.3    Corcoran, G.B.4
  • 35
    • 0014444144 scopus 로고
    • A low-viscosity embedding medium for electron microscopy
    • Spurr, A. R. (1969) A low-viscosity embedding medium for electron microscopy. J. Ultrastruct. Res. 26, 31-43.
    • (1969) J. Ultrastruct. Res. , vol.26 , pp. 31-43
    • Spurr, A.R.1
  • 36
    • 0028929328 scopus 로고
    • Mechanisms and genes of cellular suicide
    • Steller, H. (1995) Mechanisms and genes of cellular suicide. Science 267, 1445-1449.
    • (1995) Science , vol.267 , pp. 1445-1449
    • Steller, H.1
  • 38
    • 0027062881 scopus 로고
    • Substances that protect cultured hepatocytes from the toxic effects of microcystin-LR
    • Thompson, W. L. and Pace, J. G. (1992) Substances that protect cultured hepatocytes from the toxic effects of microcystin-LR. Toxic in Vitro 6, 579-587.
    • (1992) Toxic in Vitro , vol.6 , pp. 579-587
    • Thompson, W.L.1    Pace, J.G.2
  • 39
    • 0028326952 scopus 로고
    • An evolutionary perspective on apoptosis
    • Vaux, D. L., Haecker, G. and Strasser, A. (1994) An evolutionary perspective on apoptosis. Cell 76, 777-779.
    • (1994) Cell , vol.76 , pp. 777-779
    • Vaux, D.L.1    Haecker, G.2    Strasser, A.3
  • 40
    • 0028338833 scopus 로고
    • Endonuclease activities associated with high molecular weight and internucleosomal DNA fragmentation in apoptosis
    • Walker, P. R., Weaver, V. M., Lach, B., LeBlanc, J. and Sikorska, M. (1994) Endonuclease activities associated with high molecular weight and internucleosomal DNA fragmentation in apoptosis. EMBO J. 213, 100-106.
    • (1994) EMBO J. , vol.213 , pp. 100-106
    • Walker, P.R.1    Weaver, V.M.2    Lach, B.3    Leblanc, J.4    Sikorska, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.