Differential damage to auditory neurons and hair cells by ototoxins and neuroprotection by specific neurotrophins in rat cochlear organotypic cultures

European Journal of Neuroscience

Volumn 8, Issue 9, 1996, Pages 1897-1905

  Zheng, J Lisa ^a   Gao, Wei Qiang ^a  

^a GENENTECH INC   (United States)

Author keywords

Aminoglycosides; Aspirin; Cisplatin; Cochlea; Gentamicin; Hearing; Inner ear; Salicylate

Indexed keywords

CISPLATIN; FLUORESCEIN ISOTHIOCYANATE; GENTAMICIN; MONOCLONAL ANTIBODY; NERVE GROWTH FACTOR; NEUROFILAMENT PROTEIN; NEUROTROPHIC FACTOR; NEUROTROPHIN; NEUROTROPHIN 3; NEUROTROPHIN 4; PHALLOIDIN; SALICYLATE SODIUM;

ACOUSTIC NERVE FIBER; ANIMAL TISSUE; ARTICLE; CELL DEATH; COCHLEA; CONTROLLED STUDY; CULTURE MEDIUM; HAIR CELL; HEARING LOSS; INNERVATION; NERVE CELL DEGENERATION; NERVE CELL LESION; NEUROPROTECTION; NEWBORN; NONHUMAN; ORGAN CULTURE; OTOTOXICITY; PRIORITY JOURNAL; RAT; SENSORY NERVE;

EID: 0029779890     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1460-9568.1996.tb01333.x     Document Type: Article

References (26)

1. Anniko, M. and Sobin, A. (1986) Cisplalin: evaluation of its ototoxic potential. Am. J. Otolaryngol., 7, 276-293.
2. Barbacid, M. (1993) The Trk family of neurotrophin receptors: molecular characterization and oncogenic activation in human tumors. In Levin, A. G. and Schmidek, H. H. (eds), Molecular Genetics of Nervous System Tumors. Wiley-Liss, New York, pp. 123-136.
3. Boettcher, F. A., Bancroft, B. R., Salvi, R. J. and Henderson, D. (1990) Concentration of salicylate in serum and perilymph of the chinchilla. Arch. Otolaryngol. Head Neck Surg., 116, 681-684.
4. Chardin, S. and Romand, R. (1995) Regeneration and mammalian auditory hair cells. Science, 267, 707-709.
5. Despres, G. and Romand, R. (1994) Neurotrophins and the development of cochlear innervation. Life Sci., 54, 1291-1297.
6. Ernfors, P., Van De Water, T., Loring, J. and Jaenisch, R. (1995) Complementary roles of BDNF and NT-3 in vestibular and auditory development. Neuron, 14, 1153-1164.
7. Fariñas, I., Jones, K. R., Backus, C., Wang, X.-Y. and Reichardt, L. F. (1994) Severe sensory and sympathetic deficits in mice lacking neurotrophins-3. Nature, 369, 658-661.
8. Fleischman, R. W., Stadnicki, S. W., Ethier, M. F. and Schaeppi, U. (1975) Ototoxicity of cis-dichlorodiammine platinum (II) in the guinea pig. Toxicol. Appl. Pharmacol., 33, 320-332.
9. Forge, A., Li, L., Corwin, J. T. and Nevill, G. (1993) Ultrastructural evidence for hair cell regeneration in the mammalian inner ear. Science, 259, 1616-1619.
10. Fritzsch, B., Silos-Santiago, I., Smeyne, R., Fagan, A. M. and Barbacid, M. (1995) Reduction and loss of inner ear innervation in trkB and trkC receptor knockout mice: a whole mount Dil and scanning electron microscopic analysis. Auditory Neurosci., 1, 401-417.
11. Gao, W.-Q. and Zheng, J. L. (1995) Differential ototoxicity of salicylate, gentamicin and cisplatin and protective effects of specific neurotrophins in cochlear expiant cultures. Soc. Neurosci. Abstr., 21, 1054.
12. Gao, W.-Q., Heitz, N. and Hatten, M. E. (1991) Cerebellar granule cell neurogenests is regulated by cell-cell interactions in vitro. Neuron, 6, 705-715.
13. Gao, W.-Q., Zheng, J. L. and Karihaloo, M. (1995a) Neurotrophin-4/5 (NT-4/5) and brain-derived neurotrophic factor (BDNF) act at later stages of cerebellar granule cell differentiation. J. Neurosci., 15, 2656-2667.
14. Gao, W.-Q., Dybdal, N., Shinsky, N., Murnane, A., Schmelzer, C., Siegel, M., Keller, G., Hefti, F., Phillips, H. S. and Winslow, J. W. (1995b) Neurotrophin-3 reverses experimental cisplatin-induced peripheral sensory neuropathy. Ann. Neurol., 38, 30-37.
15. Hefti, F. (1986) Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after fimbrial transections. J. Neurosci., 6, 2155-2162.
16. Kelley, M. W., Xu, X.-M., Wagner, M. A., Warchol, M. E. and Corwin, J. T. (1993) The developing organ of Corti contains retinoic acid and forms upernumerary hair cells in response to exogenous retinoic acid in culture. Development, 119, 1041-1053.
17. Kopf-Maier, P. and Muhlhausen, S. K. (1992) Changes in the cytoskeleton pattern of tumor cells by cisplatin in vitro. Chein. Biol. Interact., 82, 295-316.
18. Korsching, S. (1993) The neurotrophic factor concept: a reexamination. J. Neurosci., 13, 2739-2748.
19. Lambert, P. R. (1994) Inner ear hair cell regeneration in a mammal: identification of a triggering factor. Laryngoscope, 104, 701-718.
20. Leake, P. A., Snyder, R. L., Hradek, G. T. and Rebscher, S. J. (1992) Chronic intracochlear electrical stimulation in neonatally deafened cats: effects of intensity and stimulating electrode location. Hear. Res., 64, 99-117.
21. Lefebvre, P. P., Malgrange, B., Staecker, H., Moonen, G. and Van De Water, T. R. (1993) Retinoic acid stimulates regeneration of mammalian auditory hair cells. Science, 260, 692-695.
22. Lefebvre, P. P., Malgrange, B., Staecher, H., Moghadass, M., Van De Water, T. R. and Moonen, G. (1994) Neurotrophins affect survival and neuritogenesis by adult injured auditory neurons in vitro, NeuroReport, 5, 865-868.
23. Lefebvre, P. P., Malgrange, B., Moonen, G. and Van De Water, T. R. (1995) Response: Regeneration and mammalian auditory hair cells. Science, 267, 709-711.
24. Lippe, W. R., Hathaway, O. and Parlotz, D. (1995) Loss of avian spiral ganglion neurons following aminoglycoside-induced hair cell loss and regeneration. Assoc. Res. Otolaryngol. Abstr., p. 84.
25. McAlpine, D. and Johnstone, B. M. (1990) The ototoxic mechanism of cisplatin. Hear. Res., 47, 191-204.
26. Minichiello, L., Piehl, F., Vazquez, E., Schimmang, T., Hökfelt, T., Represa, J. and Klein, R. (1995) Differential effects of combined trk receptor mutations on dorsal root ganglion and inner ear sensory neurons. Development, 121, 4067-4075.