-
1
-
-
0024336365
-
Molecular mechanisms of oncogenesis
-
Seemayer, T. A., Cavenee, W. K. Molecular Mechanisms of Oncogenesis. Lab. Invest. 60, 585-599 (1989).
-
(1989)
Lab. Invest.
, vol.60
, pp. 585-599
-
-
Seemayer, T.A.1
Cavenee, W.K.2
-
2
-
-
0033212143
-
p53 tumor suppressor gene therapy for cancer
-
Roth, J. A., Swisher, S. G., Meyn, R. E. p53 Tumor Suppressor Gene Therapy for Cancer. Oncology 13, 148-154 (1999).
-
(1999)
Oncology
, vol.13
, pp. 148-154
-
-
Roth, J.A.1
Swisher, S.G.2
Meyn, R.E.3
-
3
-
-
0033452585
-
A paradigm for cancer treatment using the retinoblastoma gene in a mouse model
-
Nikitin, A. Y., Riley, D. J., Lee, W. H. A Paradigm for Cancer Treatment Using the Retinoblastoma Gene in a Mouse Model. Ann. N. Y. Acad. Sci. 886, 12-22 (1999).
-
(1999)
Ann. N. Y. Acad. Sci.
, vol.886
, pp. 12-22
-
-
Nikitin, A.Y.1
Riley, D.J.2
Lee, W.H.3
-
4
-
-
15644369261
-
Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer
-
Cheney, I. W., Johnson, D. E., Vaillancourt, M. T., Avanzini, J., Morimoto, A., Demers, G. W., Wills, K. N., Shabram, P. W., Bolen, J. B., Tavtigian, S. V., Bookstein, R. Suppression of Tumorigenicity of Glioblastoma Cells by Adenovirus-mediated MMAC1/PTEN Gene Transfer. Cancer Res. 58, 2331-2334 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 2331-2334
-
-
Cheney, I.W.1
Johnson, D.E.2
Vaillancourt, M.T.3
Avanzini, J.4
Morimoto, A.5
Demers, G.W.6
Wills, K.N.7
Shabram, P.W.8
Bolen, J.B.9
Tavtigian, S.V.10
Bookstein, R.11
-
5
-
-
0031418312
-
Adenovirus-mediated delivery of p16 to p16-deficient human bladder cancer cells confers chemoresistance to cisplatin and paclitaxel
-
Grim, J., D'Amico, A., Frizelle, S., Zhou, J., Kratzke, R. A., Curiel, D. T. Adenovirus-mediated Delivery of p16 to p16-deficient Human Bladder Cancer Cells Confers Chemoresistance to Cisplatin and Paclitaxel. Clin. Cancer Res. 3, 2415-2423 (1997).
-
(1997)
Clin. Cancer Res.
, vol.3
, pp. 2415-2423
-
-
Grim, J.1
D'Amico, A.2
Frizelle, S.3
Zhou, J.4
Kratzke, R.A.5
Curiel, D.T.6
-
6
-
-
0035164924
-
Clinical evaluation of adenoviral-mediated p53 gene transfer: Review of INGN 201 studies
-
Merritt, J. A., Roth, J. A., Logothetis, C. J. Clinical Evaluation of Adenoviral-mediated p53 Gene Transfer: Review of INGN 201 Studies. Semin. Oncol. 28, 105-114 (2001).
-
(2001)
Semin. Oncol.
, vol.28
, pp. 105-114
-
-
Merritt, J.A.1
Roth, J.A.2
Logothetis, C.J.3
-
7
-
-
0028672529
-
The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin
-
Dameron, K. M., Volpert, O. V., Tainsky, M. A., Bouck, N. The p53 Tumor Suppressor Gene Inhibits Angiogenesis by Stimulating the Production of Thrombospondin. Cold Spring Harb. Symp. Quant. Biol. 59, 483-489 (1994).
-
(1994)
Cold Spring Harb. Symp. Quant. Biol.
, vol.59
, pp. 483-489
-
-
Dameron, K.M.1
Volpert, O.V.2
Tainsky, M.A.3
Bouck, N.4
-
8
-
-
0032101647
-
Adenovirus-mediated wild-type p53 gene transfer down-regulates vascular endothelial growth factor expression and inhibits angiogenesis in human colon cancer
-
Bouvet, M., Ellis, L. M., Nishizaki, M., Fujiwara, T., Liu, W., Bucana, C. D., Fang, B., Lee, J. J., Roth, J. A. Adenovirus-mediated Wild-type p53 Gene Transfer Down-regulates Vascular Endothelial Growth Factor Expression and Inhibits Angiogenesis in Human Colon Cancer. Cancer Res. 58, 2288-2292 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 2288-2292
-
-
Bouvet, M.1
Ellis, L.M.2
Nishizaki, M.3
Fujiwara, T.4
Liu, W.5
Bucana, C.D.6
Fang, B.7
Lee, J.J.8
Roth, J.A.9
-
9
-
-
0032902502
-
Recombinant adenovirus expressing wild-type p53 is antiangiogenic: A proposed mechanism for bystander effect
-
Nishizaki, M., Fujiwara, T., Tanida, T., Hizuta, A., Nishimori, H., Tokino, T., Nakamura, Y., Bouvet, M., Roth, J. A., Tanaka, N. Recombinant Adenovirus Expressing Wild-type p53 is Antiangiogenic: A Proposed Mechanism for Bystander Effect. Clin. Cancer Res. 5, 1015-1023 (1999).
-
(1999)
Clin. Cancer Res.
, vol.5
, pp. 1015-1023
-
-
Nishizaki, M.1
Fujiwara, T.2
Tanida, T.3
Hizuta, A.4
Nishimori, H.5
Tokino, T.6
Nakamura, Y.7
Bouvet, M.8
Roth, J.A.9
Tanaka, N.10
-
10
-
-
0035184722
-
P53 gene replacement for cancer-interactions with DNA damaging agents
-
Roth, J. A., Grammer, S. F., Swisher, S. G., Komaki, R., Nemunaitis, J., Merritt, J., Meyn, R. E. P53 Gene Replacement for Cancer-interactions with DNA Damaging Agents. Acta Oncol. 40, 739-744 (2001).
-
(2001)
Acta Oncol.
, vol.40
, pp. 739-744
-
-
Roth, J.A.1
Grammer, S.F.2
Swisher, S.G.3
Komaki, R.4
Nemunaitis, J.5
Merritt, J.6
Meyn, R.E.7
-
12
-
-
0035502497
-
Antisense anticancer oligonucleotide therapeutics
-
Wang, H., Prasad, G., Buolamwini, J. K., Zhang, R. Antisense Anticancer Oligonucleotide Therapeutics. Curr. Cancer Drug Targets 1, 177-196 (2001).
-
(2001)
Curr. Cancer Drug Targets
, vol.1
, pp. 177-196
-
-
Wang, H.1
Prasad, G.2
Buolamwini, J.K.3
Zhang, R.4
-
13
-
-
0035217928
-
BCL2 antisense transcripts decrease intracellular Bcl2 expression and sensitize LNCaP prostate cancer cells to apoptosis-inducing agents
-
Shi, X. B., Gumerlock, P. H., Muenzer, J. T., deVere White, R. W. BCL2 Antisense Transcripts Decrease Intracellular Bcl2 Expression and Sensitize LNCaP Prostate Cancer Cells to Apoptosis-inducing Agents. Cancer Biother. Radiopharm. 16. 421-429 (2001).
-
(2001)
Cancer Biother. Radiopharm.
, vol.16
, pp. 421-429
-
-
Shi, X.B.1
Gumerlock, P.H.2
Muenzer, J.T.3
DeVere White, R.W.4
-
14
-
-
0032079761
-
BCR-ABL antisense oligodeoxynucleotide in vitro purging and autologous bone marrow transplantation for patients with chronic myelogenous leukemia in advanced phase
-
de Fabritiis, P., Petti, M. C., Montefusco, E., De Propris, M. S., Sala, R., Bellucci, R., Mancini, M., Lisci, A., Bonetto, F., Geiser, T., Calabretta, B., Mandelli, F. BCR-ABL Antisense Oligodeoxynucleotide in vitro Purging and Autologous Bone Marrow Transplantation for Patients with Chronic Myelogenous Leukemia in Advanced Phase. Blood 91, 3156-3162 (1998).
-
(1998)
Blood
, vol.91
, pp. 3156-3162
-
-
De Fabritiis, P.1
Petti, M.C.2
Montefusco, E.3
De Propris, M.S.4
Sala, R.5
Bellucci, R.6
Mancini, M.7
Lisci, A.8
Bonetto, F.9
Geiser, T.10
Calabretta, B.11
Mandelli, F.12
-
15
-
-
0024580323
-
Effect of antisense c-raf-1 on tumorigenicity and radiation sensitivity of a human squamous carcinoma
-
Kasid, U., Pfeifer, A., Brennan, T., Beckett, M., Weichselbaum, R. R., Dritschilo, A., Mark, G. E. Effect of Antisense c-raf-1 on Tumorigenicity and Radiation Sensitivity of a Human Squamous Carcinoma. Science 243, 1354-1356 (1989).
-
(1989)
Science
, vol.243
, pp. 1354-1356
-
-
Kasid, U.1
Pfeifer, A.2
Brennan, T.3
Beckett, M.4
Weichselbaum, R.R.5
Dritschilo, A.6
Mark, G.E.7
-
16
-
-
0026377424
-
Inhibition of c-myc expression by phosphorothioate antisense oligonucleotide identifies a critical role for c-myc in the growth of human breast cancer
-
Watson, P. H., Pon, R. T., Shiu, R. P. Inhibition of c-myc Expression by Phosphorothioate Antisense Oligonucleotide Identifies a Critical Role for c-myc in the Growth of Human Breast Cancer. Cancer Res. 51, 3996-4000 (1991).
