Nitric oxide synthase inhibitor reduces the apoptotic change in the cisplatin-treated cochlea of guinea pigs

Anti-Cancer Drugs

Volumn 11, Issue 9, 2000, Pages 731-735

  Watanabe, Ken Ichi ^a   Hess, Alexander ^b   Michel, Olaf ^b   Yagi, Toshiaki ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b UNIVERSITY OF COLOGNE   (Germany)

Author keywords

Anti NOS drug; Apoptosis; Cisplatin; Nitric oxide; Ototoxicity; Single stranded DNA

Indexed keywords

CISPLATIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; COCHLEA; CONTROLLED STUDY; DRUG EFFECT; GUINEA PIG; NONHUMAN; OTOTOXICITY; PRIORITY JOURNAL; STRIA VASCULARIS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CISPLATIN; COCHLEA; DNA FRAGMENTATION; DNA, SINGLE-STRANDED; ENZYME INHIBITORS; GUINEA PIGS; IMMUNOHISTOCHEMISTRY; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE;

EID: 0033669739     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200010000-00010     Document Type: Article

References (24)

1. Evidence for the involvement of nitric oxide in cisplatin-treated toxicity in rats
2. Direct detection of ototoxicant-induced reactive oxygen species generation in cochlear explants
3. Nitric oxide: Physiology, pathophysiology, and pharmacology
4. Expression of inducible nitric oxide synthase (iNOS/NOS II) in the hydropic cochlea of guinea pigs
5. Expression of inducible Nitric Oxide Synthase (iNOS/NOS II) in the cochlea of guinea pigs after intratympanical endotoxin-treatment
6. Nitric oxide synthase inhibitor suppresses the ototoxic side effect of cisplatin in guinea pigs
7. Inhibition of inducible nitric oxide synthase lowers the cochlear damage by lipopolysaccharide in guinea pigs
8. A review of cis-platinum ototoxicity
9. Pathophysiology of the ototoxidty of cis-diammineclichloroplatinum
10. Carboplatin and cisplatin ototoxicity in guinea pigs
11. Pharmacological interventions to reduce platinum-induced toxicity
12. Murine peritoneal macrophages treated with cisplatin and interferon-γ undergo NO-mediated apoptosis via activation of an endonuclease
13. Cisplatin-induced lipid peroxidation and decrease of gluconeogenesis and radical scavengers
14. Nitric oxide synthases in mammals
15. Antibody against single-stranded DNA detects both programmed cell death and drug-induced apoptosis
16. An adherent cell model to study different stages of apoptosis
17. In situ end-labelling detects DNA strand breaks in apoptosis and other physiological and pathological states
18. Detection of apoptotic cells in human colorectal cancer by two different in situ methods: Antibody against single-stranded DNA and Terminal Deoxynucleotidyl Transferase-mediated dUTP-biotin Nick end-labeling (TUNEL) methods
19. Cisplatin-induced apoptotic cell death in Mongolian gerbil cochlea
20. Dose-dependent inner ear changes after I.V. administration of cisplatin
21. Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures
22. Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures
23. Cis-diammine-dichloroplatinum (II) ototoxicity in the guinea pig
24. Vulnerability of the organ of Corti in poisoning