The telomerase reverse transcriptase promoter drives efficacious tumor suicide gene therapy while preventing hepatotoxicity encountered with constitutive promoters

Gene Therapy

Volumn 8, Issue 7, 2001, Pages 568-578

  Majumdar, A S ^a   Hughes, D E ^a,b   Lichtsteiner, S P ^a,c   Wang, Z ^a   Lebkowski, J S ^a   Vasserot, A P ^a,d  

^a GERON CORPORATION   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^d Applied Molecular Evolution   (United States)

Author keywords

Adenoviral vectors; hTERT promoter; Human telomerase reverse transcriptase (hTERT); Liver toxicity; Thymidine kinase

Indexed keywords

ANTIBIOTIC G 418; GANCICLOVIR; GENE PRODUCT; LIVER ENZYME; RNA DIRECTED DNA POLYMERASE; SODIUM CHLORIDE; TELOMERASE; THYMIDINE KINASE; VIRUS VECTOR;

ADENOVIRUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CANCER SURVIVAL; CANCER TRANSPLANTATION; CATALYSIS; CELL IMMORTALIZATION; CELL LINE; CONTROLLED STUDY; CYTOMEGALOVIRUS; DISEASE SEVERITY; DRUG ACTIVITY; DRUG POTENTIATION; DRUG SENSITIVITY; ENZYME BLOOD LEVEL; ENZYME SUBUNIT; GENE CASSETTE; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INSERTION; GENE THERAPY; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN CELL; LIVER FUNCTION; LIVER TOXICITY; MOUSE; NONHUMAN; OSTEOSARCOMA; PRIORITY JOURNAL; PROMOTER REGION; SILENT GENE; SUICIDE GENE; TRANSCRIPTION REGULATION; TRANSGENE; TUMOR; TUMOR CELL; TUMOR CELL LINE; TUMOR GROWTH; TUMOR REGRESSION; TUMOR XENOGRAFT;

ADENOVIRIDAE; ANIMALS; DNA-BINDING PROTEINS; GANCICLOVIR; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE THERAPY; GENETIC VECTORS; HUMANS; LIVER DISEASES; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; OSTEOSARCOMA; PROMOTER REGIONS (GENETICS); RNA; RNA, MESSENGER; SURVIVAL RATE; TELOMERASE; THYMIDINE KINASE; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; ANIMALIA; CYTOMEGALOVIRUS; HERPES; MUS MUSCULUS; SIMPLEXVIRUS; TUMOR VIRUS;

EID: 0035030329     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301421     Document Type: Article

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