-
(1991)
Cancer Res.
, vol.51
, pp. 3996-4000
-
-
Watson, P.H.1
Pon, R.T.2
Shiu, R.P.3
-
17
-
-
0035186743
-
Antisense anti-MDM2 oligonucleotides as a novel therapeutic approach to human breast cancer: In vitro and in vivo activities and mechanisms
-
Wang, H., Nan, L., Yu, D., Agrawal, S., Zhang, R. Antisense Anti-MDM2 Oligonucleotides as a Novel Therapeutic Approach to Human Breast Cancer: in vitro and in vivo Activities and Mechanisms. Clin. Cancer Res. 7, 3613-3624 (2001).
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 3613-3624
-
-
Wang, H.1
Nan, L.2
Yu, D.3
Agrawal, S.4
Zhang, R.5
-
18
-
-
0024291288
-
Simple RNA enzymes with new and highly specific endoribonuclease activities
-
Haseloff, J., Gerlach, W. L. Simple RNA Enzymes with New and Highly Specific Endoribonuclease Activities. Nature 334, 585-591 (1988).
-
(1988)
Nature
, vol.334
, pp. 585-591
-
-
Haseloff, J.1
Gerlach, W.L.2
-
19
-
-
0023239517
-
Functional inactivation of genes by dominant negative mutations
-
Herskowitz, I. Functional Inactivation of Genes by Dominant Negative Mutations. Nature 329, 219-222 (1987).
-
(1987)
Nature
, vol.329
, pp. 219-222
-
-
Herskowitz, I.1
-
20
-
-
0026058365
-
A dominant negative mutation suppresses the function of normal epidermal growth factor receptors by heterodimerization
-
Kashles, O., Yarden, Y., Fischer, R., Ullrich, A., Schlessinger, J. A Dominant Negative Mutation Suppresses the Function of Normal Epidermal Growth Factor Receptors by Heterodimerization. Mol. Cell Biol, 11, 1454-1463 (1991).
-
(1991)
Mol. Cell Biol.
, vol.11
, pp. 1454-1463
-
-
Kashles, O.1
Yarden, Y.2
Fischer, R.3
Ullrich, A.4
Schlessinger, J.5
-
21
-
-
0025734507
-
Inhibition of PDGF beta receptor signal transduction by coexpression of a truncated receptor
-
Ueno, H., Colbert, H., Escobedo, J. A., Williams, L. T. Inhibition of PDGF Beta Receptor Signal Transduction by Coexpression of a Truncated Receptor. Science 252, 844-848 (1991).
-
(1991)
Science
, vol.252
, pp. 844-848
-
-
Ueno, H.1
Colbert, H.2
Escobedo, J.A.3
Williams, L.T.4
-
22
-
-
0026548073
-
Dominant negative mutants of transforming growth factor-beta 1 inhibit the secretion of different transforming growth factor-beta isoforms
-
Lopez, A. R., Cook, J., Deininger, P. L., Derynck, R. Dominant Negative Mutants of Transforming Growth Factor-beta 1 Inhibit the Secretion of Different Transforming Growth Factor-beta Isoforms. Mol. Cell Biol. 12, 1674-1679 (1992).
-
(1992)
Mol. Cell Biol.
, vol.12
, pp. 1674-1679
-
-
Lopez, A.R.1
Cook, J.2
Deininger, P.L.3
Derynck, R.4
-
23
-
-
0027361809
-
Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells
-
Shamah, S. M., Stiles, C. D., Guha, A. Dominant-negative Mutants of Platelet-derived Growth Factor Revert the Transformed Phenotype of Human Astrocytoma Cells. Mol. Cell Biol. 13, 7203-7212 (1993).
-
(1993)
Mol. Cell Biol.
, vol.13
, pp. 7203-7212
-
-
Shamah, S.M.1
Stiles, C.D.2
Guha, A.3
-
24
-
-
0028265209
-
Dominant negative inhibition of tumorigenesis in vivo by human insulin-like growth factor I receptor mutant
-
Prager, D., Li, H. L., Asa, S., Melmed, S. Dominant Negative Inhibition of Tumorigenesis in vivo by Human Insulin-like Growth Factor I Receptor Mutant. Proc. Natl Acad. Sci. USA 91, 2181-2185 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 2181-2185
-
-
Prager, D.1
Li, H.L.2
Asa, S.3
Melmed, S.4
-
25
-
-
0037439923
-
Overexpression of a dominant negative type II bone morphogenetic protein receptor inhibits the growth of human breast cancer cells
-
Pouliot, F., Blais, A., Labrie, C. Overexpression of a Dominant Negative Type II Bone Morphogenetic Protein Receptor Inhibits the Growth of Human Breast Cancer Cells. Cancer Res. 63, 277-281 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 277-281
-
-
Pouliot, F.1
Blais, A.2
Labrie, C.3
-
26
-
-
0028500163
-
Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines
-
Deshane, J., Loechel, F., Conry, R. M., Siegal, G. P., King, C. R., Curiel, D. T. Intracellular Single-chain Antibody Directed Against erbB2 Down-regulates Cell Surface erbB2 and Exhibits a Selective Anti-proliferative Effect in erbB2 Overexpressing Cancer Cell Lines. Gene Ther. 1, 332-337 (1994).
-
(1994)
Gene Ther.
, vol.1
, pp. 332-337
-
-
Deshane, J.1
Loechel, F.2
Conry, R.M.3
Siegal, G.P.4
King, C.R.5
Curiel, D.T.6
-
27
-
-
0028823836
-
Targeted eradication of ovarian cancer mediated by intracellular expression of anti-erbB-2 single-chain antibody
-
Deshane, J., Cabrera, G., Grim, J. E., Siegal, G. P., Pike, J., Alvarez, R. D., Curiel, D. T. Targeted Eradication of Ovarian Cancer Mediated by Intracellular Expression of Anti-erbB-2 Single-chain Antibody. Gynecol. Oncol. 59, 8-14 (1995).
-
(1995)
Gynecol. Oncol.
, vol.59
, pp. 8-14
-
-
Deshane, J.1
Cabrera, G.2
Grim, J.E.3
Siegal, G.P.4
Pike, J.5
Alvarez, R.D.6
Curiel, D.T.7
-
28
-
-
0036196127
-
Effective single chain antibody (scFv) concentrations in vivo via adenoviral vector mediated expression of secretory scFv
-
Arafat, W. O., Gomez-Navarro, J., Buchsbaum, D. J., Xiang, J., Wang, M., Casado, E., Barker, S. D., Mahasreshti, P. J., Haisma, H. J., Barnes, M. N., Siegal, G. P., Alvarez, R. D., Hemminki, A., Nettelbeck, D. M., Curiel, D. T. Effective Single Chain Antibody (scFv) Concentrations in vivo via Adenoviral Vector Mediated Expression of Secretory scFv. Gene Ther. 9, 256-262 (2002).
-
(2002)
Gene Ther.
, vol.9
, pp. 256-262
-
-
Arafat, W.O.1
Gomez-Navarro, J.2
Buchsbaum, D.J.3
Xiang, J.4
Wang, M.5
Casado, E.6
Barker, S.D.7
Mahasreshti, P.J.8
Haisma, H.J.9
Barnes, M.N.10
Siegal, G.P.11
Alvarez, R.D.12
Hemminki, A.13
Nettelbeck, D.M.14
Curiel, D.T.15
-
29
-
-
0025241769
-
Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors
-
Moolten, F. L., Wells, J. M. Curability of Tumors Bearing Herpes Thymidine Kinase Genes Transferred by Retroviral Vectors. J. Natl Cancer Inst. 82, 297-300 (1990).
-
(1990)
J. Natl. Cancer Inst.
, vol.82
, pp. 297-300
-
-
Moolten, F.L.1
Wells, J.M.2
-
30
-
-
0030937485
-
Gap junctions promote the bystander effect of herpes simplex virus thymidine kinase in vivo
-
Dilber, M. S., Abedi, M. R., Christensson, B., Bjorkstrand, B., Kidder, G. M., Naus, C. C., Gahrton, G., Smith, C. I. Gap Junctions Promote the Bystander Effect of Herpes Simplex Virus Thymidine Kinase in vivo. Cancer Res. 57, 1523-1528 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 1523-1528
-
-
Dilber, M.S.1
Abedi, M.R.2
Christensson, B.3
Bjorkstrand, B.4
Kidder, G.M.5
Naus, C.C.6
Gahrton, G.7
Smith, C.I.8
-
31
-
-
0032053744
-
Adenoviral-mediated transfer of a heat-inducible double suicide gene into prostate carcinoma cells
-
Blackburn, R. V., Galoforo, S. S., Corry, P. M., Lee, Y. J. Adenoviral-mediated Transfer of a Heat-inducible Double Suicide Gene into Prostate Carcinoma Cells. Cancer Res. 58, 1358-1362 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 1358-1362
-
-
Blackburn, R.V.1
Galoforo, S.S.2
Corry, P.M.3
Lee, Y.J.4
-
32
-
-
0031024794
-
Glioma cells transduced with an Escherichia coli CD/HSV-1 TK fusion gene exhibit enhanced metabolic suicide and radiosensitivity
-
Rogulski, K. R., Kim, J. H., Kim, S. H., Freytag, S. O. Glioma Cells Transduced with an Escherichia Coli CD/HSV-1 TK Fusion Gene Exhibit Enhanced Metabolic Suicide and Radiosensitivity. Hum. Gene Ther. 8, 73-85 (1997).
