Pifithrin-α supresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis

Neuroscience

Volumn 120, Issue 1, 2003, Pages 191-205

  Zhang, M ^a,c   Liu, W ^b   Ding, D ^a   Salvi, R ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

Caspase 1; Caspase 3; Cochlea; Hair cells; Protection; Utricle

Indexed keywords

CASPASE 3; CISPLATIN; INTERLEUKIN 1BETA CONVERTING ENZYME; PIFITHRIN ALPHA; PROTEIN INHIBITOR; PROTEIN P53; UNCLASSIFIED DRUG; BENZOTHIAZOLE DERIVATIVE; DRUG DERIVATIVE; PIFITHRIN; THIAZOLE DERIVATIVE; TOLUENE;

ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY LABELING; APOPTOSIS; ARTICLE; CELL CULTURE; CELL SURVIVAL; COCHLEA; CONCENTRATION RESPONSE; CONTROLLED STUDY; HAIR CELL; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; VESTIBULE; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; FISCHER 344 RAT; IN VITRO STUDY; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOLOGY; PHYSIOLOGY;

ANIMALS; APOPTOSIS; BENZOTHIAZOLES; CISPLATIN; COCHLEA; DOSE-RESPONSE RELATIONSHIP, DRUG; HAIR CELLS, VESTIBULAR; ORGAN CULTURE TECHNIQUES; RATS; RATS, INBRED F344; THIAZOLES; TOLUENE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0037490192     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(03)00286-0     Document Type: Article

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