Detection of single-stranded DNA (ssDNA) in the vestibule of guinea pigs after the application of cisplatinum (CDDP)

Anticancer Research

Volumn 21, Issue 2 A, 2001, Pages 1135-1138

  Watanabe, K I ^a   Jinnouchi, K ^a   Yagi, T ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Apoptosis; Cisplatinum (CDDP); Ototoxicity; Single stranded DNA (ssDNA); Vestibule

Indexed keywords

CISPLATIN; DNA FRAGMENT; PARAFFIN; SINGLE STRANDED DNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; INNER EAR; NEUROEPITHELIUM; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; TEMPORAL BONE; VESTIBULE;

ANIMALS; ANTINEOPLASTIC AGENTS; CISPLATIN; DNA, SINGLE-STRANDED; GUINEA PIGS; IMMUNOENZYME TECHNIQUES; VESTIBULE;

EID: 0035002364     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. A review of cis-platinum ototoxicity
2. Pathophysiology of the ototoxicity of cis-diamminedichloroplatinum
3. Cisplatin vestibular ototoxicity: Preliminary report
4. Cis-platinum vestibular toxicity
5. Inner ear histopathology in patients treated with cis-platinum
6. Cisplatin-induced lipid peroxidation and decrease of gluconeogenesis and free radical scavengers
7. Expression of inducible nitric oxide synthase (iNOS / NOS II) in the vestibule of guinea pigs after the application of cisplatin
8. NOS-inhibitor blocks ototoxic side effect of CDDP in the guinea pigs
9. Expression of myeloperoxidase (MPO) in the Cisplatinum (CDDP) treated inner ear
10. The biochemistry of cell death by apoptosis
11. Apoptotic death of hair cells in mammalian vestibular sensory epithelia
12. Cisplatin-induced apoptotic cell death in Mongolian gerbil cochlea
13. Apoptosis
14. Caspases: Enemies Within
15. Antibody against single-stranded DNA detects both programmed cell death and drug-induced apoptosis
16. In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states
17. Detection of apoptotic cells in human colorectal cancer by two different in situ methods: Antibody against single-stranded DNA and Terminal Deoxynucleotidyl Transferase-mediated dUTP-biotin Nick end-labeling (TUNEL) methods
18. Evidence for the involvement of nitric oxide in cisplatin-treated toxicity in rats
19. Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants
20. NOS-inhibitor reduces the apoptotoic change in the cisplatinum (CDDP) treated cochlea of the guinea pigs
21. Pharmacological interventions to reduce platinum-induced toxicity
22. Murine peritoneal macrophages treated with cisplatin and interferon-g undergo NO-mediated apoptosis via activation of an endonuclease
23. Cisplatin induced vestibular damage
24. Distribution, structure, and function of dark cells in the vestibular labyrinth