-
(1997)
Hum. Gene Ther.
, vol.8
, pp. 73-85
-
-
Rogulski, K.R.1
Kim, J.H.2
Kim, S.H.3
Freytag, S.O.4
-
33
-
-
0032481577
-
Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies
-
Aghi, M., Kramm, C. M., Chou, T. C., Breakefield, X. O., Chiocca, E. A. Synergistic Anticancer Effects of Ganciclovir/thymidine Kinase and 5-fluorocytosine/cytosine Deaminase Gene Therapies. J. Natl Cancer Inst. 90, 370-380 (1998).
-
(1998)
J. Natl. Cancer Inst.
, vol.90
, pp. 370-380
-
-
Aghi, M.1
Kramm, C.M.2
Chou, T.C.3
Breakefield, X.O.4
Chiocca, E.A.5
-
34
-
-
0030817590
-
Molecular chemotherapy combined with radiation therapy enhances killing of cholangiocarcinoma cells in vitro and in vivo
-
Pederson, L. C., Buchsbaum, D. J., Vickers, S. M., Kancharla, S. R., Mayo, M. S., Curiel, D. T., Stackhouse, M. A. Molecular Chemotherapy Combined with Radiation Therapy Enhances Killing of Cholangiocarcinoma Cells in vitro and in vivo. Cancer Res. 57, 4325-4332 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 4325-4332
-
-
Pederson, L.C.1
Buchsbaum, D.J.2
Vickers, S.M.3
Kancharla, S.R.4
Mayo, M.S.5
Curiel, D.T.6
Stackhouse, M.A.7
-
35
-
-
0026772206
-
In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
-
Culver, K. W., Ram, Z., Wallbridge, S., Ishii, H., Oldfield, E. H., Blaese, R. M. In vivo Gene Transfer with Retroviral Vector-producer Cells for Treatment of Experimental Brain Tumors. Science 256, 1550-1552 (1992).
-
(1992)
Science
, vol.256
, pp. 1550-1552
-
-
Culver, K.W.1
Ram, Z.2
Wallbridge, S.3
Ishii, H.4
Oldfield, E.H.5
Blaese, R.M.6
-
36
-
-
0034662654
-
Midkine promoter-based adenoviral vector gene delivery for pediatric solid tumors
-
Adachi, Y., Reynolds, P. N., Yamamoto, M., Grizzle, W. E., Overturf, K., Matsubara, S., Muramatsu, T., Curiel, D. T. Midkine Promoter-based Adenoviral Vector Gene Delivery for Pediatric Solid Tumors. Cancer Res. 60, 4305-4310 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 4305-4310
-
-
Adachi, Y.1
Reynolds, P.N.2
Yamamoto, M.3
Grizzle, W.E.4
Overturf, K.5
Matsubara, S.6
Muramatsu, T.7
Curiel, D.T.8
-
37
-
-
0035030329
-
The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters
-
Majumdar, A. S., Hughes, D. E., Lichtsteiner, S. P., Wang, Z., Lebkowski, J. S., Vasserot, A. P. The Telomerase Reverse Transcriptase Promoter Drives Efficacious Tumor Suicide Gene Therapy while Preventing Hepatotoxicity Encountered with Constitutive Promoters. Gene Ther. 8, 568-578 (2001).
-
(2001)
Gene Ther.
, vol.8
, pp. 568-578
-
-
Majumdar, A.S.1
Hughes, D.E.2
Lichtsteiner, S.P.3
Wang, Z.4
Lebkowski, J.S.5
Vasserot, A.P.6
-
38
-
-
0034981040
-
Characterization of the cyclooxygenase-2 promoter in an adenoviral vector and its application for the mitigation of toxicity in suicide gene therapy of gastrointestinal cancers
-
Yamamoto, M., Alemany, R., Adachi, Y., Grizzle, W. E., Curiel, D. T. Characterization of the Cyclooxygenase-2 Promoter in an Adenoviral Vector and its Application for the Mitigation of Toxicity in Suicide Gene Therapy of Gastrointestinal Cancers. Mol. Ther. 3, 385-394 (2001).
-
(2001)
Mol. Ther.
, vol.3
, pp. 385-394
-
-
Yamamoto, M.1
Alemany, R.2
Adachi, Y.3
Grizzle, W.E.4
Curiel, D.T.5
-
39
-
-
0034933220
-
A transcriptional feedback loop for tissue-specific expression of highly cytotoxic genes which incorporates an immunostimulatory component
-
Emiliusen, L., Gough, M., Bateman, A., Ahmed, A., Voellmy, R., Chester, J., Diaz, R. M., Harrington, K., Vile, R. A Transcriptional Feedback Loop for Tissue-specific Expression of Highly Cytotoxic Genes which Incorporates an Immunostimulatory Component. Gene Ther. 8, 987-998 (2001).
-
(2001)
Gene Ther.
, vol.8
, pp. 987-998
-
-
Emiliusen, L.1
Gough, M.2
Bateman, A.3
Ahmed, A.4
Voellmy, R.5
Chester, J.6
Diaz, R.M.7
Harrington, K.8
Vile, R.9
-
40
-
-
0034989410
-
Augmenting transgene expression from carcinoembryonic antigen (CEA) promoter via a GAL4 gene regulatory system
-
Koch, P. E., Guo, Z. S., Kagawa, S., Gu, J., Roth, J. A., Fang, B. Augmenting Transgene Expression from Carcinoembryonic Antigen (CEA) Promoter via a GAL4 Gene Regulatory System. Mol. Ther. 3, 278-283 (2001).
-
(2001)
Mol. Ther.
, vol.3
, pp. 278-283
-
-
Koch, P.E.1
Guo, Z.S.2
Kagawa, S.3
Gu, J.4
Roth, J.A.5
Fang, B.6
-
41
-
-
78651052482
-
Clinical studies of viruses as antineoplastic agents, with particular reference to Egypt 101 virus
-
Southam, C. M., Moore, A. E. Clinical Studies of Viruses as Antineoplastic Agents, with Particular Reference to Egypt 101 Virus. Cancer 5, 1025-1034 (1952).
-
(1952)
Cancer
, vol.5
, pp. 1025-1034
-
-
Southam, C.M.1
Moore, A.E.2
-
42
-
-
77049281450
-
Studies on the use of viruses in the treatment of carcinoma of the cervix
-
Smith, R. R., Huebner, R. J., Rowe, W. P., Schatten, W. E., B., T. L., Studies on the use of Viruses in the Treatment of Carcinoma of the Cervix. Cancer 9, 1211-1218 (1956).
-
(1956)
Cancer
, vol.9
, pp. 1211-1218
-
-
Smith, R.R.1
Huebner, R.J.2
Rowe, W.P.3
Schatten, W.E.4
-
43
-
-
0033929057
-
Exploiting tumor-specific defects in the interferon pathway with a previously unknown oncolytic virus
-
Stojdl, D. F., Lichty, B., Knowles, S., Marius, R., Atkins, H., Sonenberg, N., Bell, J. C. Exploiting Tumor-specific Defects in the Interferon Pathway with a Previously Unknown Oncolytic Virus. Nat. Med. 6, 821-825 (2000).
-
(2000)
Nat. Med.
, vol.6
, pp. 821-825
-
-
Stojdl, D.F.1
Lichty, B.2
Knowles, S.3
Marius, R.4
Atkins, H.5
Sonenberg, N.6
Bell, J.C.7
-
44
-
-
0032515141
-
Reovirus therapy of tumors with activated ras pathway
-
Coffey, M. C., Strong, J. E., Forsyth, P. A., Lee, P. W. Reovirus Therapy of Tumors with Activated Ras Pathway. Science 282, 1332-1334 (1998).
-
(1998)
Science
, vol.282
, pp. 1332-1334
-
-
Coffey, M.C.1
Strong, J.E.2
Forsyth, P.A.3
Lee, P.W.4
-
45
-
-
0035918857
-
Reovirus as an oncolytic agent against experimental human malignant gliomas
-
Wilcox, M. E., Yang, W., Senger, D., Rewcastle, N. B., Morris, D. G., Brasher, P. M., Shi, Z. Q., Johnston, R. N., Nishikawa, S., Lee, P. W., Forsyth, P. A. Reovirus as an Oncolytic Agent Against Experimental Human Malignant Gliomas. J. Natl Cancer Inst. 93, 903-912 (2001).
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 903-912
-
-
Wilcox, M.E.1
Yang, W.2
Senger, D.3
Rewcastle, N.B.4
Morris, D.G.5
Brasher, P.M.6
Shi, Z.Q.7
Johnston, R.N.8
Nishikawa, S.9
Lee, P.W.10
Forsyth, P.A.11
-
46
-
-
0036891871
-
Reovirus therapy of lymphoid malignancies
-
Alain, T., Hirasawa, K., Pon, K. J., Nishikawa, S. G., Urbanski, S. J., Auer, Y., Luider, J., Martin, A., Johnston, R. N., Janowska-Wieczorek, A., Lee, P. W., Kossakowska, A. E. Reovirus Therapy of Lymphoid Malignancies. Blood 100, 4146-4153 (2002).
