A transcriptional feedback loop for tissue-specific expression of highly cytotoxic genes which incorporates an immunostimulatory component

Gene Therapy

Volumn 8, Issue 13, 2001, Pages 987-998

  Emiliusen, L ^a   Gough, M ^a   Bateman, A ^a   Ahmed, A ^a   Voellmy, R ^b   Chester, J ^a,c   Diaz, R M ^a   Harrington, K ^a,d   Vile, R ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^c ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^d INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Fusogenic proteins; Heat shock factor; hsp70; Retroviral vectors; Tissue specific expression

Indexed keywords

CYTOTOXIC FACTOR; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; MONOPHENOL MONOOXYGENASE; TRANSCRIPTION FACTOR; TUMOR VACCINE; VIRUS VECTOR;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL KILLING; CONTROLLED STUDY; CYTOTOXICITY; FEEDBACK SYSTEM; GENE ACTIVATION; GENE AMPLIFICATION; GENE EXPRESSION; GENE INDUCTION; GENE MUTATION; GENETIC SCREENING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; LONG TERMINAL REPEAT; MELANOMA CELL; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; RETROVIRUS; TISSUE SPECIFICITY; VACCINATION; VIRUS HYBRID;

ANIMALS; BLOTTING, WESTERN; CANCER VACCINES; CELL DEATH; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC VECTORS; HUMANS; IMMUNIZATION; MELANOMA; MICE; MICE, NUDE; MONOPHENOL MONOOXYGENASE; NEOPLASM TRANSPLANTATION; PLASMIDS; PROMOTER REGIONS (GENETICS); RETROVIRIDAE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0034933220     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301470     Document Type: Article

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