-
(2002)
Blood
, vol.100
, pp. 4146-4153
-
-
Alain, T.1
Hirasawa, K.2
Pon, K.J.3
Nishikawa, S.G.4
Urbanski, S.J.5
Auer, Y.6
Luider, J.7
Martin, A.8
Johnston, R.N.9
Janowska-Wieczorek, A.10
Lee, P.W.11
Kossakowska, A.E.12
-
47
-
-
0037085930
-
Oncolytic reovirus against ovarian and colon cancer
-
Hirasawa, K., Nishikawa, S. G., Norman, K. L., Alain, T., Kossakowska, A., Lee, P. W. Oncolytic Reovirus Against Ovarian and Colon Cancer. Cancer Res. 62, 1696-1701 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 1696-1701
-
-
Hirasawa, K.1
Nishikawa, S.G.2
Norman, K.L.3
Alain, T.4
Kossakowska, A.5
Lee, P.W.6
-
48
-
-
0036210203
-
Reovirus oncolysis of human breast cancer
-
Norman, K. L., Coffey, M. C., Hirasawa, K., Demetrick, D. J., Nishikawa, S. G., DiFrancesco, L. M., Strong, J. E., Lee, P. W. Reovirus Oncolysis of Human Breast Cancer. Hum. Gene Ther. 13, 641-652 (2002).
-
(2002)
Hum. Gene Ther.
, vol.13
, pp. 641-652
-
-
Norman, K.L.1
Coffey, M.C.2
Hirasawa, K.3
Demetrick, D.J.4
Nishikawa, S.G.5
DiFrancesco, L.M.6
Strong, J.E.7
Lee, P.W.8
-
49
-
-
0035877990
-
Live attenuated measles virus induces regression of human lymphoma xenografts in immunodeficient mice
-
Grote, D., Russell, S. J., Cornu, T. I., Cattaneo, R., Vile, R., Poland, G. A., Fielding, A. K. Live Attenuated Measles Virus Induces Regression of Human Lymphoma Xenografts in Immunodeficient Mice. Blood 97, 3746-3754 (2001).
-
(2001)
Blood
, vol.97
, pp. 3746-3754
-
-
Grote, D.1
Russell, S.J.2
Cornu, T.I.3
Cattaneo, R.4
Vile, R.5
Poland, G.A.6
Fielding, A.K.7
-
50
-
-
0035496901
-
Systemic therapy of myeloma xenografts by an attenuated measles virus
-
Peng, K. W., Ahmann, G. J., Pham, L., Greipp, P. R., Cattaneo, R., Russell, S. J. Systemic Therapy of Myeloma Xenografts by an Attenuated Measles Virus. Blood 98, 2002-2007 (2001).
-
(2001)
Blood
, vol.98
, pp. 2002-2007
-
-
Peng, K.W.1
Ahmann, G.J.2
Pham, L.3
Greipp, P.R.4
Cattaneo, R.5
Russell, S.J.6
-
51
-
-
0037102288
-
Intraperitoneal therapy of ovarian cancer using an engineered measles virus
-
Peng, K. W., TenEyck, C. J., Galanis, E., Kalli, K. R., Hartmann, L. C., Russell, S. J. Intraperitoneal Therapy of Ovarian Cancer using an Engineered Measles Virus. Cancer Res. 62, 4656-4662 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 4656-4662
-
-
Peng, K.W.1
TenEyck, C.J.2
Galanis, E.3
Kalli, K.R.4
Hartmann, L.C.5
Russell, S.J.6
-
52
-
-
0036901289
-
Oncolytic herpes simplex virus vectors for cancer virotherapy
-
Varghese, S., Rabkin, S. D. Oncolytic Herpes Simplex Virus Vectors for Cancer Virotherapy. Cancer Gene Ther. 9, 967-968 (2002).
-
(2002)
Cancer Gene Ther.
, vol.9
, pp. 967-968
-
-
Varghese, S.1
Rabkin, S.D.2
-
53
-
-
0029023868
-
Attenuated multi-mutated herpes simplex virus-1 for the treatment of malignant gliomas
-
Mineta, T., Rabkin, S. D., Yazaki, T., Hunter, W. D., Martuza, R. L. Attenuated Multi-mutated Herpes Simplex Virus-1 for the Treatment of Malignant Gliomas. Nat. Med. 1, 938-943 (1995).
-
(1995)
Nat. Med.
, vol.1
, pp. 938-943
-
-
Mineta, T.1
Rabkin, S.D.2
Yazaki, T.3
Hunter, W.D.4
Martuza, R.L.5
-
54
-
-
12944315014
-
Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: Results of a phase I trial
-
Markert, J. M., Medlock, M. D., Rabkin, S. D., Gillespie, G. Y., Todo, T., Hunter, W. D., Palmer, C. A., Feigenbaum, F., Tornatore, C., Tufaro, F., Martuza, R. L. Conditionally Replicating Herpes Simplex Virus Mutant, G207 for the treatment of Malignant Glioma: Results of a Phase I Trial. Gene Ther. 7, 867-874 (2000).
-
(2000)
Gene Ther.
, vol.7
, pp. 867-874
-
-
Markert, J.M.1
Medlock, M.D.2
Rabkin, S.D.3
Gillespie, G.Y.4
Todo, T.5
Hunter, W.D.6
Palmer, C.A.7
Feigenbaum, F.8
Tornatore, C.9
Tufaro, F.10
Martuza, R.L.11
-
55
-
-
0035933088
-
Oncolytic herpes simplex virus vector with enhanced MHC class I presentation and tumor cell killing
-
Todo, T., Martuza, R. L., Rabkin, S. D., Johnson, P. A. Oncolytic Herpes Simplex Virus Vector with Enhanced MHC Class I Presentation and Tumor Cell Killing. Proc. Natl Acad. Sci. USA 98, 6396-6401 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 6396-6401
-
-
Todo, T.1
Martuza, R.L.2
Rabkin, S.D.3
Johnson, P.A.4
-
56
-
-
0344200002
-
Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies
-
Aghi, M., Chou, T. C., Suling, K., Breakefield, X. O., Chiocca, E. A. Multimodal Cancer Treatment Mediated by a Replicating Oncolytic Virus that Delivers the Oxazaphosphorine/rat Cytochrome P450 2B1 and Ganciclovir/herpes Simplex Virus Thymidine Kinase Gene Therapies. Cancer Res. 59, 3861-3865 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 3861-3865
-
-
Aghi, M.1
Chou, T.C.2
Suling, K.3
Breakefield, X.O.4
Chiocca, E.A.5
-
57
-
-
0034050884
-
Engineered herpes simplex virus expressing IL-12 in the treatment of experimental murine brain tumors
-
Parker, J. N., Gillespie, G. Y., Love, C. E., Randall, S., Whitley, R. J., Markert, J. M. Engineered Herpes Simplex Virus Expressing IL-12 in the Treatment of Experimental Murine Brain Tumors. Proc. Natl Acad. Sci. USA 97, 2208-2213 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 2208-2213
-
-
Parker, J.N.1
Gillespie, G.Y.2
Love, C.E.3
Randall, S.4
Whitley, R.J.5
Markert, J.M.6
-
58
-
-
0033926002
-
Replicative adenoviruses for cancer therapy
-
Alemany, R., Balague, C., Curiel, D. T. Replicative adenoviruses for cancer therapy. Nat. Biotechnol. 18, 723-727 (2000).
-
(2000)
Nat. Biotechnol.
, vol.18
, pp. 723-727
-
-
Alemany, R.1
Balague, C.2
Curiel, D.T.3
-
59
-
-
0344188096
-
An adenovirus mutant that replicates selectively in p53-deficient human tumor cells
-
Bischoff, J. R., Kirn, D. H., Williams, A., Heise, C., Horn, S., Muna, M., Ng, L., Nye, J. A., Sampson-Johannes, A., Fattaey, A., McCormick, F. An Adenovirus Mutant that Replicates Selectively in p53-deficient Human Tumor Cells. Science 274, 373-376 (1996).
-
(1996)
Science
, vol.274
, pp. 373-376
-
-
Bischoff, J.R.1
Kirn, D.H.2
Williams, A.3
Heise, C.4
Horn, S.5
Muna, M.6
Ng, L.7
Nye, J.A.8
Sampson-Johannes, A.9
Fattaey, A.10
McCormick, F.11
-
60
-
-
0031759169
-
ONYX-015: Clinical data are encouraging
-
Kirn, D., Hermiston, T., McCormick, F. ONYX-015: Clinical Data are Encouraging. Nat. Med. 4, 1341-1342 (1998).
-
(1998)
Nat. Med.
, vol.4
, pp. 1341-1342
-
-
Kirn, D.1
Hermiston, T.2
McCormick, F.3
-
61
-
-
12944328660
-
A phase I study of Onyx-015, an E1B attenuated adenovirus, administered intratumorally to patients with recurrent head and neck cancer
-
Ganly, I., Kirn, D., Eckhardt, G., Rodriguez, G. I., Soutar, D. S., Otto, R., Robertson, A. G., Park, O., Gulley, M. L., Heise, C., Von Hoff, D. D., Kaye, S. B., Eckhardt, S. G. A Phase I Study of Onyx-015, An E1B Attenuated Adenovirus, Administered Intratumorally to Patients with Recurrent Head and Neck Cancer. Clin. Cancer Res. 6, 798-806 (2000).
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 798-806
-
-
Ganly, I.1
Kirn, D.2
Eckhardt, G.3
Rodriguez, G.I.4
Soutar, D.S.5
Otto, R.6
Robertson, A.G.7
Park, O.8
Gulley, M.L.9
Heise, C.10
Von Hoff, D.D.11
Kaye, S.B.12
Eckhardt, S.G.13
-
62
-
-
0033831080
-
A controlled trial of intratumoral ONYX-015. A selectively-replicating adenovirus in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer
-
Khuri, F. R., Nemunaitis, J., Ganly, I., Arseneau, J., Tannock, I. F., Romel, L., Gore, M., Ironside, J., MacDougall, R. H., Heise, C., Randlev, B., Gillenwater, A. M., Bruso, P., Kaye, S. B., Hong, W. K., Kirn, D. H. A Controlled Trial of Intratumoral ONYX-015. A Selectively-replicating Adenovirus, in Combination with Cisplatin and 5-fluorouracil in Patients with Recurrent Head and Neck Cancer. Nat. Med. 6, 879-885 (2000).
-
(2000)
Nat. Med.
, vol.6
, pp. 879-885
-
-
Khuri, F.R.1
Nemunaitis, J.2
Ganly, I.3
Arseneau, J.4
Tannock, I.F.5
Romel, L.6
Gore, M.7
Ironside, J.8
MacDougall, R.H.9
Heise, C.10
Randlev, B.11
Gillenwater, A.M.12
Bruso, P.13
Kaye, S.B.14
Hong, W.K.15
Kirn, D.H.16
-
63
-
-
0034610723
-
A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo
-
Fueyo, J., Gomez-Manzano, C., Alemany, R., Lee, P. S., McDonnell, T. J., Mitlianga, P., Shi, Y. X., Levin, V. A., Yung, W. K., Kyritsis, A. P. A Mutant Oncolytic Adenovirus Targeting the Rb Pathway Produces Anti-glioma Effect in vivo. Oncogene 19, 2-12 (2000).
-
(2000)
Oncogene
, vol.19
, pp. 2-12
-
-
Fueyo, J.1
Gomez-Manzano, C.2
Alemany, R.3
Lee, P.S.4
McDonnell, T.J.5
Mitlianga, P.6
Shi, Y.X.7
Levin, V.A.8
Yung, W.K.9
Kyritsis, A.P.10
-
64
-
-
0033782862
-
An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy
-
Heise, C., Hermiston, T., Johnson, L., Brooks, G., Sampson-Johannes, A., Williams, A., Hawkins, L., Kirn, D. An Adenovirus E1A Mutant that Demonstrates Potent and Selective Systemic Anti-tumoral Efficacy. Nat. Med. 6, 1134-1139 (2000).
-
(2000)
Nat. Med.
, vol.6
, pp. 1134-1139
-
-
Heise, C.1
Hermiston, T.2
Johnson, L.3
Brooks, G.4
Sampson-Johannes, A.5
Williams, A.6
Hawkins, L.7
Kirn, D.8
-
65
-
-
0036494383
-
Treatment of ovarian cancer with a tropism modified oncolytic adenovirus
-
Bauerschmitz, G. J., Lam, J. T., Kanerva, A., Suzuki, K., Nettelbeck, D. M., Dmitriev, I., Krasnykh, V., Mikheeva, G. V., Barnes, M. N., Alvarez, R. D., Dall, P., Alemany, R., Curiel, D. T., Hemminki, A. Treatment of Ovarian Cancer with a Tropism Modified Oncolytic Adenovirus. Cancer Res. 62, 1266-1270 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 1266-1270
-
-
Bauerschmitz, G.J.1
Lam, J.T.2
Kanerva, A.3
Suzuki, K.4
Nettelbeck, D.M.5
Dmitriev, I.6
Krasnykh, V.7
Mikheeva, G.V.8
Barnes, M.N.9
Alvarez, R.D.10
Dall, P.11
Alemany, R.12
Curiel, D.T.13
Hemminki, A.14
-
66
-
-
0035503241
-
A midkine promoter-based conditionally replicative adenovirus for treatment of pediatric solid tumors and bone marrow tumor purging
-
Adachi, Y., Reynolds, P. N., Yamamoto, M., Wang, M., Takayama, K., Matsubara, S., Muramatsu, T., Curiel, D. T. A Midkine Promoter-based Conditionally Replicative Adenovirus for Treatment of Pediatric Solid Tumors and Bone Marrow Tumor Purging. Cancer Res. 61, 7882-7888 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 7882-7888
-
-
Adachi, Y.1
Reynolds, P.N.2
Yamamoto, M.3
Wang, M.4
Takayama, K.5
Matsubara, S.6
Muramatsu, T.7
Curiel, D.T.8
-
67
-
-
0036112191
-
E1B-55K-deleted adenovirus expressing E1A-13S by AFP-enhancer/promoter is capable of highly specific replication in AFP-producing hepatocellular carcinoma and eradication of established tumor
-
Takahashi, M., Sato, T., Sagawa, T., Lu, Y., Sato, Y., Iyama, S., Yamada, Y., Fukaura, J., Takahashi, S., Miyanishi, K., Yamashita, T., Sasaki, K., Kogawa, K., Hamada, H., Kato, J., Niitsu, Y. E1B-55K-Deleted Adenovirus Expressing E1A-13S by AFP-enhancer/promoter is Capable of Highly Specific Replication in AFP-producing Hepatocellular Carcinoma and Eradication of Established Tumor. Mol. Ther. 5, 627-634 (2002).
-
(2002)
Mol. Ther.
, vol.5
, pp. 627-634
-
-
Takahashi, M.1
Sato, T.2
Sagawa, T.3
Lu, Y.4
Sato, Y.5
Iyama, S.6
Yamada, Y.7
Fukaura, J.8
Takahashi, S.9
Miyanishi, K.10
Yamashita, T.11
Sasaki, K.12
Kogawa, K.13
Hamada, H.14
Kato, J.15
Niitsu, Y.16
-
68
-
-
0030790684
-
Prostate attenuated replication competent adenovirus (ARCA) CN706: A selective cytotoxic for prostate-specific antigen-positive prostate cancer cells
-
Rodriguez, R., Schuur, E. R., Lim, H. Y., Henderson, G. A., Simons, J. W., Henderson, D. R. Prostate Attenuated Replication Competent Adenovirus (ARCA) CN706: A Selective Cytotoxic for Prostate-specific Antigen-positive Prostate Cancer Cells. Cancer Res. 57, 2559-2563 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 2559-2563
-
-
Rodriguez, R.1
Schuur, E.R.2
Lim, H.Y.3
Henderson, G.A.4
Simons, J.W.5
Henderson, D.R.6
-
69
-
-
0033199188
-
The addition of adenovirus type 5 region E3 enables calydon virus 787 to eliminate distant prostate tumor xenografts
-
Yu, D. C., Chen, Y., Seng, M., Dilley, J., Henderson, D. R. The Addition of Adenovirus Type 5 Region E3 Enables Calydon Virus 787 to Eliminate Distant Prostate Tumor Xenografts. Cancer Res. 59, 4200-4203 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 4200-4203
-
-
Yu, D.C.1
Chen, Y.2
Seng, M.3
Dilley, J.4
Henderson, D.R.5
-
70
-
-
0012714587
-
A model system for the design of armed replicating adenoviruses using p53 as a candidate transgene
-
Haviv, Y. S., Takayama, K., Glasgow, J. N., Blackwell, J. L., Wang, M., Lei, X., Curiel, D. T. A Model System for the Design of Armed Replicating Adenoviruses Using p53 as a Candidate Transgene. Mol. Cancer Ther. 1, 321-328 (2002).
-
(2002)
Mol. Cancer Ther.
, vol.1
, pp. 321-328
-
-
Haviv, Y.S.1
Takayama, K.2
Glasgow, J.N.3
Blackwell, J.L.4
Wang, M.5
Lei, X.6
Curiel, D.T.7
-
71
-
-
0032503659
-
A novel three-pronged approach to kill cancer cells selectively: Concomitant viral, double suicide gene, and radiotherapy
-
Freytag, S. O., Rogulski, K. R., Paielli, D. L., Gilbert, J. D., Kim, J. H. A Novel Three-pronged Approach to Kill Cancer Cells Selectively: Concomitant Viral, Double Suicide Gene, and Radiotherapy. Hum. Gene Ther. 9, 1323-1333 (1998).
-
(1998)
Hum. Gene Ther.
, vol.9
, pp. 1323-1333
-
-
Freytag, S.O.1
Rogulski, K.R.2
Paielli, D.L.3
Gilbert, J.D.4
Kim, J.H.5
-
72
-
-
0033556003
-
Therapy of colon cancer is enhanced by the addition of herpes simplex virus thymidine kinase
-
Wildner, O., Blaese, R. M., Morris, J. C. Therapy of Colon Cancer is Enhanced by the Addition of Herpes Simplex Virus Thymidine Kinase. Cancer Res. 59, 410-413 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 410-413
-
-
Wildner, O.1
Blaese, R.M.2
Morris, J.C.3
-
73
-
-
0032922211
-
Adenoviral vectors capable of replication improve the efficacy of HSVtk/GCV suicide gene therapy of cancer
-
Wildner, O., Morris, J. C., Vahanian, N. N., Ford, H., Jr., Ramsey, W. J., Blaese, R. M. Adenoviral Vectors Capable of Replication Improve the Efficacy of HSVtk/GCV Suicide Gene Therapy of Cancer. Gene Ther. 6, 57-62 (1999).
-
(1999)
Gene Ther.
, vol.6
, pp. 57-62
-
-
Wildner, O.1
Morris, J.C.2
Vahanian, N.N.3
Ford H., Jr.4
Ramsey, W.J.5
Blaese, R.M.6
-
74
-
-
0015311426
-
Anti-angiogenesis: New concept for therapy of solid tumors
-
Folkman, J. Anti-angiogenesis: New Concept for Therapy of Solid Tumors. Ann. Surg. 175, 409-416 (1972).
-
(1972)
Ann. Surg.
, vol.175
, pp. 409-416
-
-
Folkman, J.1
-
75
-
-
0031469819
-
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
-
Boehm, T., Folkman, J., Browder, T., O'Reilly, M. S. Antiangiogenic Therapy of Experimental Cancer does not Induce Acquired Drug Resistance. Nature 390, 404-407 (1997).
-
(1997)
Nature
, vol.390
, pp. 404-407
-
-
Boehm, T.1
Folkman, J.2
Browder, T.3
O'Reilly, M.S.4
-
76
-
-
13144262858
-
Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate
-
Goldman, C. K., Kendall, R. L., Cabrera, G., Soroceanu, L., Heike, Y., Gillespie, G. Y., Siegal, G. P., Mao, X., Bett, A. J., Huckle, W. R., Thomas, K. A., Curiel, D. T. Paracrine Expression of a Native Soluble Vascular Endothelial Growth Factor Receptor Inhibits Tumor Growth, Metastasis, and Mortality Rate. Proc. Natl Acad. Sci. USA 95, 8795-8800 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 8795-8800
-
-
Goldman, C.K.1
Kendall, R.L.2
Cabrera, G.3
Soroceanu, L.4
Heike, Y.5
Gillespie, G.Y.6
Siegal, G.P.7
Mao, X.8
Bett, A.J.9
Huckle, W.R.10
Thomas, K.A.11
Curiel, D.T.12
-
77
-
-
0036021883
-
Anti-tumor angiogenesis therapy using soluble receptors: Enhanced inhibition of tumor growth when soluble fibroblast growth factor receptor-1 is used with soluble vascular endothelial growth factor receptor
-
Ogawa, T., Takayama, K., Takakura, N., Kitano, S., Ueno, H. Anti-tumor Angiogenesis Therapy Using Soluble Receptors: Enhanced Inhibition of Tumor Growth When Soluble Fibroblast Growth Factor Receptor-1 is used with Soluble Vascular Endothelial Growth Factor Receptor. Cancer Gene Ther. 9, 633-640 (2002).
-
(2002)
Cancer Gene Ther.
, vol.9
, pp. 633-640
-
-
Ogawa, T.1
Takayama, K.2
Takakura, N.3
Kitano, S.4
Ueno, H.5
-
78
-
-
0027970092
-
Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma
-
O'Reilly, M. S., Holmgren, L., Shing, Y., Chen, C., Rosenthal, R. A., Moses, M., Lane, W. S., Cao, Y., Sage, E. H., Folkman, J. Angiostatin: A Novel Angiogenesis Inhibitor that Mediates the Suppression of Metastases by a Lewis Lung Carcinoma. Cell 79, 315-328 (1994).
-
(1994)
Cell
, vol.79
, pp. 315-328
-
-
O'Reilly, M.S.1
Holmgren, L.2
Shing, Y.3
Chen, C.4
Rosenthal, R.A.5
Moses, M.6
Lane, W.S.7
Cao, Y.8
Sage, E.H.9
Folkman, J.10
-
79
-
-
0031454617
-
Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
-
O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N., Vasios, G., Lane, W. S., Flynn, E., Birkhead, J. R., Olsen, B. R., Folkman, J. Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth. Cell 88, 277-285 (1997).
-
(1997)
Cell
, vol.88
, pp. 277-285
-
-
O'Reilly, M.S.1
Boehm, T.2
Shing, Y.3
Fukai, N.4
Vasios, G.5
Lane, W.S.6
Flynn, E.7
Birkhead, J.R.8
Olsen, B.R.9
Folkman, J.10
-
80
-
-
0036606007
-
rAAV-mediated long-term liver-generated expression of an angiogenesis inhibitor can restrict renal tumor growth in mice
-
Davidoff, A. M., Nathwani, A. C., Spurbeck, W. W., Ng, C. Y., Zhou, J., Vanin, E. F. rAAV-mediated Long-term Liver-generated Expression of an Angiogenesis Inhibitor can Restrict Renal Tumor Growth in Mice. Cancer Res. 62, 3077-3083 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 3077-3083
-
-
Davidoff, A.M.1
Nathwani, A.C.2
Spurbeck, W.W.3
Ng, C.Y.4
Zhou, J.5
Vanin, E.F.6
-
81
-
-
0034667462
-
Treatment of colorectal liver metastases by adenoviral transfer of tissue inhibitor of metalloproteinases-2 into the liver tissue
-
Brand, K., Baker, A. H., Perez-Canto, A., Possling, A., Sacharjat, M., Geheeb, M., Arnold, W. Treatment of Colorectal Liver Metastases by Adenoviral Transfer of Tissue Inhibitor of Metalloproteinases-2 into the Liver Tissue. Cancer Res. 60, 5723-5730 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 5723-5730
-
-
Brand, K.1
Baker, A.H.2
Perez-Canto, A.3
Possling, A.4
Sacharjat, M.5
Geheeb, M.6
Arnold, W.7
-
82
-
-
0035937312
-
AdTIMP-2 inhibits tumor growth, angiogenesis, and metastasis, and prolongs survival in mice
-
Li, H., Lindenmeyer, F., Grenet, C., Opolon, P., Menashi, S., Soria, C., Yeh, P., Perricaudet, M., Lu, H. AdTIMP-2 Inhibits Tumor Growth, Angiogenesis, and Metastasis, and Prolongs Survival in Mice. Hum. Gene Ther. 12, 515-526 (2001).
-
(2001)
Hum. Gene Ther.
, vol.12
, pp. 515-526
-
-
Li, H.1
Lindenmeyer, F.2
Grenet, C.3
Opolon, P.4
Menashi, S.5
Soria, C.6
Yeh, P.7
Perricaudet, M.8
Lu, H.9
-
83
-
-
0036839094
-
Enforced expression of tissue inhibitor of matrix metalloproteinase-3 affects functional capillary morphogenesis and inhibits tumor growth in a murine tumor model
-
Spurbeck, W. W., Ng, C. Y., Strom, T. S., Vanin, E. F., Davidoff, A. M. Enforced Expression of Tissue Inhibitor of Matrix Metalloproteinase-3 Affects Functional Capillary Morphogenesis and Inhibits Tumor Growth in a Murine Tumor Model. Blood 100, 3361-3368 (2002).
-
(2002)
Blood
, vol.100
, pp. 3361-3368
-
-
Spurbeck, W.W.1
Ng, C.Y.2
Strom, T.S.3
Vanin, E.F.4
Davidoff, A.M.5
-
85
-
-
17444427673
-
Differential susceptibility of primary and established human glioma cells to adenovirus infection: Targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer
-
Miller, C. R., Buchsbaum, D. J., Reynolds, P. N., Douglas, J. T., Gillespie, G. Y., Mayo, M. S., Raben, D., Curiel, D. T. Differential Susceptibility of Primary and Established Human Glioma Cells to Adenovirus Infection: Targeting via the Epidermal Growth Factor Receptor Achieves Fiber Receptor-independent Gene Transfer. Cancer Res. 58, 5738-5748 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 5738-5748
-
-
Miller, C.R.1
Buchsbaum, D.J.2
Reynolds, P.N.3
Douglas, J.T.4
Gillespie, G.Y.5
Mayo, M.S.6
Raben, D.7
Curiel, D.T.8
-
86
-
-
0035114089
-
Efficient oncolysis by a replicating adenovirus (Ad) in vivo is critically dependent on tumor expression of primary Ad receptors
-
Douglas, J. T., Kim, M., Sumerel, L. A., Carey, D. E., Curiel, D. T. Efficient Oncolysis by a Replicating Adenovirus (Ad) in vivo is Critically Dependent on Tumor Expression of Primary Ad Receptors. Cancer Res. 61, 813-817 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 813-817
-
-
Douglas, J.T.1
Kim, M.2
Sumerel, L.A.3
Carey, D.E.4
Curiel, D.T.5
-
87
-
-
0036710714
-
The therapeutic efficacy of adenoviral vectors for cancer gene therapy is limited by a low level of primary adenovirus receptors on tumour cells
-
Kim, M., Zinn, K. R., Barnett, B. G., Sumerel, L. A., Krasnykh, V., Curiel, D. T., Douglas, J. T. The Therapeutic Efficacy of Adenoviral Vectors for Cancer Gene Therapy is Limited by a Low Level of Primary Adenovirus Receptors on Tumour Cells. Eur. J. Cancer 38, 1917-1926 (2002).
-
(2002)
Eur. J. Cancer
, vol.38
, pp. 1917-1926
-
-
Kim, M.1
Zinn, K.R.2
Barnett, B.G.3
Sumerel, L.A.4
Krasnykh, V.5
Curiel, D.T.6
Douglas, J.T.7
-
88
-
-
0037012664
-
Targeted adenoviral vectors
-
Barnett, B. G., Crews, C. J., Douglas, J. T. Targeted Adenoviral Vectors. Biochim. Biophys. Acta 1575, 1-14 (2002).
-
(2002)
Biochim. Biophys. Acta
, vol.1575
, pp. 1-14
-
-
Barnett, B.G.1
Crews, C.J.2
Douglas, J.T.3
-
89
-
-
0036154758
-
Targeting adenovirus to the serotype 3 receptor increases gene transfer efficiency to ovarian cancer cells
-
Kanerva, A., Mikheeva, G. V., Krasnykh, V., Coolidge, C. J., Lam, J. T., Mahasreshti, P. J., Barker, S. D., Straughn, M., Barnes, M. N., Alvarez, R. D., Hemminki, A., Curiel, D. T. Targeting Adenovirus to the Serotype 3 Receptor Increases Gene Transfer Efficiency to Ovarian Cancer Cells. Clin. Cancer Res. 8, 275-280 (2002).
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 275-280
-
-
Kanerva, A.1
Mikheeva, G.V.2
Krasnykh, V.3
Coolidge, C.J.4
Lam, J.T.5
Mahasreshti, P.J.6
Barker, S.D.7
Straughn, M.8
Barnes, M.N.9
Alvarez, R.D.10
Hemminki, A.11
Curiel, D.T.12
-
90
-
-
0031775399
-
An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism
-
Dmitriev, I., Krasnykh, V., Miller, C. R., Wang, M., Kashentseva, E., Mikheeva, G., Belousova, N., Curiel, D. T. An Adenovirus Vector with Genetically Modified Fibers Demonstrates Expanded Tropism via Utilization of a Coxsackievirus and Adenovirus Receptor-independent Cell Entry Mechanism. J. Virol. 72, 9706-9713 (1998).
-
(1998)
J. Virol.
, vol.72
, pp. 9706-9713
-
-
Dmitriev, I.1
Krasnykh, V.2
Miller, C.R.3
Wang, M.4
Kashentseva, E.5
Mikheeva, G.6
Belousova, N.7
Curiel, D.T.8
-
91
-
-
0032765539
-
An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approaches
-
Vanderkwaak, T. J., Wang, M., Gomez-Navarro, J., Rancourt, C., Dmitriev, I., Krasnykh, V., Barnes, M., Siegal, G. P., Alvarez, R., Curiel, D. T. An Advanced Generation of Adenoviral Vectors Selectively Enhances Gene Transfer for Ovarian Cancer Gene Therapy Approaches. Gynecol. Oncol. 74, 227-234 (1999).
-
(1999)
Gynecol. Oncol.
, vol.74
, pp. 227-234
-
-
Vanderkwaak, T.J.1
Wang, M.2
Gomez-Navarro, J.3
Rancourt, C.4
Dmitriev, I.5
Krasnykh, V.6
Barnes, M.7
Siegal, G.P.8
Alvarez, R.9
Curiel, D.T.10
-
92
-
-
0037094237
-
In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus
-
Hemminki, A., Zinn, K. R., Liu, B., Chaudhuri, T. R., Desmond, R. A., Rogers, B. E., Barnes, M. N., Alvarez, R. D., Curiel, D. T. In vivo Molecular Chemotherapy and Noninvasive Imaging with an Infectivity-enhanced Adenovirus. J. Natl Cancer Inst. 94, 741-749 (2002).
-
(2002)
J. Natl. Cancer Inst.
, vol.94
, pp. 741-749
-
-
Hemminki, A.1
Zinn, K.R.2
Liu, B.3
Chaudhuri, T.R.4
Desmond, R.A.5
Rogers, B.E.6
Barnes, M.N.7
Alvarez, R.D.8
Curiel, D.T.9
-
93
-
-
0032499531
-
Cell-specific viral targeting mediated by a soluble retroviral receptor-ligand fusion protein
-
Snitkovsky, S., Young, J. A. Cell-specific Viral Targeting Mediated by a Soluble Retroviral Receptor-ligand Fusion Protein. Proc. Natl Acad. Sci. USA. 95, 7063-7068 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7063-7068
-
-
Snitkovsky, S.1
Young, J.A.2
-
94
-
-
0028567517
-
Tissue-specific targeting of retroviral vectors through ligand-receptor interactions
-
Kasahara, N., Dozy, A. M., Kan, Y. W. Tissue-specific Targeting of Retroviral Vectors Through Ligand-receptor Interactions. Science 266, 1373-1376 (1994).
-
(1994)
Science
, vol.266
, pp. 1373-1376
-
-
Kasahara, N.1
Dozy, A.M.2
Kan, Y.W.3
-
95
-
-
0034192369
-
Molecular engineering of matrix-targeted retroviral vectors incorporating a surveillance function inherent in von Willebrand factor
-
Hall, F. L., Liu, L., Zhu, N. L., Stapfer, M., Anderson, W. F., Beart, R. W., Gordon, E. M. Molecular Engineering of Matrix-targeted Retroviral vectors Incorporating a Surveillance Function Inherent in von Willebrand Factor. Hum. Gene Ther. 11, 983-993 (2000).
-
(2000)
Hum. Gene Ther.
, vol.11
, pp. 983-993
-
-
Hall, F.L.1
Liu, L.2
Zhu, N.L.3
Stapfer, M.4
Anderson, W.F.5
Beart, R.W.6
Gordon, E.M.7
-
96
-
-
0029917238
-
Targeting of retroviral vectors through protease-substrate interactions
-
Nilson, B. H., Morling, F. J., Cosset, F. L., Russell, S. J. Targeting of Retroviral Vectors Through Protease-substrate Interactions. Gene Ther. 3, 280-286 (1996).
-
(1996)
Gene Ther.
, vol.3
, pp. 280-286
-
-
Nilson, B.H.1
Morling, F.J.2
Cosset, F.L.3
Russell, S.J.4
-
97
-
-
0036764768
-
Dual targeting of adenoviral vectors at the levels of transduction and transcription enhances the specificity of gene expression in cancer cells
-
Barnett, B. G., Tillman, B. W., Curiel, D. T., Douglas, J. T. Dual Targeting of Adenoviral Vectors at the Levels of Transduction and Transcription Enhances the Specificity of Gene Expression in Cancer Cells. Mol. Ther. 6, 377-385 (2002).
-
(2002)
Mol. Ther.
, vol.6
, pp. 377-385
-
-
Barnett, B.G.1
Tillman, B.W.2
Curiel, D.T.3
Douglas, J.T.4
-
98
-
-
0031975059
-
Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11
-
Danks, M. K., Morton, C. L., Pawlik, C. A., Potter, P. M. Overexpression of a Rabbit Liver Carboxylesterase Sensitizes Human Tumor Cells to CPT-11. Cancer Res. 58, 20-22 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 20-22
-
-
Danks, M.K.1
Morton, C.L.2
Pawlik, C.A.3
Potter, P.M.4
-
99
-
-
0035392940
-
A virus-directed enzyme prodrug therapy approach to purging neuroblastoma cells from hematopoietic cells using adenovirus encoding rabbit carboxylesterase and CPT-11
-
Meck, M. M., Wierdl, M., Wagner, L. M., Burger, R. A., Guichard, S. M., Krull, E. J., Harris, L. C., Potter, P. M., Danks, M. K. A Virus-directed Enzyme Prodrug Therapy Approach to Purging Neuroblastoma Cells from Hematopoietic Cells using Adenovirus Encoding Rabbit Carboxylesterase and CPT-11. Cancer Res. 61, 5083-5089 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 5083-5089
-
-
Meck, M.M.1
Wierdl, M.2
Wagner, L.M.3
Burger, R.A.4
Guichard, S.M.5
Krull, E.J.6
Harris, L.C.7
Potter, P.M.8
Danks, M.K.9
-
100
-
-
0036731992
-
Efficacy and toxicity of a virus-directed enzyme prodrug therapy purging method: Preclinical assessment and application to bone marrow samples from neuroblastoma patients
-
Wagner, L. M., Guichard, S. M., Burger, R. A., Morton, C. L., Straign, C. M., Ashmun, R. A., Harris, L. C., Houghton, P. J., Potter, P. M., Danks, M. K. Efficacy and Toxicity of a Virus-directed Enzyme Prodrug Therapy Purging Method: Preclinical Assessment and Application to Bone Marrow Samples from Neuroblastoma Patients. Cancer Res. 62, 5001-5007 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 5001-5007
-
-
Wagner, L.M.1
Guichard, S.M.2
Burger, R.A.3
Morton, C.L.4
Straign, C.M.5
Ashmun, R.A.6
Harris, L.C.7
Houghton, P.J.8
Potter, P.M.9
Danks, M.K.10
-
101
-
-
0031437780
-
A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy
-
Marais, R., Spooner, R. A., Stribbling, S. M., Light, Y., Martin, J., Springer, C. J. A Cell Surface Tethered Enzyme Improves Efficiency in Gene-directed Enzyme Prodrug Therapy. Nat. Biotechnol. 15, 1373-1377 (1997).
-
(1997)
Nat. Biotechnol.
, vol.15
, pp. 1373-1377
-
-
Marais, R.1
Spooner, R.A.2
Stribbling, S.M.3
Light, Y.4
Martin, J.5
Springer, C.J.6
-
102
-
-
0037086075
-
Three new prodrugs for suicide gene therapy using carboxypeptidase G2 elicit bystander efficacy in two xenograft models
-
Friedlos, F., Davies, L., Scanlon, I., Ogilvie, L. M., Martin, J., Stribbling, S. M., Spooner, R. A., Niculescu-Duvaz, I., Marais, R., Springer, C. J. Three New Prodrugs for Suicide Gene Therapy Using Carboxypeptidase G2 Elicit Bystander Efficacy in Two Xenograft Models. Cancer Res. 62, 1724-1729 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 1724-1729
-
-
Friedlos, F.1
Davies, L.2
Scanlon, I.3
Ogilvie, L.M.4
Martin, J.5
Stribbling, S.M.6
Spooner, R.A.7
Niculescu-Duvaz, I.8
Marais, R.9
Springer, C.J.10
-
103
-
-
0028795075
-
In vivo adenovirus-mediated gene transfer of the Escherichia coli cytosine deaminase gene to human colon carcinoma-derived tumors induces chemosensitivity to 5-fluorocytosine
-
Hirschowitz, E. A., Ohwada, A., Pascal, W. R., Russi, T. J., Crystal, R. G. In vivo Adenovirus-mediated Gene Transfer of the Escherichia Coli Cytosine Deaminase Gene to Human Colon Carcinoma-derived Tumors Induces Chemosensitivity to 5-fluorocytosine. Hum. Gene Ther. 6, 1055-1063 (1995).
-
(1995)
Hum. Gene Ther.
, vol.6
, pp. 1055-1063
-
-
Hirschowitz, E.A.1
Ohwada, A.2
Pascal, W.R.3
Russi, T.J.4
Crystal, R.G.5
-
104
-
-
0032526178
-
Preferential cytotoxicity of cells transduced with cytosine deaminase compared to bystander cells after treatment with 5-flucytosine
-
Lawrence, T. S., Rehemtulla, A., Ng, E. Y., Wilson, M., Trosko, J. E., Stetson, P. L. Preferential Cytotoxicity of Cells Transduced with Cytosine Deaminase Compared to Bystander Cells after Treatment with 5-flucytosine. Cancer Res. 58, 2588-2593 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 2588-2593
-
-
Lawrence, T.S.1
Rehemtulla, A.2
Ng, E.Y.3
Wilson, M.4
Trosko, J.E.5
Stetson, P.L.6
-
105
-
-
0031941292
-
Regional 'Prodrug' gene therapy: Intravenous administration of an adenoviral vector expressing the E. coli cytosine deaminase gene and systemic administration of 5-fluorocytosine suppresses growth of hepatic metastasis of colon carcinoma
-
Topf, N., Worgall, S., Hackett, N. R., Crystal, R. G. Regional 'Prodrug' Gene Therapy: Intravenous Administration of an Adenoviral Vector Expressing the E. Coli Cytosine Deaminase Gene and Systemic Administration of 5-fluorocytosine Suppresses Growth of Hepatic Metastasis of Colon Carcinoma. Gene Ther. 5, 507-513 (1998).
-
(1998)
Gene Ther.
, vol.5
, pp. 507-513
-
-
Topf, N.1
Worgall, S.2
Hackett, N.R.3
Crystal, R.G.4
-
106
-
-
0034660849
-
Combination of the bioreductive drug tirapazamine with the chemotherapeutic prodrug cyclophosphamide for P450/P450-reductase-based Cancer gene therapy
-
Jounaidi, Y., Waxman, D. J. Combination of the Bioreductive Drug Tirapazamine with the Chemotherapeutic Prodrug Cyclophosphamide for P450/P450-reductase-based Cancer Gene Therapy. Cancer Res. 60, 3761-3769 (2000).
-
(2000)
Cancer Res.
, vol.60
, pp. 3761-3769
-
-
Jounaidi, Y.1
Waxman, D.J.2
-
107
-
-
0035360868
-
Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy
-
Jounaidi, Y., Waxman, D. J. Frequent, Moderate-dose Cyclophosphamide Administration Improves the Efficacy of Cytochrome P-450/cytochrome P-450 Reductase-based Cancer Gene Therapy. Cancer Res. 61, 4437-4444 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 4437-4444
-
-
Jounaidi, Y.1
Waxman, D.J.2
-
108
-
-
0036894385
-
Enhanced bystander cytotoxicity of P450 gene-directed enzyme prodrug therapy by expression of the antiapoptotic factor p35
-
Schwartz, P. S., Chen, C. S., Waxman, D. J. Enhanced Bystander Cytotoxicity of P450 Gene-directed Enzyme Prodrug Therapy by Expression of the Antiapoptotic Factor p35. Cancer Res. 62, 6928-6937 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 6928-6937
-
-
Schwartz, P.S.1
Chen, C.S.2
Waxman, D.J.3
-
109
-
-
0027255414
-
Use of tissue-specific expression of the herpes simplex virus thymidine kinase gene to inhibit growth of established murine melanomas following direct intratumoral injection of DNA
-
Vile, R. G., Hart, I. R. Use of Tissue-specific Expression of the Herpes Simplex Virus Thymidine Kinase Gene to Inhibit Growth of Established Murine Melanomas Following Direct Intratumoral Injection of DNA. Cancer Res. 53, 3860-3864 (1993).
-
(1993)
Cancer Res.
, vol.53
, pp. 3860-3864
-
-
Vile, R.G.1
Hart, I.R.2
-
110
-
-
0029609610
-
Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954
-
Bridgewater, J. A., Springer, C. J., Knox, R. J., Minton, N. P., Michael, N. P., Collins, M. K. Expression of the Bacterial Nitroreductase Enzyme in Mammalian Cells Renders them Selectively Sensitive to Killing by the Prodrug CB1954. Eur. J. Cancer 31A, 2362-70 (1995).
-
(1995)
Eur. J. Cancer
, vol.31 A
, pp. 2362-2370
-
-
Bridgewater, J.A.1
Springer, C.J.2
Knox, R.J.3
Minton, N.P.4
Michael, N.P.5
Collins, M.K.6
-
111
-
-
0034988929
-
Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: A well-tolerated therapy for established solid tumors
-
Djeha, A. H., Thomson, T. A., Leung, H., Searle, P. F., Young, L. S., Kerr, D. J., Harris, P. A., Mountain, A., Wrighton, C. J. Combined Adenovirus-mediated Nitroreductase Gene Delivery and CB1954 Treatment: A Well-tolerated Therapy for Established Solid Tumors. Mol. Ther. 3, 233-240 (2001).
-
(2001)
Mol. Ther.
, vol.3
, pp. 233-240
-
-
Djeha, A.H.1
Thomson, T.A.2
Leung, H.3
Searle, P.F.4
Young, L.S.5
Kerr, D.J.6
Harris, P.A.7
Mountain, A.8
Wrighton, C.J.9
-
112
-
-
0036494169
-
Quantitation of bystander effects in nitroreductase suicide gene therapy using three-dimensional cell cultures
-
Wilson, W. R., Pullen, S. M., Hogg, A., Helsby, N. A., Hicks, K. O., Denny, W. A. Quantitation of Bystander Effects in Nitroreductase Suicide Gene Therapy Using Three-dimensional Cell Cultures. Cancer Res. 62, 1425-1432 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 1425-1432
-
-
Wilson, W.R.1
Pullen, S.M.2
Hogg, A.3
Helsby, N.A.4
Hicks, K.O.5
Denny, W.A.6
-
113
-
-
0031580711
-
In vivo gene therapy of cancer with E. coli purine nucleoside phosphorylase
-
Parker, W. B., King, S. A., Allan, P. W., Bennett, L. L., Jr., Secrist, J. A., 3rd, Montgomery, J. A., Gilbert, K. S., Waud, W. R., Wells, A. H., Gillespie, G. Y., Sorscher, E. J. In vivo Gene Therapy of Cancer with E. Coli Purine Nucleoside Phosphorylase. Hum. Gene Ther. 8, 1637-1644 (1997).
-
(1997)
Hum. Gene Ther.
, vol.8
, pp. 1637-1644
-
-
Parker, W.B.1
King, S.A.2
Allan, P.W.3
Bennett L.L., Jr.4
Secrist J.A. III5
Montgomery, J.A.6
Gilbert, K.S.7
Waud, W.R.8
Wells, A.H.9
Gillespie, G.Y.10
Sorscher, E.J.11
-
114
-
-
0031914978
-
Cell to cell contact is not required for bystander cell killing by Escherichia coli purine nucleoside phosphorylase
-
Hughes, B. W., King, S. A., Allan, P. W., Parker, W. B., Sorscher, E. J. Cell to Cell Contact is not Required for Bystander Cell Killing by Escherichia Coli Purine Nucleoside Phosphorylase. J. Biol. Chem. 273, 2322-2328 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 2322-2328
-
-
Hughes, B.W.1
King, S.A.2
Allan, P.W.3
Parker, W.B.4
Sorscher, E.J.5
-
115
-
-
0033759371
-
In vivo sensitization of ovarian tumors to chemotherapy by expression of E. coli purine nucleoside phosphorylase in a small fraction of cells
-
Gadi, V. K., Alexander, S. D., Kudlow, J. E., Allan, P., Parker, W. B., Sorscher, E. J. In vivo Sensitization of Ovarian Tumors to Chemotherapy by Expression of E. Coli Purine Nucleoside Phosphorylase in a Small Fraction of Cells. Gene Ther. 7, 1738-1743 (2000).
-
(2000)
Gene Ther.
, vol.7
, pp. 1738-1743
-
-
Gadi, V.K.1
Alexander, S.D.2
Kudlow, J.E.3
Allan, P.4
Parker, W.B.5
Sorscher, E.J.6
-
116
-
-
0033993506
-
Secreted human beta-glucuronidase: A novel tool for gene-directed enzyme prodrug therapy
-
Weyel, D., Sedlacek, H. H., Muller, R., Brusselbach, S. Secreted Human Beta-glucuronidase: A Novel Tool for Gene-directed Enzyme Prodrug Therapy. Gene Ther. 7, 224-231 (2000).
-
(2000)
Gene Ther.
, vol.7
, pp. 224-231
-
-
Weyel, D.1
Sedlacek, H.H.2
Muller, R.3
Brusselbach, S.4
|